My best friend is in college right now, thinking about getting his PhD, and what he really wants to do is create a cure for HIV. He even works with the virus at his practicum. I think it's super admirable, since he's going against the anti-cancer grain and doing something that's not only important to him, but to the world at large. I'm rooting for my nerd's success. :)
I just wanted to say Thank You for all of your research. This is a terrible disease. We have come so far since HIV became mainstream. I hope to see a cure in my lifetime for all the very sick and not so sick HIV positive patients I take care of.
@@xxnotmuchxx interesting question, I wonder if they magnified it 500x under a petri like dish and snapped a photo and animated what it would look like in 3D
As someone that lived through this, I wish you could too. It was crazy the way the HIV/AIDS crisis was handled in the U.S. It wasn't handled, in the media, as a medical concern but as a moral/religious concern and that condemned so many people.
In memory of my uncle Patrick. Had he known what we know now, maybe he would not have taken his life. Thanks for these videos. My stepdad (his brother) had (and still has) major views on the virus and his brothers "life choices". Honestly, he was the best uncle I had, even if he was technically my "step-uncle". He was my actual uncle and THE BEST uncle I had. We still remember ya Pat and always will.
Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
People love to be appreciated. It inspires us to do more, Thanks to Dr Osunmeh i met through youtube for doing what no other doctor could do. Thanks for curing my of HIV, you are amazing !
I really appreciate the effort put in making this videos. My father is an HIV expert and since I was little he taught me the risk and importance of treatment and responsibility. He lost many friends and I do not wish anyone the pain he has gone through along the way. Anyway, thanks for spreading knowledge in a matter as important as this one.
No, it is only a death sentence for the poor if you live in the US or other third world countries without national healthcare. If you live in a developed country that has a working healthcare system, it is no big deal and will cost you nothing.
Fadel Adam what he meant was that if he could have stayed relatively disease free for a while longer an AIDS treatment may have been able to save his life. I think you thought he meant that Freddie didn’t fight hard enough. I get that because my husband died of cancer and sometimes people say that he lost the fight. It irks me, like he didn’t fight hard enough? Right? But I don’t think that’s how most people mean it.
Freddie Mercury RIP, had some form of medication he simply chose not to drag out a losing battle. If only he was celibate or married to Mary Austin for real.
I work together with @MPT I donate my time and talent to create paintings from Freddie Mercury to fight AIDS worldwide in Memory of the Legend Instagram @winkler.annette
I took PEP (post-exposure prophylaxis) in 2019 and I was SO SICK. I definitely took every dose as recommended but I spent most of that month incredibly depressed and sick. My mom had actually researched HIV in the 90's so she was able to give me some information on the modern day medicines and also scare me into never missing a dose. I truly hope that one day there is a cure/vaccine that everyone is able to get access to. I did a couple projects in college on HIV after that and was so grateful for all of the research towards the medications I had to take in 2019. I tested negative at 6 weeks, 3 months, 6 months, 1 year and on and I truly wish these drugs were more widely available (still exorbitantly expensive even with insurance, I luckily got a coupon to waive the full cost for the month I took them).
That's so brave of you. Even I was on PEP early this year. And I can totally relate with being sick and depressed while you're on PEP. My tests came negative at 3months then 6months. I was fortunate that PEP is provided in INDIA free of cost in Hospitals so didn't had to gave a penny.
@@sagarborah9978 Hey I started my course yesterday its my 2nd day today its damn tiring I am talking the pep course with med called vonaday how was your experience through out ?
Great video, but as someone studying HIV, I have one correction and one additional point. Correction: there were actually two Berlin patients. One of them is less well known, as he was one of the ones that they did early ART for, and he just stopped taking them and his viral load didn’t regrow. (Source: Cured, by Nathalia Holt) Additional point: many HIV+ patients struggle taking their medication daily because it’s a brutal reminder of the fact that they are ill. For lots of people who suffer from HIV there are overwhelming psychological challenges as well, lots of people from the beginning of the crisis have PTSD from seeing so much death and if they contract HIV now, it can add to their survivors guilt.
My dad had a cousin who was in Berkeley at the beginning of the Hippie Movement. Was still in the Bay area when he passed a few years ago. Went out there quite a few times to visit. Got to hear all the stories from back in the day while passing a j with him and all his old hippie buddies. A lot of fun times did happen back then but mixed in with them was a few really tragic ones dealing with how HIV/AIDS takes a personal toll on people and their close friends and families.
john martin Like Mindy said, they are reminded everyday of their status. I’m best friend died from AIDS complications just last year. (2018). Why? He stopped taking his medication. It’s easy for us negative folks to sit in a seat of judgment but I don’t like taking the 2 pills a day for my acne and I couldn’t imagine talking medication for the duration.
A friend got infected recently and I'm really glad there is all this stuff to help him nowadays. The strain his boyfriend is infected with developed a resistance, so he could transmit it despite being on ART. The poor little guy is 21 and it's just so unfair. 😭
No one gets it nowadays by accident. People have known how it was spread since 1986. Your friend is a bug chaser. Don't tear me one, I'm not homophobic, I'm being honest and you outed your friend.
@@sleekoduck Your statements are blindly judgemental and not helpful. One cannot be honest about something for which you do not have the facts. Unless it is that you personally know these individuals you cannot be certain that this individual outed a friend and if you do know their situations then you are making public statements that are indicative signs of being vindictive for reasons unknown. People place trust in others because they sincerely believe that the others' intentions come from love respect and knowledge. Life is full of risks yet we continue to explore and live it hoping for the best outcomes and when that doesn't happen it is referred to as a mistake or an accident in judgement. So I repeat that unless you know these individuals your statements categorizing them negatively is pure conjecture and designed to sow discord either way. Certainly not a desirable community or family value! If you are experiencing a betrayal I suggest you seek help of a trained professional. Most are very good at their profession and should be able to assist you in dealing with your attacks against statements of compassion. Life is a journey to share and enjoy.
PEP and PrEP exist and are free under health insurance and MedicAid. If his boyfriend had HIV and was taking ARV's as prescribed he should have been undetectable and therefore untransmittable. My partner is HIV Positive (and undetectable, tested bi-annually) and I am HIV Negative and on PrEP (tested quarterly). We don't use condoms and are in an exclusive, monogamous relationship.
@sleekoduck Which makes his supposed boyfriend a "gift giver". And part of the reason why Truvada/Descovy and Apretude have failed as PrEP in some people who ended up seroconverting anyway. And why Maravirioc, Fostemsavir, and Lenacapavir were developed as salvage therapy.
It's hard to catch, I've been with my positive husband for 22 years and I am negative, because we practiced everything safe. Your friend, made bad life choices and now suffers the consequences of those choices. That's all on him, the blame is 100% at his feet, that's what he wanted, that's what he got. Free testing is everywhere, and condoms are free at any planned Parenthood or county clinic. Nobody just catches HIV by accident anymore, you almost have to seek it out and demand an infection!
I think it's important to not down play HIV. I don't want to contract it even if it's not a death sentence. It's a treatable terminal illiness that will rob you of a dating life and having children. Stigma and possibly death is very much a reality.
There are also people who chose to stay with an infected partner because they have ab emotional attachment to them. The world is not black and white as you say...
I was actually diagnosed when 9 wks pregnant with baby #2. She's now 23 and not infected. If you keep mom's viral load below 1500 copies/nl the transmission rate goes to below 1% and with a nondetectable viral the disease doesn't transmit. Sooo important to have that test with your prenatal work up...saved both of our lives...
Once rich people realized this was gonna affect they’re sex orgies, they put in the funding needed for a treatment/cure. This has nothing to do with good for humanity. Money was the reason we found a treatment quickly.
@@breaknfiction21 so do you think rich people should think about poor idiots who is f*cking like a rabbits while rich is working hard? Buy some condoms, don't be a moron
Science is now evolving. We can't thank scientists and researchers enough for saving our lives everyday. You may be thinking: 'Scientists don't save our lives everyday. Its because of my personal hygiene'. Well, if scientists didn't make vaccines, I think 50% of the people alive now wouldn't be here. Respect to the scientists who are working hard everyday to make the world a better place.
Grace Ngugi well if he gives life then he is also responsible for taking it away, like in all these HIV victims that died from the disease, whereas these scientists and researchers only save lives as their goal and aren’t constantly killing people. Scientists > God
@@TheRemnant8The most popular treatments are one pill a day, like Atripla or Complera (in Canada at least). They are a combination of 2 or 3 medicines in one pill, that act on different stages on the HIV life cycle (blocking receptors, or inhibiting protease etc)
@@TheRemnant8 I have before, maybe a few times over these 11 years. Of course I don't recommend doing it, but the half-life of the pill I take is about 45-50 hours so I can take it the following night at the usual time with no problems. My specialist assured me that it's ok to miss the odd one, but never more than one in a row. That's when it can start to cause problems apparently. That said, my viral load has remained undetectable, as they're not "take it daily or die!!!" meds. There's some leeway. CD4 counts have stayed healthy as well.
@@YungStinkyWinky Honest question since I'm going through this now. I have all HIV symptoms I mean everyone after being stab in the back on a bus 12months ago. All my 4th generation test are negative, but I'm wondering have you heard of a poz not having antibodies?
No words - excellent summary of ARV development. You explained perfectly why very expensive treatment of those infected with HIV is beneficial for the WHOLE society. Thank you for such terrific level of professionalism.
