Dr. Stephen Cunnane - Brain Glucose and Ketone Metabolism
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- čas přidán 24. 07. 2024
- Filmed at the Emerging Science of Carbohydrate Restriction and Nutritional Ketosis, Scientific Sessions at The Ohio State University
Learn more at blog.virtahealth.com/category...
An impressive body of scientific evidence over the last 15 years documents long term benefits of carbohydrate-restricted, especially ketogenic, diets. We now understand molecular mechanisms and why they work. Popular books and articles now challenge the advice ‘carbohydrates are good and fats are bad.’ Circa mid-19th century urinary ketones were identified in diabetics sealing their toxic label for the next 150 years. Despite work four decades ago showing ketones were highly functional metabolites, they are still misidentified as toxic byproducts of fat metabolism. The vilification of fat by regulatory and popular dogma perpetuates this myth. But the nutrition-metabolic landscape is improving dramatically.
A growing number of researchers have contributed to what is now a critical mass of science that provides compelling clinical evidence that ketogenic diets uniquely benefit weight loss, pre-diabetes, and type-2 diabetes. In the last five years, basic scientists have discovered that b-hydroxybutyrate (BHB), the primary circulating ketone, is a potent signaling molecule that decreases inflammation and oxidative stress. BHB has been suggested to be a longevity metabolite, with strong support from recently published mouse studies showing decreased midlife mortality and extended longevity and healthspan. Although type-2 diabetes is often described as a chronic progressive disease, emerging evidence indicates that sustained nutritional ketosis can reverses the disease. There is growing interest in studying potential therapeutic effects of ketosis on cardiovascular diseases, cancer, and neurodegenerative diseases including Alzheimer’s and Parkinson’s. There are even reasons certain athletes may benefit from nutritional ketosis and ketone supplements ─ debunking the long-standing dogma that high carbohydrate intake is required to perform optimally.
With the support of the well-established Ohio State Food Innovation Center, this conference will bring together the top experts in these fields to share what has been achieved and what remains to be done to advance this exciting field of scientific discovery. - Věda a technologie
The people doing these expirments are incredible! Thank you Dr. Stephen and your team for such insightful research.
Such an incredibly interesting lecture and very well presented. Thank you.
Thank you for your research. Such encouraging findings and so much more to learn.
Thanks for your research and presentation. Fascinating stuff!
Also thanks for this insightful research.
The more reason I've to stay in this keto-if lifestyle diet..thx for the presentation Dr Sthephe..
Brilliant lecture and explanation 👌
Thank you
I can do experiments with my parents with dementia and their cognitive function is improving a little after 10 days of MCT oil. Amazing. The amount given is only half of what is recommended. I will increase the dosage and change it to 95% C8 MCT oil.
Excellent, thank you.
It's fascinating to hear that human milk is said to be the food that puts / keeps human infants (babies) in ketosis. After all, human milk has a higher lactose content - milk sugar - than cows' milk. Of course, human milk is usually served raw.
Some people cannot make good use of the milk from cattle. However, many who think they cannot find that they can enjoy milk from cows, IF it is consumed unprocessed. 'Raw' milk is a very different thing from the highly processed stuff sold in supermarkets:
- It contains enzymes which aid digestion, including lactase which digests the lactose, so people don't need to 'have the adaptive gene' to produce lactose.
- Unprocessed milk contains beneficial bacteria, also known as 'probiotics'.
- Unprocessed milk also contains all the vitamins we need, including those destroyed by the heat treatment, like Vit C.
- The cooking process alters the proteins in milk, making them more allergenic.
- In processing, the butterfat is separated from the rest of the milk. The fat globules are artificially reduced in size, allowing them to be absorrbed across the gut wall without being digested, especially those with 'leaky gut'.
- The butterfat is then added back to a level of 3.25% in 'whole' milk. Unprocessed milk from well managed Holstein cows averages nearly 4%. Cattle from many breeds on high forage or all 'grassfed' diets averages as high as 5-6% butterrfat, or more.
- The processing steps expose the milk to air which can oxidize the fats. And to surfaces that can collect bacteria.
