New MS Medication Class [2022]
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- čas přidán 7. 09. 2024
- In this video, I introduce a new MS medication class that has me super excited! This new MS medication class brings tools to the table to treat MS that we've never seen before! Learn more- start watching NOW!
The Boster Center for Multiple Sclerosis is actively enrolling Clinical Trials in Multiple Sclerosis: www.BosterMS.com or call 614-304-3444 to to learn more!
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NOTE: Make sure to talk to your provider before ANY treatment decision. We hope to educate, empower and energize those impacted by Multiple Sclerosis. This channel consists of a collection of formal lectures and informal video clips about MS (and in this case, a New MS Medication Class) to help educate others. These videos do not provide medical advice and are for informational/educational purposes only. This one is just to teach you about a New MS Medication Class! The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any of our videos. They are just to help educate you about the condition guys!
Such exciting news!
#StrongerTogether #WeHaveMS BosterMS.com
@@AaronBosterMD thanks 😊 🙏
Almost 9pm on Thursday night down here in Australia. It takes quite a lot for me to get excited at this time of night
but I'm feeling pretty optimistic after seeing this one Dr. A 🙂 thanks fir putting a smile on my face, and a little bit of hope in my heart.
Oh Dr.Boster I am so thrilled!🙏
I have secondary MS and recently did a trial for Mayzent in Canada and because of the trial I was involved in, Mayzent I’d now available in Canada YAY!! 😉👍🏼
So the research and trials you are involved in bring me much hopefulness!👍🏼🥰
Bless you for all you do Dr B.🙏🫶🏻
Because of all your hard work ….You may live to see a cure or outright stop to MS 😉🫶🏻👍🏼
Is not I’d 😆
Secondary progressive MS 😉😆👍🏼
🤞
❤️ 🙏🏼
This is the most promising so far, and the best thing is no risk of infections! I hope these studies will finish well soon... Great news Dr B! Thank you for sharing! 🤓
Also being a fan of true crime (specifically serial killers), the moniker of BTK has just a hint of irony. BTK was the self given identifier of Dennis Rader, the evil serial killer active in Kansas in the 80's. BTK stood for Bind, Torture, Kill.
BTK = bruton's tyrosine Kinase, NOT THAT BTK!
@@AaronBosterMD 🤣🤣🤣
Good Morning Dr. Boster. I just found your channel a couple of weeks ago, absolutely love it!!! I was was just diagnosed with MS at UofM on Tuesday and I'm scared like crazy, soooo much information to take in all at once. So I just wanted to give you a great big thank you for a all your wonderful videos and helpful information to help me understand this disease.
I’m in the same
Boat George. We
Got this 💪🏻
i am recently diagnosed too and so scared and worried, yet doctors like to dr Aaron bring much relief by raising awareness, and hope which we need the most. Thank you! I hope advances in better treatments options and re-mylination cure show so soon.
George, please learn as much as you can by listening to Dr Boston's you tube.
He talks about importance of healthy diet and optimization of vitamin D levels and importance of exercise and definitely not smoking. My daughter was diagnosed with MS and has responded very well on Mavenclad.
Rita from Australia
Thanks for a sizable dose of optimism. This class could (in best case scenario) sort-of replace all of the oldtimer medications, w-o-w 👍🏼🥰
Interesting. I have had PPMS for ~20 years but I have never been on a disease modifying medication because the risks associated with the medication always outweighed the potential benefit (i’m ambulatory and fairly stable). This new class of medications may change the pros/cons. Fingers crossed!
Amazing news! Thank you for sharing. I am just about to have my second dose of ocrevus and whilst I’m thrilled to have it, infection risk is a worry. This sounds amazing. If we could get some re-myelination going on at the same time, sounds like we’d have a winner!
Cool!!! Dr. B, is there any clue on when those BTK inhibitors would be available? Thanks as always
I'm guessing in less than 5 years
💔💔
Thank God for you, sir!!!
I love geeking out on this stuff! So exciting!
And you're not alone in that!
Nice video. My preliminary opinion is that BTK inhibitors are likely safer but less efficacious than b-cell depleters, but given the effects on the innate immune system, it is theoretically possible that they are more effective than b-cell depleters in older people with insidiously progressive "smouldering" MS. I guess we will see if future research bears this out or if it is just hype.
I agree with you. Fingers crossed and excited to get phase III readout
Does that mean older people with MS have a chance of stopping progression altogether?
@@hilarykerr8912 Let me first state I'm not a dr. I've learned from reading that the older we get the less "active" slows down leading to less active disease. I'll let Dr Boster confirm or deny this theory
Fantastic news. I'm considering stopping Ocrevus due to the lack of response to Covid vaccines. This could be a game changer. Thanks for sharing.
