Paper breakdown: Could NLRP3 inhibitors be therapeutic in Alzheimer's disease? (Figure 1)

In this video series I'm diving into this paper:
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.
Daniels MJD, Rivers-Auty J, .... Lawrence CB, Brough D,
pubmed.ncbi.nl...
Learning Objectives:
Understand the historical context and research question that led to the hypothesis presented in Daniels et al.'s 2016 paper.
Gain a comprehensive understanding of the experimental methods and techniques employed by Daniels et al. to screen for potential NLRP3 inhibitors.
Explain the findings of the study, specifically how a group of structurally similar NSAIDs were identified as NLRP3 inhibitors.
Understand how Daniels et al. demonstrated the NLRP3 selectivity of these NSAIDs and ruled out the possibility of inhibiting other inflammasomes.