Thank you Dr. Ryan you are an effective teacher. All the way from Philippines 🇵🇭 I want to express my gratitude in all of your videos! Thank you Mental Dental 🦷
I think it is just CZcams's algorithm/code to mess up with people. I have never seen a video that has Zero dislike :)). Great videos, keep it up bro. Thank you!
Thank u v. much .. belive me this is the first time that i like to hear about pharma😣 .. always it was difficult until i heard u .. now pharma is much better 😍
Hello Ryan! Please please upload new pharma videos (like cardiovascular drugs and anti fungal drugs!) you’re awesome by making them so easy to understand and memorize (my exam is in June BTW hahaha)
really good videos cleared concept and also doesn't need to memorize, When will the anticholinergics adrenergic drugs video will come up? really looking forward one on that, exams approaching really very near.
Hi Ryan, thank you for all of your videos ! they are just awesome . I have a question though .. what is the difference between Tid and q8h ? both mean three times a day but what is the difference and uses of each ? your answer is much appreciated.
Hi there! That's a fantastic question. From a purely technical perspective, I see them as exactly the same because TID means three times per day and q8h means every 8 hours (which would again be three times in a 24-hour day). However, there are slight nuances to each of these. When you use BID or TID on a prescription, this is usually referring to whenever the patient is awake so TID may be once during each main meal (breakfast, lunch, and dinner), but q8h is a bit more strict meaning the medication should be spread out every 8 hours so as to maintain an appropriate therapeutic dose. Additionally, whenever "PRN" is used on a prescription this means "as needed" and is often used when prescribing something for pain. PRN is almost always paired with qXh as in q6h or q8h (instead of TID) because this clearly denotes that the medication can be taken every X hours as needed for pain. Hopefully this makes sense!
Rayan Hi could you please explain what you mean by having irreversible or reversible effect, not that I do not know what that means but in terms of drug effect I need to know a difference between for instance Aspirin being irreversible and Ibuprofen being reversible NSAIDs. Thanks
Hi there, aspirin and ibuprofen both work by inhibiting the COX 1 and 2 enzymes which catalyze the reaction to form prostaglandins. Aspirin is a bit "stronger" than ibuprofen in that it causes an irreversible inactivation of the cyclooxygenase enzyme rather than a reversible inactivation of it.
Thank you so much for these amazing videos. I have question regarding the acetaminophen you mentioned that it should not be use for patient with liver dysfunction. However, it should be safe to use it at low dose instead of giving NSAIDs as it should be avoided with liver dysfunction patients.
Good question, it's definitely a point of contention out there. If it were me, I'd go with 4000mg/day since it seems like that is what the board examiners are going with.
Hi Ryan quick question about that rule of 2s you mentioned I need to know if pt has fallowed this rule will need steroids perior to dental appointment?? or if pt used the amount you mentioned for 2 weeks in 2 years will develop this condition?? I did not get the idea because there are people out there using much higher dosage of steroids than what you said and not showing any side effects or at least as far as I know they don't need anything special before treatments. So if you can briefly explain the idea of rule of 2 that would be great
This is adapted from Little and Falace's "Dental Management of the Medically Compromised Patient." In general, if a patient has been on steroids for a long course and recently stopped it, the body has not had a chance to build up its own cortisol reserve. The Rule of Twos states that adrenal suppression may occur if a patient was taking 20 mg of cortisone or its equivalent daily, for 2 weeks within 2 years of the dental treatment. If they fall in this category, that is when you would consider corticosteroid supplementation prior to dental treatment to avoid an adrenal crisis.
Hey Doctor, in this video u said naloxone is inverse agonist, while decks says it is competitive antagonist in opioid overdose.. so which one is right?
You won’t have to know these nitty-gritty details for the board exam, but nitrous oxide can cause nausea due to its effects on the central nervous system and its potential to disturb the balance of neurotransmitters in the brain, leading to feelings of dizziness and queasiness. It may also have some direct effects on the gastrointestinal system.
Respiratory difficulties. Is that the mu2 receptors. FYI. Off topic legal and a good painkiller. Kratom. A leave made into tea that does not affect respiration. You may be interested in just knowing, it exists. Why because you are so good at what you do
Thanks for watching! For more high yield dental content, subscribe to Mental Dental today: czcams.com/users/mentaldental
I wish you never had to apologize for taking so long to explain these topics in such a simple manner!! God bless you..love always!!
Very nice and well explaind Dr Rayan. Many thanks for all your time and effort making all these videos. Thank you so much
Thank you so much for this information. I was looking for this the whole time!
Salute to you Dr. Rayan! You are slightly better than "BEST!"
Thank you Dr. Ryan you are an effective teacher. All the way from Philippines 🇵🇭 I want to express my gratitude in all of your videos! Thank you Mental Dental 🦷
Thanks again for your help Dr Ryan !
Hey thank you for these videos!
You are just an amazing teacher,its not soo long ,but could hear from you more on these imp topics..
Who would ever dislike any video you make ? Smh 🤦♂️ love you so much xx
Thank you for your kind words! We all have haters I guess, haha.
I think it is just CZcams's algorithm/code to mess up with people. I have never seen a video that has Zero dislike :)). Great videos, keep it up bro. Thank you!
Very helpful! Thank you doctor Ryan
Thank u v. much .. belive me this is the first time that i like to hear about pharma😣 .. always it was difficult until i heard u .. now pharma is much better 😍
Dr yousef from Persia.
What an amazing presentation.
Very helpful..
Thank you Dr Rayan.
Great videos. Thank you!
Thsnks a lot. I just found your channel and I really like it.
Awesome! Thank u so much and keep it up
Thank you so much for your videos
Hello Ryan! Please please upload new pharma videos (like cardiovascular drugs and anti fungal drugs!) you’re awesome by making them so easy to understand and memorize (my exam is in June BTW hahaha)
All your videos are great!! Would it be possible to upload more of them about pharmacology ?