- Supermarket milk almost always comes from CAFOs - not ecologically sustainable. Instead of allowing the cows to harvest much of their own feed themselves from perennial pastures, which they naturally fertilize. Properly managed, livestock grazing pasture asequesters carbon, reduces or eliminates soil erosion, increases the diversity of the soil life below the surface and the plant community above, provides habitat and food for a range of wildlife, including pollinators, birds, etc, increases rain infiltration which mitigates the effects of drought and reduces flooding, while replenishing springs, ponds & lakes, streams, rivers, and aquifers...
Cows in CAFO operations are confined, then fed a TMR (total mixed ration) that does not allow each cow to select what she needs that day. The feedstuffs in the TMR are farmed mechanically, using petroleum, synthetic fertilizers, and an array of toxic chemical 'cides'.
- CAFO milk is usually from cows given GMO hormones, rGBH.
- In the North and East, CAFO cows are increasingly being kept indoors 24/7 with little or no access to pasture or sunlight.
- Processed milk is almost always from cows fed a high grain ration, dropping levels of the beneficial Omega 3 fatty acids to nearly nothing.
- Many raw milk producers bottle their milk in glass. The plastic lined cartons and plastic jugs transfer synthetic chemicals to the milk, which some people can even taste and smell.
Most raw milk is produced on pasture-based farms, and some is 100% 'grassfed' with levels as much as 7+ times higher than grass + grain fed milk. The farms producing this milk generally avoid synthetic hormones, antibiotics (except in emergencies, which are rare in pasture-based cows), The profits from milk sold in supernarkets go mostly to the processor, and to the stores. Dairy farmers are often paid little over the cost of production, sometimes less than the cost to produce the milk.
Whenever we make a purchase we are voting with our dollars - the vote that counts most. Seeking high quality milk, meat, eggs, etc from small farms and buying DIRECTLY from those farms is a vote for sustainable, ethical, regenerative farming.
Best of all - the flavor is fantastic!
Reading your [ ] prompts me to research the detailed digestion process.
Can’t get raw milk here legally in Illinois
I guess I'm lucky because I mostly am able to tolerate pasteurised dairy.
Thank you for your research
I l try the best i can to practice ketone diet .
Thanks, very well received. The problem is that this is too academic for most of the normal ppl. Maybe it should be more easy for the ppl who needs this knowledge (not us we have PhD's or Diploma's). That is the problem in the world, the scientific knowledge is to complicated for the normal ppl to understand.
How can I reach full ketosis while being on the classic keto diet but still drinking 5 antiepileptic drugs for my refractory epilepsy? My doctors are not keen about the diet because a healing brain from ketones means that they may loose a patient and no financial benefit for the neurologist and psychiatrist. The drugs have destroyed my memory and they never mind the strength of the benzoazepines and other prescribed drugs. Thanks dr.Stephen Cunnane
If you are willing to answer this question, am curious if the benzos are prescribed for sleep purposes (among others?) in that being in ketosis can undermine sleep structure. (most definitely it does for me)?
Any elaboration I would much appreciate, but in any event I am wishing that Dr. Stephen Cunnane, and other stellar researchers, can help get the answers to you asap. Hang in there . . . (you are saying the drugs are undermining reaching full ketosis, correct?).
You might want to look around for a different doctor.
Yes! Ketones are REQUIRED by the brain. Spend your life blocking ketone production by constantly consuming glucose you do not need (the liver makes all you need) and see what happens.
How is ketones related to improve memory
Hello, I have a question about sugar on keto, can I have it in small amounts as they are in some products? For example sausage that have 3 grams of carbs but 1.5 grams in it are sugar. What is the safe limit of sugar in that form per meal and per day?
Tom Wolf That is going to depend on your goals, individual diet plan, metabolism and more. It’s best to keep added sugar as low as possible but some people will choose foods that have small added amounts and include it in their full carb count for the day.
Wow!
50g MCT oil is 1/4 cup, or four tablespoons.
Just think if these people were fat adapted compared to 60 yrs on glucose these stats would be way more in favor of ketones
Yellowjacket45Wall yep!!!
Very informative. Thanks.
So brains love ketones. And ketones stop the brain cells from dying and thus prevent alzhimers ?
