Autoimmune Diseases Are Sexist. Here’s Why
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- čas přidán 24. 04. 2024
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Autoimmune diseases like lupus disproportionately affect women five to one. Researchers have finally pinpointed a unique silencing gene on the X chromosome that may help explain why.
Women Get More AutoImmune Diseases. Here’s Why.
Hosted by: Niba @NotesByNiba (she/her)
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I just got diagnosed with an autoimmune disorder (psoriatic arthritis). It took me years to get a diagnosis. Because I have a mental health history and am a woman, I was so often dismissed as "simply needing antidepressants".
It usually takes years to get diagnosed, especially if it's not life threatening! It took 10 years for me to get diagnosed with ibd
Now I need a stronger medication (with higher risks) because it caused scarring due to being untreated so long
Antidepressants seems like the new medical equivalent of « have you tried turning it off and on? » which is kind of sad, I blame more big pharma pushing it than doctors being dumbs dumbs cause they people too but still
Another problem with the gender imbalance of autoimmune diseases: It's quite hard for men to get diagnosed timely and correctly. Literally quoting a doctor here: "Well, that disease is so rare it practically doesn't exist. And you don't seem the type. Must be something else". It wasn't.
I'm really sorry you experienced that. Our medical systems need to do better.
That’s awful, I’m very sorry ❤ I hope you have had more caring doctors and received actually adequate medical care since then.
Welcome to women's World of medicine where it is all in our heads and we don't feel real pain and we can't possibly be experiencing that.
@@lenabreijer1311 Not sure if this is just a US problem or if both my mum's and grandmother's situations are different but both their doctors are really good. They do listen the issue is just figuring out what the problem is, which is the case with my mum. If anyone is diagnosed with something with the word syndrome in it good luck, because that basically means medicine has little idea what is causing it and how to fix it.
I've been told that doctors are supposed to look for horses (common) not zebras (uncommon). Well, guess what. I have zebras.
People with XX chromosomes: have a higher chance of getting auto-immune diseases
Doctors, somehow: it's just stress
That's the worst part. And what they are saying really is that you are overly dramatic and emotional. That's why they add the "just".
@@shakeyj4523 And you're giving them back up with the comments 😂
Well Stress can be a killer and activate your genes. Cortisol can be a real bugger.
Doctor... "Autoimmune disease? Huh. Funny thing, Mrs Johnson... the one thing yer health plan doesn't cover."
(Healthcare also sexist)
Also doctors: It's probably all in your head, but if you insist on making a fuss I _guess_ I can give you some anti-depressants...
I have Hashimoto’s and two former coworkers have lupus. This video helped me understand the mechanism of why we women experience autoimmune disorders more often than men. Now, if we could figure out how to make it stop.
Our son has 11 autoimmune diagnoses. Having all of these diagnoses, that primarily occur in females, makes me wonder why he ended up with these diseases. What does that mean for him? It’s difficult being a minority with medical conditions. And yes, I get the irony of that, but he’s an amazing child who deserves as much compassion as the next person. In case there are questions, I had an amniocentesis due to my age at pregnancy, and he has an XY chromosome.
i only ask this because i am going through it, and it's apparently can trigger them, but is there any chance your son experienced trauma? if so, look up ptsd and cpstd. also, i read once you have one autoimmune disease, it increases your chances of developing another. i have psoriasis and hashimoto's as a 42 year old man.
I swear I read it as “sexiest”, I was very confused for the first couple of minutes.😂
That’s a fine looking autoimmune disease you have there. 😘
Lol, we're just so attractive! Fashion IS Suffering?
@@mayaenglish5424 if beauty is pain I'm a goddamn primadonna
I know my minds there too👍👍👍😆🥁😆
I have one,,,going to assume this as a compliment to me specifically,
there's one more piece to the puzzle. women generally have a "more active/agressive" (that's the general idea, but ofc the picture is a lot more complicated) immune response to make up for the downregulation of the immune system necessary for pregnancy. over evolutionary time women have spent more time of their life pregnant than they do now, so that makes sense to get roughly equal function of the immune system for both. right now, women are therefore better equipped to fight off various infectious diseases like tuberculosis or amoeba hepatitis, but are disproportionally affected by autoimmune diseases.
