Pregabalin (Lyrica): What You Need To Know
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- čas přidán 11. 05. 2017
- Pregabalin (Lyrica) is a medication in the gabapentinoid class. It has anticonvulsant, anxiolytic, and analgesic properties. As such, it's used for epilepsy, neuropathic pain, anxiety, and other conditions.
Despite being a GABA derivative, it doesn't appear to be operating through a GABA-related mechanism.
The substance is also used recreationally due to its euphoric, anxiolytic, and pro-social effects.
Overview Page (Including References): thedrugclassroom.com/video/pr...
Reddit discussion: / pregabalin_lyrica
Pregabalin = Lyrica; (S)-3-isobutyl-GABA
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Special thanks to Benjamin/BronzeManul ( / snowkayt ) for helping with the legality info.
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Timestamps
Effects (medical) - 00:23
Effects (non-medical & recreational) - 04:38
Pharmacology & Chemistry - 08:19
How It's Used - 11:34
History - 12:24
Legal Status - 16:44
Safety - 16:54
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Email - seth@thedrugclassroom.com
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Therefore, it only makes sense to provide real education free from propaganda.
TDC doesn't advocate drug use. Rather, we operate with the intention of reducing the harm some substances can bring.
Feel free to ask questions!
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Do you gonna make a video about lean?
The Drug Classroom Can you make a video on Cylobenzaprine?
The Drug Classroom hello can you do a video on abilify ? Just started using it love your videos :) would love to see one on abilify
lyrica is very helpful against anxiety, but for best results it should be combined with Lorazepam.
The Drug Classroom pregabalina 75mg. traduciral castellano
Thank you for the detailed information. Your deep dive into Lyrica is impressive. I feel more confident about taking the drug with a full understanding of the benefits and side effects.
I couldn't remember if my name was Lindy when I was at my girlfriend's front door and called out it's Lindy I was confusion about my name and had to ask my girlfriend if my name was Lindy, memory loss and forgetful and this was a couple of years ago and still I have a bad memory.stops the brain or prevents the brain renewing the connections and new connections, There is a article on lyrica and the brain and preventing new connections and renewing connections.i still have nerve pain but I will not take Lyrica ever again.
❤💕💖💝💜👣
@@lindyoneill8779 may I ask the amount of dosage you were taking and for how long? Also, were you on any other medication before or while on Lyrica?
merncat75 I was on 75mg 2 x a day,so 150mg daily, years before I was prescribed lyrica I’ve been on antidepressants since November the year of September 11 planes ,twin towers,I stopped living and just exist ever since. Cipramil 2x20mg once at night ,muralax (oxazepam 30mg) 0-2 a day extreme anxiety and ptsd and it’s the only way I can find me or bring me back when I disassociate from me(it’s very complex)lol, and I was also on anti inflammatory medication for my lower back,that was (BRUFEN 200mg) 1 a day. I think I started taking that about maybe 5 months before I started on lyrica then I found out brufen was linked to heart attacks so I stopped taking them,I don’t think I was on brufen when I started lyrica,I’ve been reading the comments and I read antidepressants and lyrica are not good together,I know it was lyrica that made my memory all messed up and my eye sight blurry and I don’t know if this feeling of ice going down my back and the back of my legs and the feeling of being burnt mostly the size of a smoke burning me but sometimes it can be the size of my hand burning like a flame oh and electric shocks i feel at least 2-3 times a week,this could be because the nerve damage I have is from my neck and daily migraines and nerve damage around my elbow. I hope this helps.🙏💞Sorry I don’t think I said how long I was on lyrica to be honest I don’t know or remember exactly how long I was on it but I know it was less than a year.
Be prepared to take it forever...😢😢
Have been taking it for about 7-8 years for pinched nerve in my spine.. - It was horrible pain.. - Was prescribed Lyrica and the pain stopped.. - After 6 months of intense pain, I was ‘cured’.. - Had to adjust it a bit, am taking 225mg a day.. - Not only did it stop the pain in my spine,, it also stopped all migraines I was having for years.. - Was having at least two migraines a week, but when I started taking Lyrica, they simply disappeared..
Taper this drug if you’re stopping. Believe me the positive effects disappear and tolerance shoots ip fast, stopping cold turkey causes terrible mental and physical effects, I’d compare it to benzo and opioid like withdrawals combined!
I have myalgia 😢
I made a little change to the TDC website pages. From here on out, particularly for pharmaceuticals, I'm including short "conflict of interest" sections for each paper I talk about. I'll mention if the study was sponsored by a pharmaceutical company or if the authors have some form of connection to a company.
Company-sponsored papers can obviously be useful and are often entirely fine. But the potential for bias exists, so it's worth pointing it out.
A bigger issue is ultimately publication bias and there's not much I can do to address that issue. So, I'll do what I can in terms of highlighting possible conflicts.
Brain synapses? What exactly do you mean?
@Paul Allen what do you mean? Like addiction?
@Paul Allen What do u mean ?
