Marburg: The Completely Untreatable Virus
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- čas přidán 12. 09. 2024
- 90 percent mortality rate. Maybe stay away from this one.
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Marburg: "Killing up to 88% of people"
Rabies: "You gotta pump those numbers up. Those are rookies numbers"
Can't rabies be treated by injection if given shortly after infection, which are possible do to symptoms it shows.
@@minecraft425 rabies can be prevented by immunizations if given immediately after infection, but once symptoms start it's 100% fatal.
@@susantindall3625 Almost 100% fatal* there are a handful of people that have survived
@@susantindall3625 sorry I more meant do to animals symptoms, not a person's fairly easy to guess when the animals acting strange or seriously wrong you need the dozen or so needles I believe they give you.
@@minecraft425 They've gotten it down to 4 shots now. delivered over two weeks.
Bats are so susceptible to virus infection because they breathe differently from the other flying vertebrates, birds. Flight requires a lot of oxygen. The breathing system of birds (and fellow archosaurs such as crocodlians) allows a constant flow of fresh air through their lungs when they both inhale and exhale. Bats and other mammals, however, aren't so blessed. To make up for less oxygen absorption per breath, bats evolved an extremely high metabolism that makes the most use of every molecule of oxygen they intake.
As a downside, however, that high metabolism results in an extremely high level of oxidants in their systems. The oxidants cause cellular destruction that leaves them vulnerable to viruses. In turn, bats had to evolve a correspondingly powerful immune system to keep their constant viral infections from killing them. In other words, bats' ability to fly is near-fatal. They remain vulnerable to fungal infections like "white nose disease" that can wipe out whole colonies.
Wow, thanks for that info
@@jendubay3782 you're welcome. I learned that on a video by @SciShow. Ironically, if I remember correctly, white nose fungus was introduced to the Americas by humans, possibly spelunkers, who had been in European or Asian caves inhabited by bats that had evolved resistance to the fungus. Now, whole populations of North American brown bats and other species are seriously threatened.
Yes and no. Bats don’t suffer illnesses from most of the human-melting viruses that they carry. Filoviruses (Ebola and Marburg), Henipaviruses (Hendra and Nipah (which I consider the scariest virus on earth)), Coronaviruses (you know three big ones), and even rabies aren’t known to cause illness in bats. What’s likely the reason for so many viruses adapting to bats is the fact that they’re highly social creatures so the viruses have ample opportunity for infecting new hosts, and many bats are highly mobile so they’ll have the opportunity to infect new communities as well as pick up new pathogens along the way. Coincidentally, these are the same traits that make humans such perfect hosts. Anytime a zoonotic disease pops up, that’s just another life form trying to adapt to us. It’s frankly kind of chilling.
@@GoatThatWasALamp Just curious, why do you consider the Nipah virus to be the most frightening?
It’s also because their inflammatory system is much different than most mammals, making them a better reservoir for viruses without actually getting sick and dying themselves.
My thoughts on this
1. Stay away from bats and caves
2. We need needleproof gloves for scientist working with potentially deadly viruses.
They exist, well anything can get thru with enough force but they are pretty cut and puncture resistant already, just unfortunately when you’re using needles, you need dexterity and literally can’t use the gloves to be accurate.
@@shannond1511use gloves with latex fingertips
@@paling1872 I would bet that due to pitching the skin when injecting, fingers are the most stuck by accident
Staying away from bats and caves will prevent you from getting Marburg and Rabies, the most deadly viruses known.
@@shannon6876This. Robots are much more capable of extreme precision than humans are, so we should really be using robots for dangerous shit like this unless it's just impossible.
I remember reading "The Hot Zone" in 1994 and learning about this disease as well as others in the hemorrhagic fever category. Terrifying. All of them.
"The Hot Zone" overstates symptoms somewhat, with rarer effects treated as near-universal. Death often comes from multiple organ failure due to blood clotting, rather than blood loss. What happens in the book *can* happen, but it isn't incredibly common.
That said, viral hemorrhagic fevers are in fact quite terrifying.
hemorrhagic fever viruses are terrifying for sure. Smallpox has a small chance of causing hemorrhagic fever. The thought of it ever managing to come back is truly terrifying, thankfully very, very unlikely.
Now can you imagine, in light of the fact the Covid Pandemic is NOT over( I don't hear no Fat Lady!)
if instead of Covid, we had Ebola?
-Damn Straight folk would obey distancing and masking rules!
Out of Terror, something not seen with the Covid outbreak. Who wants to bleed to death at the end of the worst and last week of your life?
- Put THAT way, I think even the refuseniks would join the masses if That Virus was doing the current crop of Reaping. . .
@@FoxDragon given how much smallpox virus was available in Soviet bioweapons labs and factories, it's a miracle none of it has made it into the hands of terrorists or been used by countries like Iran and North Korea by now...
Is this the book contagion was based on?
First responders during an epidemic of something so deadly deserve so much recognition for their bravery
I would quit immediately
You mean pay and benefits
They're like a S.W.A.T team...but for deadly pathogens.
They're like a S.W.A.T team...but for deadly pathogens.
