47. Assessment of Initial Depressive State and Pain Relief With Ketamine in Patients With Chronic Re

Drug management of chronic pain with antidepressants, antiepileptics, and opioids remains inconclusive, as 60% of patients show little improvement, experience adverse effects, and often require other treatment options.1,2 Ketamine, a nonselective N-methyl-D-aspartate receptor (NMDAR) antagonist with anesthetic properties, can relieve chronic pain.3-5 A recent clinical study3 in patients with refractory chronic pain identified distinct pain relief trajectories with variables that are associated with the response to a single dose of ketamine according to pain characteristics, level of anxiety, depression, or quality of life.