The Truth about Tamoxifen and Aromatase Inhibitors - Update with Dr. Rahul Singh
VloĆŸit
- Äas pĆidĂĄn 9. 11. 2023
- learnlooklocate.com đ¶ There are two big classes of drugs just as a general overview recap. There's tamoxifen, which we're going to talk about, and then there's aromatase inhibitors, which is a whole nother group that we've talked about before. And so Tamoxifen is usually reserved for pre menopausal women and you submit post menopausal but unfortunately we cannot use the aromatase inhibitors in pre menopausal women unless we put them into menopause.
Chapters (time stamps):
00:03 Hormone-positive breast cancer treatment with tamoxifen.
07:41 Breast cancer recurrence risk and endocrine therapy.
12:44 Managing breast cancer treatment side effects.
17:08 Hormone therapy side effects and management options for breast cancer patients.
22:58 Tamoxifen side effects and recurrence risk for breast cancer patients.
28:09 Breast cancer treatment and side effects.
Rahul Singh, MD is an Oncologist & Hematologist located in the Northern Virginia & Washington D.C. area. Trained at George Washington University and in the Veterans Administration System, he is focused on promoting awareness and knowledge in different types of cancers and blood-related disorders. Dr. Singh is an advocate for breast cancer awareness, specifically given the many different misconceptions regarding prognosis and treatment. â
Cynthia Jordan, Founder of Learn Look Locate LLC in 2018 has generated a global movement to provide critical education for the early detection of breast cancer. It is estimated that one in eight women in the United States will develop breast cancer in her lifetime. While most of these cases are diagnosed in women over the age of 50, the disease can affect women of any age. Early detection is critical to survival, yet many women are not familiar with the signs and symptoms of breast cancer.
We advocate the importance of self-breast exams, what to look for when performing a self-exam, and when to see a doctor. We provide resources for women who have been diagnosed with breast cancer, as well as for their families and friends.
The five-year survival rate for women who catch their cancer early is nearly 100%. Hereâs an important statistic. Many women do not perform self-breast exams or see a doctor for regular screenings. Learn Look Locate LLC wants to highlight the work of organizations around the world that are working to promote early detection of breast cancer. We will feature stories of women who have been diagnosed with breast cancer and share their journeys.
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Thanks you two! I agree about who to go to when you are taking either therapy. My oncologist who I see every 6 months doesnt appear to be interested in any side effects and tells me to tell my doctor who doesnt have much knowledge, so I am left in the wilderness.
thank you so much for watching and sharing-have you seen my website-so much information and Q and A
Iâm 5 weeks into Anastrozole and my oncologist is giving me a 2 weeks break. Insomnia, joint pain, dizziness, nausea and blurred vision became overwhelming. Not happy about all this, but grateful my oncologist is giving me a 2 week break and then will cut my dosage in half. Heâs working with me which I appreciate.
I refused hormone treatment. My family doctor advised me to eat ground flaxseed. This was an unusual conversation to have with her.
The gynecologist continues to recommend hormones again and again.
There are many things in nature that help. As long as it's part of my usual diet, I won't let it stop me. Much of Asian cuisine is good for a healthy life also.
Funny how Dr. Singh failed to mention diet to reduce estrogen, natural supplements and that some estrogen is necessary for our immune health, etc. Instead he spoke manly of dealing with side effects or possibly switching to another AI which has its own negative side effects.
thank you for sharing, I agree with you and we will work on addressing more of these issues in our next call
This was really helpful from the UK. THANK YOU.
So glad we are reaching you in the UK-we want to educate globally-please see website if you have not seen yet. www.learnlooklocate.com
Yes, a discussion of natural alternatives is critical. Also, with pharmaceutical drugs/meds, they test for max amount that can be prescribed right at the threshold of toxicity. They don't test for minimum amount needed for efficacy, and for routine personal hormonal testing to see if it's even being effective for each particular patient, or if even needed. It's great you mentioned that 10 mg is effective! Testing for lowest dosage needed for efficacy needs to be thrle norm, not the exception. This would ensure lower side effects and increase patient compliance.