Though it may not be a death sentence any longer, it’s a still life-long health problem. The medication is horrible and people always worry about their numbers. It’s stupid to throw caution to the wind. Be smart and safe out there.
To be clear most medications these days are very well tolerated, and if your on your meds, your numbers are not really a concern because nothing is attacking your tcells. (Once undetectable) The only virus left at that point is what we call latent virus. Very rarely are there liver issues with today's meds. Azt is not used in today's practice. Dolutegravir, bictegravir, emtricitabine.
Wow. So Freddie Mercury was only four short years away from a drug to help manage the disease ! Sad beyond all belief ! Thank you for presenting the facts in a way that the lay person can understand them. I’m a sub after this presentation. I want to learn more of what ails the world, and hopefully some good news about other scientific pursuits.
It's not a death sentence anymore if you can afford the expensive treatments and drugs necessary to slow down it's development and keep it under control.
Cadmus Drugs cost $6:20 in Australia where healthcare is important for all citizens for all ailments. The Swedes and Canadians are also laughing at you Americans who think public healthcare is an invasion of your privacy ! Get your priorities straight
Or if you live in the vast majority of the first/educated world where healthcare is universal and therefore the cost is spread amongst everyone and conglomerated for cheaper and better health outcomes.
@@Muckydoggy1 Argentina is not a fist world country but still we have free healthcare. I think it's mostly an USA problem and I don't know why they don't fight for it all together.
@@Muckydoggy1 oh yeah? Tell me that. My relatives in Netherlands are fed to f*ck with public health. Government taxes them for 37% of salary and they have to wait 14 DAYS to get a doctors appointment (government hopes that you gonna die or recover for that amount of time so appointment would be cancelled). You should better know more before praising those shitty system. I live in Ukraine and we also have a public health and it is a complete disaster - you should pay for anything except a visit for a doctor (which is cheap because doctors are highly under-payed by government) and imagine you need a surgery that will cost you 10 times of your salary and they call it "FREE PUBLIC HEALTH - admire it mutherf*ker". It is all lies and false promises to force you to give government more money with your taxes.
@@FlorenciaVM1 Because they're such idiots they think they want it like that. …Well, ok, maybe many aren't, but I think enough that it may well not win a referendum, and at very least not enough people who care enough to make that referendum happen.
It is a walk in the park now :v one pill a day and I have no negative impacts from the infection -or- the medicine. Getting a cold is more annoying than having HIV for me by a long shot. I'm very fortunate to be alive when I am now
@@diogobernardino54 With the meds it -should- be a walk in the park, of course not everyone has perfect reactions to every medication ever but still, compared to how it used to be? One pill a day is a nothing compared to taking 5+ pills multiple times a day like people did early on. That drug cocktail killed people too, not just HIV/AIDS But in a broad sense it's not a walk in the park.. we have a lot of work to do with ease of access to medicine, making it free, getting it to areas that are hardest hit etc (though human trials for a vaccine are starting soon so!!! That's friggin exciting). Not to mention the stigma and internalized shame that being positive can bring.. Though in my 11 years of being positive I've been very fortunate not to have faced discrimination for it in any real way. Family/friends all accepted me and wanted to help/learn more, no piercers/tattoo artists have denied me, and quite literally only a couple people have ever turned me down for dating/sex because of it. Most people these days are pretty cool with it and understand the science, or at least want to learn more and understand something that honestly doesn't get talked about much (or the right way) anymore. The scariest part of being diagnosed was the fear of what would happen to me, and with the marvels of science (and free medicine in Canada), paired with society growing up and being much more accepting of positive people, it's quite literally a walk in the park for me now. Very blessed.
@@TheRemnant8 From the estimated time of my exposure, it was maybe a month before I got sick. What hit me was the -worst- sickness I've ever had, and it lasted a couple weeks. Constant fever, vomiting, diarrhea, aches, weakness, headache, dizziness, no appetite, it's like my body had every possible symptom to something. Then, like it never even happened, I woke up all better. It was only a year later that my mom noticed I was looking "especially tired lately", my eyes were looking a little sunken to her. Got tested, and bam. Positive. My viral load was 118,000 at diagnosis, down to only 1,000 after a month of treatment, the fastest the specialist had ever seen. I've been undetectable for 11 years now, and it has never caused me any issues. I did notice, however, that I get sick very rarely, and don't often catch my husband's colds. I asked my specialist about this, and he said that some people who get HIV young and bounce back from treatment quickly can actually have bolstered immune systems, but not enough research into that specifically to say quite yet. So in my case, my immune system is -healthier- because I got HIV.. quite the opposite of what HIV does untreated, eh? Bless science.
I feel like covid-19 have actually been a really important step in developing vaccines for something like this. A lot of this technology we have now could potentially be adapted to HIV relatively quickly
@@silaswilburthe idea is that both COVID 19 and HIV are RNA viruses. As far as I'm aware, the COVID vaccine is the first vaccine developed for an RNA virus, which suggests we can make one for HIV too.
This is all great, but can someone explain to me when Jerry Brown or anyone thought it was a good idea to reduce penalties for knowingly infecting someone with HIV?
I don't think there's a reasonable explanation for that at all. It was a pretty risky piece of legislation, which could have long lasting effects in a lot of people's lives. Especially if they have terrible people in their lives who also happen to be infected with HIV, or know someone else who's been infected. People have purposely injected other people with syringes containing blood from an HIV infected person. People willing to do that need to be separated from humanity.
I don't know if this is right but I read a previous comment that said that they were bringing it down to the same level as other diseases a person knowingly transmits; I don't agree with that (knowingly spreading disease in my mind is bio-terrorism), however it does make sense if they plan on leaving the other ones as is, especially given how treatable HIV now is.
This is a functional treatment to HIVs spread , as sex-workers won't have to fear losing virtually everything when they know that they are infected anymore, they under the new legislation are more likely to get diagnosed, medicated and stop spreading the virus. Them being diagnosed also helps to find the people they could have infected and get them diagnosed as well. (Also other sex related diseases (edit removed: "could be perceived as more danger to the individuals health than hiv today") and when someone working in this field is afraid of going to the doctor these will be spread and become a danger of building resistances as well. ) And last but not least the punishment was reduced to the same level as other diseases, which seems fair to me. Which level of punishment is enough is a different discussion of course.
I think it would be important to note that the deletion of the gene for the CCR5 protein only makes people resistant to a specific strain of HIV. There are strains which can infect someone without needing the CCR5 protein to be present in the host's cells. HIV as almost all other pathogens has multiple strains with their particularities after all CRISPR would be more useful to remove viral DNA from latent reservoirs without damaging them or healthy cells
HauntedShadowsLegacy Viruses inserts DNA into your cells which your cell unknowingly makes it apart of it's DNA. Once done the cell reads the DNA like it normally would but would read the Viruses DNA and start using resources meant to make things like proteins to instead make viruses instead. This goes on until the cell dies and the new viruses leave to infect other cells. CRISPR can be used to cut out the inserted virus DNA before it does damage.
As far as i know there are only two strains of HIV( HIV1/HIV2) . Also, as far as i know HIV2 is uncommon and isn't spread in the hole wide world as much as HIV1 . It mostly exist in West Africa . Is this the strain (HIV2) that doesn't need the CCR5 protein to infect the host cell?
For someone that has lived in the world of HIV these two short videos have been extremely informative and easy to digest. Many thanks for your time making these films.kind regards Paul from London
@@jayhan94 Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
@@johanne7 Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
roguedogx I saw a video that said his T cells were defects and did not have a receptor for the virus to attach to. After that every thing was over my head.
Depends where in the world you are. In a very developed country, it's not a big deal (not counting the US), but in less developed countries it still poses as a huge risk.
Actually, even in developed countries it's making a come back and getting worse. That's because not many people get an HIV test. There are many people who don't know they've Aids who go around infecting others. Then we have those idiots who stop taking their meds because they think they are now better, virus load increases again, and bam again further infections. People don't take AIDS serious anymore.
Thank You for this video. I work for a non-profit agency called House of Hesed here in Winnipeg Canada. Where we provide a safe non-judgemental home those with addiction issues and are HIV positive. There is such a need for the public to be educated.
Ooh yes, yes!!!! I've also heard Gabapentin lactate can serve as an inhibitor of neurodegeneration. Can gene editing technology force existing cells to express HTT proteins with less CAG repeat?