Very good explanation of how BTK inhibitors work. Exciting news as this opens up a whole new way to treat MS without all the risk of infection ( due to low B/T cells). 🙏🏻
#sharingiscaring
Thank you! I'm super pumped! #WeHaveMS #StrongerTogether BosterMS.com
This could be a whole new way to treat MS without damaging our actual immune system response.❤️🤘🏻💪🏻 if your pumped… it only means great things for us!🤗
this brought me so much hope! thank you dr B!!
I'm so glad!
I’m excited.. great news !! Available in 5 years 🙏 for sooner!!
Fingers crossed!
Exciting! Can't wait to hear more!
super cool allway good to get help without increasing infections I cant wait to see what comes of it thanks for sharing doc lol and ps compared to your last live stream I can see your weightloss truly was the first thing I noticed I hope you have cant wait for your next video and what else you find out about this medicaion
#StrongerTogether
pff this video just gave me a little hope on my depression ms trip ! thanks dr. A for sharing these things to us !
#StrongerTogether
Thank you for the awesome explanation of this new class of drugs! Can't wait to see what the trials show!
Very encouraging development.
I've been watching you since about October of 2020 when my MS was diagnosed at Secondary Progressive, and it is now July 2023. I've had challenges dealing with this stupit (spelled that way on purpose) decease and the progression of mobility, cognitive and focusing abilities getting worse and emotional ability to cope has added challenges and I have not been actively looking into DMTs. I have not taken any DMTs, at first primaily due to cost and no insurance to help, that resulted when diagnosed with MS 4/2002 when experience Optic Neuritis. After intrenous drip steroids, then 65 mg Prednisone 3 times per day for months (70 lbs gain - not happy about that), the neuroligist suggested 3 different interferons, which all were a minimum of $1,000 per month and as a single mom, that wasn't going to happen. MS Society wanted insurance information, which I didn't have and so, no MS medication has been taken. In 2017, I started to notice weaken in my lower left extremity. Ok - tmi, I'm sure, but now my neurologist made a valid point for me to consider DMTs. This new drug, BTK Inhibitor does sound like something I would like to know more about. Is there a drug available now? Otherwise, I have been leaning toward Mavenclad, even watched more on Lemtrada. I'm 64, my neurologist said I'm "a candidate for a wheelchair", and have just recently gone on short-term disability, still have insurance. After a breakdown this morning, the one other drug recommended, I've decided totally against.
😱 whenever I think of BTK, I think about the serial killer, guess I'm gonna have to get over that.
overjoyed! where do I sign?? Thanks so much for sharing!!😀🎉🎊🎉
Thank you for the wonderful video on BTK inhibitors. Can’t wait to hear about the progress in the trials,. Doug coffee in hand from Lyndhurst.
Cheers
Thanks for the heads-up Doc, preciate you!~John
Fuck yeah!!!😆😆😆😆
Im all smiles right now, thank you dr. Boster. Been 3 years since diagnosed and relapse free 🥳🥳🥳
I like good news, thanks for sharing
Such great news! Thanks for sharing!
Thank you I'm excited!
Very hopeful! Will talk to my neurologist about this !’
I quit smoking cigarettes after 30 something years to start ocrevus and I was told that pretty much only 24% of people reported any kind of benefit from it so that was what I was told by my doctor at least
Thank you Dr Boster for your simplified explanation on BTK. I am very excited to see this kind of rapid development in medicine. 👍👍👍
Glad it was helpful!
Thanks Dr for all your videos. Very excited about this new drug and hope to adopt it in the future. Just switched to Kesimpta from Zeposia to help make sure I am 5 for 5. Thanks again. With your videos as inspiration I have been eating the healthiest in my life and I have never been more fit. Thanks for helping us.
Sweet!! Any time there is a breakthrough for M.S treatments, I get excited. My questions are can it replace Ocrevus and does it have any effect on the JC virus? My husband has an allergy to Alpha and Beta Blockers, could the BTK treatment be helpful for him? Thank you, again for making things easy to understand. 🔥🔥🔥🔥🔥🔥🔥🔥🔥
Thanks Dr. B, for your compassion. #cure #MS 🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥
Really cool video! What's the safety and side-effect profile on these?
I'm planning that video next
Thanks again for this
Any time!
I've been hearing about this in clinical trials. I'm still not on a DMT waiting the okay after getting medical Cleared for Kesimpta.
This is so promising 💞
I’m in the same boat. Just received my welcome packet. How are you doing on Kesimpta so far?