I agree with you completely 100% it takes an enormous amount of courage to risk your own life to save the lives of Marburg patients and I also believe that the same thing applies to all first responders who are responding to any other kind of viral hemorrhagic fever outbreak as well and treating those patients for example Ebola which is related to Marburg virus and is also extremely deadly Ebola has a fatality rate of up to 90% which means that as many as up to 9 out of every 10 Ebola patients who are infected with Ebola will not survive. One of the most dangerous things about caring for patients who are infected with viral hemorrhagic fevers like Ebola or Marburg is that all that it takes to become infected with those viral hemorrhagic fevers is one mistake and there are no second chances a single mistake caring for patients infected with viral hemorrhagic fevers is likely to prove fatal
This is one of the diseases that as a nurse, makes me shudder to imagine it breaking free and mutating to pass even more easily.
I did my final in AP biology on Marburg. Someone already picked Ebola, so I picked the next worse filo virus. I tried to plead my case that Ebola Sudan and Ebola Zaire were different enough for two separate research projects, but to no avail. The year was 1994 so pretty much no one had heard of Marburg.
Unless your high school was obsessed with the book Hot Zone like mine
In fairness Marburg RAVN is only less dangerous than Zaire I believe(I think that’s the worst strain).
@@commondirtbagz7130 Yes. Zaire is the worst strain of Ebola, averaging at about 83% fatality rate, usually 90%
Read about it in Hot Zone years back.. and I still feel bad for Peter Cardinal.
Fake.
Not going to lie, I was expecting something a lot worse than "severe fines" for possession of select agents.
I would like to think that bleeding out from the inside is deterrant enough:)
@@Metallica4Life92 for many. Lots of people are... iffy about working around them even in BH4 labs.
Luckily those publicly known and.... more common generally burn themselves out quicker than some other outbreaks.
Thank God the punishment isn't a slap on the wrists. That shit hurts!
@@otakuman706 for which I am grateful towards mother Nature to not make a more... balanced and less furious version of Ebola.
That's just for possession or transportation, which would just be the start. I'd be willing to be there would be a lot of questions asked and likely a lot more than just fines once it was all said and done...
As unbelievable as it may sound, the office room my dad is working in is actually the one from the first person that got infected with the Marburg virus. My grandma still recalls the hysteria in the city when it was made public shortly after. She compares it to the beginnings of Covid when everyone started to keep a distance from others and use face masks. Well, even this beautiful city has some very dark history.
My mom worked at a bat sanctuary when I was a baby, she brought me to work with her for years. Her job also meant cleaning the poop and feeding the bats. Her boss asked her to bring me, saying it was safe. My mom didn't know better.
I as a toddler/kid used to play in the big bat rooms where they flew around freely.
It's a wonder we didn't get sick.
Did the bats get healthcare? I mean I'd suppose that at a sanctuary the bats are treated. Maybe with antivirals.
You weren’t at a lab in wuhan
@@solar0wind silence murican
@@qjtvaddict What? If I were American, I wouldn't ask whether the animals get medical care because I'd probably not even know what it is. (slightly exaggerated, but y'know)
@Bella Capulet
Animals in a sanctuary usually get vet checkups and new arrivals are quarantined until they are checked, so as not to infect the other animals or people with an illness they are carrying.
Bats who arent carrying a zoonotic illness and are in a sanctuary where they dont act with wild members of their species are completely safe to interact with.
Source: Ive worked in wild animal rehabilitation and sanctuaries.
I'm from Marburg and my grandma worked at the "Behring Werke" (the pharma complex where the outbreak took place) back then. She told me about people bleeding from their eyes when i was a kid. It's always kind of weird to hear the name of my little home town in that context.
I know what you mean. The case Simon mentioned, about the 2 female tourists who contracted Marburg after visiting a cave with bats in Uganda, the woman who ended up dying was a Dutch woman who ended up dying in the hospital (LUMC, the Leiden University Medical Center) where my girlfriend works and where I study. In fact in one of the hallways of my college there's even a large presentation poster about her case, and the doctor who was part of her care team gave a lecture to my department.
That's got to be weird. If only these nasty pharmaceutical companies would stop encouraging wildlife trafficking and experimenting on animals, none of this would ever happen
Z4 or M484 park
@v.pareix - I feel you. When I was a kid we once were on a day-trip to Marburg ... and all I could think about was "What if this virus gets out of the lab when we are there?". Wasn´t a very pleasant experience 😂😂😂
This terrified me when I researched it awhile back. God, hemorrhagic fevers are absolutely horrifying. I respect healthcare workers to the utmost.
Imagine how scary a 90% mortality rate virus is..? That lady who survived it must of been so worried.. I'm glad she and some survive, even if very few..
hmm. actually. Since, it's only spread through bodily fluids such as semen or blood. Because most people feel ill quickly, the chance of spreading is relatively small. Sick people often do not feel like sex and are not allowed to donate blood, so the risk of spreading remains low. Would this virus suddenly acquire the same properties as a corona or flu virus due to a (very unlikely) mutation? Yes, then we're fucked.
@@BatMan-to8im Oh come on, you're clearly deflecting from the fact that you're in on the conspiracy of bat people and bats to subjugate the human species via biological warfare, to teach them all a lesson about respecting the privacy of bats and stop nosing about in their toilets. It's all in the open, even your username betrays you /s
@@TheExplorder Indeed it shows that the true danger of a disease lies in its transmission rate, not its mortality rate. Of course, a COVID-Marburg love-child could be terrifying, but viruses generally evolve to become more transmissible and less deadly. There is no evolutionary advantage in killing your host.