Information on a lot of cures came out in the 80s. The FDA did everything they could to suppress the information to protect pharmaceutical profits including hiding the proven fact that the primary cause of AIDS is the drug AZT given to people testing HIV+, which DOES NOT mean HIV infected. There are over 65 known causes for false positives for these tests including common vaccines, gammaglobulin, various autoimmune disorders, pregnancy and multiple pregnancies, etc. AZT can do what HIV cannot, which is to completely collapse the immune system by reducing all key immune cells including CD4s. In fact HIV could not even cause AIDS under the original definition. It was not until the early 80s when one of the government's top scientists, Robert Gallo, who had already been busted for scientific fraud, once again committed fraud by claiming before a world wide AIDS symposium that HIV was the cause of AIDS for his own financial gain that the definition of AIDS was changed to fit the HIV virus. Gallo lied because he held the patent rights on the highly inaccurate HIV antibody test at the time. So he was profiting as ling as people fell for his fraud. This was going to embarrass the government again though so in the early 80s to cover up Gallo's lie they changed the definition of AIDS to include the drop in CD4 counts since this is all HIV could do. The only virus known that could cause AIDS under the original definition is human herpes virus type 6 variant A (HHV6A), which unlike HIV completely collapses the immune system by reducing all key immune cells including CD4s leading to the opportunistic infections (OIs) that originally defined AIDS. The only other cause of AIDS under the original definition was the drug AZT that was originally developed as a chemotherapy drug in 1962, but was not allowed on the market at the time because it was deemed too deadly for human use. AZT destroys the bone marrow, which produces the stem cells that are the precursor for all immune cells. It is the destruction of the bone marrow that also leads to the other well known side effect of AZT, which is severe anemia. The loss of all immune cells due to the adverse effects of AZT lead to AIDS through the formation of OIs that originally defined AIDS and still causes AIDS under the expanded definition of AIDS since the destruction of the bone marrow also leads to a loss of CD4 cells. This is also why the largest study ever done on AZT, the Concorde Study, came to the conclusion that AZT SHORTENED the lives of people testing HIV+. AIDS is just a man-made syndrome promoted as usual for financial gain. This is also why so many cures such as ozone therapy, hyperthermia, Compound Q, lentinan, etc, have all been suppressed by the FDA who works to protect the pharmaceutical companies. In fact, former Commissioner for the FDA, Herbert Ley, testified before Congress that the FDA was using governmental police powers to protect the profits of the drug companies and were in return rewarded with money, gifts and high level positions within the drug companies they were protecting. If you research this you will find all sorts of examples such as when the FDA left 710 prescription drugs found to be worthless or deemed too dangerous for human use on the market despite a Court order to remove these drugs. Many of them such as dextromethorphan (DM) in cough medicines is one of them found in multiple studies to be no better than placebo. Not only is it still on the market, it is now available over the counter as are so many drugs deemed too dangerous to have without a prescription until their patents expire then suddenly the FDA deems them magically safe enough to be sold without a prescription. Or look in to the generic drug scandal in which the FDA was approving untested drugs in exchange for payoffs then violated the law again when they targeted the drug company that exposed the FDA's criminal activity in violation of the Whistle Blower's Act. Not a single FDA official has ever gone to jail over their illegal activity because big pharma has too much political power. It has even been reported for over 30 years that over 150 FDA officials own stock in the pharmaceutical companies they regulate in violation of insider trading laws. Yet again not a single FDA official violating the law has ever been charged or sent to prison.
@@hircine92h No, it is all facts that can be easily verified with a little simple research from the medical journals. That takes at least a minimal amount of intelligence though, so those with IQs smaller than their shoe size label these facts as "conspiracy crap" since they lack the intelligence to do basic research and they completely lack common sense. These are the kind of complete imbeciles that you you think and wonder, how do these people manage to tie their own shoe laces without hanging themselves?!!!
@@hircine92h ROTFLMAO!!!! I see you lack the education and intelligence to know what a theory is so here, let me help you out. It all starts with a a hypothesis, which is just an educated guess. When that hypothesis is backed by actual evidence, it is called a theory. So a conspiracy theory is a conspiracy backed by actual evidence. Uneducated people though throw the term around as an insult, especially when they cannot debate the actual topic, which involves providing evidence to back their beliefs. Of course an intelligent person would also stay on and debate the actual topic, which in this case is HIV/AIDS. When unintelligent people cannot debate the actual topic then they try diversionary tactics such as shifting the debate to a different topic. For example, attempting to shift the debate away from the topic of HIV/AIDS to Covid, for which they also cannot back their beliefs with actual evidence.
Zidovudine is a legacy drug that is rarely prescribed these days. Lamivudine has less side effects and is much more potent & has a higher barrier to resistance.
Retroviruses are much harder to make vaccines for as they mutate extremely fast. Neither Polio nor Smallpox are caused by retroviruses, so are much easier to vaccinate for.
@@dynamicworlds1 well this is not the main reason, the reason why its difficult to cure is because it kinda make immune system blind, so the body cant make any antibodies and vaccines mainly work by practising the body about how to make those antibodies
@@user-lehsun-le-garib humans do make HIV antibodies, and even if they didn't, higher rates of mutation make developing vaccines more difficult. What are you even talking about?
HIV is different because it infects the immune system. Polio and tetanus technically cause problems through toxins,yes, but the toxins are produced by bacteria and you can be vaccinated against those bacteria. Aside from the massive human tragedy it caused, HIV is a singularly fascinating disease. I did my paper on it in AP Biology in high school in the late 1980s. There's no disease like it.
Harris Grey, GREAT IDEA! Not many people know about Huntington's (Chorea). My friend's Mom had it when we were growing up and enlightening people about it would be SO FKN GREAT because people can be real mean when they are ignorant or do not know the facts on a person who has it.
I learned so much from this video, I don't even have the energy to make a terrible pun. :) Seriously made me realize I had a lot of misconceptions, so thanks. Great work.
I wonder what would happen if a doctor or group of doctors went scorched earth on an HIV infected person's immune system, destroying the whole thing, then treating the person with antiretrovirals for a long time, then going after a bone marrow donation for the patient.
If they did that, how, exactly, would someone survive with zero immune system? It’s very likely they could die within a week or even a few days. Unless they were in a bubble/hermetically sealed environment, even the regular, (usually) harmless bacteria and fungi which cover us from head to toe could do the job since the patient wouldn’t have any means of fighting the infection. Even for someone without HIV, if they had their immune system destroyed, they’d be dead VERY quickly. I’m speaking from experience as I’ve had cancer twice and the 2nd time round, had my immune system almost completely wiped out, on purpose, by high dose chemotherapy and high dose radiotherapy as well as a bone marrow and stem-cell transplant (no, nothing like that, not embryonic stem-cells, they were my own bone marrow and stem-cells, harvested prior to the chemo/radiation, obviously). My point is that even though I still had some small amount of immune and T cells, and a severely degraded but still active immune system, my counts did actually go to zero but I was told that only meant their lab equipment resolution wasn’t sufficient. They can’t see individual cells, there have to be hundreds of thousands of them essentially just to register on the machines used for detection. Even though I wasn’t allowed any visitors besides my mum and wasn’t allowed to go outside/leave the inside of the hospital for 23 days, and I still managed to catch some infection within just a couple of days. If that’s what happens to someone inside a hospital, with an extremely depleted immune system, I don’t think there’s much, if any chance for someone who’s already unwell to have whatever immune response is still remaining, just completely obliterated. Doesn’t sound like such a great idea imho.
Why do people smoke knowing their chance of getting cancer are drastically increased? Why do people drink? Why are people assholes? Because they're humans and terrible people.
this is an incredibly complicated question and answer. but the answer is probably very related to stigma. rates of viral suppression are weakest in youth, particularly youth who have been living with hiv through lateral transmission. (aka, from their mother during childbirth or feeding on breastmilk) Youth are taught this a very secret part of their life, for fear of social stigma and isolation from making friends. as such, it's common for them to simply stop taking medication for a variety of reasons, whether they are missing school for doctor's appointments, while the teacher is asking them in front of the class why they need so many doctor's appointments... or maybe they are at a sleepover or fieldtrip, and don't have time to step away from friends to take their medication in privacy... or maybe they just want to feel like a normal kid.
There are LOTS of pills, and the schedules can be confusing, esp if they are tweaked often based on how they are working....it isnt exactly like just remembering to take one pill with breakfast....medication compliance is a difficult thing. ESP when the patient starts to feel better and they might think it isnt as important. Side effects making a patient feel bad can also affect their compliance. Esp when faced with a lifetime of treatment (it isnt like say, remembering to take the eye drops that sting and burn like hell after eye surgery for a few weeks, which most people just bear with rather than have post op problems-becasue they know eventually they can stop doing it. There is a light at the end of the tunnel. Despite this, people are still not often as compliant as they should be with that-even though it could affect something as precious as their SIGHT!) Being chronically ill comes with som many other issues-brain fog is common either from the disease itself or the medication, or depression (which is common with chronic illness). That doenst help with remembering. And depression itself makes you just not care about things (like dying....)...it is complicated and often a battle of will....then there is the issue of having access to your medication-which is a whole other issue...some might choose to stop taking something due to financial issues....
@@leonardpfeifer6361 hospital social worker here for 34 years; try telling that to the dozens of patients I saw with AIDS throughout the '80s and '90s. In the 2000s I only was seeing a few here and there, and those I was seeing either had stopped being compliant with their meds or had fallen for homeopathic remedies for their dwindling immune systems.
Good morning. Thank you for this video. Would you consider updating this video to include some of the other classes on medications and the long-acting injectables that's given to HIV patients now. Additionally I think there's more than just the Berlin patient who had a complete eradication of HIV. Thank you.
Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
Spam Ham Abby Slug | Senate Bill Number 239 will make knowingly spreading the HIV virus to a partner that is unaware of your HIV status into a mere misdemeanor, with a maximum jail time of 6 months.
Since it was NOT mentioned, I will, THANK YOU Elizabeth Taylor for making people aware since 1980 about what AIDS is and is not. And thank you for so many millions raised with your organization ETAF!