@@whoosh_angel not bad started end of June, had more ms Spasticity in August went on Baclofen and been better since. Not sure if it's related or not.
Not as tired. Are you going on Kesimpta?
@@MysticalDreamFire good to hear, I hope it gets better for you soon. Yes Kesimpta, just approved. I’ve been having muscle cramping at night, hopefully k doesn’t make it worse. Thank you for your reply!
@@whoosh_angel np ask away sometimes it feels better to ask someone else whom has MS and same DMT 🤗
@@whoosh_angel also about the muscles cramping have you tried taking magnesium supplements? They have helped me as well
I thought this video was very informative and insightful, especially considering my mom was diagnosed with MS back in the summer of 2015.
Great! Explanations. Thank you 😊
you're very welcome Elizabeth
I’m 22 years old and have been diagnosed with MS 4 month ago I’m using tecfidera for 4 months now I’m happy to hear that news !!
do you get the rash with Tecfidera. It ok if it's mild
@@barrykavanagh_ No, Flushing was the only thing i had at first but know I really don’t have any side effects anymore alhamdulillah 🙏🏻
@@Itsme1. thats good . . only get the flushing the odd time, or if iv'e stopped taking them waiting on blood test results. it's only a little uncomfortable for the most part. so you are happy with Techfidera? was it the first one you tried?
@@barrykavanagh_ yes, it’s the first after diagnosed , It has been 4 months now i’m happy with it but I didn’t do MRI scan yet hope it also has good results 🙏🏻
@@Itsme1. best of luck with your MRI whenever you get it 🤞
I have been following the science on the btk inhibitors. I wish they were years ahead in research on this. Having multiple health issues that affect each other, my body seems to be in a full on never-ending cytokine storm. I'm sure if it was all visible to the naked eye, my entire body inside would like the aftermath on the grounds after The Battle of Antietam during the Civil War.
That's great news, it will probably be a few years before it arrives on our Irish shores.( I'm on Ocrevus at the moment for PPMS.) All the more reason to follow you're advice on staying as fit and healthy as possible. Thank you. 😊
Sounds exciting!
Super exciting news!!! I’ll have to do my research on the clinical trials and eligibility.
Thank you for explaining how this new line of therapy works. You rock Dr. B!!! 🔥🧡
Starting this hopefully in June looking forward to this versus monoclonal antibodies
Howdy Dr Aaron thank you for sharing.you say this is a game changer so it must be excitingly good news for all. Take care till next time. Derby England
You bet!
Woohoo 🎉
Thanks for the promising update.
Do you have any thoughts about using this for folks on Gilenya?
What about metformin, statins, and clemestine to repair myelin? What are your thoughts?
This is great
Thank you Dr Boster- I’m super excited too! Thank you for your awesome explanation of how BTK inhibitors work. Good to see River in the background too! 🔥🔥🔥🔥🔥
Wonderful!
Love ya Doc !
#StrongerTogether
Wow! Very exciting
I agree mom!
Thank you for this information! So exciting! Can't wait until the studies are done.
I wish I could get help. 2 years can't walk & my VEP came our normal. Everything else is there. Have a syrinx too so I can't get a spinal tap. I just dont know how I'm going to stay alive anymore. I'm really scared 😢💙 I wish I could find a doctor like you
Very interesting stuff. Im on tecfidera now
Good to hear about BTKi's. Your explanation is simple and easy to understand. Would this be a DMT for someone that is older with PPMS? As always, Thank you.
We are currently involved in BTKi clinical trials involving PPMS patients. And a separate trial in SPMS.
You are awesome, Dr. Boster. Thank you for this.
Glad it was helpful!
Wow Dr. Boster, what an amazing surprise. You come alive and it’s so refreshing to see and hear the excitement. I have had several very bad symptoms of MS and I’ve been cleared of all causes. They can not find anything in my brain or spine to explain my severe symptoms that are coupling and not fading away. I asked for a Spinal and was grated one so waiting for it. My neurologist is so confused that my body is screaming Primary MS but he can’t prove it. Dr. Boster please, what can I do? Appreciate you time very much 😊
Have you had a spinal tap yet? And if so, what did it show? If you don’t mind me asking.
@@lindseys8039 yes I’ve had two. No answers but still all symptoms. My Neurologist is stumped
@@NovaGoose2 how long has this been going on for you? I’m about at a year and my body is screaming ppms also, but the doctors are having a hard time with me also. No relapses, just gradual onset of terrible symptoms.
@@lindseys8039 Hello and yes I’m going on 14 yrs. I’m so sorry you have to know such pain. Thank you for reaching out, I appreciate you.
