Rectal cancer & total neoadjuvant therapy - RAPIDO trial, POLISH 2 and OPRA trial, PRODIGE 23 trial
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- čas přidán 5. 08. 2024
- Total neoadjuvant therapy (TNT) is an approach to treating rectal cancer that involves giving chemotherapy and radiation therapy before surgery. The aim of TNT is to shrink the tumor, making it easier to remove during surgery, and potentially reducing the risk of the cancer coming back.
A lot of trials happened in this area in the last 4-5 years and this video summarizes the evidence in a very simplified and practical manner including the Polish 2 trial, RAPIDO trial, OPRA trial, and PRODIGE 23 trial.
TNT typically involves a combination of chemotherapy and radiation therapy given over a period of several weeks. The chemotherapy drugs used are often fluoropyrimidines, such as capecitabine or 5-fluorouracil (5-FU). Radiation therapy is usually given in daily fractions over a period of 5 to 6 weeks, with a total dose of around 45 to 50 Gy.
After completing TNT, patients undergo surgery to remove the remaining tumor. This is usually followed by additional chemotherapy, called adjuvant chemotherapy, to further reduce the risk of cancer returning.
TNT has been shown to improve outcomes for patients with locally advanced rectal cancer, particularly in terms of reducing the risk of local recurrence. However, it may not be suitable for all patients, and the decision to use TNT should be made on a case-by-case basis by a team of experienced healthcare professionals.
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So far the benefits of TNT are established but the sequencing of chemo ( induction or consolidation ) and the extent of radiation remains the subject of several ongoing studies.
Thank you sir
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I was diagnosed with stage 3C rectal cancer on January 5th, 2024. Through a rectal MRI, I was found to have a miss-matched mutant tumors. In 2023, 18 rectal cancer patients with various stages went through a clinical trial at Memorial Sloan Kettering Cancer Center with Immunotherapy and six months later ALL 18 patients were cured 100%. Their tumors shrunk and completely vanished. Nothing like this has ever happened before and this therapy adds a newer way with those who have this type of tumor to have a new lease on life. I'm starting this immunotherapy on March 4th in the Southern California area and I will post my reactions, progress and side effects after all of the eight infusions I'll be receiving every three weeks.
Best wishes. Hope it works out well.
Too good sir
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Very nice
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@@edusurgclinics site can't be reached I want to open it
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Thank you for the video sir.
Is there a video on the watch and wait approach for rectal cancer Sir?
Hi, Thank you very much for your appreciation. There's no separate specific video on watch and wait. We will add that to our video list and put it up soon. For other collection, Do visit the website www.learnwithedusurg.in
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What is your website? Please
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Sir please cover latest prospect trial 2023
And also latest prodige 2023 trial
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