I enjoyed Part 1 of the HIV video way more than I did Part 2. The guy talks so fast and everything is like one big blob of information with no personality or charisma to keep you engaged. It was so difficult to try and grasp the core concepts of this video because the delivery method was ineffective.
thank you for this. so many people regard HIV positive people as "diseased" or dying, and that hasn't been true for nearly a decade. good work, scishow.
Today with recommended treaments someone who's HIV-positive is expected to live nearly as long as someone who's uninfected. Yeah ofcif only that person earns at least 200k in a year. People who lives below average still suffering and dying
In the US there are several avenues for those of us who aren't at the top of the money heap to get our meds...MedicAid and ADAP cover those meds for those of us who can't pay for them ourselves. Cheaper to pay for the pills than for the costs associated with not getting them....different story in the Third World unfortunately....
Given the recent highly unethical laws passed in California, I think it is important to clarify. HIV is absolutely still a death sentence. It might take decades but it will get you in the end. Deliberately infecting someone is no different than paying a hitman to wait 20 years before killing someone.
Riz2336 the victims can have solace in the fact that it's no longer a death sentence. Knowing that you're going to die in a certain time frame is kinda scary. All the more traumatic is that your organs are gradually shutting down till death puts you out of your misery.
Nah - not “basically” at all. It’s not just about taking “pills”. There are ways to help ones body “amplify” the immune system. So much in fact, you’re* like the Wolverine and your body’s immune system can heal itself quicker and make you almost invulnerable to other diseases or infections.. Here’s what I mean; the body’s immune system IS white blood cells. And white bloods cells, which as an entity, we refer to them as, simply, the immune system. However, it’s important to note that the white blood cells are made up of “coworkers” - different kinds with different jobs all working together as a TEAM (again, that make up your immune system) You have CD4 white blood cells, CD8 white blood cells, just to name a couple.. Each type have a unique responsibility for fighting infection in the body. CD4 cells find and destroy germs, bacteria, and invaders. (but HIV invades and INFECTS the CD4 cells).... [Stay with me here...] Well, CD8 cells’ jobs, in the human body, are to destroy INFECTED cells that are found IN the body and that does also include destroying infected CD4 cells. So, they will DESTROY the CD4 cells that are infected with the HIV. The “pills” I spoke about earlier, stop the replication of the HIV inside the HIV-infected CD4 cells. The CD8 cells then destroy those cells. Step 1. Stop the growth and replication - pills do that. Step 2. Help immune CD8 cells kill and destroy the CD4 cells that are HIV infected and “lying dormant (secretly awaiting a chance to mutant and reproduce again)” Step 3. Boost your body’s production of new white blood cells. So how can one “help the process along”? Ingest plenty of vitamin C. Keep forcing the body to produce more and more new white blood cells. Most produced will be CD4 cells - which will be (naturally, of course) HIV NEGATIVE ones. And second most produced will be CD8 cells. As long as they are able to work together and do their “jobs”, over time, they can eradicate the HIV in the blood. Last step. Find a way to get those HIV VIRUS leftovers hiding in the lymph nodes. As soon as scientists figure that one out, there will be an official CURE. And I, for one, believe we should encourage HIV infected individuals to follow these steps listed above awaiting it. I certainly hope you found this “useful information”. So no, you’re* not screwed at all.
My best friend is in college right now, thinking about getting his PhD, and what he really wants to do is create a cure for HIV. He even works with the virus at his practicum. I think it's super admirable, since he's going against the anti-cancer grain and doing something that's not only important to him, but to the world at large. I'm rooting for my nerd's success. :)
Rooting for him!
you are lucky to have a friend like that! That's a "keeper".
We're rooting for the nerd
If he wants to cure HIV, maybe he should get an M.D. instead of a PhD
I wish I was a nerd. I was never book smart.
From someone who is involved in HIV cure research I want to commend you on a job well done with your explanation.
I just wanted to say Thank You for all of your research. This is a terrible disease. We have come so far since HIV became mainstream. I hope to see a cure in my lifetime for all the very sick and not so sick HIV positive patients I take care of.
Is there a picture of the hiv virus?
czcams.com/video/6JkixH27Dh4/video.html ✅
@@idiocracy2806 czcams.com/video/6JkixH27Dh4/video.html 😇
@@xxnotmuchxx interesting question, I wonder if they magnified it 500x under a petri like dish and snapped a photo and animated what it would look like in 3D
I wish I had some way to send all this info back to folks in 1980.
I know what you mean but it probably wouldn't work. You would be dismissed as crazy like so many are until its too late.
Delorean and some plutonium my friend jk
Scientist made them, and they escaped....
As someone that lived through this, I wish you could too. It was crazy the way the HIV/AIDS crisis was handled in the U.S. It wasn't handled, in the media, as a medical concern but as a moral/religious concern and that condemned so many people.
I wish they had this info back in the early days. So many lives would’ve been saved.
In memory of my uncle Patrick. Had he known what we know now, maybe he would not have taken his life.
Thanks for these videos. My stepdad (his brother) had (and still has) major views on the virus and his brothers "life choices".
Honestly, he was the best uncle I had, even if he was technically my "step-uncle". He was my actual uncle and THE BEST uncle I had.
We still remember ya Pat and always will.
Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
People love to be appreciated. It inspires us to do more, Thanks to Dr Osunmeh i met through youtube for doing what no other doctor could do. Thanks for curing my of HIV, you are amazing !
Your step-uncle let another man ejaculate inside his poop chute. He got what was, uh, coming to (in) him.
This is why I don't believe in euthanasia
I am so sorry for your loss. I can relate 😢
I really appreciate the effort put in making this videos. My father is an HIV expert and since I was little he taught me the risk and importance of treatment and responsibility. He lost many friends and I do not wish anyone the pain he has gone through along the way. Anyway, thanks for spreading knowledge in a matter as important as this one.
how to get cure vaccines for HIV
It's still a death sentence for poor people.
not if you live in a country where there's a public health system
We live somewhere in Southeast Asia so good luck to us.
With Obamacare dying...it'll be a death sentence soon for poor people in US..
No, it is only a death sentence for the poor if you live in the US or other third world countries without national healthcare. If you live in a developed country that has a working healthcare system, it is no big deal and will cost you nothing.
Indonesia have national public care. All u need for HIV treatment is all free.
If only Freddie had this treatment.. We will still have a legend
And the fact is if he had been able to hold on just a bit longer...he might still be here today
That's the sad thing
@@JenniferMannette what do you mean " hold on " ?
Fadel Adam what he meant was that if he could have stayed relatively disease free for a while longer an AIDS treatment may have been able to save his life.
I think you thought he meant that Freddie didn’t fight hard enough. I get that because my husband died of cancer and sometimes people say that he lost the fight. It irks me, like he didn’t fight hard enough? Right? But I don’t think that’s how most people mean it.
Freddie Mercury RIP, had some form of medication he simply chose not to drag out a losing battle. If only he was celibate or married to Mary Austin for real.
I work together with @MPT I donate my time and talent to create paintings from Freddie Mercury to fight AIDS worldwide in Memory of the Legend Instagram @winkler.annette
I took PEP (post-exposure prophylaxis) in 2019 and I was SO SICK. I definitely took every dose as recommended but I spent most of that month incredibly depressed and sick. My mom had actually researched HIV in the 90's so she was able to give me some information on the modern day medicines and also scare me into never missing a dose. I truly hope that one day there is a cure/vaccine that everyone is able to get access to. I did a couple projects in college on HIV after that and was so grateful for all of the research towards the medications I had to take in 2019. I tested negative at 6 weeks, 3 months, 6 months, 1 year and on and I truly wish these drugs were more widely available (still exorbitantly expensive even with insurance, I luckily got a coupon to waive the full cost for the month I took them).
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That's so brave of you. Even I was on PEP early this year. And I can totally relate with being sick and depressed while you're on PEP. My tests came negative at 3months then 6months. I was fortunate that PEP is provided in INDIA free of cost in Hospitals so didn't had to gave a penny.
@@sagarborah9978 Hey I started my course yesterday its my 2nd day today its damn tiring I am talking the pep course with med called vonaday how was your experience through out ?
Heyy r u positive
@@user-xk6wr4nc4m No, I am not! The post exposure works well the closer to exposure it is taken, and I believe you need to take it within 72 hours.
Great video, but as someone studying HIV, I have one correction and one additional point.
Correction: there were actually two Berlin patients. One of them is less well known, as he was one of the ones that they did early ART for, and he just stopped taking them and his viral load didn’t regrow. (Source: Cured, by Nathalia Holt)
Additional point: many HIV+ patients struggle taking their medication daily because it’s a brutal reminder of the fact that they are ill. For lots of people who suffer from HIV there are overwhelming psychological challenges as well, lots of people from the beginning of the crisis have PTSD from seeing so much death and if they contract HIV now, it can add to their survivors guilt.
Mindy Nafziger cool story
Very cool. Did you read Nathlia Holt's book Cured?
Sean Webb yeah, great book!! It’s my source for the correction.
My dad had a cousin who was in Berkeley at the beginning of the Hippie Movement. Was still in the Bay area when he passed a few years ago. Went out there quite a few times to visit. Got to hear all the stories from back in the day while passing a j with him and all his old hippie buddies. A lot of fun times did happen back then but mixed in with them was a few really tragic ones dealing with how HIV/AIDS takes a personal toll on people and their close friends and families.
john martin Like Mindy said, they are reminded everyday of their status. I’m best friend died from AIDS complications just last year. (2018). Why? He stopped taking his medication. It’s easy for us negative folks to sit in a seat of judgment but I don’t like taking the 2 pills a day for my acne and I couldn’t imagine talking medication for the duration.
