Acute Promyelocytic Leukema (aPML) - AML/ M3 Subtype - t(15;17) - Vitamin A (ATRA) - Hematology
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- čas přidán 23. 07. 2018
- Acute Promyelocytic Leukema (aPML) - Acute Myeloid Leukemia (AML) Subtype: M3 - AML/ M3 Subtype - t(15;17) - Vitamin A (ATRA) - Hematology.
Acute Promyelocytic Leukema (aPML) is a chromosomal translocation: t(15;17) translocation...AML-M3 is associated with disseminated intravascular coagulation (DIC)...Treated with ATRA (tretinoin) which is vitamin A (can cause differentiation syndrome). aPML can also be treated with Arsenic trioxide.
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MALTomas caused by H. pylori can be treated with antibiotics aimed at eradicating H. pylori. Also ,there is a class of antibiotic chemotherapy including doxorubicin ,bleomycin ,etc. used in various cancers.
You’re excellent
You know you've peaked when medicosis tells you that you're excellent.
MALT lymphomas caused by Helicobacter pylori infection in gastric mucosa can be treated with antibiotic therapy aimed at eradicating the organism... If not successful, gentle oral chemotherapy... Nice question BTW, 😂👍👍
Excellent! You got it...Very well done 👍
Damm, nicee
LEUKEMIA: APML |Acute Promyelocytic Leukemia: Symptoms, Pathology, Diagnosis, Treatment; AML
Man!! The work you're doing is simply amazing, best medical channel by far!! Love your way of explaining!
APL patient right now. 4 months in. Incredible adventure out of the blue. Getting treated with ATRA and Arsenic. Dealing with side effects but staying positive. A long way to go and hopefully i can get those words of cancer free this coming year of 2021. I'm having a grand kid baby boom and i need to be here with them. I pray.. Amen..
I wish you the best!
Keep fighting!
This type of cancer is treatable. Don’t give up!
Gmoney, I was diagnosed last Mothers Day. I initially presented with a vicious staph infection in my arm pit. The ER drained it and sent me home. The next day I couldn't get out of the bed, the next day I had blood pooling under my skin, brown urine, rolling fever and sever fatigue.
Day 3 after the staph drain I was back at the ER. Diagnosed within 30 minutes but pending bone marrow sample. I spent 2 months in the hospital. The most concerning thing was falling and bleeding out. I had a nasty flareup of gout in my feet from the cancer dying off. Complete remission in 60 days and then home. At home for another month before starting outpatient infusion of Arsenic Triox, 4 weeks on then off for 4 cycles and ATRA 2 weeks on and off for 32 weeks.
I finished therapy in February. It was a total success. My only side effects has been mild neuropathy, meers lines in my nails. I had mild tachycardia from the Arsenic early on but it dissipated. I'm still not 100%, after being bedridden for almost 2 months I left the hospital walking like a newborn calf. Now I'm actually able to bench 300lbs and feel like my old life is coming back but with a new outlook. My oncologist told me there are no guarantees but my likelihood of APL returning is only about 10-15%. I'll take those odds all day. This illness can be conquered and attitude plays a lot into in. I never lost hope and never lost my sense of humor. My cancer ward nurses cried when I left and told me I was the best patient they had in years and loved my positive outlook.
Just wanted to share my story, you feel like you have a long way to go but the hardest part is behind you. Stay safe and God bless.
M
Keep fighting . You got this
Great ! I always become happy and less stressed when i find a hard topic explained by this channel ! Thanks
My pleasure 😇
you deserve way more views! amazing videos and simple and understandable explanations! thank you:))
That’s awesome...I can’t thank you enough! Can you help me by sharing these videos, please? Thanks again :)
RARA gene is located on 17 and PML on 15! We need lots more APML research on youtube :)
Thank you soooooo so so much!!! Amazing explanation :) I'll be sharing with my med students colleagues.
Great u really help me in studying during quarantine 🙏❤️🇮🇶thanks from Iraq
1. Dactinomycin is highly potent in Wilms tumor / childhood rhabdomyosarcoma
2. Bleomycin might be used in testicular cancer
3. Donorubicin / doxorubicin might be used .. but is cardiotoxic
Antibiotics: Anthracyclins which include doxorubicin; Included in the ABVD regimen for Hodgkin's Lymphoma
Thank you for sharing this video filled with quality and value. I was diagnosed with APL and I’m currently being treated with ATRA and Arsenic. Amazing how this can and is being treated.
You’re welcome...I am sorry that you are facing this...How is your health now?
Medicosis Perfectionalis I’m on day 14 of 30 in the inpatient setting. The first couple days were difficult I think it was the shock. But so far I haven’t had any side effects, I’m treated well and I’m glad to know it’s a rare but highly treatable form of leukemia. Long road ahead but definitely life changing.