31 infected and 7 dead (only statistic given in this clip besides ) is a lot less scary haha
truth be told if the symptoms are as bad as Simon says, I would imagine the lady that survived spent a good amount of time praying for death
The P.P.E being scary is an issue I've had to deal with before this pandemic. I had that when I had to care for a service user with suspected T.B. the service user's husband told me to remove my mask and shoe coverings or get out so I went to leave and he called me back. Everyday I went, the man and his wife complained about me wearing my P.P.E. Finally I was told it wasn't T.B just a chest infection. I really can't understand why wearing a mask was such an issue but then both service users refused to go into hospital. The husband also phoned my manager everyday to put in a complaint about me wearing my P.P.E and everyday my boss stuck up for me as I was the only carer who would go in with the suspected T.B case and without me they would have had to go into a care home or hospital. The husband also didn't want me wearing my gloves or apron. Even when I explained it was for his protection he said it was over dramatic
There is a word for that. The word is stupidity.
This is so weird to me! If you're seriously ill and someone is being kind enough to care for you, how does it harm you if they're taking precautions to prevent also becoming ill thenselves...? I guess it's the same kind of mentality that rails against maskwearing to slow down epidemic spread & considers basic safety precautions to be an infringement on personal ego. I just can't get my head around it 🤯
I've seen many (100s-1000s) of patients with PTB without PPE, over the years. But in high prevalence areas medical staff build up immunity to TB and a colleague doctor from the States would contract it very easily compared to me. Only relatively recently did I have access to PPE. Not sure why people have issues with masked up people. Around here some people have issues with my nursing staff attending their homes when we do Covid-19 vaccine studies, because the community gossips that they have Covid-19 even though staff arrive to merely sample a nose swab or maybe deliver a new sats probe.
At that point, I would have refused to take care of the patient/family. If they have such an issue with providers protecting ourselves, that's their problem. How selfish and awful can you be...Just unfathomable levels of callousness
Human ignorance is probably the statistically highest cause of misery and mass death in our historic AND modern times. It would be interesting to see an anthropologist measure if our tendency has grown, lessened, or stayed the same over the centuries.
Rabies: Hold my RNA
😅😅😅😅😅
"Please"
@@bonafidehomicide5742 🤣🤣🤣
Suddenly, Ace Ventura's fear of bats becomes extremely rational.
😱
Same with Hunter S. Thompson.
SHIKAKA!!!
They are far too cute to be taken seriously as a threat.... That's how they get you.
"Three darts is too much"
I'm sitting here playing plague Inc and decided to see what has been posted in the Simonverse today and low and behold this.
Lo and behold. The lo is short for "look".
Once you win the game a few times/get good (plague Inc), like I have, its fun, but then a deep dark wave of cold realization washes over you.... the strategy to repeatedly win the game, is exactly what you see outside or in the news. Be prepared to vomit, and not because your sick.
@@MrWolfheart111 yeah I played quite a bit more now I was just starting playing it when I posted that. I quickly moved on from the realistic viruses to the more amusing ones like vampires and zombies you know the ones that can't happen in real life. Or if they do we're all fucked anyway so.
@@duncanbrock7303no body is fucked if they place their trust in Jesus Christ.
The stupid anxiety part of my brain when I get random bad stomach pain: you have Marburg, start planning your ✨will✨
Fatal case of WebMD
Stop playing with bat poop? Well there goes my social life.
g u a n o
It has a lot of uses. It's a really good fertilizer
Reddit moment
Or just stop playing with poop period
I'm so sorry for your loss
The hemorrhagic fevers scare the shit out of me. I mean...there's really nothing you can do but pray you never get it. With the current news of two cases in Ghana recently, it's brought these thoughts back to the forefront of my mind. I hope that we can prevent large outbreaks of these diseases
Just got recommended this video that was made a year ago, i looked the virus up, and apparently there's been an outbreak in Africa this week 💀
Bats are also extremely resilient against Damaged caused by a radioactive source. There was this interesting display of a bat blood cell which, after being blasted by a radioactive isotope, it was able to reconstitute its DNA.
Wow!
Bats are *the* shit!
Still believing bats are spreaders😂🤣then you are stupid. It is all men made
Bat immortality elixir when?
only the elite will get it.
Marburg - another lesson in not playing with dead monkey bodies.
Yeah stop playing with dead monkey's and stop eating bats are things we seem to consistently lapse on as a species.
Dosen't seem to bother Tigers much.( the, er, playing with dead monkey bodies bit .) 🐯🐾
@@1xoACEox1 yeah they ate the bat in a lab who does gain of function research on bat pathogens.
@@shannonballspen1s482 * Alphabet bois will remember that *
@@ETCABEZON i gotta go guys
I remember reading the Hot Zone in high school. That first chapter literally made me sick to my stomach
Oh gosh, as a claustrophobic Canadian I'll do my best to stay out of east African caves, but no promises.
As a Canadian, Id be far more worried about the meth lab in your basement, just saying;)
@@Metallica4Life92 Joke's on you, I live in my landlord's basement! Ah, the glory of being a poor grad student.
@@rachelwebber3605 at least he's not cooking meth in it, I guess?:')
@@Metallica4Life92 To be fair, I only live in half of his basement, so it's entirely possible that he's got a whole meth setup in the other half lol
There are caves full of bats containing extremely virulent virusses in South America and South East Asia as well, not to mention other parts of Africa too.... Probably even some in North America actually, although very few and very far between.
