3.Anticholinergic Drugs / Muscarinic antagonists (Antimuscarinic agents) -Part 3
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3.Anticholinergic Drugs / Muscarinic antagonists (Antimuscarinic agents) -Part 3
Muscarinic antagonists (antimuscarinic agents) are a group of anticholinergic drugs that competitively inhibit postganglionic muscarinic receptors. As such, they have a variety of applications that involve the parasympathetic nervous system. Which organ systems are most affected by an antimuscarinic agent depends on the specific characteristics of the agent, particularly its lipophilicity. Lipophilic agents (i.e., atropine or benztropine) are able to cross the blood-brain barrier and therefore affect the central nervous system (CNS) in addition to other organ systems. Less lipophilic agents (i.e., ipratropium or butylscopolamine) are administered if the CNS does not need to be targeted, specifically for respiratory (e.g., asthma), gastrointestinal (e.g., irritable bowel syndrome), or genitourinary applications (e.g., urinary incontinence). Numerous adverse effects have been reported, the most common of which is dry mouth. An overdose can result in anticholinergic syndrome, which manifests in disorientation, hyperthermia, tachycardia, and/or coma. To avoid toxicity, it is especially important to consider the anticholinergic effects of other drug classes before administering muscarinic antagonists.
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Dr i have no real words to say how much i am excited and wanna appreciated your presentations. Be blessed and i hope long live. 👏👏👏👏👍👍👍. Thanks so much🙏🙏🙏
You are most welcome.
Thank you so much sir..simply you teach these,very helpful..
Thank u soo much sir💓
Thanks a lot sir.
Most welcome
I think there is wrong about M2 receptor at pre-synaptic, it should be nicotinic receptor, so the bradycardia is due to M2 receptor at post-synaptic and the tachycardia is due to stimulation of nicotinic receptor at pre-synaptic. Correct me if i'm wrong
Sir,pls explain in detail history taking and case presentation of ENT, Ophthal , and community practical exam cases in detail.plsplsplsplsplsplsplsplsplsplspls sir.
Sir which book you refer
Sir ye konsi books ka reference haii
I am ISM Student
nicee
Video is very nice. But would be even better if some things were more clarified . For example, for new 3rd year students it would be beneficial if it would be explained why there is reflex bronchospasm during general anesthesia hence the use of glycopyrolate.
Right it is my wish
may allah guides you in the light of islam
Explanation kaha hai ? Sirf action bataya hai
It makes sense that atropine would lead to tachycardia by acting on the M2 receptor on the SA node, but the initial effect of bradycardia doesn't make sense. What does presynaptic M receptor mean?
Normally, binding of ACh to presynaptic Muscarinic autoreceptors inhibits the further release of ACh into the synaptic cleft. When these autoreceptors are blocked by atropine, there will be no more inhibition of ACh release.... so excess ACh is released which acts on postsynaptic M2 receptors on heart and causes Bradycardia