Dam this drug had me eating barbecue sauce with crumpets and Netflix has never been so good 😆 🤣 😂
😂🤣😃
@@larryphillipsjr.1607 its mad how good that actually tasted 😋👌😍
if you would only know how stupid your comment is. people are struggling with epilepsy attacks, this is not joke. your stupid comments keep for yourself and your dearest. this pills have different results on different patients, it is so sensitive matter.
@@zorzobukumica628 Dude chill out, that only happens to people with Epilepsy or at a strong high dose like 900mg which can cause a seizure.
@@zorzobukumica628 but it's true 👍
always a pleasure to listen to you and you speek in easy to understand terms some of the tables you talked about in you're videos my doctor has been able to try these meds as I haven't had to go on listening to the the way they work and I always end up with the right meds,my doctor said that I. should be a doctor cause I understand what he is talking about,and that makes it easier to get me on the right meds,thanks again, keep up the good work
I have general anxiety and social anxiety and at 150mg a day (seems low doesn't it) it really helps my anxiety, by reducing physical symptoms (and panic attacks) and making me more confident around people and relaxed and also helps me sleep (used to have horrible insomnia with around 4 hours or less sleep)
Brilliant. I am on pregabalin in England where it became a control drug on April 1st. This was a great run through of all aspects. Thanks.
No fkin way lol…
Lol I took 1200mgs and I started eating yogurt with tostitos chips I had the munchies and I cleaned my whole room and I felt very confident and good. Music sounds awesome too
U know that brother I got Spotify at the ready 😆🤣😂
gabapentinoids are hands down the best type of drugs. Nothing compares whatsoever to me and I've tried virtually everything.
@@marksmanmerc1 better than cocaine with xanax?
@@apfelsaft160 Last longer, completely functional while also feeling great, minimal side effects and instead of a comedown you usually get an afterglow the next day. Maybe my physiology is weird idk, but they're so far the only drugs I've found where the pros outweigh any cons. But if you're into being completely shitfaced(blacking out, can't even talk right, etc.) you'd probably not like them.
@@apfelsaft160 Only real downside that I've only noticed specifically and only with gabapentin is that occasionally some weird suicidal thoughts creep into you're head if you stop after a couple week long binge. Not serious ones just unusual ones.
I've been following this channel for a while now, after having tried some of these drugs, what is described here is so accurate, that it is perfect for those who are interested in trying any of these drugs, who wants some truthful information about them first.
I get severe sciatica at least once a year or more from a herniated disc and the pain lasts months.
I get prescribed lyrica, it's works well and I can move with minimal pain but I do get many side effects. It makes me eat more, I want to drink alcohol when I usually don't, I feel dizzy and it makes me think and act differently. I do like talking to friends on it though and I can string a sentence better than when I'm pain free and soba, it kinda enhances cognitive ability. If I had the choice I wouldn't take it but the pain I experience is extreme and debilitating. I do feel drugged up on it. I usually take 150mg a day but somtimes do 300mg.
Thank you, you do great work and your research is very helpful to others
I currently live in Thailand and recently went to one of the government hospitals to get consultation for back surgery. Before I left America two and a half years ago a neurologist said I need back surgery to fix the L4, L5, & S1 but I opted out, out of fear, Hind site...LOL! Well with all the doctors and test I went through here in Thailand and although all the other doctors cleared me for surgery the spine surgeon here said that he did not recommend surgery due to my age (70) and medical history (heart disease) and prescribed Brillion 50mg three time daily which helped with the lower back and sciatica pain to a degree but did not stop the pain. I have been on Brillion 50mg for about two months now and thinking about increasing my dosage ever so slightly to see if I can improve its effects. I think this video was very informative and really mirrored the comments made by the spine surgeon here on its effects.
A most excellent breakdown that just earned a subscription, well done very informative.
After 2 years of suffering from severe anxiety and depression and being on propanalol 80mg and duloxitine 60mg I am now trying this medicine at 600mg a day.I can say it’s brought back the person I use to be,Get me out of bed and I’m so happy now.
Just DO NOT attempt to abuse this medication as I can see the abuse potential and I know people who have took large doses with no prescription to feel good and high .
This video says exactly what effects I got and is great information.👍
ااا
Youre getting high on that medicine as well. It just helps you cope with your problem. Taking a pill is never a fix all eventually youll havw to learn to manage without it. Withdraw from this medication sounds awful from what i have read and that is another thing youll have to take into consideration.
Thats so good to hear. When I first started on Lyrica it cost nearly 600$ but it helped more than anything else so it was worth it. Now Pfizer sends it to me monthly for no cost and I am also on 600mg a day.
@Barribudda ́ loser
Barribudda ́ take 900mg for every single day for one months and you’ll be the one whining bud
Lyrica is okay for the first few months then all aspects of it go away, and it's torture to come off/ extreme weight gain is also a serious issue.
are you talking about recreational use or therapeutic? If recreatoinally then you shouldn't take it more than 1 time a week maybe 2 at the very max cause otherwise the tolerance increases.