A friend got infected recently and I'm really glad there is all this stuff to help him nowadays. The strain his boyfriend is infected with developed a resistance, so he could transmit it despite being on ART. The poor little guy is 21 and it's just so unfair. 😭
No one gets it nowadays by accident. People have known how it was spread since 1986. Your friend is a bug chaser. Don't tear me one, I'm not homophobic, I'm being honest and you outed your friend.
@@sleekoduck Your statements are blindly judgemental and not helpful. One cannot be honest about something for which you do not have the facts. Unless it is that you personally know these individuals you cannot be certain that this individual outed a friend and if you do know their situations then you are making public statements that are indicative signs of being vindictive for reasons unknown. People place trust in others because they sincerely believe that the others' intentions come from love respect and knowledge. Life is full of risks yet we continue to explore and live it hoping for the best outcomes and when that doesn't happen it is referred to as a mistake or an accident in judgement. So I repeat that unless you know these individuals your statements categorizing them negatively is pure conjecture and designed to sow discord either way. Certainly not a desirable community or family value! If you are experiencing a betrayal I suggest you seek help of a trained professional. Most are very good at their profession and should be able to assist you in dealing with your attacks against statements of compassion.
Life is a journey to share and enjoy.
PEP and PrEP exist and are free under health insurance and MedicAid. If his boyfriend had HIV and was taking ARV's as prescribed he should have been undetectable and therefore untransmittable. My partner is HIV Positive (and undetectable, tested bi-annually) and I am HIV Negative and on PrEP (tested quarterly). We don't use condoms and are in an exclusive, monogamous relationship.
@sleekoduck Which makes his supposed boyfriend a "gift giver". And part of the reason why Truvada/Descovy and Apretude have failed as PrEP in some people who ended up seroconverting anyway. And why Maravirioc, Fostemsavir, and Lenacapavir were developed as salvage therapy.
It's hard to catch, I've been with my positive husband for 22 years and I am negative, because we practiced everything safe.
Your friend, made bad life choices and now suffers the consequences of those choices.
That's all on him, the blame is 100% at his feet, that's what he wanted, that's what he got.
Free testing is everywhere, and condoms are free at any planned Parenthood or county clinic.
Nobody just catches HIV by accident anymore, you almost have to seek it out and demand an infection!
I think it's important to not down play HIV. I don't want to contract it even if it's not a death sentence. It's a treatable terminal illiness that will rob you of a dating life and having children. Stigma and possibly death is very much a reality.
People have children and are infected it's now 2019
There are also people who chose to stay with an infected partner because they have ab emotional attachment to them. The world is not black and white as you say...
I was actually diagnosed when 9 wks pregnant with baby #2. She's now 23 and not infected. If you keep mom's viral load below 1500 copies/nl the transmission rate goes to below 1% and with a nondetectable viral the disease doesn't transmit. Sooo important to have that test with your prenatal work up...saved both of our lives...
It's no longer a death sentence, just a LIFE sentence. Especially if you are a straight man... 😕
If both are undetectable, they won’t transmit the virus to the baby.
I’m so grateful to you for making this video. It really helped me to understand this disease and how there will always be hope.
The way the WORLD came together to beat HIV makes me proud of humanity.
*Laughs in Martin Skreli*
Once rich people realized this was gonna affect they’re sex orgies, they put in the funding needed for a treatment/cure. This has nothing to do with good for humanity. Money was the reason we found a treatment quickly.
proud to know people make cure for disease which would not contaminate smart and alerted people, die from coronavirus
@@breaknfiction21 so do you think rich people should think about poor idiots who is f*cking like a rabbits while rich is working hard? Buy some condoms, don't be a moron
HIV treatments are violent poisons. And expensive poisons at that. So, yeah, not exactly a great accomplishment.
I really wish that everyone had access to such drugs, but it's so amazing that so much progress has been made.
lloyd lloyd For the rich.
These drugs are violent poisons. Why anyone would want to deliberately inject very expensive liquid poison into their veins is a complete mystery.
Lloyd lloyd,,,don't be fooled by these videos...HIV will kill you,,,no other ways to it...once you contract it,,,then that's it man...
@@nazzalwinchester8728 nah i know someone who's been taking ARV and been living for 10 years.
@@MsEliteForever HIV medicine isn't just for the rich. Who told you that?
Science is now evolving.
We can't thank scientists and researchers enough for saving our lives everyday. You may be thinking: 'Scientists don't save our lives everyday. Its because of my personal hygiene'. Well, if scientists didn't make vaccines, I think 50% of the people alive now wouldn't be here. Respect to the scientists who are working hard everyday to make the world a better place.
My God help them
But more thanks to the giver of life,God.
@@wangugigrace lol
Grace Ngugi well if he gives life then he is also responsible for taking it away, like in all these HIV victims that died from the disease, whereas these scientists and researchers only save lives as their goal and aren’t constantly killing people. Scientists > God
@@perryoparsonneseatingjuicy8738 hell yeah
I’m ready for this to be eradicated completely. I don’t like taking meds everyday.
How many meds do you take?
@@TheRemnant8The most popular treatments are one pill a day, like Atripla or Complera (in Canada at least). They are a combination of 2 or 3 medicines in one pill, that act on different stages on the HIV life cycle (blocking receptors, or inhibiting protease etc)
@@YungStinkyWinky have you ever accidentally skipped your meds?
@@TheRemnant8 I have before, maybe a few times over these 11 years. Of course I don't recommend doing it, but the half-life of the pill I take is about 45-50 hours so I can take it the following night at the usual time with no problems. My specialist assured me that it's ok to miss the odd one, but never more than one in a row. That's when it can start to cause problems apparently. That said, my viral load has remained undetectable, as they're not "take it daily or die!!!" meds. There's some leeway. CD4 counts have stayed healthy as well.
@@YungStinkyWinky Honest question since I'm going through this now. I have all HIV symptoms I mean everyone after being stab in the back on a bus 12months ago. All my 4th generation test are negative, but I'm wondering have you heard of a poz not having antibodies?
No words - excellent summary of ARV development. You explained perfectly why very expensive treatment of those infected with HIV is beneficial for the WHOLE society. Thank you for such terrific level of professionalism.
These two HIV awareness videos are some of your best work.
Though it may not be a death sentence any longer, it’s a still life-long health problem. The medication is horrible and people always worry about their numbers. It’s stupid to throw caution to the wind. Be smart and safe out there.
To be clear most medications these days are very well tolerated, and if your on your meds, your numbers are not really a concern because nothing is attacking your tcells. (Once undetectable) The only virus left at that point is what we call latent virus. Very rarely are there liver issues with today's meds. Azt is not used in today's practice. Dolutegravir, bictegravir, emtricitabine.
@@ryangrant3414 that said, I'd rather wear a condom than have to waste money on meds
@@ryangrant3414Irrelevant, if someone gave it to me, _their_ days are numbered_ lets just leave it at that.
@grl9917
I came here to say this.
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Wow. So Freddie Mercury was only four short years away from a drug to help manage the disease ! Sad beyond all belief ! Thank you for presenting the facts in a way that the lay person can understand them. I’m a sub after this presentation. I want to learn more of what ails the world, and hopefully some good news about other scientific pursuits.
Thank you so much for this series. This is something I would have never found out on my own research. It's always good to know the enemy.
Can you do a vid on why Africanized honey bees are so aggressive
It's bc their dad left them at a young age and they grew up in the hood👊🏿
Not exactly what you're looking for but it's a playlist by "It's Ok to be Smart" on bees
czcams.com/video/iyvXZcWUbI0/video.html
They don't have any food
Proton Gaming why are africanized humans so aggressive?
grumpybill kek
It's not a death sentence anymore if you can afford the expensive treatments and drugs necessary to slow down it's development and keep it under control.
Cadmus
Drugs cost $6:20 in Australia where healthcare is important for all citizens for all ailments. The Swedes and Canadians are also laughing at you Americans who think public healthcare is an invasion of your privacy ! Get your priorities straight
Or if you live in the vast majority of the first/educated world where healthcare is universal and therefore the cost is spread amongst everyone and conglomerated for cheaper and better health outcomes.
@@Muckydoggy1 Argentina is not a fist world country but still we have free healthcare. I think it's mostly an USA problem and I don't know why they don't fight for it all together.
@@Muckydoggy1 oh yeah? Tell me that. My relatives in Netherlands are fed to f*ck with public health. Government taxes them for 37% of salary and they have to wait 14 DAYS to get a doctors appointment (government hopes that you gonna die or recover for that amount of time so appointment would be cancelled). You should better know more before praising those shitty system. I live in Ukraine and we also have a public health and it is a complete disaster - you should pay for anything except a visit for a doctor (which is cheap because doctors are highly under-payed by government) and imagine you need a surgery that will cost you 10 times of your salary and they call it "FREE PUBLIC HEALTH - admire it mutherf*ker". It is all lies and false promises to force you to give government more money with your taxes.
@@FlorenciaVM1 Because they're such idiots they think they want it like that. …Well, ok, maybe many aren't, but I think enough that it may well not win a referendum, and at very least not enough people who care enough to make that referendum happen.