If I learned one thing from this video, it is to keep Russian Doctors away from syringes. Accidentally stabbing themselves seems almost as common as Russian Journalists falling out of windows
Or Russian doctors falling out of windows…
Or Russian spy’s visiting Salisbury Cathedral for a spot of sight seeing.
Oh yes, the Putinvirus. Very deadly.
Don’t drink and research
Or terrorists killed in northen Africa being identified by their passports that they so conviniently for identification they tend to carry.
As an animal biology nerd, bats and non human primates are the 2 animals I don’t wanna be anywhere near because of this reason.
H5N1 has spread from birds to cows, and now is threatening humans. About 800 cases so far, over 50% fatality rate. If it becomes a human to human kind of thing, we are going to have a hard time...
Bats: spread every deadly plague.
Joker: I told you so.
At first I thought this read "Marburg: The Completely Untreatable City" and I was really confused for a second because Marburg is such a nice, small city
Ever tried to treat it?
It is! Herrlich kleine Stadt. '13 bis '18, beste Studistadt ever!
😳
😂😂😂😂😂 THAT WAS SOME FUNNY MISREADING!!
"...Or is it? VSauce, Michael here. Today we are going to talk about Marburg."
@@Steve_V1066 not sure if Bomber Harris had a go at it or not.
Simon: The only solution may be contentious…
Me: Right, right kill all the ba-
Simon: Try and keep out of caves full of bat feces.
Me: Yup exactly what I was thinking.
Bats are very useful to the ecosystem. Fruit bats pollinate fruits, and insect-eating bats are valuable pest control. If people would stop destroying their natural habitats, they wouldn't need to seek shelter in buildings/houses. So many species are endangered, so it's illegal to kill them. We need bats, but we also need to keep our distance from them for the health and safety of both.
@@nancyf290and thats is quite a problem when a bats favorite spot to chill at is someones roof
@@filipbitala2624or under their couch and chase you across the room, getting rabbies vaccine sucks. I can definitely live without them.
As a healthcare worker, I don’t know why I like to torture myself by watching these things. My paranoia levels are already sky high
Yup. That's the downside of being a health care worker. You actually have to take care of sick people.
Same
Ditto
Could it be that it is just for this purpose?
. . . BOO! 👿👿👿
What you don’t learn in health class:
Ok kids! Sexually transmitted diseases include Syphilis, AIDS, Herpes, Ebola, and Marburg Fever.
This reminds me of my favorite author, Richard Preston. He writes NF books about various deadly viruses, if you have never read of his book, they are worth a read. The Hot Zone was one of my favorites
Also read "The Demon in the Freezer", by him.
You should read The Cobra Event. It's probably my favorite novel by Preston. It gave me chills
Who would have thought monkey trappers are shady characters?
who doesn't want some bush meat
I know! What's the world coming too when you can't even trust your local endangered animal poacher
puts a whole new dark spin on Curious George and the man in yellow.
Honest Abbo's quality discount monkey's.
Et oh tiens, un camion de singes de laboratoire contaminés vient de se crasher et a laissé des singes s'échapper en Pennsylvanie...
On transporte des singes contaminés libres comme l'air dans un camion ben tiens...
J'en ai marre de ce monde où l'on est des putains de jouets.
On se fout de notre gueule.
No more hanging out in bat caves full of bat feces? Well, there goes my career.
- The Batman
GIVE ME BACK MY "THE" YOU DORK KNIGHT!
- The Joker.
Hahahaha!
no, Western scientists working for for-profit pharmaceutical companies had a shipment of green monkeys from Uganda shipped to them and they performed a myriad of awful experiments on them while developing various inoculation tech. through needle stick accidents occurring to the scientists, it spread to human hosts
Neat. I came to CZcams looking for this video because the BBC reports a Marburg outbreak in Tanzania.
Edit : I added "Where did it come from" after a comment pointed out i missed it...
0:45 - Chapter 1 - Symptoms
1:40 - Chapter 2 - Treatment
1:55 - Chapter 3 - Transmission
3:15 - Chapter 4 - Where did it come from ?
5:50 - Chapter 5 - Why bats ?
7:30 - Chapter 6 - Outbreaks
7:45 - Chapter 7 - The outbreak of 2004 to 2005
9:30 - Chapter 8 - Recent cases
10:30 - Chapter 9 - Potential as a biological weapon
12:25 - Chapter 10 - How can Marburg be contained ?
Yes, and his info on flying foxes fruit bats, we have them where I live on the NA continent.
3:14 Chapter 4 (for real) - Where did it come from?
Ah yes, barely a minute and a half in, and the chills are already running down my spine.
There are also variants of the Ebola virus that have a lethality rate of 92%. Only the most common variant from the 2014 outbreak (Ebola Zaire) has a lower lethality rate of about 50% after a series of mutations. Marburg and Ebola are equally bad haemorragic fevers.
I have experienced a different viral hemorrhagic disease, specifically Dengue. Its horrible, extreme headache, cannot eat nor drink, felt tired, diarrhea, vomiting, fever like nothing, and some bleeding.
Luckily, the bleeding I experienced is rashes in the skin with a bit of gum bleeding. Everything healed up after a month, stayed in an ICU for half a month, ever since that I usually put insect repellant lotions especially at dawn, dusk, and night or places where mosquitoes are prevalent.
Getting vaccinated would be a good idea too - the second round is much worse.
@@allangibson2408 ah no worries, will take the vaccine. Especially that the current commercially available vaccine, Dengvaxia is only allowed to be administered to people whom had previously had Dengue.