@@endriu55 sounds like gabapentin with the tolerance going way up in only a few days
@Kentish Rebel Interesting, I’m having those issues and the Dr said it’s not the lyrica Now I’m wondering if he knows anything at all.
@Kentish Rebel damn.. glad u feel ok now
@Kentish Rebel I HOPE 🤞 you’re feeling well, I’m so sorry all those Drs. have left you to suffer. It’s the exact way I feel were I live. As if I’m not good enough or they have something better to do. You deserve to be treat fairly, I’m sure you’re a good person with much to offer. You’re not alone. I’ve got your back (for what it’s worth) and will do what I can from where I’m at.
loving how detailed and balanced your review is, super useful for anyone who might be using/prescribed/used/ or even have a family member using - great work, how long does it take to gather all the info you use?
easily the best drug info / harm reduction channel on youtube by far!
i hope in the near future you do a video on MXP / Methoxphenidine
i never clicked so fast , i was waiting for this thank you ♡
People who like recreational drugs really sleep on pregabalin. It is probably one of the best medications to use for recreational use, it can be addictive but compared to benzo's, opiods and even alcohol it is alot harder to get addicted. The high is best described as the euphoria and sociability that mdma gives first time users, and the anxiety reduction and relaxation associated with benzos like diazapam. This is a great substance and the only thing someone needs to be careful with is mixing it will alcohol, I have had full blackouts mixing it with large amounts of alcohol even when taking it at medical doses
Wish there was more information on how to cope with the confusion and euphoria (more happy, just, a really good day, things that make you angry, are very short). I'm trying to get used to it as it's prescribed for pain (which it does really help for that).
Thank u Seth. Wow the amount Northwestern got from this drug! I've been on it for fibromyalgia for a number of years, and among the various prescriptions I've had or have, this is the one that seems to help the most, with the fewest negative cognitive effects - and that's a big deal for me. As a professor I don't know if I could continue working if I had to rely only on opioids and/or benzos. I do think it's begun contributing to vision problems over time but that could be just normal aging.
Sal hi I notice your black and white fern are you from NZ?, has PGN been avalible here for years?
Timestamps:
Effects (medical) - 00:23
Effects (non-medical & recreational) - 04:38
Pharmacology & Chemistry - 08:19
How It's Used - 11:34
History - 12:24
Legal Status - 16:44
Safety - 16:54
+The drug Classroom I suffer from both a back injury and PTSD from my service in the army with extreme anxiety and panic attacks. I cant take the dozes of Lyrica on an everyday basis? I loose the effect. So I take larger dozes with 2 days without the medication and I also take larger dozes to get my apatite back and to get some sleep. The Veteran service doctor gives me Tramadol, Zopiclone, Xanax and anti depressives. The withdrawal symptoms when I have tried to get rid of the Lyrica is incredible painful. I have it way much easier to stop eating Tramadol or Xanax. I left Afghanistan in 2005 and used morphine and alcohol in the beginning and my doctor refused to give me any other addictive medication for a long time. After many suicide attempts he changed his mind and just asked me "What medication works for you? I can give you anything you feels working for you,cause I cant watch you end up in the statistics of suicidal veterans?"! I wrote a list of dozes of Xanax, Lyrica and Zopiclone which probably could sedate a heard of Elephants?
Striker Orwell same
Striker Orwell
i hope you get this message. try to get methadone. it is a miracle. it is nothing like other opiates. i take it for nerve pain and it has zero side effects,no high feeling at all and is the closest thing to feeling "normal" i have had. lyrica is expensive poison. and mentally fucked my head bad. methadone is a fucking miracle. once at the right dose,you will never need an increase. methadone and weed.oh. and for some reason. it makes me not care for alcohol. .i've had a bottle of brandy here for so long i think it might not be good any more. last six pack i got.i only had 3. and i used to love to drink.
+immrnoidall personal question that how many mg you take it per day? and just for pain?
Once again thank u drug classroom for your insightful and informative videos! Keep up the good work!
Excellent and very informative video thank you very much for the information.
absolutely great video, you are totally spot on i am impressed very comprehensive
It has been shown in some studies that Lyrica can cause both atrial fibulation and congestive heart failure. A family member just went through this. That fluid retained can also collect around the lungs and cause congestive heart, which it did in our case. Of course the dr.'s didn't agree with my suspicions so I searched and found some legit study cases, printed them out and gave to the dr.s.
I love how asshole doctors always think that they always in every situation know better even when what they're talking about isn't in their area of expertise
Good on you, doctors being submissive to a persons concerns without knowing the truth is so wrong.