Part 1 & 2 did an excellent job of explaining HIV. Lots of talk. Both presenters did an excellent job.
Just because it's still manageable doesn't mean it's a walk in the park , it isn't even with the meds
It is a walk in the park now :v one pill a day and I have no negative impacts from the infection -or- the medicine. Getting a cold is more annoying than having HIV for me by a long shot. I'm very fortunate to be alive when I am now
@@YungStinkyWinky I guess they mean that it isn't a walk in the park for the vast majority of people
Glad to know you're doing well!
@@diogobernardino54 With the meds it -should- be a walk in the park, of course not everyone has perfect reactions to every medication ever but still, compared to how it used to be? One pill a day is a nothing compared to taking 5+ pills multiple times a day like people did early on. That drug cocktail killed people too, not just HIV/AIDS
But in a broad sense it's not a walk in the park.. we have a lot of work to do with ease of access to medicine, making it free, getting it to areas that are hardest hit etc (though human trials for a vaccine are starting soon so!!! That's friggin exciting). Not to mention the stigma and internalized shame that being positive can bring.. Though in my 11 years of being positive I've been very fortunate not to have faced discrimination for it in any real way. Family/friends all accepted me and wanted to help/learn more, no piercers/tattoo artists have denied me, and quite literally only a couple people have ever turned me down for dating/sex because of it. Most people these days are pretty cool with it and understand the science, or at least want to learn more and understand something that honestly doesn't get talked about much (or the right way) anymore.
The scariest part of being diagnosed was the fear of what would happen to me, and with the marvels of science (and free medicine in Canada), paired with society growing up and being much more accepting of positive people, it's quite literally a walk in the park for me now. Very blessed.
@@YungStinkyWinky , How did you know you had it? What were your first symptoms?
@@TheRemnant8 From the estimated time of my exposure, it was maybe a month before I got sick. What hit me was the -worst- sickness I've ever had, and it lasted a couple weeks.
Constant fever, vomiting, diarrhea, aches, weakness, headache, dizziness, no appetite, it's like my body had every possible symptom to something. Then, like it never even happened, I woke up all better. It was only a year later that my mom noticed I was looking "especially tired lately", my eyes were looking a little sunken to her. Got tested, and bam. Positive. My viral load was 118,000 at diagnosis, down to only 1,000 after a month of treatment, the fastest the specialist had ever seen.
I've been undetectable for 11 years now, and it has never caused me any issues. I did notice, however, that I get sick very rarely, and don't often catch my husband's colds. I asked my specialist about this, and he said that some people who get HIV young and bounce back from treatment quickly can actually have bolstered immune systems, but not enough research into that specifically to say quite yet. So in my case, my immune system is -healthier- because I got HIV.. quite the opposite of what HIV does untreated, eh? Bless science.
I feel like covid-19 have actually been a really important step in developing vaccines for something like this. A lot of this technology we have now could potentially be adapted to HIV relatively quickly
Source?
@@silaswilburthe idea is that both COVID 19 and HIV are RNA viruses. As far as I'm aware, the COVID vaccine is the first vaccine developed for an RNA virus, which suggests we can make one for HIV too.
@stuartdilts2729 The COVID vaccine hardly worked. I got it and still got COVID, so did everyone else in my family.
Actually I think it is the other way around - the research on AIDS and HIV made it so we were better prepared when COVID came around.
@@Sniperboy5551 you don't seem to know what it means when a vaccine works.
This is all great, but can someone explain to me when Jerry Brown or anyone thought it was a good idea to reduce penalties for knowingly infecting someone with HIV?
Professionally the sort of reasoning that lead to it is known as "severe mental retardation".
I don't think there's a reasonable explanation for that at all. It was a pretty risky piece of legislation, which could have long lasting effects in a lot of people's lives. Especially if they have terrible people in their lives who also happen to be infected with HIV, or know someone else who's been infected. People have purposely injected other people with syringes containing blood from an HIV infected person. People willing to do that need to be separated from humanity.
I don't know if this is right but I read a previous comment that said that they were bringing it down to the same level as other diseases a person knowingly transmits; I don't agree with that (knowingly spreading disease in my mind is bio-terrorism), however it does make sense if they plan on leaving the other ones as is, especially given how treatable HIV now is.
HeavyRayne I knew this comment would show up. Always does on Hiv videos. At least yours you put "knowingly" and your post is genuine
This is a functional treatment to HIVs spread , as sex-workers won't have to fear losing virtually everything when they know that they are infected anymore, they under the new legislation are more likely to get diagnosed, medicated and stop spreading the virus.
Them being diagnosed also helps to find the people they could have infected and get them diagnosed as well.
(Also other sex related diseases (edit removed: "could be perceived as more danger to the individuals health than hiv today") and when someone working in this field is afraid of going to the doctor these will be spread and become a danger of building resistances as well. )
And last but not least the punishment was reduced to the same level as other diseases, which seems fair to me.
Which level of punishment is enough is a different discussion of course.
I think it would be important to note that the deletion of the gene for the CCR5 protein only makes people resistant to a specific strain of HIV. There are strains which can infect someone without needing the CCR5 protein to be present in the host's cells. HIV as almost all other pathogens has multiple strains with their particularities after all
CRISPR would be more useful to remove viral DNA from latent reservoirs without damaging them or healthy cells
Rodrigo Borges How did you write all this, boy?
Wouldn't it be an edit of the gene rather than a deletion? But yeah, you bring up a good point. There's more than one strain of HIV.
HauntedShadowsLegacy Viruses inserts DNA into your cells which your cell unknowingly makes it apart of it's DNA. Once done the cell reads the DNA like it normally would but would read the Viruses DNA and start using resources meant to make things like proteins to instead make viruses instead. This goes on until the cell dies and the new viruses leave to infect other cells. CRISPR can be used to cut out the inserted virus DNA before it does damage.
As far as i know there are only two strains of HIV( HIV1/HIV2) . Also, as far as i know HIV2 is uncommon and isn't spread in the hole wide world as much as HIV1 . It mostly exist in West Africa . Is this the strain (HIV2) that doesn't need the CCR5 protein to infect the host cell?
But how to genetically modify all trillions of cells in body dude!
For someone that has lived in the world of HIV these two short videos have been extremely informative and easy to digest. Many thanks for your time making these films.kind regards Paul from London
Very much so, it really opened my eyes.
Finally, part 2 of educational video schools won't teach
Actually, you will learn all of that but in medical school.
johanne7 kinda sad that its not common knowledge though since not all schools teach this stuff
@@jayhan94 Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
@@johanne7 Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
"the Berlin patient" now that's a pretty good name. I'm guessing it's just because he lived in Berlin, but still.
roguedogx I saw a video that said his T cells were defects and did not have a receptor for the virus to attach to. After that every thing was over my head.
its crazy to think people like freddie mercury would be alive and well today
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I remember hearing about AZT as a kid. These advances now are a scientific miracle. I’m so happy they are so far along in treating HIV/AIDS. ❤
Hey
This was very informative but the title made it sound like HIV is barely a problem anymore and that is simply not true.
Not a death sentence=/=not a problem. IDK how you get the latter from the former.
Depends where in the world you are. In a very developed country, it's not a big deal (not counting the US), but in less developed countries it still poses as a huge risk.
Actually, even in developed countries it's making a come back and getting worse. That's because not many people get an HIV test. There are many people who don't know they've Aids who go around infecting others.
Then we have those idiots who stop taking their meds because they think they are now better, virus load increases again, and bam again further infections. People don't take AIDS serious anymore.
It's now only a problem in places it doesn't matter.
Should be eradicated with the knowledge we have
2 years later we're almost there. HIV got cured in a 2nd patient
By stem cell
Using basically the exact same method as the first. We're no closer lol.
2/35million
@@ThebigGLRams No lol.
Yay, part 2 finally arrived
Excellent series! You guys explain things in a simple enough way for me to understand, and you make it interesting! Keep up the good work!!
Wowww !!!! Another great video , thank you so much for sharing this useful data ! Greatly appreciated
Thank You for this video. I work for a non-profit agency called House of Hesed here in Winnipeg Canada. Where we provide a safe non-judgemental home those with addiction issues and are HIV positive. There is such a need for the public to be educated.
Can you guys do a segment discussing Huntington's disease and the recent breakthrough made in the UK?
Ooh yes, yes!!!! I've also heard Gabapentin lactate can serve as an inhibitor of neurodegeneration. Can gene editing technology force existing cells to express HTT proteins with less CAG repeat?
I wish this was out in the the 80's....I lost plenty of class mates and military buddies 😭😭😭...
