Protein Structure (Part 1 of 4) - Levels of Protein Structure
Vložit
- čas přidán 28. 09. 2013
- UPDATED Protein Structure Series: • Protein Structure (Par...
Moof's Medical Biochemistry Video Course: moof-university.thinkific.com/...
For Related Practice Problems with Worked Video Solutions on Protein Structure and Function, visit courses.moofuniversity.com.
The four levels of protein structure EXPLAINED in this video!
Primary structure of proteins describes the actual sequence of amino acids in a polypeptide; namely, it describes the order in which the amino acids are connection reading from the N (amino) terminus to the C (carboxy) terminus of a polypeptide. Two polypeptides (or proteins) can have the same amino acid contents, but if they are connected in different orders in the two polypeptides, the two polypeptides will end up folding in different ways and yield different structures. It's often said that, because of this idea, the primary structure of a protein determines its overall 3D structure.
Secondary structure of proteins describes the ordered patterns of 3D arrangements on localized regions of the BACKBONE of the polypeptide. The word BACKBONE is particularly important, as it implies the repeating N-C-C units of each amino acid, and specifically the interactions between the components of said backbone, the carbonyl and amide. It is often mentioned that the interactions that hold secondary structure together are hydrogen bonds, which is, of course, true. It is also mentioned that secondary structure consists of alpha helices and beta pleated sheets are the actual secondary structures held together by said hydrogen bonds. That's also true. It must be specifically noted, though, that the hydrogen bonds that hold together the alpha helices and beta pleated sheets are the hydrogen bonds between the carbonyl oxygen and the amide hydrogen of the backbone. This does NOT include any other hydrogen bonds (like those that hold together side chains), which brings me to ....
Tertiary structure of proteins is often describe simply as the overall 3D arrangement of a polypeptide after folding. That's hardly it. Tertiary structure further includes the interactions between and among the side chains of the amino acids, as well as the interactions between and among secondary structures. Prosthetic groups, which are non amino acid components of proteins, that are a part of a protein's overall structure, are included in tertiary structure as well. The different types of interactions between side chains include the noncovalent interactions (hydrophobic interactions, hydrogen bonds, and electrostatic interactions) as well as a specific type of covalent interaction (disulfide bonds / disulfide bridges). All are important components of a protein's tertiary structure.
Quaternary structure of proteins simply describes the idea that multiple polypeptide chains can come together and form a multi-subunit protein. If and when this happens, it is classified as quaternary structure.
For a suggested viewing order of the videos, information on tutoring, personalized video solutions, and an opportunity to support Moof University financially, visit MoofUniversity.com, and follow Moof University on the different social media platforms.
Don't forget to LIKE, COMMENT, and SUBSCRIBE:
czcams.com/users/subscription_c...
SUPPORT MOOF UNIVERSITY:
www.moofuniversity.com/support...
BUY A T-SHIRT
shop.spreadshirt.com/moofuniv...
INFORMATION ABOUT TUTORING AND PERSONALIZED VIDEO SOLUTIONS:
www.moofuniversity.com/tutoring/
INSTAGRAM:
/ moofuniversity
FACEBOOK:
/ 1554858934727545
TWITTER:
/ moofuniversity
great style of teaching , answering all questions can bump to students mind
Dude you need to do an MCAT moof university.... A grade quality young sir
wowwowowowowowowoow! best explanation about protein structures in CZcams! helped me a lottttt!
Great Videos...Taking molecular cell Bio class..this is a nice primer before reading the book...Thanks!
just to be sure, so ur going to talk about each type of structure separately in another video?
This is awesome!
Awesome sauce! Its helped me so much for biochemistry!
jency george Awesome sauce indeed!
awesome for NCSU Bio-chemistry, will be recommending
you're awesome, thanks big guy
this is perfect for my biochem test
like it ... much informative ... and useful as well ...
dankie
That is a great work .... Thank you so much it was very helpfulllllllll :) ;) :)
you seemed quite funny. I really like your vids. Keep it up!
are there also hydrophilic interactions in the tertiary structure?
xVbM1 yes
Nice video dude! I have two questions!
First, I'm about to major in biochem and I need your advice on something. I really love biology and chemistry, and I'm really really good at them. Like I understood the first 4 lessons/courses without any help. Do you think I can make it? Cause I have the passion for it.
Second, what's the two most hardest lessons in biochem? Thank you.
did you end up majoring in biochem?
great lectures.....
Shahedul Islam Thanks!
OMG! This is like you've translated to english what my biochem professor says hahaha. Great job!
Lol. Awesome! Thanks! I'm glad it helped.
Amazing>Thanks alot ♥
ruqaya suadad Sure thing!
awesome
Like Khan Academy, but for degree level study!
EliseRoseann Thanks! That's kind of the hope for Moof University! I'm glad you feel that way!
You're doing gods work!
EliseRoseann should i
I think you mean covalent bonds when talking about h-bonds in secondary structures
+jlovt11tzzzz No. I definitely don't mean covalent bonds. I 100% mean h-bonds.
my professor uses your videos for when we don't have class due to snow cancellations. haha. thanks for providing organized note-taking material!
Chelsea Bright Whaaaaaaaaaaaaaattttttt?! That's pretty cool. Which school? Which professor?
Moof University Our teacher uses yours and khan academy videos :)
King James Sweet! Which school? Which teacher?
University of Windsor and Professor Boffa he teaches Biomolecules
King James Sweet! Shout out to Canada, the University of Windsor, as well as Professor Boffa! Haha!
absolutely terrific , however superfacial.....deep info needed somehow :)
Ur simply the best im so thankful to u:-)
Sonali Saha Thank you so much! It means a lot.
the video doesnt work?
Really? It's working for me. I'm not sure what's wrong.
Click to the middle of the video, and then drag it back to the beginning. It should work.
awesome thank you very much :)
soheib kerbache You're welcome very much! :]
it doesn't work .
stuck
דר-לוגיי דר-לוגי Try dragging it to the middle of the video and drag it back to the beginning. It should work.
1.25 speed ftw
falling asleep
I always use 1.5
can be better :(