Pharmacology - ANTIVIRAL DRUGS (MADE EASY)
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- čas přidán 13. 06. 2024
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Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development. This pharmacology lecture discusses the replication cycle of selected viruses such as influenza, HIV (human immunodeficiency virus), hepatitis B & C, herpes virus, as well as mechanism of action of drugs used in treatment of infections caused by these pathogens. Drugs mentioned include: Anti-influenza agents: M2 ion channel inhibitors - Amantadine, Rimantadine; Endonuclease inhibitor - Baloxavir; Neuraminidase inhibitors - Oseltamivir, Peramivir, Zanamivir; Anti-HIV agents: Entry inhibitors - Enfuvirtide, Maraviroc, Ibalizumab; Nucleoside reverse transcriptase inhibitors (NRTIs) - Abacavir, Emtricitabine, Lamivudine, Tenofovir, Zidovudine; Non-nucleoside reverse transcriptase inhibitors (NNRTIs) - Doravirine, Efavirenz, Etravirine, Nevirapine, Rilpivirine; Integrase inhibitors - Dolutegravir, Raltegravir; Protease inhibitors - Atazanavir, Darunavir, Fosamprenavir, Ritonavir, Saquinavir, Tipranavir; Anti-hepatitis B agents: Nucleoside/Nucleotide analogues - Entecavir, Lamivudine, Adefovir, Telbivudine, Tenofovir; Anti-hepatitis C agents: NS3/4A protease inhibitors - Boceprevir, Glecaprevir, Grazoprevir, Paritaprevir, Simeprevir, Telaprevir, Voxilaprevir; NS5A inhibitors - Daclatasvir, Elbasvir, Ledipasvir, Ombitasvir, Pibrentasvir, Velpatasvir; NS5B polymerase inhibitors - Dasabuvir, Sofosbuvir; PEGylated interferons α-2a and α-2b, Ribavirin; Anti-herpes agents: Acyclovir, Ganciclovir, Penciclovir, Valacyclovir, Valganciclovir, Famciclovir.
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References/source of selected illustrations:
commons.wikimedia.org/wiki/Fi...
commons.wikimedia.org/wiki/Fi...
doi.org/10.3389/fimmu.2017.00436
00:00 Intro
00:34 Anti-influenza drugs
03:41 Anti-HIV drugs
08:21 Anti-hepatitis B drugs
10:34 Anti-hepatitis C drugs
13:25 Anti-herpes drugs
Hi, I watched all your videos and they helped me a lot in learning pharmacology. Could you please make one video about immunosupressants? Really appreciated!!!
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Excellent video! We are both in our 80's and are all about healthy aging. We continually strive for a strong body & a calm mind. Keep up the good work!
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I can’t believe that my professor project your video in our class and thanks in advance, your videos helped me in passing pharmacology last semester 🙏 😊
thank you so much for making this video. antivirals are really annoying for me and i really really needed this video i pray for you to be safe from covid and all sickness and hope you keep giving us your amazing way of teaching us pharmacology
thank you again
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Thank you,just what I needed.👌🏾
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Sir you have genuinely presented the above topic. Thank you
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Thanks to you for these really informative videos. Keep going!
thank you, ive watched all antibiotic and antifungic and antiviral videos, very helpful
Thank you so much for an excellent video! Best regards Caroline from Denmark
Good to see you.
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Great video, and thanks for putting it together. One thing I did notice was you stated that ganciclovir is phosphorylated by viral thymidine kinase. While TK acts on acyclovir/valacyclovir it does not act on ganciclovir. A different viral kinase is in play here. This is why in acyclovir resistance (most commonly due to absent or decreased activity of viral TK) ganciclovir will remain active and an option for treatment of HSV and VZV. Thanks again for putting together this video. It was a good review
Keep up the great work!
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Thanks for the support!
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Excellent presentation of complex subject
I liked the visual presentation
Many thanks
Thank you so much!! Very helpful:)
i have been waiting this......i hope you will complete the CHEMOTHERPEUTIC section...antiTB...antifungi/antiparasite/antihelminth........really your videos are the most fruitful pharmacology lectures in the youtupe......thanks🙏🙏🙏🙏
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Great video thx , a small thing i wanna mention here is that M2 ion channel inhibitors are only effective against influenza A , beside these drugs are associated with rapid emergence of drug resistant isolates of influenza A
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Thanks for the support!
Thanks for this comment. I'll also not be skipping them from now on.
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Love your videos! Can you make an NMDA one?
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Let’s pass pharmacology 🥳🤩🤩 my pmc exams here I come 🤓thank you sir make more videos 🥰
Just amazing tysm
Thank you sooo much
Please make a video for immunosuppressants
Expecting more kind medical related concepts
Thank you so much sir 🙏🙏🙏
big thanks!!
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Thank you 😇
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I hope u must check my channel..
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Soon: Anti-COVID Drugs
😂😂
Very relevant topic ;)
Thank you for the video... could you do one for anti malarial drugs
Hello Sir ! When will a short lecture on Antimalarial Drugs upload?
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Sir please upload a video on Congestive Heart Failure...
explain about general principle of chemotherapy
Excellent teachings and videos.
Hello sir, can you make a lecture video on Anti-helminthic drugs?
Can you please make a video about respiratory drugs? Thank you for the great videos
Hlo sir .. I love ur videos.. Please make videos on other topics too..i suggested my frnds and they are watching ur video..Do a video on asthma, antianginal etc
Can you make a video for anifungal drugs? Thank you so much for your hard work
Perfect 👌
Thank u
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Also anti fungal drugs 🙏🏼
Simply represented.learn daily a drug with me @ home tutor drug of the day
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So more difficult antiviral drug
Kindly upload a video on antianginal drugs also
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Its not "made easy" its just textbook facts and the list of drugs 😂 But thats pharma i guess. Great video.