Ok I'm 33 and had 5 Af attacks and now have af. It seems to come on when using benzos. Now I'm getting prepared to do an opiate withdrawal and had planned on using pregabs to help with the withdrawals. Now this is the first I've heard anyone else mention atrial fibrillation so it's got my attention. I've got emphysema, no right pulmonary artery and AF. I need to get off opiates to save my life. I'd planned on using either gabapentin or pregablin and some benzos, just whatever will help me succeed once and for all, 🤔
Dan Curry it sucks how well gabapentinoids help opiate withdrawal because they block your brains ability to create new synapses, thus making you just as as likely to be an addict. The best way by far is cold turkey, if you have the strength. Get ahold of some shrooms if you need motivation, overkill is the only way you can hurt yourself so don't go over 3 grams. They definitively help mental illness and it's a shame about their reputation.
@@digforbritain6225 Hope you're doing better man.
You are the man to ask about all drugs great video.
i have been taking it for 4 years now (not continuously, only when i need it), as recreation use. and it is really helpful, it keeps me motivated and helps me get things done quickly and more efficiently.
How much dose do you take?
@@AndT101 150-300.. occasionally
@@omarxawneh I took 225mg once. I just got uncomfortably dizzy and slept for 14 hours. Idk how it helps you recreationally at that dose.
@@AndT101 lol.. just lower ur dose.. not all bodies are the same
@@AndT101 bruh I started out on 25
I took it one time and made chips and cheese then itook it out of the microwave and poured tons of whip cream on it and brought it to my dad and said" here. This is a new recipe I'm trying"
As someone who's used high levels of gabapentin [3200mg daily/7000+mg recreationally] I can tell you that withdrawal from gabapentin is longer lasting as far as sleep disruption and intense night sweats. I've abused lyrica as well at levels as high as 3000+mg per day and although withdrawals are much worse [flu-like symptoms], they will only last 3-4 days. The addiction potential is very low with lyrica. I'm sober now [from an intense bout with all drugs, but mainly benzodiazepines and amphetamines] and currently studying to be an addiction specialist, while continuing to take Lyrica at levels of 150mg TID. I often forget to dose and have only taken it as prescribed since getting sober. It also has greatly removed any craving, but mostly regarding the desire for alcohol/benzos which makes sense due to GABA activity (even though they differ on the site). I've been watching you since way back. Thanks TDC!
Since you seem to have plenty of experience with the same regimen of substances as myself, I've never been tempted to use my scripts in a purely recreational way. After getting off benzos (with all the fun "brain shocks") Gabapentin and hydros for over two years, my pain levels returned with a vengeance.
I'm now prescribed 150mg Lyrica tid, and 5mg oxy's, up to pid, along with both a muscle relaxant and anti-anxiety med.
I've experienced that feeling of euphoria a few times and am curious if that is the "high" so sought after when looking for alternative uses?
Also, I've noticed a definite flu-like response if I accidentally miss even a single dose of the Lyrica. Sinuses are a real problem when using these in tandem (at least for me), but I've never read in either the printed or online version of warnings and side effects about it.
Best Regards.
I used to take lyrica and tramadol together and then i was off them for years but due to pain I have been prescribed codeine, horrendous withdrawal and I can't seem to come off of it. In your opinion, would switching to lyrica help? I'm really at my wits end.
Very informative video, thankyou
It's good that it works for some people. But remember, when you're on the max dosage for a few months or years and the doc cuts you off, you will wish that you're dead.
Randy Bobandy
It's not working, bcuz something else is being damaged. Your getting something for that pain but that something is going to give you a new pain somewhere else .lol
Hence the sticker the pharmacist puts on box: do not stop taking abruptly. In Australia.
Its EXTREMELY controversial in terms of of withdrawal, following discontinuation... Therefore, people have HORRIBLE withdrawal due to Dr.'s not 'believing in' w/d symptoms. MANY Patients go through HELL due to this controversial view on it, within the medical field. Something NEEDS to be done about that because abrupt use can cause reoccurring seizures and the dreadful 'glutamate storm' which is arguably cause irreversible damage on the brain... WAYYY more long term research needed for this drug. WAYYYY to easily and inconsiderably prescribed. That being said... Some find extreme benefits and minimal negative side effects, IF/when the drug us discontinued... Theirs a game of Russian-roulette for ya'! Sounds desirable...
At 300mg/day for almost 2 years and I stop from 300 to 0 no problems without withdrawal...
@@vapor4denyou say that
It really helps me to fall asleep, obviously. The trouble is in the morning I simply cannot talk. I feel fine and youd never know id taken anything until I try to speak. Its as if my tongue goes numb.
Mixed this with Subutex (Buprenorphine) which I take daily. Man it's like having 20 pints physically you can't stand, walk properly but your anxiety is none existent and euophoria is bliss especially with the opiates like I said.
Brilliantly detailed description of the substance keep it up man!
I'm on 10 mg sub what you on? 🇬🇧
@@mattcurtis3019 I was on 16mg back then I've tapered down to 9.4mg slowly but surely I WILL get off this drug.
@@johnbambrough3189 some people r on it for life uknown I'm 43
i did this today
@@DavidOrz me too. 600mg/lyrica at 5am & 4mg/sub 6pm.
I love ur videos so interesting ur user name fits I feel like I'm in a class about drugs keep up the good work
Lyrica was a godsent for me. It took me off of any antidepressants, it took away most of my general anxiety, it took away my back pain and it keeps my depression very well in check.