Information on a lot of cures came out in the 80s. The FDA did everything they could to suppress the information to protect pharmaceutical profits including hiding the proven fact that the primary cause of AIDS is the drug AZT given to people testing HIV+, which DOES NOT mean HIV infected. There are over 65 known causes for false positives for these tests including common vaccines, gammaglobulin, various autoimmune disorders, pregnancy and multiple pregnancies, etc. AZT can do what HIV cannot, which is to completely collapse the immune system by reducing all key immune cells including CD4s. In fact HIV could not even cause AIDS under the original definition. It was not until the early 80s when one of the government's top scientists, Robert Gallo, who had already been busted for scientific fraud, once again committed fraud by claiming before a world wide AIDS symposium that HIV was the cause of AIDS for his own financial gain that the definition of AIDS was changed to fit the HIV virus. Gallo lied because he held the patent rights on the highly inaccurate HIV antibody test at the time. So he was profiting as ling as people fell for his fraud. This was going to embarrass the government again though so in the early 80s to cover up Gallo's lie they changed the definition of AIDS to include the drop in CD4 counts since this is all HIV could do. The only virus known that could cause AIDS under the original definition is human herpes virus type 6 variant A (HHV6A), which unlike HIV completely collapses the immune system by reducing all key immune cells including CD4s leading to the opportunistic infections (OIs) that originally defined AIDS. The only other cause of AIDS under the original definition was the drug AZT that was originally developed as a chemotherapy drug in 1962, but was not allowed on the market at the time because it was deemed too deadly for human use. AZT destroys the bone marrow, which produces the stem cells that are the precursor for all immune cells. It is the destruction of the bone marrow that also leads to the other well known side effect of AZT, which is severe anemia. The loss of all immune cells due to the adverse effects of AZT lead to AIDS through the formation of OIs that originally defined AIDS and still causes AIDS under the expanded definition of AIDS since the destruction of the bone marrow also leads to a loss of CD4 cells. This is also why the largest study ever done on AZT, the Concorde Study, came to the conclusion that AZT SHORTENED the lives of people testing HIV+.
AIDS is just a man-made syndrome promoted as usual for financial gain. This is also why so many cures such as ozone therapy, hyperthermia, Compound Q, lentinan, etc, have all been suppressed by the FDA who works to protect the pharmaceutical companies. In fact, former Commissioner for the FDA, Herbert Ley, testified before Congress that the FDA was using governmental police powers to protect the profits of the drug companies and were in return rewarded with money, gifts and high level positions within the drug companies they were protecting. If you research this you will find all sorts of examples such as when the FDA left 710 prescription drugs found to be worthless or deemed too dangerous for human use on the market despite a Court order to remove these drugs. Many of them such as dextromethorphan (DM) in cough medicines is one of them found in multiple studies to be no better than placebo. Not only is it still on the market, it is now available over the counter as are so many drugs deemed too dangerous to have without a prescription until their patents expire then suddenly the FDA deems them magically safe enough to be sold without a prescription. Or look in to the generic drug scandal in which the FDA was approving untested drugs in exchange for payoffs then violated the law again when they targeted the drug company that exposed the FDA's criminal activity in violation of the Whistle Blower's Act. Not a single FDA official has ever gone to jail over their illegal activity because big pharma has too much political power. It has even been reported for over 30 years that over 150 FDA officials own stock in the pharmaceutical companies they regulate in violation of insider trading laws. Yet again not a single FDA official violating the law has ever been charged or sent to prison.
@@Hveragerthi what is this pile of conspiracy crap lmao
@@hircine92h No, it is all facts that can be easily verified with a little simple research from the medical journals. That takes at least a minimal amount of intelligence though, so those with IQs smaller than their shoe size label these facts as "conspiracy crap" since they lack the intelligence to do basic research and they completely lack common sense. These are the kind of complete imbeciles that you you think and wonder, how do these people manage to tie their own shoe laces without hanging themselves?!!!
@@Hveragerthi haha ye just like whats happening now with Covid with all those conspiracy theories. Its always like this lmao
@@hircine92h ROTFLMAO!!!! I see you lack the education and intelligence to know what a theory is so here, let me help you out. It all starts with a a hypothesis, which is just an educated guess. When that hypothesis is backed by actual evidence, it is called a theory. So a conspiracy theory is a conspiracy backed by actual evidence. Uneducated people though throw the term around as an insult, especially when they cannot debate the actual topic, which involves providing evidence to back their beliefs. Of course an intelligent person would also stay on and debate the actual topic, which in this case is HIV/AIDS. When unintelligent people cannot debate the actual topic then they try diversionary tactics such as shifting the debate to a different topic. For example, attempting to shift the debate away from the topic of HIV/AIDS to Covid, for which they also cannot back their beliefs with actual evidence.
Fun fact: AZT is now renamed as Zidovudine. If your prescription writes "AZT", the pharmacist is more likely to dispense azathioprine or azithromycin.
If it is in the U.S. I certainly hope not. I would never write "AZT" on a prescription. You write out the drug you want the patient to have
Zidovudine is a legacy drug that is rarely prescribed these days. Lamivudine has less side effects and is much more potent & has a higher barrier to resistance.
I know someone who died in 1988 from AIDS. It was so sad.
Thank you SciShow. I learned a lot from this video.
Why no discussions on vaccines? Mankind has had much more success with vaccines for viral diseases than cures (Polio, Smallpox).
Retroviruses are much harder to make vaccines for as they mutate extremely fast.
Neither Polio nor Smallpox are caused by retroviruses, so are much easier to vaccinate for.
Polio was not caused by a virus, it was caused by environmental toxins.
@@dynamicworlds1 well this is not the main reason, the reason why its difficult to cure is because it kinda make immune system blind, so the body cant make any antibodies and vaccines mainly work by practising the body about how to make those antibodies
@@user-lehsun-le-garib humans do make HIV antibodies, and even if they didn't, higher rates of mutation make developing vaccines more difficult. What are you even talking about?
HIV is different because it infects the immune system. Polio and tetanus technically cause problems through toxins,yes, but the toxins are produced by bacteria and you can be vaccinated against those bacteria. Aside from the massive human tragedy it caused, HIV is a singularly fascinating disease. I did my paper on it in AP Biology in high school in the late 1980s. There's no disease like it.
Really like your HIV mini serious, thanks a lot
Could you do a video on the new Huntington's disease treatment?
Harris Grey, GREAT IDEA! Not many people know about Huntington's (Chorea). My friend's Mom had it when we were growing up and enlightening people about it would be SO FKN GREAT because people can be real mean when they are ignorant or do not know the facts on a person who has it.
It's a general problem with people, not just regarding Huntington's.
Afwul thing to have, people who have it should get a PID before having a child.
@@johndifrancisco3642 *(chorea)
@@ziadoonal-akashi2479 Thanks. I always screw that up.
Thanks to this guy for improving my science grades back in secondary school 👍🏽👍🏽👍🏽✊🏽
I learned so much from this video, I don't even have the energy to make a terrible pun. :) Seriously made me realize I had a lot of misconceptions, so thanks. Great work.
I enjoyed this video, very in depth.
"We've come a long way, but there's plenty of work left to do." Hope.
There is now a second person that is cured. From the same process as the Berlin Patient
literally JUST read this. he’s referred to as “the london patient”
Good presentation, better narrator in first half, still informative and nicely presented.
Very good information and well-explained!
I wonder what would happen if a doctor or group of doctors went scorched earth on an HIV infected person's immune system, destroying the whole thing, then treating the person with antiretrovirals for a long time, then going after a bone marrow donation for the patient.
If they did that, how, exactly, would someone survive with zero immune system? It’s very likely they could die within a week or even a few days. Unless they were in a bubble/hermetically sealed environment, even the regular, (usually) harmless bacteria and fungi which cover us from head to toe could do the job since the patient wouldn’t have any means of fighting the infection. Even for someone without HIV, if they had their immune system destroyed, they’d be dead VERY quickly.
I’m speaking from experience as I’ve had cancer twice and the 2nd time round, had my immune system almost completely wiped out, on purpose, by high dose chemotherapy and high dose radiotherapy as well as a bone marrow and stem-cell transplant (no, nothing like that, not embryonic stem-cells, they were my own bone marrow and stem-cells, harvested prior to the chemo/radiation, obviously). My point is that even though I still had some small amount of immune and T cells, and a severely degraded but still active immune system, my counts did actually go to zero but I was told that only meant their lab equipment resolution wasn’t sufficient. They can’t see individual cells, there have to be hundreds of thousands of them essentially just to register on the machines used for detection. Even though I wasn’t allowed any visitors besides my mum and wasn’t allowed to go outside/leave the inside of the hospital for 23 days, and I still managed to catch some infection within just a couple of days. If that’s what happens to someone inside a hospital, with an extremely depleted immune system, I don’t think there’s much, if any chance for someone who’s already unwell to have whatever immune response is still remaining, just completely obliterated. Doesn’t sound like such a great idea imho.
They’d die the same way an AIDS patient dies, from an opportunistic infection.
How do you forget to take the pills keeping you from dying an early unpleasant death?
Why do people smoke knowing their chance of getting cancer are drastically increased? Why do people drink? Why are people assholes? Because they're humans and terrible people.
this is an incredibly complicated question and answer.
but the answer is probably very related to stigma.
rates of viral suppression are weakest in youth, particularly youth who have been living with hiv through lateral transmission. (aka, from their mother during childbirth or feeding on breastmilk)
Youth are taught this a very secret part of their life, for fear of social stigma and isolation from making friends.
as such, it's common for them to simply stop taking medication for a variety of reasons, whether they are missing school for doctor's appointments, while the teacher is asking them in front of the class why they need so many doctor's appointments... or maybe they are at a sleepover or fieldtrip, and don't have time to step away from friends to take their medication in privacy... or maybe they just want to feel like a normal kid.
Because you happen to be a human.