Why does glucose to the brain reduce as we grow older ????
Because of glucose overload (insulin resistance and diabetes), therefore the rate of diabetics is correlated to the rate of AD patients. The brain or better the damaged mitochondria is not able to use the glucose, if we would have a diet like our ancestors (Ketosis at times of no food) we would be fine today.
@@svenhuber6533 Thanks a lot for your reply. I researched about it a bit, and what you are telling is absolutely right. Thanks.
Do you have a research on how ketones can help improve memory of healthy students? How about MCT COCONUT OIL?
Fantastic study results!
9:30 Glucose Hypometabolism
Great news suggesting to eat more fat and going towards lchf especially with age
I'm still thinking that the cause of alzheimer's is tissue damage due to excessive glucose levels, so then it's reasonable to expect that energy deficit would be a side effect, not a cause. The fact that ketone metabolism is preserved is consistent with either model. The exercise cohort backs this up too. Exercise lowers average glucose/insulin levels. Lower glucose/insulin should result in additional energy deficit in cells with impaired glucose metabolism. However, if it is shown, that low carb/ketogenic not only improves energy balance - but also slows progression of the disease then either the ketones are protective OR lower glucose levels are sparing the remaining undamaged tissues.....
Could be excessive Insulin levels rather than excessive Glucose per se.
@@xenobob2773 Agreed. Excessive insulin causes excess glucose levels in cells with insulin mediated glucose uptake. This can trigger the polyol cycle which can actually destroy the cell with either xylitol or fructose. So....some cells are damaged by high insulin while others are damaged by high glucose, which is why diabetes symptoms present before A1c or fasting glucose levels indicate a problem. I should have been more clear.
Outstanding discussion here.
Don't forget the correlation with the increased ketone/glucose ratio to the energy metabolism of the brain. It seems not only that high insulin lower the energy uptake, but that ketones increase the uptake up to 120%regardless the insulin if enough ketones are in the blood. That would mean that even somebody with diabetes and high insulin levels could improve their brain functions with ketone supplements or by lowering the permanent insulin levels. Which could be a double strategy for them.
ketones seem to be well advertised but who and where can get product?
they arent sold. They are a fuel your body makes them from your food. Anyone who tries to sell you ketones is a fraud.
Or take exogenous ketone esters can get you into ketosis within an hour
LOL, people nowadays are so "consumeristic".
Just get MCT oil (google it) or just take 40 grams of cold pressed organic coconut oils per day
Do you support keto diet?
yes or fasting for a certain time, but the key is always no processed food and from everything in moderation.
👍☺️🙏
Helly Hansen makes me hella handsome while I lend a helping hand son
Mendi because honesty and integrity are part of their corporate policy.
2:10 baby body is in ketosis.
I am sold on the ketone being the preferred brain fuel but how can you answer the question "If it is the preferred fuel, why do the brain still need 25% glucose with 75% ketone to function?"
Is it that ketones burn in the flame of sugar?
@@simonderijk2052 An interesting question, but probably not.
Glucosamines, glycosaminoglycans..... What if it's structural and not fuel??? Nerves are very long and stringy, I'd guess that at least some of the brain tissues are long chain polymers. The glycocalix is a "slimy" film in blood vessels that is made up of long strands, and was only recently discovered. I'd guess that there is some sort of similar "stuff" in the brain.
One particular part of the brain needs glucose and the rest of the brain can thrive on ketones.
When you eat 0 carbs your liver will produce just enough glycogen to power that part of the brain while rest runs on ketones.
@@johndohart895 yes this is why it is so good to reduce Carbohydrate intake to reduce insulin and become sensitive to insulin and alow insulin to open the cells for glucose. its awesome
Hey, look! Christopher Walken is presenting metabolic science!
this guy's definitely French
This guy is totally ignoring the fact that breast milk has a lot of carbs. Infants are not in ketosis.
I wonder if the carb count in breast milk would lower if the mother at HFLC?
The baby is definitely in ketosis and that has been well proven and that's easy to show with blood tests. The human baby can be easily slip into ketosis even while drinking milk
i can see by your complexion that you haven't tried a ketogenic diet