In this particular podcast, I must acknowledge that I began with my own biases toward human growth hormone (HGH). I have several competitive friends and acquaintances who regularly use HGH, many of whom have used it in isolation. Our findings indicated that for muscle building, HGH alone is not particularly effective. Conversely, when combined with anabolic steroids-or even better, anabolic steroids with insulin-HGH yielded remarkable results for about half of the users. The other half were either unimpressed or had to discontinue use due to unwanted side effects. Ironically, the main unwanted side effect I am referring to is a lack of energy (sleepiness). That is somewhat contrary to some reports out there in the “bio-hacking ethos.” That said, the danger is in the dose and these athletes I am referring to are certainly not micro dosing. The outcomes of using HGH are influenced by numerous caveats and nuances, which we will explore in a multi-part series. My goal is to present this information to you, the audience, in a concise and practical manner. As Einstein said, "If you can't explain it simply, you don't understand it well enough." Thank you all for your support. Your kind comments motivate me to continue.
It's the passion behind the curses. That's what had built the knowledge and wisdom this man has. And...one of the reasons I think Professor Broderick and the way he dispenses and explains his actual information, is fantastic. Dude extensively knows the cellular basics better than most everyone online.
Broderick explains everything exceptionally well. If you feel you need to keep "dumbing it down" for your audience, time to attract a better following. They definitely aren't ready for any of this. If they're that uninformed
Tip for the next podcast: I think that people would love one that Broderick will go deep into blood work, he has one with Revive Stronger but I am sure Daniel can do a better job with this topic and ask better questions and make better scenarios.
Hello there. Thank you for watching. I do have podcasts on this specific topic planned in future. Thank you for watching and I apologise if I could not make this video sooner for you.
Comment for the algorithm Great video, thanks for the information. I would like Broderick to go in more detail on the equations the liver uses to produce igf1. Is T4 or T3 that plays a part in that or is it both? Cheers
Hello there. Your question is on the short list. I too am rather confused when the topic is thyroid and IGF-1. Perhaps that in of itself needs a podcast of its own. We can’t rush this stuff. I apologise that your question was not answered in depth. I’ll do my best to cover thyroid and IGF-1 in future; whether it be Broderick or another guest. Thanks for contributing and for watching.
In sedentary people without drugs, insulin resistance starts measurably happening in fat well before it starts noticeably affecting day-to-day health. So you can get an early warning of developing insulin resistance by comparing levels of non-esterified fatty acids and insulin in your blood at the same time (if insulin is high and fat is still escaping adipocytes, they must not be listening).
@@troy3423 I haven't seen any studies confirming this, but mechanistically it'd have to, wouldn't it? If you look at the way type 2 diabetes develops, first some cells become less insulin sensitive, then insulin levels rise to maintain the same whole-body insulin signal, then glucose rises, and eventually insulin starts gradually falling because hyperglycemia has damaged the pancreas. The Adipo-IR score (fasting insulin × fasting non-esterified fatty acids) would seem like it ought to rise either right at the beginning or in the rising insulin/euglycemia stage. Whereas A1C measures damage done by too much glucose, so it would only detect a problem once insulin can't go high enough to keep blood sugar normal. EDIT: DOI 10.2337/db16-1167 would seem to confirm my hunch. Adipo-IR score nearly doubles (from 4.1 to 8.0) as people gain weight before oral glucose tolerance is measurably impaired, while A1C only goes up from 5.1 to 5.3 during the same process.
Testosterone levels reduce binding proteins because the same binding protein (SHBG) is used for both testosterone and estrogen, but it works better on testosterone, so when the liver sees testosterone it assumes it won't have to regulate estrogen and doesn't bother making enough SHBG to effectively regulate estrogen. Drugs with estrogenic effects in liver, like raloxifene and oral estradiol, increase SHBG levels for related reasons.
Hello there. This supplement is unlikely going to be something I discuss with guests as the focus is on the PEDs, nothing OTC. May I suggest looking up Alex Kikel. He seems to be the man on this topic. Thank you for watching and I apologise for not being able to give you the answer you were after.
Serious question here, So BPH (enlarged prostate) According to literature is cause by too much Androgens floating around in the prostatehence why Finasteride is prescribed to block the AR5 RECEPTOR. But i find this somewhat odd as BPH happens in older life, generally after 50 and men have less tesosterone or may even be hypogonadal by then. So my question is, Does tasking insulin for BB purposes in older life affect BPH as I am led to believe there may be a link between high glucose levels (hyperinsulemia) in the body & BPH?
