Sodium-glucose cotransporter-2 (SGLT2) inhibitors

Sodium-glucose cotransporter-2 (SGLT2) inhibitors is a new class of Oral Hypoglycemic Drug. Usually this category of drug is known as Gliflozins and use in the management of Type 2 Diabetes Mellitus. Recently, few drugs under SGLT2 inhibitors recommended by EU in the management of Type 1 DM along with insulin.
In this lecture we will cover the following topics:
1. Sodium-glucose cotransporter (SGLT)
2. History of SGLT2 inhibitors
3. Chemistry of SGLT2 inhibitors
4. Mechanism of action of SGLT2 inhibitors
5. Uses of SGLT2 inhibitors
6. Risk of SGLT2 inhibitors
This is our 7th lecture on Diabetes Mellitus & Antidiabetic Drugs.
More Lectures on Diabetes mellitus:
Pancreatic Hormones & Diabetes Mellitus: • Pancreatic Hormones & ...
Insulin: • Glucagon & Insulin (...
Glucagon: • Glucagon & Insulin (Pa...
Classification of Antidiabetic Agents & Injectable Drugs in Diabetes: • Classification of Anti...
Sulfonylureas and Meglitinides: • Sulfonylureas and Megl...
Metformin (Biguanides): • Metformin (Biguanides)...
Sodium-glucose cotransporter-2 (SGLT2) inhibitors: • Sodium-glucose cotrans...
Alpha-glucosidase inhibitors: • Alpha-glucosidase inhi...
Stay connected with SR PHARMA GYAN:
Subscribe, Like, Share SR Pharma Gyan on:
CZcams:
/ @srpharmagyan
Facebook:
/ srpharmagyan
Instagram ID:
/ sr.pharmagyan
#SRPharmaGyan
Note: Figures used in this video were taken from different sources available in public domine under CC BY or CC BY-SA and duly attribution given to the original source.'
Attribution:
Cell enterocyte image: upload.wikimedia.org/wikipedi...
Nephron image: en.wikipedia.org/wiki/Nephron...
Reabsorption of glucose in the nephron image: commons.wikimedia.org/wiki/Fi...
References:
Sen, Saikat, Raja Chakraborty, and Biplab De. Diabetes mellitus in 21st century. Springer, 2016.
Scheepers A, Joost HG, Schurmann A. The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. Journal of parenteral and enteral nutrition. 2004 Sep;28(5):364-71.
en.wikipedia.org/wiki/Sodium-...
Kshirsagar RP, Kulkarni AA, Chouthe RS, Pathan SK, Une HD, Reddy GB, Diwan PV, Ansari SA, Sangshetti JN. SGLT inhibitors as antidiabetic agents: a comprehensive review. RSC Advances. 2020;10(3):1733-56.
Sano R, Shinozaki Y, Ohta T. Sodium-glucose cotransporters: Functional properties and pharmaceutical potential. Journal of diabetes investigation. 2020 Jul;11(4):770-82.
Manoj A, Das S, Kunnath Ramachandran A, Alex AT, Joseph A. SGLT2 inhibitors, an accomplished development in field of medicinal chemistry: an extensive review. Future Medicinal Chemistry. 2020 Nov;12(21):1961-90.
Lu H, Meyer P, Hullin R. Use of SGLT2 inhibitors in cardiovascular diseases: why, when and how?. Swiss Medical Weekly. 2020 Sep 1;150(3536).
www.fda.gov/drugs/postmarket-...
Pittampalli S, Upadyayula S, Mekala HM, Lippmann S. Risks vs Benefits for SGLT2 Inhibitor Medications. Fed Pract. 2018 Jul;35(7):45-48. PMID: 30766374; PMCID: PMC6368009.
www.straighthealthcare.com/sg...
About SR Pharma Gyan
You will find videos/lectures on different topics related to M.Pharmacy, B.Pharmacy, Pharm D, D.Pharmacy courses, and on recent Pharma related advancements on Pharma Gyan. Dedicated, experienced Pharmacy Faculties will share their lectures/experience in a simple way. Highlighting the current advancement in the relative field will help you to enrich your professional knowledge.
Currently, we are focusing on lectures on Pharmacology & Pharmaceutical Chemistry.
#SGLT2Inhibitors
#SGLT2Inhibitors
#OralHypoglycemicDrugs
#MechanismOfActionOfSGLT2Inhibitors
#HistoryOfSGLT2Inhibitors
#ChemistryOfSGLT2Inhibitors
#UsesOfSGLT2Inhibitors
#SideEffectsOfSGLT2Inhibitors
#ContraindicationOfSGLT2Inhibitorsin
#AntidiabeticDrug
#Pharmacology
#EndocrinePharmacology
#AdvancedPharmacology
#Type2DiabetesMellitus

[@rohailmuhammmadali2026]

really good knowledge 👏