iMetaOmics | Salmonella-Host-microbiota interactions: Immunity and metabolism

Salmonella-Host-microbiota interactions: Immunity and metabolism
Bingxin Tang, Wenwen Cui, Xiao Li, Huan Yang
First published: 04 July 2024 doi.org/10.100...
Bingxin Tang and Wenwen Cui contributed equally to this work.
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Salmonella is a group of zoonotic pathogens that causes intestinal infections, primarily transmitted through contaminated food or water. Salmonella invasion can trigger intestinal inflammation and exploit the electron receptors produced by inflamed cells to promote its infectivity [1]. Moreover, Salmonella-containing vacuole (SCV) can form within infected macrophages, which enables Salmonella to effectively evade the host immune response. Infected macrophages undergo a reprogramming of cellular oxidative metabolism, producing metabolic byproducts that serve as an energy source for Salmonella and as virulence activation signals, thus promoting further infection.