This is a fair question. Unfortunately, there will not be a study paper that can give you this insight as the insulin use in an athlete is in an obviously different environment to that of someone who is dependent on insulin for metabolic syndrome. That said, hyperinsulinemia caused by supra-physiological doses of insulin can cause some of the same detriments as a metabolically unhealthy person. This is a situation where you will likely benefit from aggressive monitoring of the prostrate and other bio-markers-as the answer is largely a black box. You may just find other issues early you never considered from aggressive monitoring, too. The more you measure, the more you can manage. Thank you for watching.
@@raymondkarlsen9995 Hello there. The rest of the videos are on Broderick’s members site. I have more planned with Broderick in the future. Thank you for watching and I apologise if not all of the videos are publicly available any longer. I’ll make up for it!
Could you guys do some content on how to get metabolically fit and maintain it through different periods like offseason-bridge-prep and how this would look like for a bodybuilder? how much what forms/intensities/heartrates and how to not have it negatively impact your local and systemic recovery and programming it around your leg lifts. Where would one start to get "optimally fit metabolically" as a bodybuilder? what would some good benchmarks be to know you are fit enough metabolically? Maybe there are some pharmacological gippety goop B. could educate us on too haha. Dont forget to touch on how this benefits recovery-progress-health and how this benefits PED users and different types of our ped using population.
I am curious as to his reasoning for 5 on/2 off for GH instead of daily use. Great podcast overall. You do a very good job asking good questions and letting the guest speak without interrupting.
Thank you. Those words mean a lot. Broderick’s main reason behind the 5 on and 2 off is such that the side effects have a moment to “cool” on the 2 days off, but the overall net IGF-1 resulting from 5 days of usage is sufficient to produce the results the user is after. It seems that even more important than the weekly dose of rHGH, is the frequency of the dosing. I will explain with a hypothetical. If a user had a budget of 30 iu of rHGH per week, he would likely see a greater chance of insulin resistance if he was to split the dosing up multiple times per day as opposed to once daily. Remember, these are not absolutes, and many will not have issues with increased dosing frequency iu for iu.
@@DanielPekic thanks for the explanation. I think I may need to implement this as the side effects such as numb hands are starting to catch up with me with daily use. Looking forward to more content from you.
This is a good question. May I ask though if this question is for a diabetic or non diabetic? Or, someone with a degree of insulin resistance that is considered dependent on pharmacological intervention. Thanks for watching.
@DanielPekic non diabetic, using tirzepatide for appetite suppression purposes. I'm assuming it helps with HGH to IGF1 conversion as it stimulates the pancreas to produce insulin but Brodericks thoughts would be great (I know you guys did a deep dive on GLP1s already but I didn't hear that one covered)
Nebivolol, Finerenone, GH, T3, Masteron, and Estradiol would be a good combo. Prevent a lot of the mineralcorticoid effects while potentiating growth. Still a recipe for gyno though. I guess you gotta put away 6k for gyno surgery if you were a professional BBer
Not if u keep ur shit in check, most guys do not get gyno...but obviously there's alot of dipshits that no nothing about the drugs they take and run Into issues, like gyno and well good on them for not taking time to understand something before putting it in there body
He is of the belief that because he did NOT use exogenous thyroid, and ignored the warning signs, that this is the reason why he is now hypothyroid. Anabolic steroids and Human Growth Hormone can both affect the thyroid. Of course, there is a long list of things that also can affect the thyroid, so it is important to consider any n = 1 as exactly that. Thank you for watching.
I can tell you were getting frustrated I had a old hippy friend that had a chemistry degree wicked smart like Broderick when I would pick his brain he wanted questions answered in a specific way or he'd pick it apart like mofo your too smart to not be picking up what I'm putting down quit being difficult dammit lol
This is great content but does Broderick have some form of autism in that he cannot answer a hypothetical question like a normal person? I get being specific but there’s a difference between being specific and being extremely nit picky. Half the time spent “correcting you” could be spent just answering the question at hand.
I have received a number of messages like these. I cannot disagree, it has been challenging and more so lately than ever. I will have a conversation with him before the next podcast in the hopes we can improve this. Thank you for the honest criticism. I agree with you.