I wish you speedy recovery, bro...If you have any question, please let me know...Good luck and stay happy!
Medicosis Perfectionalis I appreciate the positivity! Like many say, it could be worse. I’m glad science has come a long way to help folks like me. Won’t be easy but we all continue to fight.
Indeed! I believe you will come out stronger! Keep fighting and don’t let it beat you.
Great content thank you, just a quick remark: RARA is on C17 not 15!
Thank you for this video.
Ur vids really make me feel great 😊😊..thanks a lot!
My pleasure 😊
I haven't found any comment on it but I may have overseen it. Treatment of APL is not vitamin A or arsenic. It is combination of both. vitamin A treatment only will lead to remission but is not persistent and will lead to relapse in nearly all cases
Great work Bro.(as usual) I think you mixed up the breakpoints for the two genes on the chromosomes... I think it's 15 fr PML and 17 for RARa... Not like it's so important.. just for clarification purposes... Great job again...
It actually is important because personally I almost died from this cancer and my rara count is checked periodically. There also is not enough information about apl leukemia on CZcams
you are right
Very informative and entertaining!
Thank you so much 😊
Gastric MALTomas caused by H pylori can b ttt by Antibiotics. Am I right?
Excellent! That was a tough one...very well done 👍
@@MedicosisPerfectionalis But this MALT gastric lymphoma should be low grade. The high grade is obviously surgical. But yeah, give triple eradication therapy and eradicate the cancer as well. Medicine is cool.
Thanks for this channel
You’re very welcome 😊
Would you please help me by sharing?
Excellent video!
Thanks!
in the last case the blast was 9% why we don"t suspect CML ? is that because of the t (15:17) mutation ?
شكراا شرح متقن جدا.
My pleasure 😇
Yay vitamins are used!!😍
I’m just a simple person not studying for a test or anything I just wanted to know! So happy. Still wonder if iron pills are used.
You guys have fun with these science terms lol hope you all pass😁
Thank you so much 😊
Yes, iron pills are still used for patients who are iron deficient.
@@MedicosisPerfectionalis Awesome. I think I get what cancer is now. It’s a lot simpler than I thought. The lymph nodes try to contain it wherever the cancer is. The immune system is attacked and responds with no real fight power😞. It is a strange but easy to follow disease. Wherever it goes it just ruins organs.
Your vids are as always epic.
thank you for your helpful topics!!!
My pleasure 😇
Hello ! Please why did you say that 9% of blasts make us think of a Leukemia? As we need à 20% of blasts in Bone marrow Biopsy to be able to say it's a Leukemia... Thank you again for the amazing job you are doing !
anthracyclines are antibiotics that are used as chemotherapy
PML GENE is on chromosome 15 and RAR on 17 ...
Actinomycin D, the -rubicins, and I think bleomycin are all anti-tumor antibiotics
just finished my chemo. 4 months going every day plus atra pills! went into remission after first month and everything went the way they said it would. just have one last bone marrow test. only bad thing that happened was a bit of differentiation syndrome for 3 days. so stopped chemo and started back when it went away(3 days later)
yes antibiotics can be used as an antineoplastic drugs, daunorubicin is used to treat acute leukemias
What else?
Great video i love it thanks
Thanks a lot for taking the time to share that with me...I am so grateful!
Sorry if my english bad, I have something to ask.
My dad (59 year old) diagnosed with AML and the doctor told us to cure it with atra medicine. The doctor told us it will only take 3-4 months untill my dad recover, but it's already 4 months and nothing much happens to my dad condition. Is there any way to cure it? Because the doctor said there is no chemotherapy for my dad disease. Thank you!
Why 9% basts? In APL There are abnormal promyelocytes. Promyelocytes are not blast; actually they are next stage of blast ( myeloblast). Is not it?
Your videos are just amazing!
Is the Antibiotic Meant for H Pylori infection treatment?
Excellent!
The OCLAM regimen is meant to eradicate the H. Pylori bacteria.
شكرًا! 🌟
😊😊
Question: Where is your accent from? I am wanting to say one of the baltic/eastern euro countries. Great video as always thank you so much :)
I am Egyptian...and thank you for watching :)
Explosion, You know accents only from (poor) movies, obviously.
Why the blast in the question is 9%? Isn’t it should be more than 20%? And thank u for ur great videos ^^
genetic translocation already mentioned in question stem which is diagnostic
Thank you for this
My pleasure 😇
Very helpful. I like ur vdos
Thank you 🙏
Why is the clinical case only have 9% blast peripheral smear? Isn't all acute leukemia supposedly have greater than 20% blast?
Here's one to add to the '3's memory aid…… 3 chromosomes: 15, 16, and 17, to remember t(15:17)
Really informative videos! Wanted to know why can promyelocytic anemia (M3) lead to DIC specifically?