This happened after the vaccination incident here in the Philippines back then for Dengue, here's a Wikipedia article about it: en.m.wikipedia.org/wiki/Dengvaxia_controversy
I live in the Philippines btw, Dengue is prevalent here especially from June to August.
I'll just take the COVID vaccine first, my mom stops me from taking it, she is a firm believer of the Anti-vax movement, and also my family is Christian (including me, though only my mom is the Anti-vax), she's ~60 years old.
@@ninjasiren so sorry to hear. My brother is big anti vax. Has had covid twice now. Second time just last week.
@@YaakovEzraAmiChi I'm not anti vax but however, I am still skeptical of the covid 19 vaccines
What was her name 😜
My sister gave me a copy of Hot Zone about 25 years ago. I hadn't heard of Ebola/Marburg at that time, and had no computer to look into it. Information about it was hard to come by in our local library.
Needless to say, it scared the s*** out of me. Any symptom that struck me over the next few months left me wondering if I had been infected with Marburg. I remember the guy in the book had contracted Marburg and was flying in a plane when he puked into a barf bag. The author described the vomit as looking like coffee grounds. It was dried blood. That visual thought has never left my mind
Bleeding ulcers can produce the same
I'm a scientist developing a deadly virus weapon. I infect myself and die horribly. They name the virus after me. Yea, I'm honored. Smfh.
This was fascinating to learn about, in the sense of where it and other hemorogic come from, what precautions to take etc thank you Simon for another informative video Sir.
@E Van That comment would make sense if SARS-Cov-2 did indeed come from a laboratory.
Thank you :)
@@angrydoggy9170 I tend to NOT believe what is told to me by the Communist State-run propaganda machine that is the Chinese news media. Taiwan doesn't either, that's why they fared so well. You would fare well to do the same... just a suggestion
@@joshuam.1215 Didn’t know that just about every geneticist/virologist is being controlled by the Chinese state media. Thanks for the information.
@@angrydoggy9170 it did come from a lab you drooling muppet.
Into the Shadows is that thing you want to look away from but can't. As much as it scares the hell out of me. It's better to know the ugly side of the world than stay in a happy little bubble. Thanks Simon and Co.
It's like watching a car crash. Terrible, but impossible to look away from.
@@TheExplorder And then you spent an hour on lifeleak and can't go into elevators without literally jumping in and out of them...
And click, click and click, and boom, you saw enough disgusting stuff to make you question why couriosity is so strong and weird.
>posession of a select agent results in a severe fine
*laughs in billionaire*
I live in Marburg..... but in Australia, here we have Hendra Virus, also from bats and with a very low survival rate. Bats spread it, but it kills humans and horses.
Omg, what's with bats? Why do they carry so many viruses.
@@JuneCarpenter35 Here's another worthy mention that I learned in my microbiology class: Histoplasma (causes Histoplasmosis) is a fungal infection that affects the lungs, is found in soil and bat droppings.
Nipah and hendra are almost as terrifying a filoviruses
@@JuneCarpenter35flying without bird lungs is hard, as birds have basically one way pipes for lungs. Bats therefore had to become super oxygen efficient, and evolved super high metabolisms. However, this caused problems with cell destroying molecules building up as a by product. Basically, they have strong immune systems because of that, and their body temperature is surprisingly higj
Simon I love your videos. Keep up the good work. As a veterinarian I would ask you to please consider making a video on Rabies. It's deadlier than Marburg. Something like 99% mortality rate.
Rabies is indeed horrifying and as you say, very deadly. But there is a vaccine for it [NB! Do not wait for symptoms to show guys or it's too late] and it's only caught through bites or scratces from an infected animal [the vast majority of the time] but it is not transmitted through just touching the person like Marburg or Ebola.
Having said that, a lot of people die from it every year. Here's a good video on it: czcams.com/video/L2ZVokk54Iw/video.html&ab_channel=InstituteofHumanAnatomy
czcams.com/video/wfjDgnpDMvM/video.html
@@paulohagan3309 It doesn't matter how it's transmitted. The issue is that Rabies has a higher mortality rate. Yes vaccination exists and immunoglobulin can be adminstered after a suspected bite as well but if you get Rabies your chances are lower than with Marburg.
When it comes to TB at 43% mortality rate, thankfully with treatment we don't see that. I've attended so many TB patients without any PPE it's not funny, over the years. I hear that a TB patient in the States is almost like an Ebola patient. Around here, they're behind you at the post office. There are many deadly things. A needlestick from someone who has HIV which is resistant to INSTis, NNRTIs, PIs and nukes is very scary.
@@peterc.1419 There are many deadly things. Agreed but there is a big difference between a disease that spreads easily and turns into a pandemic/epidemic and one like rabies that can only spread slowly no matter how lethal it is [and I grant that to the individual who unfortunately gets it, it's deadly].
@@paulohagan3309 Normally one considere mortality / prognosis of an illness seperately from its etiology, epidemiology, pathogenesis, presentation, diagnosis and treatment. :) These fall under different rubrics.
I suppose I approach this from a professional angle and should not quibble over these lay videos and the senationalist claims they throw out and their dramatic presentation.
There is an outbreak right now in Tanzania and New Equatoria. right now.
Really digging the new channel. I've never heard of Marburg until now.
