George Church on the Biggest Thing to Happen to Biomedicine in Decades
Vložit
- čas přidán 8. 07. 2024
- Over the course of his 30-plus-year career, George Church has pioneered several transformative fields in medicine, including genomic sequencing, synthetic biology, and, most recently, genome engineering. In this One-on-One, Medscape Editor-in-Chief Eric Topol talked with Dr Church about CRISPR, editing embryos, and bringing back the woolly mammoth.
To learn more, join www.Medscape.com for free today. - Věda a technologie
George Church is by far one of my top favourite people on the planet. The guy is incredible and probably one of the most valuable assets that humanity has today. I cannot wait to see where his research takes us in the coming decade.
hard to believe atheist wanted to harm him when he was talking to some Christian Group on science
Interesting George Church
Loved how Dr. Topol is a fanboy for Prof. Church!
George church says we are getting safe from the technique if not from generally what gets done.
Cas9 has been shown to associate with cut sites for
over six hours after the double-strand break 5 , preventing a
successful repair; this is likely to amplify the effect of a single
DSB, leading to a generalized DNA damage response. Our results show
that decreasing DNA damage signaling dramatically improves the
efficiency of precision genome editing in normal cells. At the same
time, inhibition of p53 leaves the cell transiently vulnerable to the
introduction of chromosomal rearrangements and other tumorigenic
mutations. It should be noted that some other reported improvements of
genome editing may also sensitize cells to additional DNA damage.
selective pressure that leads to a preferential growth of p53
deficient cells, we strongly advise caution in the therapeutic use of
CRISPR/Cas. The temporary inhibition of p53 in normal cells will have
both positive and negative effects on the tumorigenic potential of the
edited cell population. On one hand, it could potentially allow escape
of cells whose genome is damaged during the editing process. On the
other hand, it will increase the editing efficiency, and decrease the
selective advantage of pre-existing p53 deficient clones. To improve
the balance, future work should focus on understanding the DNA damage
response induced by Cas9. Controlling the DNA damage signaling process
in such a way that allows efficient genome editing, but does not
select for or facilitate the formation of potentially tumorigenic
cells will be critically important for future efforts in therapeutic
genome editing.
I believe this is the future of medicine! Otherwise, current practitioners are just shooting in the dark.
Wow!
the same problems we mother's r having..trying to tie in past memories of survival to our children..pre cell an computers..
this was filmed in 2016???
interesting that he thought perv was the big pig problem.
Despite the evidence for extended exposure to pig cells and despite concomitant immunosuppressive therapy, we were unable to detect markers of PERV infection in any patient. Screening for two PERV sequences in peripheral blood lymphocytes collected 4-7 years after the xenotransplantation was negative. Markers of PERV expression, including viral RNA and reverse transcriptase, were undetectable in sera from both early (day 3 to day 180) and late (4-7 years) time points. Western blot analysis for antibodies was consistently negative.
their will be zero learned from brain connect that will transfer to machine able to do.
That host looks like he believes in God.