I work in the software industry and I've met a few guys like this. They have super deep knowledge on certain subjects and are practically geniuses in their own field of interest but they also just happen to be incredibly pedantic nerds during discussions. It's aggravating at first but you learn to deal with it, and I'm even friends with several of them now. And no they will never change, so good luck trying to change Broderick's ways 😂
Can you ask him on the next live stream, why does the body only allegedly only recognize 22kDa GH and operates better on 22kDa rather than anything that’s not 22kDa
This question is set for Part 2 of the HGH deep dive. Off the bat, the 22kDa is the predominant version of GH we naturally produce as humans by the pituitary gland. Some other "off shoots" had some consequences I believe. I will ask and I hope to receive the answer you are seeking from Broderick. If not from Broderick, perhaps from Alex Kikel. Thank you for your comment and thank you for watching.
In this particular podcast, I must acknowledge that I began with my own biases toward human growth hormone (HGH). I have several competitive friends and acquaintances who regularly use HGH, many of whom have used it in isolation. Our findings indicated that for muscle building, HGH alone is not particularly effective. Conversely, when combined with anabolic steroids-or even better, anabolic steroids with insulin-HGH yielded remarkable results for about half of the users. The other half were either unimpressed or had to discontinue use due to unwanted side effects. Ironically, the main unwanted side effect I am referring to is a lack of energy (sleepiness). That is somewhat contrary to some reports out there in the “bio-hacking ethos.” That said, the danger is in the dose and these athletes I am referring to are certainly not micro dosing.
The outcomes of using HGH are influenced by numerous caveats and nuances, which we will explore in a multi-part series. My goal is to present this information to you, the audience, in a concise and practical manner. As Einstein said, "If you can't explain it simply, you don't understand it well enough."
Thank you all for your support. Your kind comments motivate me to continue.
*applause*
Well done with this podcast. Great job asking the right questions.
I’m surprised Broderick is legally allowed out in public
You can tell he lives in some woods in a derelict camper
Lol
just keeps getting better every time you post. Fuck those who just want 30sek videos. This is real content
Thank you. This means a lot. I will continue.
YESSSS. reels can suc... good for pull though
The TikTok tards would be lost in minute one.
Some really sassy Banter 😂 Broderick is one of a kind. I like how you push back a bit
You do such a good job of being an interviewer Daniel. Great stuff man you ask really important questions and follow-ups
Thank you. That means a lot to me.
Turns out all I needed was swear words to learn shit
Certainly one way of teaching. Thank you for watching.
It's the passion behind the curses. That's what had built the knowledge and wisdom this man has. And...one of the reasons I think Professor Broderick and the way he dispenses and explains his actual information, is fantastic. Dude extensively knows the cellular basics better than most everyone online.
Broderick explains everything exceptionally well. If you feel you need to keep "dumbing it down" for your audience, time to attract a better following. They definitely aren't ready for any of this. If they're that uninformed
Tip for the next podcast: I think that people would love one that Broderick will go deep into blood work, he has one with Revive Stronger but I am sure Daniel can do a better job with this topic and ask better questions and make better scenarios.
Hello there. Thank you for watching. I do have podcasts on this specific topic planned in future. Thank you for watching and I apologise if I could not make this video sooner for you.
Great content mate. Appreciate you.
I appreciate that!
This is great. Thanks for this
Daniel, could you ask in part 2 if GH then acts as an inhibitor of myostatin when it “whispers to the cells that it’s ok to grow”?
Daniel is a great interviewer. But especially for broderick, who seems to kinda enjoy this specific slightly straight up no bullshit communication.
Very interesting !!! thanks
You are welcome!
Has some of the older podcasts disappeared, or were they deleted? Unable to watch them anylonger.
Like which ones? I see them all
Comment for the algorithm
Great video, thanks for the information. I would like Broderick to go in more detail on the equations the liver uses to produce igf1. Is T4 or T3 that plays a part in that or is it both?
Cheers
Hello there. Your question is on the short list. I too am rather confused when the topic is thyroid and IGF-1. Perhaps that in of itself needs a podcast of its own. We can’t rush this stuff. I apologise that your question was not answered in depth. I’ll do my best to cover thyroid and IGF-1 in future; whether it be Broderick or another guest. Thanks for contributing and for watching.
In sedentary people without drugs, insulin resistance starts measurably happening in fat well before it starts noticeably affecting day-to-day health. So you can get an early warning of developing insulin resistance by comparing levels of non-esterified fatty acids and insulin in your blood at the same time (if insulin is high and fat is still escaping adipocytes, they must not be listening).