That excuse doesnt work anymore.... I tried it with condoms, no go...fyi
I had to do a research paper a few years ago on zoonotic illnesses. This was apparently so rare that it never showed up in my research. Would have Loved to have studied this for my Veterinary Assistance course.
Recall reading about this ages ago - “Marburg *Green Monkey* disease.”
Marburg has been widely discussed as Bill Gates ideal plan for reducing the population as he so desires.
Well dang it Mr Simon, my grandsons and myself are huge fans of your channels (the ones I’ll let them watch at least). I am pretty old and I really appreciate the vast amounts of content your companies release and it lessen the boredom of being an old “has been”.
Please don’t stop your domination of this media and I will give you my views.
I wish you and your writers good health, happiness and all the best to you and your families. Thank You!
Covid came from a lab lmao
Ripley: I say we take off and nuke the entire site from orbit. It's the only way to be sure.
Hudson: Fuckin' A!
Burke: Ho- ho- Hold on a second. This installation has a substantial dollar value attached to it.
Ripley: [scoffs] They can bill me.
I'm a Ripley too. Big Sis is correct. Nuke 'em. Now. ⚡💥
The thing is, diseases like this with high mortality tend to have lower transmission and kill fewer people. It is taken more seriously.
Diseases with lower mortality kill more, because they have more opportunity to spread and people decide they should protest sensible precautions.
LOL lockdowns could hardly be considered "sensible precautions" for a 1% mortality rate. Especially given the age of the affected populations involved.
They got the mortality rate wrong too. It's only a fraction of a %. Lockdowns are ineffective and cause more problems than they solve. Depression, suicide, drug use, domestic abuse, crime, famine conditions, shortages, and school absences have all skyrocketed over the last 2 years. Civilians during The Blitz came out of the tunnels while they were still being bombed because they didn't want to rot to death. Life must go on. Stop being cowards and accept death as inevitable.
@@stevencooper4422 They also fail to mention that obesity is a primary factor in mortality for EVERY illness. Get healthy and survivability drastically improves.
There is a significant difference between treatment and cure. In this case, there is no cure but there is treatment.
There is treatment for most things that aren't instant death, as any mitigation of symptom is a treatment.
I first heard of Marburg reading The Coming Plague by Laurie Garrett, which is a scary but riveting book.
One of my all time favourite books! Such a classic on virology and epidemiology.
@@neuralmute how did humanity survive all these pandemics? Now we have them every 10 years and have to medicate everyone with questionable vaccines from profiting private companies
@@neuralmute that sounds strange. If viruses come from wild animals should not people have been more exposed to it back then? Could it be that people had better immunity back then when they consumed less chemicals? So that diseases that did not affect us suddenly turns lethal. I know alot of medical companies that would love if people got worse immunity through some injection.
The black plague came to europe because of the first trading with asia. Now we have a "pandemic" every 10th year.
@@patrikpass2962 Please just read some information from scientists rather than facebook. They are not trying to kill you. The book I recommended is a great place to start.
As for wild animals, people are coming into closer contact with more species now, because we're destroying their habitats, and they're being forced into ours. The destruction of African rainforest is how SIV (a virus that infects chimpanzees) was able to jump species into humans and become HIV. And massively expanding world travel was how HIV managed to sweep the globe in just a few decades.
@@neuralmute I dont use facebook. We should not use youtube or google at all either as they censor information about a "world threatening disease we all have to give up our rights for". But the scientists you talk about care about our health, right?
The fact that there are still so many things out there where we essentially just have to try and keep the person alive while the body tries to handle everything on its own (when the body can easily go completely overboard and drown you in your own phlegm like the 1918 flu-) is a scary thought. We're just sort of hoping that your body can handle itself against the threat long enough to find out how to take it down, if it even can.
Is this the same as Parvo for dogs?
Remember, Batman chose his name because bats are scary. Apparently, even scarier than I thought.
The Russian scientists stinging themselves on the syrines made me think of American nuclear scientists involed in the events with the infamous "Demon core" that killed at least two and as a great finale while used in a nuclear weapons test fue to a miscalculation had a higher yield then intended. As a result the safe exclusion zone around the test sight was just barely large enough.
Accidents happen. In Russia, the US, Europe, no one is immune to musfortune
I had no idea the demon core was used in castle bravo
@@jhdsfalsjhdfjashdkhvjfldld8301thats why we have additional safety features, so that when something goes wrong, it wont be wrong enough to cause a disaster
@@filipbitala2624The issue with additional safety features is that people need to actually use the safety features instead of a screwdriver.
that guy dying while injecting a Guinea pig with marburg is peak
Into the shadows should be named Bleak Blaze.
Every time I see Into The Shadows my brain reads it as What We Do In The Shadows
Reminds me of Edgar Allan Poe's story, "The Masque of the Red Death."
Marburg is treatable by a blood transfusion from someone who has survived Marburg.
Would you be able to do one on MRSA? Seems like a lot of people in my area are getting this infection and nobody is getting rid of it.
I mean, by its very nature MRSA is difficult to treat, we only have a select few agents we can use and strains keep getting more and more resistant to the medications we do use.
It's not possible to get rid of MRSA. MRSA is everywhere. You're probably exposed to it quite frequently, maybe even daily. The thing is, most people who are exposed to it don't become infected because it is easily fought off by a healthy immune system. It's generally only a problem for people who have a weakened immune system or people who've had a recent course of antibiotics.
