TGF-Beta Receptor | Structure and Dimerization

The Transforming Growth Factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway. These receptors bind growth factor and cytokine signaling proteins in the TGF-beta family such as TGFβs (TGFβ1, TGFβ2, TGFβ3), bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activin and inhibin, myostatin, anti-Müllerian hormone (AMH), and NODAL.
The TGF beta ligand binds to a type II receptor dimer, which recruits a type I receptor dimer forming a hetero-tetrameric complex with the ligand.[4] These receptors are serine/threonine kinase receptors. They have a cysteine rich extracellular domain, a transmembrane domain and a cytoplasmic serine/threonine rich domain. The GS domain of the type I receptor consists of a series of about thirty serine-glycine repeats.The binding of a TGF beta family ligand causes the rotation of the receptors so that their cytoplasmic kinase domains are arranged in a catalytically favorable orientation. The Type II receptor phosphorylates serine residues of the Type I receptor, which activates the protein.
The TGF beta superfamily of ligands include: Bone morphogenetic proteins (BMPs), Growth and differentiation factors (GDFs), Anti-müllerian hormone (AMH), Activin, Nodal and TGFβ's.Signaling begins with the binding of a TGF beta superfamily ligand to a TGF beta type II receptor. The type II receptor is a serine/threonine receptor kinase, which catalyzes the phosphorylation of the Type I receptor. Each class of ligand binds to a specific type II receptor.In mammals there are seven known type I receptors and five type II receptors.

[@michaeleisenberg7867]

Shabir, It's absolutely amazing what the PhD students in the lab are discovering. Where all these cell components came from remains a mystery my brain is too small to comprehend--we're missing a billion years of data. Good job and thank you!!! Best Wishes, Michael E.

[@hussainbiology]

Thanks Sir...... And surely some researching is astonishing in labs

[@apurbamukherjee794]

Nicely explained in a very little amount of time. Thank you for such good videos

[@trboskogaming1144]

very good explanation..... we are waiting for next part of tif beta receptor

[@trboskogaming1144]

you are really excellent

[@mohdshahwaj5454]

Thank you sir
... Sir abhi aaya is topic pr... Or aapne abhi video upload ki..
Thank u❤

[@hussainbiology]

thanks for appreciation..Glad to know that it helps ✌️

[@prodbytj8271]

amazing video

[@hussainbiology]

Thanks!

[@ruqayayousuf53]

Amazing and helpful as usual
💜💜💜!Part2?

[@hussainbiology]

Part 2 very soon...

[@sanjaisrao484]

thanks

[@hussainbiology]

Welcome

[@biology_mcqs3037]

👌

[@sreekuttys5921]

Thanku very much

[@hussainbiology]

most welcome

[@TALKyLIKEENGLISH]

😍

[@innayatullahkhan1185]

good work, through which software, you are creating animation of your videos?

[@hussainbiology]

Final Cut Pro

[@mishaldar4563]

What will happen if MH2 instead of MH1 of Smad 4
contains nuclear localization segment? can you please explain

[@hussainbiology]

I think only importin dependent import will get affected since MH1 interacts with importin ( A lysine-rich motif present in the Smad4 MH1 domain bipartites NLS motif for interaction with importin α and facilitating nuclear import of Smad4 )....
So if we have NLS on MH2 importin independent transport will occur occur easily.

[@mohdshahwaj5454]

When will part 2 come.
?

[@shinebright1151]

Wow Sir, your voice is like Sharukh Khan. ☺☺☺

[@hussainbiology]

Thanks for appreciation....
BTW level of Sarcasm is too high😁

[@nishatfatima2091]

👍

[@evamadaan4933]

From which books you prefer cell biology

[@hussainbiology]

Mostly I study Alberts Cell Biology and Lodish Cell Biology...But in my opinion Lodish provides more holistic approach for every topic out there.

[@afeefawani2295]

❤❤️💕💕💞💞

[@godsmagic9656]

Hi, how do I contact you?

[@hussainbiology]

[e-mail]

[@2dwlee]

잘못된 그림과 설명입니다. TGF beta는 생체내에서 이미 dimer 로 만들어져 존재하며, 설명한 것과 같이 monomeric TGF가 dimer가 되면서 receptor II의 dimerization을 촉진하지 않습니다. 과학은 과학자에게.