What are the reasons for mass balance failure during forced degradation

What are the reasons for mass balance failure during forced degradation

[@Dileeppharma]

"You did a great job! sir what a informative presentation."

[@pankajshah1084]

Nice video sir, very clear voice and clarity, one day you will cross 1M subscribers.

[@rahulkulkarni3037]

Fantastic explanation 👏 Sir

[@sambhajimasal928]

This is wonderful ❤

[@chandrasekhar-kr2uu]

Really very informative tnx

[@rahulgunjal663]

Sir kindly make video on CAD detector method development in hplc.

[@visweswararao8049]

Sir, you gave clear all probable reasons to get variation in mass balance.

[@vivekghosh7364]

Please tell us about the different techniques to check peak purity other than purity angle and threshold or with mass spectroscopic method.

[@krish_krish354]

For analytical calculation which guidelines chapter have to see. Can you refer

[@sbshaikh30]

How to overcome these mass balance issues??.. Plz explain

[@anushapulipati2642]

Can u please tell me the Different types of RS method,in which case to we go for the diluted standard method,and area normalisation method,and impurity vs impurity method..

[@ambikapanda409]

Sir can u tell me about metal degradation,like with cupper and iron

[@krish_krish354]

How to do alkali forced degradation

[@ghadahalharbi1814]

Sir please what is your reference? I have looked on ICH Q1E and I don’t find it

[@buddepumohanarao8309]

Sir if degradation impurity have no chromphorcity then what to do for identification.

[@mitalipereira446]

In case of higher mass balance where aduct is formed with main ingredient, what do we expect about peak purity, is it passing or failing?

[@suriyasuriya-xt7dt]

For Api assay method ,force degradation study will be conduct🧐🧐🧐

[@naceranaci4139]

0:34

[@sachinsawant6932]

Degradent peak RRF value consider as 1

[@buddepumohanarao8309]

Sir in case of degradation impurity is co eluting with main peak then peak purity is fail.then how to it justfied