I got it In my left ventricle in 2011 and spent 7 months in the hospital. Barely made it alive and have permanent damage to my heart and have a bunch of other health problems stemming from it that will never go away 🫠
Had that as a kid, thats what turned me into a germaphobe ever since, I wash my hands after touching almost anything
Yet even with MRSA general public still beg for antibiotics for viral infections and MDs have to stand firm saying NO, antibiotics don't kill viruses.
the terrifying thing about marbug is unlike ebola or even rabies which are more or less incompatible with being airborne, marbug could be coaxed into becoming airborn fairly easily, as the Russians found out. the other terrifying aspect is that even though its classified as a select agent, marbug is actually incredibly easy to get a sample of. with so many african bats having the potential to carry the disease anyone with access to a cave and a marburg test could collect guano samples find one that's positive and transport it easily in plain site anywhere in the world in something as innocuous as some gel caps in a bottle of aspirin. I'd wager good money that there are people with marburg in their basements in cold storage waiting for consumer grade tech to reach a point where people can successfuly gene edit in their own home...you know for fun. Hey the idea of a 3D printer 10 years ago was scifi and university grant study, now you can buy high end 3D printers on amazon for $300 and make damn near anything. Biotech will follow the same path in the next 10 years, all in the name of entertainment.... which like 3d printed guns serve a much darker purpose.
I'm looking for an exotic vacation. I know. I'll go visit a feces filled bat cave in Uganda and then come home to my family.
Millennium, the tv series from the late 90’s starring Lance Henriksen, covered this really well!
Africa is perhaps the scariest continent in terms of deadly diseases.
This makes me wonder about the safety of using bat guano as a fertilizer. You already need to use caution handling it due to other (usually air borne via the guano dust) disease factors. I make an AACT (Actively Aeriated Compost Tea) with guano as a major component. Seems I may need to tighten up my handling protocol.
Make sure you read both of Richard Preston's books, The Hot Zone (Ebola Restin), or The Demon In The Freezer (smallpox) when you have a cold or the flu. I did, and it's great fun. Kind of analogous to watching a big movie in 3D.
Oh dear! I’ve read both and can fully agree that that timing might be really bad.
@@andreagriffiths3512 bet you keep doctors phone really close.
@@patrickgriffitt6551 not that close as they’re not on speed dial lol but they are in my phone.
@@andreagriffiths3512 so is mine. But I am old.
Awesome work Simon to you and all your collegues!
I am very surprised that Marburg is still resisting medical action to stop it but Ebola has been successfully addressed.
this stuff scares the shit out of me. when mother nature comes for us we are going to pay the price,
Being the ridiculous nerd that I am , I know far more about the type of hemorrhagic viruses than I care to admit.
Tracy, moi aussi!
I remember reading "Hot Zone" by Richard Preston about the Ebola Virus...(but also talked about Marburg) and it talked about Kitum Cave and all the bats and guano and I thought "right there! It's in the bats!!"
Now this was in like '97 WAAAAYYY before anyone knew where Ebola or Marburg was "hosted" they just knew the "host" wasn't primates.
well, that was horrifying to watch in the middle of a pandemic
That’s the goal….TO ALWAYS FEAR MONGER AND SCARE THE SHIT OUT OF YOU. MISSION ACCOMPLISHED!!! Fear invokes COMPLETE CONTROL.
God wins! In Jesus Christs name! King of Kings! Lord of Lords!
This isn’t a really scary pandemic we’re in the middle of. In the next two years or so they predict a virus similar to Marburg is coming and will affect those who keep on decimating their immune system with pharmaceutical injectables.
@@Jcremo God wins!!!
The dumb replies are strong with this one.
There is an excellent book called "Spillover", which discusses Marburg among other zoonotic diseases. Highly recommend for anyone interested in the topic.
Who is the author?
David Quamman. And the story about Marburg is really fascinating.
@@zoundstreetop I’ve added it to my reading list. Richard Preston has touched on it in a couple of his books. Virology is fascinating. And a little terrifying.
I'll look that one up. I haven't read it !
"Hot Zone" is one of my favorite books. I'll have to look up "Spillover".
Flashbacks to reading The Hot Zone in Jr. High ... it will always haunt me.
Oh I can’t wait to watch this! “When will we have another chance to see bats and pythons in the same cave?” A question best left as a “let’s pass.”
"90% mortality rate? That's it?" --Rabies
Aids: hold my beer
Reading Richard Preston's "Panic in the Hot Zone" which was about the Marburg virus, gave me perhaps the greatest fear I've ever had as an adult---I count myself as *VERY* lucky that *reading something* is as frightening as my life has ever gotten.
Covid 19 up to November of 2020, by a WHO study, has a mortality rate of about 0.24%.
Which would be rather low, but you apply that to hundreds of millions of people and this isn't anything to sneeze at.
@@graced1338 and then you compare it to the the millions of ppl dying every year from something "trivial" like ooooh idk malaria, or heart disease ect... And you do realise then that it is not something to CLOSE DOWN the whole f*cking world for! And put the basic human rights of 100% of the population "on hold" because of the 0.24%... Oh sorry, apparently its more like 0.15% now...
And not, covid in nothing to sneeze about (for about 0.24, sorry, 0.15% of the population), but bloody hell neither are the basic human right for 100% of the population!
@@graced1338 just like the flu
Keep out of caves filled with bat faeces? Well that's my weekend plans ruined then. cheers
It's astonishing how CZcams's algorithm suggested this video to me today as there is now a current oubreak of Marburg.