I take 150mg/day but it is a medicine for me, however, i took it recreationally several times out of curiosity and i found out that a good recreational dose is around 600mg at once with mild or no tolerance at all. If you go over 600mg, the side effects like dizziness and drowsiness, impaired motion will be too intense to call it a nice experience so, yeah.To describe the high is very similar to mdma but without the energy and the visual enhancement just the cozy, loving and relaxed feeling with a really strong mental euphoria in the first hour. There is no comedown, it has a pleasent afterglow of general good mood that can last the other day too. Good to know is that pregabalin builds tolerance incredibly fast so basically every other reacreational dose will be significanly less intense so you might wanna use it rarely to enjoy it.
As i said i personally use it daily as medication at a common dose, worked very well for me. The only noticeble side effect in 3 years is weight gain so you might keep in check your diet because you will have increased appetite in time from pregabalin (you will get fat fast if you dont pay attention to it), otherwise nothing negative, i feel way less anxious overall, i'm more empathic (i know for sure that for me it has a mild but welcomed entactogenic effect even at a small common dose), and more relaxed in general both physically and mentally.
If you wanna quit it after a prelonged daily use DO NOT go cold turkey because you will experience bad withdrawal symptoms like headaches, unsettleness and bad migraines that can last for days. Please taper it down, gradually reduce the dosage until you finally quit, take weeks or even a month if necessary dont go cold turkey on it.
Thanks for the information my friend it’s very much appreciated 🙏🏼
how did you ask for doctor for this for anxiety / depression? I tried but they didnt give it to me.
@@DavidOrz just as that, i asked.
I've been taking lyrica for anxiety for about 9-10 years. The only good thing it has done for me is to lessen the amounts of panic attacks I have, and the intensity of the attacks. But the body just wants more and more with time, to keep the good effects. I take 150mg now. I have gained a lot of weight, I'm tired and I can't think clearly.. theres like a heavy fog in my brain.
I'm gonna go down in strength very soon and phase it out of my system slowly, because it's very addictive. In my country it's classed as a narcotic now. Withdrawals here I come..
Come off slowly mate, l was on 300mg per day (150 x 2)..after watching this l now realise this wasn't a large dosage.. it helped ptsd & anxiety somewhat..lve got pinched nerves in my neck, it didn't help with this tho.
Anyway, reducing your dose, try not to cut down by greater than 30% decreases.. My anxiety flared ridiculously as did my insomnia...l read a fair bit online in forums, not a gd idea, they're never positive places.
But l took about 14 mths to rid myself of taking it slowly..none for over a year now.. so good luck with it mate..it has gd results..but definitely wasn't for me.
Im on it since 2 years and gained almost 30 Kilos. But my doc have me the okay to Go Higher and lower with the dosage If needed im on 150mg now from 450 mg a few weeks ago. Right now im better with my rls but there are Times i need more Medication. Its a good Medication If you dont abuse it (in my country thats a big Problem) but the weight gain is too much for me even though im Tracking my cal intake im keep gaining weight 😩
@@inciMoawad I mean.. it has helped me a little bit with my anxiety. But my weight gain has crushed the little bit of self-esteem that I had. Right now I'm down at 25mg per day.. so almost off it.
WOW, you did an amazing job with giving such detailed information in this video.. I really appreciate it !!!
You are doing god's work seth
Roupization Lyrica is Gods best high lol
Yah right ☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️☠️😱(+_+)
Your welcome , taking nbome everyday isn't easy but it does come with its side effects
lyrica was the only non opiod medication that allowed me to feel halfway decent and get a little sleep during withdrawal from opiate medications.
I'm a introvert. When i take over 900mg lyrica i turn into an extrovert.
YES. lol
Be Careful that's scary high !
Are you alive still? Just wondering
Agree there brother 🙌 👍 👌 🙏 💯
Same haha motormouthing like a mf 😂
Just watched a documentary on this stuff. I had no idea people were strung out on it
Lyrica as given me back my every day life back again. No more severe nerve pain in my back and hips, but I am on a low dose of 75 mgs per day. I had back surgery 2 years ago .
Works great for my daughter's diabetic pain but we had to stop it due to the high cost of this medication in South Africa.
This drug helped me control my anxiety and get my life back on track I never felt addicted and chose to stop talking it as my life is in control.
'more effective than placebo' lol.. I'd say.
if you take it the once, yeah.
if you take it every day, i have doubts how much better than palecbo it is.
I'm on lyrica I was unaware how popular they are
@@Noah-wv4td There is a lot to be said about psychosomatic effects. I'd rather leave the conclusions based on results and hard knowledge.
@@Noah-wv4td for that matter trip balls
Watched your Nos video, now im benige watching. Great content!
I use Lyrica for nerve pain in my leg and it definitely helps with that . When I don't take it and I fall asleep I wake up 30 minutes later like someones has been flashing a light in my face.