I have an extra X chromosome (trisomy x), no wonder I'm Autistic with multiple chronic illnesses, I have been told I seem like I have autoimmune diseases but whenever they try to test or scan me, nothing ever comes up. But very interesting!
Hello extra X human
Yoooooo! You're a whole lotta woman! 🎉
I’m autistic and have fibromyalgia, which was only recently confirmed to be autoimmune. It’s still a diagnosis of exclusion rn tho. No test, just you have the symptoms and they’ve ruled out everything else.
You might want to add a correction, Hashimoto’s Thyroiditis is much more common than Lupus(SLE). It’s like 350/100,000 for women per year for HT vs 78.73/100,000 for women total with 3.04 million women affected worldwide. The total Lupus(SLE) diagnosis worldwide at 3.41 million people comes no where close to the estimated 2% of the world population effect by Hashimoto’s. Edit: Even if you count all forms of Lupus and not just SLE the total amount of people affected in the world is around 5 million.
I have Hashimoto's thyroiditis and I am definitely confused by that wrong statement...Even by experience Hashimoto's thyroiditis seems more common than lupus.
@@cfromnowhere
I have been tested for Hashimoto at least 4 times (my thyroid's fine), but when I state I belive I might have Lupus (my aunt and sister got that) that definitely isn't what I'm experiencing.
I also do not believe Lupus is more common.
Id love an episode on fibromyalgia, its so hard to find any information on it
This it seems to be linked to chronic fatigue syndrome
As someone with a notable amount of family with autoimmune things about them, I'm aware of the jist of this. Feels good to get more details about the 'hows' and 'whys'. Thanks!
Also... the x-chromsome emiting XIST... it being tied to the feminine sex gene... seXist... gonna be a funky way of remembering this, ngl.
Lol
Me watching this while in an RA flare: 😨
solidarity!
@@deedrole5296 thanks, much needed right now!
Well, Niba, its the second video ive seen you in! so i assume you are here to stay! Welcome to SciShow! I look forward to seeing more videos hosted by you.
Solid presentation, Niba is rocking these 😊
It is interesting how much balance on the tightrope of DNA life is always dealing with and how too much or too little causes issues, but yet we maintain enough variation that DNA keeps cooking up new mutations… like any good chef, you will stick close to the good recipe but experiment to see if there is any room for improvement.
Thanks to the whole team that makes these amazing vids 🎉
I‘m sorry, but Hashimoto‘s thyreoiditis is way more common than lupus!
Yeah lupus is something like 1-2 over 10.000 incidence while hashimoto is more like 5-10 over 100
Maybe they meant better-known -- I'd heard of lupus long before Hashimoto's thyroiditis.
I didn't gather that they said Lupus was more common.
@@KrisRyanStallardshe very clearly says "in the far less common hashimotos thyroiditis" immediately after discussing Lupus.
@@KrisRyanStallard They did say in the video “far less common Hashimoto’s thyroiditis” according to the subtitles.
Given how often most women are ignored when they complain of symptoms, I would guess that the extra stress is a real factor!
The problem is we get " you're stressed (that solves the problem) would you like to try a yoga class I know". or....x tablet in the Valium group.
My maternal great grandmother, grandmother, aunt, and mother all had/have autoimmune issues. I and my two sisters have always had strong immune systems, but I got bit by a tick with Lyme's when I was in my late teens. Two decades on, I have four diagnosed autoimmune disorders and CRPS. So, I was genetically primed to get chronically ill, and the tick bite was the match to the fuse.
People with an autoimmune disease often have aggressively strong immune systems.
You have an aggressive immune system. It's not weak. We take immune system modulators to help treat our illnesses.
I’m so sorry. CRPS sucks and autoimmune diseases suck. 🙁
@@yvonnetruelove2270 Yep, they do. Thank you.
I was diagnosed with hashimotos at 7 and its difficult. Always nice to hear people talking about it.
This stuff is why, as a non-intersex trans man, I still have F on my legal documents and when I change it, I want it to be X. There ARE medical differences between the different genomic sexes (and non-genomic influences, like hormones) and I want doctors to be able to tell at a glance that things may not be as they seem. I have too many medical issues to feel comfortable with doctors assuming I'm a cis man, especially if I end up in an emergency situation and they don't have my medical history or time to check.