I wonder if this happens before elevations in A1c
@@troy3423 I haven't seen any studies confirming this, but mechanistically it'd have to, wouldn't it? If you look at the way type 2 diabetes develops, first some cells become less insulin sensitive, then insulin levels rise to maintain the same whole-body insulin signal, then glucose rises, and eventually insulin starts gradually falling because hyperglycemia has damaged the pancreas. The Adipo-IR score (fasting insulin × fasting non-esterified fatty acids) would seem like it ought to rise either right at the beginning or in the rising insulin/euglycemia stage. Whereas A1C measures damage done by too much glucose, so it would only detect a problem once insulin can't go high enough to keep blood sugar normal.
EDIT: DOI 10.2337/db16-1167 would seem to confirm my hunch. Adipo-IR score nearly doubles (from 4.1 to 8.0) as people gain weight before oral glucose tolerance is measurably impaired, while A1C only goes up from 5.1 to 5.3 during the same process.
Excellent information
Thank you 🙏
Insulin on its own: Use only around your workout, preferably in the morning
Testosterone levels reduce binding proteins because the same binding protein (SHBG) is used for both testosterone and estrogen, but it works better on testosterone, so when the liver sees testosterone it assumes it won't have to regulate estrogen and doesn't bother making enough SHBG to effectively regulate estrogen. Drugs with estrogenic effects in liver, like raloxifene and oral estradiol, increase SHBG levels for related reasons.
Daniel, could you do a video on injectable carnatine and contest prep videos
Hello there. This supplement is unlikely going to be something I discuss with guests as the focus is on the PEDs, nothing OTC. May I suggest looking up Alex Kikel. He seems to be the man on this topic. Thank you for watching and I apologise for not being able to give you the answer you were after.
Serious question here, So BPH (enlarged prostate) According to literature is cause by too much Androgens floating around in the prostatehence why Finasteride is prescribed to block the AR5 RECEPTOR. But i find this somewhat odd as BPH happens in older life, generally after 50 and men have less tesosterone or may even be hypogonadal by then.
So my question is, Does tasking insulin for BB purposes in older life affect BPH as I am led to believe there may be a link between high glucose levels (hyperinsulemia) in the body & BPH?
This is a fair question. Unfortunately, there will not be a study paper that can give you this insight as the insulin use in an athlete is in an obviously different environment to that of someone who is dependent on insulin for metabolic syndrome. That said, hyperinsulinemia caused by supra-physiological doses of insulin can cause some of the same detriments as a metabolically unhealthy person. This is a situation where you will likely benefit from aggressive monitoring of the prostrate and other bio-markers-as the answer is largely a black box. You may just find other issues early you never considered from aggressive monitoring, too. The more you measure, the more you can manage. Thank you for watching.
There is supposed to be 26 videos with Broderick. I can only see/play 8! Is the rest sensored by youtube or something?
@@raymondkarlsen9995 Hello there. The rest of the videos are on Broderick’s members site. I have more planned with Broderick in the future. Thank you for watching and I apologise if not all of the videos are publicly available any longer. I’ll make up for it!
Could you guys do some content on how to get metabolically fit and maintain it through different periods like offseason-bridge-prep and how this would look like for a bodybuilder? how much what forms/intensities/heartrates and how to not have it negatively impact your local and systemic recovery and programming it around your leg lifts. Where would one start to get "optimally fit metabolically" as a bodybuilder? what would some good benchmarks be to know you are fit enough metabolically? Maybe there are some pharmacological gippety goop B. could educate us on too haha. Dont forget to touch on how this benefits recovery-progress-health and how this benefits PED users and different types of our ped using population.
I am curious as to his reasoning for 5 on/2 off for GH instead of daily use. Great podcast overall. You do a very good job asking good questions and letting the guest speak without interrupting.
He covers this in the original podcast series Daniel did with him. On the Team Evil GSP website.
@@keelancranfield-brooks8103 oh awesome. Thanks man
Thank you. Those words mean a lot. Broderick’s main reason behind the 5 on and 2 off is such that the side effects have a moment to “cool” on the 2 days off, but the overall net IGF-1 resulting from 5 days of usage is sufficient to produce the results the user is after. It seems that even more important than the weekly dose of rHGH, is the frequency of the dosing. I will explain with a hypothetical. If a user had a budget of 30 iu of rHGH per week, he would likely see a greater chance of insulin resistance if he was to split the dosing up multiple times per day as opposed to once daily. Remember, these are not absolutes, and many will not have issues with increased dosing frequency iu for iu.