I always thought monocytes were implicated in the pathogenesis of MS, but I don't understand how. Can you please explain how macrophages and monocytes do damage in MS? You explained so well how the microglial cells do. Thank you!
I gather they are what eat/destroy the actual myelin. But why are they activated? Virus? Fungi? What are they getting to get at?
Very cool info. I always crack up when you say “murder “in regard to a B cell 😝🤣
HA
Hi 👋 Dr, I from Boca Raton Florida ,,I'm so happy to hear about the new medicine, my cuestión is what is the side effects, thanks 😊 God bless you
It's always great news to hear new medication coming down the pipeline in the future. 👏🏻👏🏻👏🏻👏🏻💯💯✅✅✅🎯🎯🔥🔥🔥🔥🔥🔥♥️
I'm going to be starting OCREVUS on May 29th. I tested positive for the JVC, so I can't take TYSABRI anymore 😭
This is awesome. 🙃
I'm pumped
Nice video! Hoping to be in Perseus trial. Which subsets of B cells express BTK? Also plasma blasts? Is phagocytosis also inhibited in macrophage and Microglia? Still seems a bit like scary stuff. That said it is nothing compared to PPMS. Greetings from Holland
I have MS.ive had for 20 years I do my infusions every 6 moths they said I won't get better but I won't get worse all stay the same.i wish I could meet someone that I can talk to over the phone.cause I feel like I'm all alone.with MS.
Thank you so much! Great news, great doctor, thank you 💫
#StrongerTogether
Dr Boster, what is the time line for the BTK inhibitors? From my understanding that since the Russian and Ukrainian war that the clinical trial research has been extended due to the loss of patients that were participating in this. I think there was a 24 - 36 months addition added on to the clinical research trial. My next question is will the BTK inhibitors stop the progression or do like all the other dmt's do and just slow the progression down? I know that these BTK inhibitors have the ability to cross the bbb (blood brain barrier) since most of them are in the 3rd stage, has there been any update or release of data that shows this? Being a MS patient it's very imperative to stop the progression, then to try to heal the damage that is already done
Thanks, Dr. B! You explain things so well! Keep it going!!!
Thank you! Will do!
God bless you Dr, you are giving us hope. thank you
It IS exciting. I'll believe it when I hear it. I guess I've had MS for too long.
Thanks for the great video 🏆🥇😁
Thanks for watching!
Good morning
Morning, Howdy!
This sounds amazing! 🧡 Thank you for explaining it so well! 😊
Are the microglia responsible for creating damage before a person even has diagnosed MS? Is that where it starts?
when I think of chronic microglial activation I think about "smouldering MS"
I guess it goes without saying that everyone with MS will be desperately keen for the trials to be successful and for the BTK inhibitors to come on line as treatment asap. I’m assuming that lots of those with RRMS and SPMS currently involved in the trials, will have received treatment from one of the many DMTs now available: will it be the case that anyone of us who’ve had DMTs, will be then eligible for treatment with the BTK inhibitors. Or are any of the current DMTs a cause for non access to the new treatments. Also can you see any other barriers being put in place that will act as denial of access to treatment such as EDSS score or age.
Wonderful information, as always! Thank you!
When BTKi are prime time, would they be used as a replacement for high efficacy DMTs? Especially in 60+ group with SPMS?
Love the video Dr. B! Any guesstimate as to when this will be prime time?
under 5 years
Thanks Aaron - I think you just explained my situation - On Ocrevus and now I have debilitating inflammation. Has this happened to any of you patients? How long does it usally take to get thing back to normal? Best Regards - I learn a lot.
May be to early to ask but would cost be similar that current B cell killer medicine?
too early to know I'm afraid.
I will be taking Fenebrutinib in 2023
Dr B. There’s another doctor (Dr Brandon Beaber) who is talking about risks of being in B cell depleters long term. Is there a risk of being on these long term?
Hi. I know this is probably not the right place to ask this question could you do a short video or explanation more on the Dawson finger criteria in MRIS
Hi. What happened that makes you this confident about BTKi? Did some new data come out?
This video focuses on the unique mechanism of action of BTKi compared to currently available DMTs. I'm always excited about bring new modalities to treat this disease. Also the phase II data looks encouraging. I'll make a video soon on phase II efficacy and safety
Side effects please?
Any idea when these will be available outside of clinical trials?
That's so cool!! Do we know of side effects yet? Please keep us updated!!
That will come in a later video
Hi Dr. Boster, Thank you for the video. I just wanted to let you know that the visual effect between segments, which has colors of red and green and seems to to be spinning, is uncomfortable for patients like me who experience vertigo.