Are you still using it for nerve pain?
I took one last night for the first time. What an awful experience.
Couldn’t sleep, restless, rash and gave me a headache. Its safe to say I won’t be taking it anytime soon.
For me this caused dizziness a bit but I felt super upbeat too.
Sorry, I was prescribed Lyrica at one time for mixed connective tissue disorder (lupus, fibromyalgia, schleroderma etc) and lost 4 days of my life to one starter dose pill. I don't remember anything but my mother said I became very belligerent and refused to allow her to take me to the hospital. We're still not sure why it did this but I will never even touch the stuff ever again.
My son was prescribed this crap for leg pain. He took it for 2 weeks and it made him go crazy for a month. I would steer clear of this drug !!
I had several episodes of amnesia. Used lyrica sporadically, had a half hour of amnesia, then a couple years later I lost an entire day. Don’t remember much. After many tests, it was decided the lyrica was the most likely cause.
I tried twice. She helped me quickly recover after a couple of days partying. Quickly acted and I fell asleep and saw very beautiful and bright with a lot of color shades, dreams!! And for three or four hours of sleep, I woke up and felt good, as if I had not been hanging out for days
same to me 3 hour sleep with it feels like 8 hour or more
I take this medication to help me get through work.
Great! Now do one on Phenylpiracetam.
Thank you so much for this information
Long but very useful details of Pre gaba !!!! Thanks !!!!Dr !!!
Hi seth awesome video! Question: Are you ever going to talk about drug politics, decriminalization, legalization, harm reduction programs, drug law enforcement, etc?
Certainly. I was actually speaking with someone about that recently and I think it'll be good to cover policy as well. It may be a little while, but that's an area I want to expand into.
I just got em today i love them... For anxiety and depression
twitches do happen, I have noticed people self included will even drop objects during a twitch.....excellent for every other day use especially for wd from opiates.
Hi Seth. Great video mate!
I spent around 5 or 6 years on pregabalin whilst waiting for an operation on my neck. The surgeon now refuses to do the operation due to "ongoing other health problems". I asked him about this stuff that he had put me on all those years ago and was told, that, "It's ok, you can continue to have these prescribed each month at 300 mg x 2 per day".
I spoke to my GP and spent the first 3 months or so of this year, whittling the dosage down until I was finally free of the stuff.
Kids, if you wanna get off your face then there are plenty of less harmful things than this awful shite. Months after bein free of it, my head is still clouded to hell. I forget way more stuff than I even hope to remember. Which sounds ok until you start forgetting more important things in your life. Like how to get home!
I was always dropping shit like an old person. Totally messing with motor function. Didn’t find it helpful for pain at all.
Helped my pain but I was zombiefied
Insomnia was the biggest issue for me in withdrawal
I have Fibromyalgia, severe anxiety and panic disorder.. along with arthritis... i have refused medication since diagnosis. Since then I have really had times where Ive struggled so bad I couldn't get out of bed.... this medication was suggested and given to me, but I never filled the prescription, that was a few years ago.. I'm now Considering it... ugh
Lyrica works great for my anxiety. I contacted Pfizer and they actually send me the drug for free. It would have cost me 560$ a month.
Do it
Yes I’m prescribed this. It’s good with adders although I’m not even into uppers. Just prescribed.
good quality content / delivery... a credit to the WWW
Can you cover Temazepam?
Yo Seth! So this is kinda a tangent but it's still relevant to pregabalin. One of the primary active constituents in 'Valerian root' is something called valeric acid. Valeric acid is closely related to this class of drugs, as well as drugs like valproate (depakote). I've been taking about 500mg Valerian root 3 times a day and it's been helping with my bipolar disorder. Do you think there is some pharmacology going on there? Or is valeric acid just a precursor and I'm mostly experiencing placebo?
I'll have to research valerian more to give a true answer, but from my current understanding the primary actives of valerian might be functioning in a manner that's more directly GABA-related, while pregabalin is based around calcium channels.
Clearly there's some kind of pharmacological action of the substances in valerian. It does have an effect on the body after all.
You could be experiencing placebo, but it might be a real effect.
There are several "valerian acids" in valerian root, while there are scant studies the action does seem to work partially in the section of the brain as benzodiazapenes..so GABA mediation is at work here. First Use a Standardized extract for right amount of Active components-usually 4:1 extract.sometimes a mix of powdered herb with the extract works well.Valproate or valproic acid works on the post synaptic actions of GABA so tends to be used in bi-polar disorders, and some scizo-affective disorders so probably has some dopamine blockade activity..there is no evidence for this with valerian root, though it works quite well as a mild anxiolytic-sleep aid.One Herb in Extract form is KAVA KAVA, this is one of the best Natural anti -anxiety herbs available. it's main components are Kava-Lactones, lactones are well known from other plants , but kava probably has its main mediation through at least in part the GABAa receptor, mediates sedation as well..iv'e gone on too long. but hope this adds to discussion. Seth B.
The Drug Classroom
Have you researched valerian root more yet?