Once again, Simon has found a way to keep me up all night, and no, it's NOT gonna be fun.
I still remember the 2004 outbreak in Angola. I looked into the disease with whatever limited resources I had, damn thing gave me sleepless nights
Well if an outbreaks happens Marburg would eventually mutate to a less deadly virus and people will build immunity to it overtime like Covid
My wife and I visited Marburg, Germany, and I couldn't help thinking about that as being the site of the outbreak.
The Soviet scientist "accidentally" stuck himself, and the coroner examining his body "accidentally" stuck himself too? Wow, I'm surprised they didn't fall out of a window onto some bullets.
Then fell into an acid vat and then buried themself in the middle of Siberia.
After everything we learned about our fellow humans, near and far, during this rather mild pandemic.... we're doomed if Marburg ever goes 'viral'...
Well Bill Gates did say "the next one will get their attention." Then smirked like he does.
Realistically if you model it, with such a high fatality rate it would not spread to worldwide level since most people would die before transporting it. Take Ebola for instance, similar fatality to it and ended up killing only tens of thousands.
About fellow humans?
What do you think drives the paranoia? Media, for one
I assure you, people would take this one much differently. Covid has a low mortality rate to begin with. Even lower when you look at the 65 and below without pre existing medical conditions. Covid was politicized and that has led to severe distrust, and rightfully so. The governments handling of it has been criminal. Get a disease that's an actual certified banger. I know I would be far far away from civilization.
@540マンモス yep
Bats have very strong immune systems, which is why when a disease crosses over to humans from bats, they're very difficult to cure in humans
Can you make a video about Huntington's disease? It's a really scary one but I think more people should be aware of it, there is no cure, and it's life destroying but they can help prolong the effects a little. Also I really find your channel interesting
It's hereditary and so obvious that the family of the sufferer should be tested for the gene, and then ve inv9lved in genetic counseling before accidently reproducing with another carrier. I once took care of a lovely man with severe Huntingtons, and then one day his elderly parents came in with his sister to visit, and ibwas shocked to see her doing the beginnings of the chorea movements. So sad that 2 of 3 of their children by age 40 were affected. I think a video on the diseases that have high incidence of occurrence when two carriers mate are so ignored when one at least knows they are a carrier....huntingtons, bipolar disease, muscular dystrophy, cystic fibrosis, etc. Society doesn't push for testing and ask them to adopt vs 2 carriers mating. We have this belief it won't happen to me.
I wonder why they're not investigating why only 22% of the 31 infected died. That's not 90% so why did fewer people die than should've died? What made them so unique?
If I remember correctly there are 3 different strains and only one has the 90% fatality rate.
The 31 infected had the blessings of modern western medicine in central Europe, and so only 22% died.
The people reporting 90% loss rates are in areas where clean water is uncommon.
The difference in lethality rates is well known.
Probably because those infections took place in a first-world country where the people were relatively healthy to begin with, and they had access to good medical care. I imagine this is not the case for the rural parts of Africa.
So the 90% is a bit of a misnomer. One outbreak had a mortality rate of 88% while another 24 %. The overall mortality rate is 54%, still
Extremely high. 1/2 is a hell of a lot better than 1/10
I heard that „early & aggressive hydration therapy“ has produced good results in the treatment of Ebola…maybe this would be an option for Marburg as well? And no, „aggressive hydration“ is not a euphemism for „waterboarding“.
This was one of the earliest agents I wrote a virology paper about. Good pick, it's a fascinating subject.
All those years ago before the pandemic, and prior to the more recent, and larger, ebola outbreaks. Went through a period where I researched all I could find on any filoviridae.
Great. Now the next time I cough I'll think I have 10% chance of survival
I believe we have saved exactly 1 human rabies patient.
That has to beat 90% fatality rate.
Rabies in my eyes is just as scary as any hemorrhagic fever
I read a news story a few months ago about a guy who refused the rabies vaccine after being bitten by a rabid animal. On the one hand I want to pity him for dying what is probably the most horrible disease death I've ever heard of. On the other hand, this is why anti-vaxxers are so dangerous. Just imagine if the next pandemic has an astronomical mortality rate, I have no doubt that the vast majority of armchair epidemiologists we're dealing with re: COVID would be just as stupid and bloody-minded about it.
@@erraticonteuse this paints a terrifying picture of an epidemic of something like ebola or anthrax.
@@erraticonteuse On the strategic front, I am sure many nations bio-warfare deprtments are taking notes on how well each country handles the current outbreak...
@@erraticonteuse it's also dangerous to just go ahead and get any vaccine willy nilly, but I guess your crazy if you say that.
Whelp, the title scares me. Solid start to my day.
Damn. I've had TB. It was a severe hospitalization, so I wouldn't say the 43% mortality rate sounds crazy to me, but I didn't realize how close I came to death statistically.
43% is way off. Not sure where that statistic came from. It is about 10%, which is still very high.
43% is for cases of TB without medical treatment. It is still potentially fatal and I'm glad your better now.
Without medicine or medical intervention TB *used* to have very high mortality rate! Now it's very low in a modernized setting.
I think this is why the Rosalia virus from Trauma Team is the most terrifying outbreak in the entire Trauma Center series for me. GUILT, Neo-GUILT, and Stigma were a little out there--I mean, they're parasitoids that slice you up from the inside. However, Rosalia had very realistic symptoms and spread in a logical manner, so something like it could very well become a thing in our world too...