Methotrexate Mechanism and Side Effects

Methotrexate is a medication used to treat a variety of medical conditions, primarily autoimmune diseases and certain types of cancer. It is a versatile drug with a wide range of applications, and it can be taken orally, injected into a muscle, or given intravenously, depending on the condition being treated.
Here are some key uses and information about methotrexate:
1. Cancer Treatment: Methotrexate is commonly used in the treatment of certain types of cancer, including leukemia, lymphoma, and gestational trophoblastic neoplasia. It works by interfering with the growth of cancer cells.
2. Rheumatoid Arthritis: Methotrexate is a cornerstone medication for the treatment of rheumatoid arthritis, an autoimmune disease that causes joint inflammation and pain. It helps reduce joint damage and control symptoms.
3. Psoriasis: This drug can also be used to treat severe psoriasis, a chronic skin condition characterized by red, scaly patches. Methotrexate helps to slow the growth of skin cells and reduce inflammation.
4. Inflammatory Bowel Disease (IBD): Methotrexate may be prescribed for individuals with Crohn's disease or ulcerative colitis, two forms of IBD, when other treatments have been ineffective.
5. Ectopic Pregnancy: In some cases of ectopic pregnancy (when a fertilized egg implants outside the uterus), methotrexate can be used to terminate the pregnancy to prevent life-threatening complications.
6. Dosage: The dosage of methotrexate varies depending on the condition being treated and the individual's response. It is usually taken once a week. It's crucial to follow the prescribed dosage and schedule carefully.
7. Side Effects: Methotrexate can cause a range of side effects, including nausea, vomiting, fatigue, mouth sores, and liver abnormalities. Regular monitoring of liver function and blood cell counts is necessary while on this medication.
8. Contraindications: Methotrexate is not suitable for everyone. It should be avoided during pregnancy, as it can cause birth defects. People with certain medical conditions, such as severe liver or kidney disease, may not be candidates for this medication.
9. Interaction with Other Medications: Methotrexate can interact with other drugs, including some antibiotics and nonsteroidal anti-inflammatory drugs (NSAIDs). It's important to inform your healthcare provider of all medications you are taking to avoid potential interactions.
10. Folate Supplementation: To mitigate some of the side effects of methotrexate, such as mouth sores and nausea, folate (a B vitamin) supplements are often prescribed. These supplements help counteract the effects of methotrexate on normal, healthy cells.
11. Regular Monitoring: When taking methotrexate, regular blood tests are essential to monitor your liver function, blood cell counts, and overall health.
Methotrexate is a potent medication with the potential for both significant benefits and side effects. It should only be used under the supervision of a qualified healthcare professional who can carefully monitor its effects and adjust the treatment plan as needed. Patients prescribed methotrexate should also receive counseling on its potential risks and benefits.

[@henrysiegertsz8204]

I'm not medical but the answer would be Immuno-suppressed patients, as Methotrexate is an Immuno-suppressant. I've just started today on 10 mg weekly dose of Methotrexate for Rheumatoid Arthritis, and Folic Acid (two days after Methotrexate). I also have Primary Adrenal Insufficiency on Hydrocortisone and Fludrocortisone, with Type 2 Diabetes on Glargine, Metformin, Gliclazide, and Dapaglifozin.

[@Asantewarrior]

IMunderstanding while what you said can be applied, methotrexate would lead to a pregnancy termination, making it an almost absolute contraindication. I am just a student by the way, my word is no gospel. Methotrexate would make you immunocompromised, being already immunocompromised would make medical professional cautious in starting the medication

[@mohansinhjhala9754]

MTX has also got an adverse effect on brain but nobody seems to have noticed.

[@kfiedl3600]

Take muscinex DM the day after shot day. You can also take doses of Rubatuasin DM instead of the Muscinex DM the day after. Try it.

[@mahamadomar4993]

Thank you so much.

[@samarfayyad4281]

So thankful for the time you spent in this video 📹.. It's helpful.

[@rozainahmohdsaid999]

I've taken MTX and I can feel it mess with my brain. I used to be an intelligent lawyer but I can feel my intelligence level going down🥺

[@khinnanoo]

I start take two months ago .I found that my memory fuzzy ish at times....I too have very good memory and am a chartered management accountant too

[@csyd22]

did it go away

[@khinnanoo]

@csyd22 it eventually...but there are times I think i feel slow to come up with names or places..

[@csyd22]

@@khinnanoo ok I'm on it for hand eczema, did you take folic acid with it supposed to stop the side effects. I am thinking yo stop using it been 4 weeks

[@khinnanoo]

@@csyd22 I take folic acid daily 5mg..I also the supplements omega 3 black( green lips muscle) and glucosamine with collagen etc

[@vanjayb]

Is it helpful for psoriasis or extreme eczema? My doctor prescribed

[@Rautelakimi]

Yes it's helpful and see other utube video to know more about

[@aameralzaman1467]

Thank you

[@eileencorcoran3090]

Not if you immune suppressed😊

[@suzannerose8635]

Mess with the brain that's for sure.🇦🇺🐨

[@nonoo8952]

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