@@DanielPekic thanks for the explanation. I think I may need to implement this as the side effects such as numb hands are starting to catch up with me with daily use. Looking forward to more content from you.
I’m curious where Lee Priest fits into the GH discussion as he said he started using GH at 13 y/o?
What are Brodericks thoughts on the impact of GLP1s on IGF1 in the "liver equation" for converting hgh to igf1?
This is a good question. May I ask though if this question is for a diabetic or non diabetic? Or, someone with a degree of insulin resistance that is considered dependent on pharmacological intervention. Thanks for watching.
@DanielPekic non diabetic, using tirzepatide for appetite suppression purposes. I'm assuming it helps with HGH to IGF1 conversion as it stimulates the pancreas to produce insulin but Brodericks thoughts would be great (I know you guys did a deep dive on GLP1s already but I didn't hear that one covered)
Nebivolol, Finerenone, GH, T3, Masteron, and Estradiol would be a good combo. Prevent a lot of the mineralcorticoid effects while potentiating growth. Still a recipe for gyno though. I guess you gotta put away 6k for gyno surgery if you were a professional BBer
Not if u keep ur shit in check, most guys do not get gyno...but obviously there's alot of dipshits that no nothing about the drugs they take and run Into issues, like gyno and well good on them for not taking time to understand something before putting it in there body
Love these guys lol
Thank you kind Sir.
DNP actually acts a lot like uncoupling protein.
Just in time...just got my blue tops in the mail yesterday 💪💪
Love Broderick but God damn would he be a difficult guy to have a conversation with lmao
How does he know his exogenous thyroid use made him go hypothyroid earlier in life?
He is of the belief that because he did NOT use exogenous thyroid, and ignored the warning signs, that this is the reason why he is now hypothyroid. Anabolic steroids and Human Growth Hormone can both affect the thyroid. Of course, there is a long list of things that also can affect the thyroid, so it is important to consider any n = 1 as exactly that. Thank you for watching.
Algorithm
Kind of you. Thank you for your support.
42:00 Kurt Havens would disagree
Kurt (no personality) Havens will also tell you he’s the smartest person in this genre, just ask him.
@@giovannigiorgio8664I can’t listen to Curt for more than ten seconds
I can tell you were getting frustrated I had a old hippy friend that had a chemistry degree wicked smart like Broderick when I would pick his brain he wanted questions answered in a specific way or he'd pick it apart like mofo your too smart to not be picking up what I'm putting down quit being difficult dammit lol
Perhaps I am easily annoyed. I need to improve.
Dude is literally more plates in 20 years
I think this is a compliment. Derek is a good lad. Thank you for your support.
This is great content but does Broderick have some form of autism in that he cannot answer a hypothetical question like a normal person? I get being specific but there’s a difference between being specific and being extremely nit picky. Half the time spent “correcting you” could be spent just answering the question at hand.
I have received a number of messages like these. I cannot disagree, it has been challenging and more so lately than ever. I will have a conversation with him before the next podcast in the hopes we can improve this. Thank you for the honest criticism. I agree with you.
I work in the software industry and I've met a few guys like this. They have super deep knowledge on certain subjects and are practically geniuses in their own field of interest but they also just happen to be incredibly pedantic nerds during discussions. It's aggravating at first but you learn to deal with it, and I'm even friends with several of them now. And no they will never change, so good luck trying to change Broderick's ways 😂
Broderick is sharp but insufferable.
Dude could lighten up a little lol
He has terrible insomnia. I'd be short as well
Can you ask him on the next live stream, why does the body only allegedly only recognize 22kDa GH and operates better on 22kDa rather than anything that’s not 22kDa
This question is set for Part 2 of the HGH deep dive. Off the bat, the 22kDa is the predominant version of GH we naturally produce as humans by the pituitary gland. Some other "off shoots" had some consequences I believe. I will ask and I hope to receive the answer you are seeking from Broderick. If not from Broderick, perhaps from Alex Kikel. Thank you for your comment and thank you for watching.
@@DanielPekic well from what I understand most generic GH is not 22kDa the only ones that I know of are genotropin serostim and the body works better.
this interviewer has less character than a wooden spoon!
We're here for the top quality content, not to be entertained. Go somewhere else with your negativity.
@@eamonnryan4092 🤣🤣🤣 you're trolling yourself if you believe that !!