Thank you for explaining this to me. I'll look to use a different transition.
1:15 But my neurologist said (and repeated when asked) "The ONLY eye problems associated with MS are total blindness". I was telling him how I have double vision that is worsened by turning my head. He said I'm just blaming all my problems on MS. He must be right, because he's the leading MS neurologist at that hospital. He also told me things like, "You're just walking like you have a bad back", and also when I said I feel like I need to talk to a psychiatrist or therapist, he said, "No you don't". Thing is, I've had, and continue to have suicidal thoughts every day, but he must be right. After all, he knew me for almost half an hour when he said it.
He said other things that don't make sense to me or my research, but to tell you them I would have to go find the list of things he said, because I can't remember things anymore. There I go again, blaming something on MS. Memory issues may just be me getting old. What was I just saying?? lol!! Why do all my problems happen to also be MS symptoms? Just because I have MS doesn't mean they are caused by MS. Doc knows best. Why am I so freaking stupid????!!!! I question thigs and that's why I don't deserve a doctor. Good thing too, since now I'm afraid to even go to the store, let alone go out and get another doctor who could possibly put me down again.
Now, I believe I'm on a problem patient list just for inquiring why his "answers" don't seem to be right. He's the head of the MS team though, so wow, I really must be wrong, and deserve to not have a doctor. I've tried to reach out to others, but there seems to be no accountability for his actions. Further proof that I'm wrong and he's right. After all, I didn't kill myself yet.
Now I have some problem teeth that are severely worsening my MS, but I'm sure I'm probably just blaming my MS again. Feel so bad I don't know how much more I can stand, before......never mind,....I don't need a therapist. Doc said so. I need to stop blaming MS and realize when I kill myself, it was my own fault.
Don't bother replying. I know your reply. Get another neurologist. Tell that to my EXTREME anxiety. Goodbye.
Sorry, I forgot to mention how this video is GREAT, and how much I appreciate you telling us about this new medication breakthrough. MUCH appreciated!! Thank you!!
Would recommend that you see another neurologist outside of your current facility to get a second opinion, then you decide. I had a similar situation and ended up changing neurologists and glad I did. Wishing I had done it sooner as I would be in much better shape than I am right now. Providers should not be threatened or insulted when a patient gets a second opinion . Most should welcome it, at least that is what my primary care physician advised me. Reread what you wrote. You already know that you should get another opinion. Best to you.
Definitely get a new neurologist. I had a dinosaur & transferred to a younger, female neurologist. Just do it. You will be glad you did.
So sorry you are going through all of this. Fight on. You know, I know your doc is wrong. You can do this. See another MS specialist.
I have multiple sclerosis 3 years I have ppms multiple sclerosis
I am 67 and was diagnosed with MS in October 2022, I was put on Simvastatin 80 mg since I wanted to try something less invasive. Recently for a few seconds my vision was blurred and this also happened a month ago. I was told not to worry this was also something that happens with MS. TAKING Simvastatin it causes me to itch at times and I asked for another medication. Now I was offered Clemastine. What are your thoughts, can you give me information. I was also told I am not a good candidate for the other medications I assume it is because of my age. Please help me.
Looks great also as combination dmt maybe? 🤔
Possibly!
@@AaronBosterMD I hope to see a good reduction of ARR and an high rate of NEDA. But it would be interesting seeing the effects on PIRA! I don’t want to be too optimistic but I think something big is going on here! Thank you Dr Boster, have a nice day from Italy 🇮🇹
From an (almost) colleague
#WeHaveMs
do we know if they impact vaccine efficacy like the B Cell depleters?
what about PML risk?
No PML risk to date, No impact on vaccine status as we understand it.
@@AaronBosterMD super exciting
thank you
I picked up something about iron from your video. Should MS patients not supplement with iron?
I believe (from what limited research I’ve done) that the iron is released from the myelin when it is attacked, not that iron is bad to supplement, per se. Personally I think it’s important that if one is supplementing iron, they are also making sure to include copper and zinc to round that out. Specifically copper, as it regulates where iron goes (keeping it out of the tissues).
Do you see a problem with being able to repair new damage/lesions without microglia being able to work properly?
Any idea of when this might be available to us?? 😘
Hey how are you.... I want to ask about Sphingomod this drug
Tell us more! If you have been working with Phase 3 trials, are you allowed to share if the patients are doing better? I'm guessing from your enthusiasm that they are.
The reason I ask is a just saw a trial for it in Toronto, Ontario. But it would be risky going off Ocrevus to try it. I had a lot of damage before Ocrevus so I can't take any chances.
Do you think these new class of meds will be better at controlling ms than current high profile infusion therapy