I had a much more detailed post written out however my internet connection is touch and go here for some reason so I'll keep this short and to the point:
I'm currently using Lyrica for acute opioid withdrawals (and have in the past) which I find works very well. I take 300mgs per day, which is the bare minimum dose I find to work. I've heard about it coming with its own set of nasty withdrawals which I definitely don't want to experience which is why I just take the bare minimum and for no longer than 7-10 days (which is about the length of time I would experience the worst of the opioid withdrawals).
I tend to clear out my schedule for approximately 10 days at the very least due to Lyrica causing me to become very dizzy and making my eyes noticeably red. I've been accused of smoking marijana and/or taking other substances due to this. It also causes extreme sedation so I find I cant get much of anything done within those first 7 days at the very least. Even though it does induce drowsiness within me, I do find myself waking up several times.
It also greatly increases my appetite and gives me dry mouth.
I've also heard about it having its own set of very harsh withdrawal symptoms so thats why I keep it to the bare minimum dose required and I dont take it for any more than 10 days.
I've heard about people using it at much higher doses for recreation, however I don't have any interest in it other than its ability to get me through the initial, abject misery of the physical symptoms of opiate withdrawal.
One other effect I've noticed is that it enhances my dreams, making them extremely lucid even at a 300mg dose (which many people have told me is quite a low dose, however these are the same people who are taking upwards of 900mgs to achieve recreational effects.
If I think of anything else I will write edit this post.
Was taking for a while, but on an irregular basis. Had a short case of amnesia, then a much longer case. Ended up in the hospital and didn’t remember the previous day. After a lot of tests, it was decided that the most likely cause was the lyrica.
preagabalin is the ultimate of ultimates
This drug worked well for me but it was the most intense withdrawal symptoms I've ever experienced.
I took pregaballin for 3 weeks for a spinal injury. I was on oxycotin for 3 weeks also and experienced a very limited withdrawal compared to pregabalin.
I'm now taking no pain meds
Mawk Grasper I’ve been on it for 11 years & in some ways it’s worse than opiate withdrawal if one tries quitting cold turkey. Withdraw symptoms are so bad that I try to keep at least half a month extra as a safety net in case of the “unknown” & I have to find a new doctor or something. It HAS improved my quality of life, I was suffering with severe nerve pain. I’m almost 53 & ok with the fact I’m gonna be on it for life. Anyone who decides to start taking this medication needs to talk with their dentist about dry mouth & a proactive plan to battle tooth decay.
Does it make an difference to take the pregabalin powder with or without the capsule?
No
How long do you need to take it before you feel the drugs effects?
There are so many 'i know from experience, NEVER TAKE (insert drug)' comments. Every person's body and brain are different, telling someone to never take a drug because you had a bad experience is just silly. I've been on clonazepam for seven years, and by not using it every day I am still taking the same 2mg dose as I did seven years ago. I have stopped using it for weeks at a time to test for withdrawals, and there were none.
Every person is different!!!
Clonazepam saved my life and I got myself of opiates 20yrs mate and now I'm on this (Arthritis and nerve damage in my spine yep it hurts) I am having horrific side effects to this new wonder pill and truly at a loss now what to do.
dothejordman 7 years on 2mg there is No way you did cold turkey with No side effect
@@JacobafJelling He said he doesn't take it every day
dothejordman I’ve been taking 30 mg clonazepam and 50 mg alprazolam every day for 20 years and I quit cold turkey and no effects!!
@@Aypher don't piss down my back and tell me its raining. We all know that is bullshit
I had agonising sciatic pain and pregabalin helped massively. The side effects were pretty bad but faded after a week.
No weight gain, but I sleep for much longer now (7-8 hours) than I did before.
Pain releif is a side effect as is phantom pain
Weight gain is a sideffect as is weight loss
It can fix anxiety and it can cause anxiety
It has no actual use its just a big bag of maybe
@@justinblake420 - clinical trials, and punctuation have their advantages.
@@justinblake420 Excellent Ted Talk
@@NapoleonGelignite Your comma is entirely redundant.
@@naughtymonkey1563 - fixed
Thanks for the video. Did you skip opiate withdrawal part on purpose?
I didn't. It's mentioned in the video and is discussed in more detail on the linked TDC page.
From video: "For people who are dependent on drugs like alcohol, benzodiazepines, and opioids, pregabalin might be helpful. Some evidence suggests it can reduce withdrawal symptoms and even reduce craving."
Thank you
Been on it for 3 years it's a miracle for nerve damage
Ever tried to stop it? Wondering bc of withdrawals.
It's better for the night.
For pain and insomnia.
man I love this drug it makes me so warm and fuzzy and incredibly relaxed and also pretty dissociated also there is a very strong rush of euphoria
was gonna ask my psych to prescribe this thanks for the vid
I took this for three days but my hands and feet became really numb. I couldn't feel them for all most a week after stoping the drug. Im back on my gabapentins for my seizures now and I am staying on it. I didnt like lyrica at all.