There are LOTS of pills, and the schedules can be confusing, esp if they are tweaked often based on how they are working....it isnt exactly like just remembering to take one pill with breakfast....medication compliance is a difficult thing. ESP when the patient starts to feel better and they might think it isnt as important. Side effects making a patient feel bad can also affect their compliance. Esp when faced with a lifetime of treatment (it isnt like say, remembering to take the eye drops that sting and burn like hell after eye surgery for a few weeks, which most people just bear with rather than have post op problems-becasue they know eventually they can stop doing it. There is a light at the end of the tunnel. Despite this, people are still not often as compliant as they should be with that-even though it could affect something as precious as their SIGHT!) Being chronically ill comes with som many other issues-brain fog is common either from the disease itself or the medication, or depression (which is common with chronic illness). That doenst help with remembering. And depression itself makes you just not care about things (like dying....)...it is complicated and often a battle of will....then there is the issue of having access to your medication-which is a whole other issue...some might choose to stop taking something due to financial issues....
maybe they are poor educated people or people with mental disorder etc
1:08 I hate to be THAT person but isn't HIV virus like saying ATM machine?
Quantum Shooter Yes.
Yes. I was probably going to be that person if you weren't.
Quantum Shooter HIV is a hoax!!! It has nothing to do with AIDS!
Leonard Pfeifer are you being fr right now
@@leonardpfeifer6361 hospital social worker here for 34 years; try telling that to the dozens of patients I saw with AIDS throughout the '80s and '90s. In the 2000s I only was seeing a few here and there, and those I was seeing either had stopped being compliant with their meds or had fallen for homeopathic remedies for their dwindling immune systems.
This was SO informative! Thank you!
Finally this got recommended, I watched the first part from recommended and couldn’t find the second part!!!
HIV vs 1000 degree knife
Can't live without a host
Now 2 guy have been cured 💜
Do a video on CAR-T pleaseeeee
Good morning. Thank you for this video. Would you consider updating this video to include some of the other classes on medications and the long-acting injectables that's given to HIV patients now. Additionally I think there's more than just the Berlin patient who had a complete eradication of HIV. Thank you.
Sars Cov 2 just pales in comparison to HIV, I can’t begin to think what it would mean have it in the 80’s. Poor people
Behold the results was negative. I'm HIV negative it's been 4 years since I got my complete healing naturally with the help of Drchala from west Africa who I find here on CZcams channel
@@pardonchipepera Scammer
I wish Freddie mercury lived till this day and age 😭
There is no excuse for the change California is making.
I'm certain the only people happy about this are those with hiv.
What happened?
What change are they making?
Spam Ham Abby Slug | Senate Bill Number 239 will make knowingly spreading the HIV virus to a partner that is unaware of your HIV status into a mere misdemeanor, with a maximum jail time of 6 months.
smoking pot is now legal in cali....woot
The life cycle of retro viruses are so clever. It's an amazingly fascinating trick. Hopefully scientists can use the principles in gene therapy.
Oh, I didnt expect Hank Green on this channel
Informative as always. Thank you, Hank!
Since it was NOT mentioned, I will, THANK YOU Elizabeth Taylor for making people aware since 1980 about what AIDS is and is not. And thank you for so many millions raised with your organization ETAF!
I enjoyed Part 1 of the HIV video way more than I did Part 2. The guy talks so fast and everything is like one big blob of information with no personality or charisma to keep you engaged. It was so difficult to try and grasp the core concepts of this video because the delivery method was ineffective.
It should be a felony to - - > knowingly
It is always amazing how scientists, doctors, among others, be able to remove proteins from cells. Like, that's pretty small.
I've been waiting a long time for this second part
general leukemia and HIV kinda counter each other.
Bottom line: damn nature, you scary.
If only my dad could have lived for 20 more years.
thank you for this. so many people regard HIV positive people as "diseased" or dying, and that hasn't been true for nearly a decade. good work, scishow.
Wow, the couple participants who were in that 2016 study were brave or were okay with the chance of getting infected.
Does ART work for other viruses?
Joshua Hillerup
I think HIV is only known antiretroviral virus, so everything else we can blast with radiation and chemo.
Some antiretrovirals like tenofovir can be used to treat chronic hepatitis B, but most of them are specific to HIV.
Today with recommended treaments someone who's HIV-positive is expected to live nearly as long as someone who's uninfected. Yeah ofcif only that person earns at least 200k in a year. People who lives below average still suffering and dying
Good thing the world isn't the US. Poor nation like those in Africa got an excuse, but what's the excuse of the richest nation on earth?
In the US there are several avenues for those of us who aren't at the top of the money heap to get our meds...MedicAid and ADAP cover those meds for those of us who can't pay for them ourselves. Cheaper to pay for the pills than for the costs associated with not getting them....different story in the Third World unfortunately....
Oh no... HIV has a sequel?! Now we're truly doomed.
Well done video, and easy to understand for the layperson.
The fact that they mutate to resist drugs is scary.....its almost like it was designed by somebody with far more intellectual ability than humans
I learned more about diseases in 10 minutes than a year of doing science in school
You should have payed attention, or shown a little interest while studying.
Yeah you should have paid attention
Omae wa mo shinderu
NANI!
BAKA!
Vai Fate OK Google what does this mean
おまえ わ も しんでる
Mamasay mamasa mamakusa.
Given the recent highly unethical laws passed in California, I think it is important to clarify. HIV is absolutely still a death sentence. It might take decades but it will get you in the end. Deliberately infecting someone is no different than paying a hitman to wait 20 years before killing someone.
Great miniseries guys well done - really informative.
Thank u for ur accurate information and simple to understand... Many pple will have the right knowledge
The cure is concentrated money
Like if you got the refrence
zombie blood we'll need alot of money dude but Atleast eric and Kyle don't have aids
We should drive to Africa and tell all people the good news
Lol
Eric and kenny don't have it anymore👏😜
South Park pretty much roasted this entire video
It still is a death sentence
To those who can't afford the drugs. Or don't want to take them.
No it is not
Independence In Mind
Explain yourself buddy. Show me the science not your opinion.
Nobody wants hiv people need to keep it real
LayDollas so is being born
Basically your kind of screwed if you have it, but useful information.
Riz2336 the victims can have solace in the fact that it's no longer a death sentence. Knowing that you're going to die in a certain time frame is kinda scary. All the more traumatic is that your organs are gradually shutting down till death puts you out of your misery.
You're not screwed. HIV really isn't a big issue today. Did you even watch the series? You'd be far worse off getting something like hepatitis.
You're*
Nah - not “basically” at all. It’s not just about taking “pills”. There are ways to help ones body “amplify” the immune system. So much in fact, you’re* like the Wolverine and your body’s immune system can heal itself quicker and make you almost invulnerable to other diseases or infections..
Here’s what I mean; the body’s immune system IS white blood cells. And white bloods cells, which as an entity, we refer to them as, simply, the immune system. However, it’s important to note that the white blood cells are made up of “coworkers” - different kinds with different jobs all working together as a TEAM (again, that make up your immune system)
You have CD4 white blood cells, CD8 white blood cells, just to name a couple..
Each type have a unique responsibility for fighting infection in the body. CD4 cells find and destroy germs, bacteria, and invaders. (but HIV invades and INFECTS the CD4 cells)....
[Stay with me here...]
Well, CD8 cells’ jobs, in the human body, are to destroy INFECTED cells that are found IN the body and that does also include destroying infected CD4 cells. So, they will DESTROY the CD4 cells that are infected with the HIV. The “pills” I spoke about earlier, stop the replication of the HIV inside the HIV-infected CD4 cells. The CD8 cells then destroy those cells.
Step 1. Stop the growth and replication - pills do that.
Step 2. Help immune CD8 cells kill and destroy the CD4 cells that are HIV infected and “lying dormant (secretly awaiting a chance to mutant and reproduce again)”
Step 3. Boost your body’s production of new white blood cells.
So how can one “help the process along”? Ingest plenty of vitamin C. Keep forcing the body to produce more and more new white blood cells. Most produced will be CD4 cells - which will be (naturally, of course) HIV NEGATIVE ones. And second most produced will be CD8 cells. As long as they are able to work together and do their “jobs”, over time, they can eradicate the HIV in the blood.
Last step. Find a way to get those HIV VIRUS leftovers hiding in the lymph nodes.
As soon as scientists figure that one out, there will be an official CURE. And I, for one, believe we should encourage HIV infected individuals to follow these steps listed above awaiting it.
I certainly hope you found this “useful information”. So no, you’re* not screwed at all.
Actually, if you have HIV the one thing you probably won't be getting is 'screwed'.
Been waiting for two weeks for this one
That cellular replacement bit is awesome.
What about a countervirus? Breaking the virus code in that has been implanted is always a good way to stop it.
Well viruses usually dont reproduce by its own, and its really hard to engineer a virus
God bless science
why? science killed god
DirtyMilkMan this statement contradicts itself..more like Science bless Scientology
DirtyMilkMan, VERY cool comment!
There should be a fine print somewhere: "Remember, there are things worst than death folks."
Thank you for making this video.
Whatching this from 2020 in the middle of covid pandemic. Desperately looking for a treatment or a vaccine too. Wishing us luck
Why does it take dogs forever to poop ? Or at least to find a spot to poop in
you reply this....... on a video about AIDs??
Ha, my dog goes on command.
Video on aids? Yes. Why? I wanna know
It needs to get a pill every day till the rest of its life. And 1 of these pills costs 10$. If it stops the pills it will take even longer to poop.
Why not? AIDS and poop have a lot in common.