I don't know 🤷♂️
Because of auer rods present especially in m3 variety of blast cells...when patient is given chemotherapy the cells get destroyed increases the auer rods in blood leads to activation of coagulation cascade results in DIC.
I always end up wanting some lemonade after your lessons :(
🍋 🥤 Enjoy 😉
Stunning demonstration!!
Wow 🤩
Thank you 🙏
Hy I am from India and iam a patient of apml I am trated with arsenox and atra can you tell me how many months I am go for this treatment
Can you tell me how many months for this treatment please?
Great video
Thank you 🙏
Can vitamin A tablates intake is prevention of APML r
please answer me how can 9% blast cell lead to diagnosis of LEUKEMIA( ALL)????
Good question.
To diagnose acute leukemia, the blasts should constitute more than 10% of THE BONE MARROW.
In the case, The 9% blasts was in the peripheral smear, not the bone marrow.
Got it? 😉
@@MedicosisPerfectionalis yess i got it exactly. Thank you.
You’re welcome :)
Poison and Vitamin made me laugh 😀
😊😊😊
yes i have a question when you can teach so damn great and explain everything in a great detail that even my PHD teachers can not then why don't you just add the cytological images to make your content unbeatable at any level?
Thank you so much 😊
Copyright © is the answer to your question!
amazing..thanks
My pleasure 😇
Make an video on Rheumatoid arthritis
Coming soon 👌
Hi there, in some notes it says that CML presents with anaemia and thrombocytosis with basophiia, mostly asymptomatic except for splenomegaly and the anaemia. Is this true?
Which notes? Mine?
@@MedicosisPerfectionalis No sorry on passmed (a uk revision website)
My husband died from this type of leukemia, 4 days after he was diagnosed that it was leukemia.
I am so sorry!
thank u so much
My pleasure 😇
how it is AML and the blast are just 9%??
That’s a good point...It should have been higher
after the new WHO classification its no longer named M3 its now one of the AML w recurrent genetics abnormality t (15,17)
and its no longer to have more than 20% of blast to diagnose the genetic abnormalities is enough
Correct
U R Great❤️❤️
Thanks a ton!
Pierson 30 years old has M3 leukemia
It's treatable or not? I mean it's can be treated for ever ?
It’s treatable.
Talk to your doctor.
Which antibiotic used in the treatment of cancer?
Watch my video on MALToma.
To say a leukemia to be acute, does the blast count need to be more than 20% in bone marrow only or also in peripheral blood
The diagnosis (definition) is based on the bone marrow.
@@MedicosisPerfectionalis thanks
Why is it AML if there are less than 10% blasts....????
The t(15;17) is diagnostic.
وضرب لنا مثلا ونسي خلقه قال من يحيي العظام وهي رميم قل يحييها الذي أنشأها أول مرة وهو بكل خلق عليم
Plz when you speak about treatment point to dose and side effect of chemotherapy
I will do side effects in Pharmacology....Doses will take a lot of time and not required for most students in the medical field...Thanks!
@@MedicosisPerfectionalis i am not a medical student, I AM A SINIOR RESIDEN OF HEMATOLOGICAL DISEASES
but thank you too much you presented very well i liked your presentation too much be continue plz
make an app for android or iphon
I am honored... Thank you so much!
every day i listen you vedios 2 to 3 times you are good presentater thank you too much
Rara on chr 17 while apml on chr 15
Correct
Vincristine and vinblastine anticancer antibiotics?
Nope...Please try again!
Love you 🎉❤
i have very low blood cells but everything else is fine in my body. I''m 21 years old. the doctors today said that they think i have APML. they will get the report within 48 hours. i'm an international student in italy all alone by myself. they say that they can fix it without chemo with the medicine only and i have to be hospitalised for atleast one month. how is the prognosis rate in my case?
are you doing okey right now?
كيف حالك الان ؟
Thank youuu so muchh..
My pleasure 😇
You mentioned RARA on chromosome 15 and PML on chromosome 17, isn't it just reverse!!!
You’re right...All my mistakes are corrected on my website in a PDF titled: “mistakes in my videos.”.
www.medicosisperfectionalis.com/
Thank u .. But plz DIC is an abbrv for what ?
Disseminated intravascular coagulation
Polium b
???
im lovin it smile 😊
Thank you 😊
How it happen
Reason for having APl?
Cancer has an unknown etiology...We don’t know the cause.
Tq sir🎉🎉🎉
My pleasure 😇
Dear sir,. APML Cancer curable or not curable
👏👍
👏👏👏👏👏👏👏❤️💯
Dic is common complication, but you spend 15 minutes explaining what leukemia is. Should invest more time on your lectures