I had a pinched nerve in my back and the pain even with percocet and vicodin was so great I was contemplating suicide, solely due to the pain. I am quite strong minded but I was about to give up hope getting relief. I took one Lyrica capsule from a blister pack and my pain was COMPLETELY GONE it was an answer to my prayers. This is the most amazing drug in the world if you have nerve pain. It made me crazy though I had extreme anxiety and pretty bad paranoia. I took it only until surgery, I didnt have any desire to abuse it.
How many mg was it?
Its weird how its perscribed for anxiety but causes it in some people
@@ThaGVPSon that's what I'm paranoid about. I have to say Gabapentin makes my anxiety melt away almost instantly but I haven't tried Lyrica yet.. I'm nervous but hopeful
Exact same situation, about five days using it, my pain was greatly reduced, and after 10 days there was no pain at all.
That... was a LOT of info. Thanks!
I got this suggestion and remembered what i need to know about pregabalin......its time to dose.... yay
This is great drug for anxiety! But much like benzo would not recommend for Longterm use (years) on 450mg a day atm, yes it has abuse potential but not worth it if you’re taking it for a general reason.
Yeah tollerance builds up crazy fast. Even though I dont get the same euphoria it still helps my anxiety immensely.
Very accurate about the recreation effects
Excellent information, well researched, i am a registered nurse and will use this information to guide my actions.
Your voice is soothing
thanks man, I know you partially did this for me.
love & peace from The Netherlands
Werkt het nog steeds?
It worked really well for me to treat anxiety. But the withdrawal can be hell.
For how long have you used it and what dosage? How long did withdrawal last? Why did you stop taking it if it worked well? Thanks.
@@johnj6743 why you asking
Because he wants to know and so do i
Works great for my fibromyalgia pain.
Are you ok taking it..any effects
It also has negatives. Such as being so deep asleep your "I need a pee" waking fails to happen. What does happen is 15 minutes later your "There is something wrong with the bed" waking works. Then you find wet boxers and a patch of bed wetting. I had a week of this every night, by the end, my wife and I went from me very upset and her calming me down, to both getting up she changes the sheets and duvet cover and puts the one the absorbent puppy pads down. I got my ass into the shower and then took the soiled stuff down to the washing machine. Amazing how quickly you automated things! By the end, we didn't say a word until it was all sorted, and then we resumed the conversation we were having before dropping off. That was me dropping off mid-word.
It's damn strong stuff!
Great stuff we call them buds in belfast
do you guys use it recreationally? hor many MG wouls give me a good high withourth getting sleepy
@@danielzapata9865 so many knockoffs now I used to get the Pfizer ones before the generic ones came out they where ery good , I wouldn't take the ones from a dealer or any generic ones as they're shite. At one stage I check the price for 1kg of pregabalin wasn't very expensive so dealers must have started to buy it from the net make they're own 1 pound or more a tablet.
I ate strips of 14 loads before but I didn't realize how dangerous it was at the time . many people n northerners Ireland's have died from poly drug use taking the buds tramadol booze diazepam and strong coke together can just make you stop breathing I heard. Peace and stay safe, and smoke weed everyday.
@@danielzapata9865 1 300 would be enough I would say the lighter mg used to make me be rude they also make ya talk alot of shite so have to learn to try and be quiet if your at work or with people who might suspect your taking owl gear.
I took recently 300 mg of pregabalin from my mother's medications, It was a really good experience don't know why but I felt like I was on LSD but without the hallucinations just the colors were more powerful like I put a filter or something, I can say that pregabalin is a good one time try as a recreational drug because it can be really addictive.
Thats what I though yesterday, felt weirdly psychedelic/dissociative. Ive never tooken lsd before but it felt kinda trippy like 2cb
I find this quite common in 900mgs and above and greatly increased Opiate medications too
@@2koP7tooken? Wtf bro 😅
Could you please do one on Lamotrigine (Lamictal)
Hi so one year ago i damaged my costal cartlidge in my third rib. I was diagnpsed wrong and only 2 weeks ago i had an mri which told me the problem. I stay in thailand and they have prescribed me with lyrica, arcoxia and cybalt. Lyrica makes me so sleepy. I wake up and my head feels heavy. Im constantly in pain due to the cartlidge growing back deformed.
One of my favourite medications. Truly is a wonder drug!
Indeed ❤
How are you finding it now?
I've heard it's really hard to come off, a mix of opioid and benzo withdrawal. I love it personally, recreationally to begin and for anxiety etc
@@justanotheryoutubeaccount8011 It still works amazingly well even after years of use for myself.
England and surrounding areas (Scotland especially) have a huge problem with this drug it's so weird to hear it but kids are going crazy over that weird stuff
I'm on 1000mg right now
Dont know why, i think its horrible
Is it safe for kidney and liver?
Is this a good non addicting alternative to benzos if you want muscle relaxation only?If not which drug has the least side effects for reducing muscle spasms without risking addiction?
It would not be a go-to drug for that use. Baclofen may be of use.