I agree that more discussion is so necessary, many people need to openly discuss how they feel about the side effects.
@learnlooklocate I've recently learned about EMA certified studies in Sweden, Italy, and the UK that found 2.g and 5 mg are more effective than anything higher. For 1, there are no side effects, so patients take their medicine and get its benefits. 2. Their studies measured for minimal amount needed for efficacy and found anything greater than 5.mg is actually poisoning the body which is why there are negative effects for most women. They aren't side effects. They are the effects of toxicity.
What are the alternatives for the AIs?
I too am a rebel and seek other options!
Thank you so much, Cynthia for helping to educate us and being an advocate for a better way!
A DUTCH test measures estrogen metabolites as well as progesterone, and testosterone. Hormones also affect immunity so reducing all estrogen lowers immunity. DIM and D-calcium glucarate also reduce estrogen but are natural and don't have side effects. Why don't conventional doctors measure the estrogen levels to make sure our immune system is not decreased? Estrogen blockers are like statins, they can lower cholesterol too far causing harm.
Hi Judy-thank you so much for watching and for your kind words-so much more needs to be talked about regarding to breast cancer
Iâm 77 years and I really donât want to take this. Just wondering how long it takes for it to come back.
I was diagnosed with IDC in 2022. ER/PR positive, HER negative. Had a double mastectomy in February 2022. My cancer was sent off for recommend treatment chemotherapy treatment. I had 3 types of chemotherapy for 12 treatments. Couldnât do radiation because of my pacemaker. I was put on aromasin therapy for 10 years. My endo predict is 55% chance of distance recurrence. I am having awful side effects from the medication. I have just stopped it about a week ago. Iâm hoping that I made the best decision. Any advice?
Thank you so much for sharing-it is so important we process everything for ourselves and make our own choices
Thanks for the video. What is the 3rd test which is for everyone whoâs not under treatment? Thanks
What is the drug that starts with a V? I tried to GoogleâŠbut nothing comes up.
When the dr says hormone positive cancer relapses more often, later 5-10 years; is this with pre menopause women or menopausal or both?
I donât need cataracts as Iâm already getting shots in my eyes for wet macular degeneration!!
Since the original branded AI is so expensive, can I switch to the generic one on my own without consulting my oncologist? I was told they are the same. Same ingredients except generic is much cheaper.
great question -good to ask oncologist:)
So I have HER 2 positive and I am on tamoxifen need to take for ten years scares me so much
I am on Exestemene for 10 years too!It is fearful because of the life threatening side affects.
My Dr.prescribed tamoxifen for me at 67 years old.He must have not been up to date on his education.
In a clinical trial for a first line SERD that may hit the market soon.
Well said Cynthia. Our onchologist are not emphatic enough about the side affects patients have to face. đąThey won't even discuss it. It's a very lonely place to be when faced with having to make a decision to take this without any meaningful support. The medical profession needs to address this very real problem.
How about the choice of taking only 5mcg to start.
Have you seen the dedicated page on www.learnlooklocate.com that takes a deep dive into Tamoxifen
I had Brest cancer almost 2yr ago and my Dr wanted me to take this meds and I said no to many side aff..
Hello hope everything is ok .may I know what you did if you didnt take this please?
Iâm curious as well as Iâm thinking of stopping mine. How are you doing? What was your recurrence rate? Mine is 30% with no treatment
I completely understand:)
Please comment on ESR1 mutations. NIH studies showing up to 50% occurring in hormone positive breast cancer with AI hormone therapy. Overall survival is poor on subsequent meds.
I felt like a statistic. No help after my treatment.
I can completely relate! Thank you for sharing so much more discussion needs to happen after we are diagnosed.
What about Aromatase? You mostly talked about Tamoxifen. Iâm very interested about Aromatase.đ
Would have been interesting to hear more about AI's
working on this next!
Interesting about pharmacists. Mine could care less.
You got a very bad audio system. A lot a noise liked your flushing the toilet.
aga na lang 6:30