CRUX: safety of ruxolitinib in newly-diagnosed high-grade gliomas

Manmeet Ahluwalia, MD, MBA, FASCO, Baptist Health South Florida, Miami, FL, presents findings from a toxicity report of a Phase I trial (NCT03514069) of ruxolitinib, a JAK inhibitor, with radiotherapy in patients with newly-diagnosed high-grade gliomas. Patients with MGMT unmethylated and methylated gliomas received ruxolitinib and radiotherapy with and without temozolomide respectively. Ruxolitinib and radiotherapy with temozolomide is a promising therapy, where no dose limiting toxicities were reported. This interview took place at the American Society of Clinical Oncology (ASCO) 2023 Annual Congress in Chicago, IL.
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