Thanks so much., was very helpful !👍😊
really good videos cleared concept and also doesn't need to memorize,
When will the anticholinergics adrenergic drugs video will come up?
really looking forward one on that, exams approaching really very near.
Great job sir
Thank you so much Dr Ryan! 🌸
My pleasure!
Great teacher
Ur best of the best x thank youuuuu so much
thank you again !
Thanks 🙏, very clearly 👏🏻👏🏻👏🏻
Thank you for the information
dr that was very good
Thax u so much ,for u have simplified life here for mi
thank you
Thankyou so much😇
All those videos are fantastic. I hope one day i can meet you for thank you
Please! Do more pharma videos!!!
Thank you⚘⚘
Thank for
Tysm 😊
its a great video. bt i have a question. in theraputic and side effect of morphine .what u meant out of it??????can u explain???
Sir what is the difference between analgesic and nsaids?
Hi Ryan, thank you for all of your videos ! they are just awesome . I have a question though .. what is the difference between Tid and q8h ? both mean three times a day but what is the difference and uses of each ? your answer is much appreciated.
Hi there! That's a fantastic question. From a purely technical perspective, I see them as exactly the same because TID means three times per day and q8h means every 8 hours (which would again be three times in a 24-hour day). However, there are slight nuances to each of these. When you use BID or TID on a prescription, this is usually referring to whenever the patient is awake so TID may be once during each main meal (breakfast, lunch, and dinner), but q8h is a bit more strict meaning the medication should be spread out every 8 hours so as to maintain an appropriate therapeutic dose. Additionally, whenever "PRN" is used on a prescription this means "as needed" and is often used when prescribing something for pain. PRN is almost always paired with qXh as in q6h or q8h (instead of TID) because this clearly denotes that the medication can be taken every X hours as needed for pain. Hopefully this makes sense!
@@mentaldental Thank you so much for your answer, very informative and comprehensive.. really appreciate it :)
Thankyou so much
You are so welcome!
I found different values of maximum dose of Ibuprofen I found it 2400 mg/day , does it depend on the country like in Canada?
Yup, great find! It does look like the max dose differs depending on where you are. I always base my numbers on the US.
Rayan Hi could you please explain what you mean by having irreversible or reversible effect, not that I do not know what that means but in terms of drug effect I need to know a difference between for instance Aspirin being irreversible and Ibuprofen being reversible NSAIDs.
Thanks
Hi there, aspirin and ibuprofen both work by inhibiting the COX 1 and 2 enzymes which catalyze the reaction to form prostaglandins. Aspirin is a bit "stronger" than ibuprofen in that it causes an irreversible inactivation of the cyclooxygenase enzyme rather than a reversible inactivation of it.
Thank you so much for these amazing videos. I have question regarding the acetaminophen you mentioned that it should not be use for patient with liver dysfunction. However, it should be safe to use it at low dose instead of giving NSAIDs as it should be avoided with liver dysfunction patients.
I found the maximum dosage/day for Acetaminophen to be 3000 mg/day, which one is correct?
Good question, it's definitely a point of contention out there. If it were me, I'd go with 4000mg/day since it seems like that is what the board examiners are going with.
Please take more water 😄😄 a little humour from Dr.Ryan 21:48
Haha, yes. Have to stay hydrated! 😅
Hi Ryan quick question about that rule of 2s you mentioned I need to know if pt has fallowed this rule will need steroids perior to dental appointment?? or if pt used the amount you mentioned for 2 weeks in 2 years will develop this condition?? I did not get the idea because there are people out there using much higher dosage of steroids than what you said and not showing any side effects or at least as far as I know they don't need anything special before treatments. So if you can briefly explain the idea of rule of 2 that would be great
This is adapted from Little and Falace's "Dental Management of the Medically Compromised Patient." In general, if a patient has been on steroids for a long course and recently stopped it, the body has not had a chance to build up its own cortisol reserve. The Rule of Twos states that adrenal suppression may occur if a patient was taking 20 mg of cortisone or its equivalent daily, for 2 weeks within 2 years of the dental treatment. If they fall in this category, that is when you would consider corticosteroid supplementation prior to dental treatment to avoid an adrenal crisis.
Thanks a lot Rayan I really appreciate your response and love all your series about all topics you posted on youtube @@mentaldental
Hey Doctor, in this video u said naloxone is inverse agonist, while decks says it is competitive antagonist in opioid overdose.. so which one is right?
It has actually been shown to have both mechanisms of action, but I prefer to think of it as an inverse agonist as presented in the video.
@@mentaldental Okay Doctor Ryan. Thanks much :)
That was awesome and smoothly explained.. but why u are mentioning dental again and again is it not for other medical students??
I designed this series specifically for the dental board exams. However, this information can certainly be relevant for medical students as well!
I would appreciate it if you drank oral therapy my freind and thank you for all video's
Dr rayan, why is nitrous oxide side effect nausea? Like what is the reason?
You won’t have to know these nitty-gritty details for the board exam, but nitrous oxide can cause nausea due to its effects on the central nervous system and its potential to disturb the balance of neurotransmitters in the brain, leading to feelings of dizziness and queasiness. It may also have some direct effects on the gastrointestinal system.
what is the Analgesic drug of choice for heart diseased patients .
Acetaminophen is usually the recommended choice in those cases.
Respiratory difficulties. Is that the mu2 receptors. FYI. Off topic legal and a good painkiller. Kratom. A leave made into tea that does not affect respiration. You may be interested in just knowing, it exists. Why because you are so good at what you do
Doc , please update the Max dose of Ibuprofen to 2.4g a day
Godsend (nothing more needs to be said