Types of Fill Material for soft gelatin capsules, base adsorption, minim per gram factor

‪@thepharmaguidechannel‬
Fill material in softgel capsules refers to the substance that you encapsulate or seal inside the gelatin shell.
Soft gelatin capsules contain a single liquid, a combination of miscible liquids, a solution of a drug in a liquid, or a suspension of a drug in a liquid. The liquids are limited to those that do not have an adverse effect on the gelatin walls.
Base adsorption is expressed as the number of grams of liquid base required to produce a capsulatable mixture when mixed with one gram of solid(s). It is influenced by factors as the solid's particle size and shape, physical state (fibrous, amorphous, or crystalline), density, its moisture content, and oleophilic or hydrophilic nature.
The minim per gram factor is the volume in minims that is occupied by one gram (S) of the solid plus the weight of liquid base (BA) required to make a capsulatable mixture.

[@ramasoni6309]

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