And you 100% should have that right and it sucks that for a lot it’s just not an option
Nonbinary doctor here. Even if you get it changed, we're still supposed to do an organ inventory. I wouldn't base my own legal gender listing on how I'm going to have my medical care addressed.
Edit: and if a doctor doesn't do an organ inventory or ask you about your history in a culturally competent manner like they are supposed to, then the patient can bring it up.
SMART AND AUTHENTIC 💗🫶🏻💯
@@Dx-Dm glad there are better practices out there
in a lot of cases they really do just assume, from what ive heard and experienced (probably depends on the country)
on the other hand there are also health issues that _are_ predominantly affected by hormones rather than genetic, which means trans people are affected in the same way as the gender they are presenting as, so being treated as your AGAB would actively be harmful, but that is exactly what misinformed doctors would do
we need better education, and more research
@@fghsgh I agree with all of your statements. Receiving gender-affirming hormone therapy or surgeries are very important things to discuss with your doctor. All the more reason to not change how you legally list your gender on the basis of your assumed medical treatment.
Howdy hi hi,
Thanks for doing this episode. I'd always wondered why autoimmune disorders were so much more prevalent in women. I am male, genetically and in every other way. However I've developed not just one but two autoimmune disorders. I have a family history of Lupus, but I am thankful to report that hasn't manifested and I hope it never does. What is do have however is primary antiphospholipid syndrome positive for anticardiolipin auto antibodies, anti beta 2 glycoprotein 1 auto antibodies, the lupus anticoagulant (again, not lupus YAY) and something called polygonal phase that I still have no idea what it means. As well as factor V Leiden with activated protein C resistance. And to top off that quaint little cocktail let's toss in ocular migraines for good measure. Yeah migraine, another disorder far more prevalent in women.
While I've not heard any estimates as to how many people might have this spectrum of disorders. I have to imagine that it's pretty rare overall. I lived with this, let's see...this is my 25th year surviving this stuff. Too stubborn to let it get the better of me. Next month I'll hit 53 years young and (hopefully), still kicking.
If there is one thing I'd like to share is that if you know someone who is dealing with an autoimmune disorder of any type. Be kind to them. Understand that it's not a matter of learning and living within your limits. The rules can change from year to year, month to month, day to day, or even hour to hour. I might have extreme difficulty doing the easiest of tasks in the morning. Only to breeze through it later in the day. Or vice versa. So when they cancel on plans, or just can't keep up. Maybe sit with them for a while, or include them in ways that work for them. For those who suffer through these things. It really makes a world of difference when we see others making an effort to do what they can. Even if that means just leaving them alone to rest for a while.
Anyways, thanks for reading this. I hope your day treats you well.
Thank you for your post. ❤
Really informative video for how short the watch time was, thank you SciShow for keeping my brain occupied, and interested. Thank you Niba for another awesome video
I didn’t realize how rare it is for men to get this disorder. I actually got lupus when I was younger where my body started attacking my kidneys. Considering I didn’t realize though that it mostly occurred in women.
Well now as a genetic XY with Crohn's and Ankylosing Spondylitis as well as the constellation of other side "benefits" linked to autoimmune issues like painful joints and recurrent uveitis I am feeling extra unlucky!
The genetic lottery is more like landing on a Bowser space in Mario Party and just hoping that you don't get outright punted into the sun, LMAO
Lmfaooo DEFECT
Fyi: I'm a man with psoriasis and psoriatic arthritis, and I've had women doctors completely disregard me over it.
I'm sure they have, it's really not fair. I've also been disregarded by doctors for my issues, male and female alike; it took me 2 years to get diagnosed with hashimotos, and 2 more before they got me with endometriosis. The medical establishment has a habit of saying "when you hear hoofbeats, think horses, not zebras".
Sometimes, it is a zebra. And those mf's are nasty.
And psoriasis is one of the few that affect both genders! I'm sorry you go through that, it's not fair...
Truth😱😱😭😭@@gemmydoadance1593
Women reproduce medical gaslighting too, even if not based on gender.
Not all autoimmune diseases are more common in people with XX chromosomes though - ALS for example is more common in XY men. Granted that one we don't really understand as far as I know.
I thought the evidence for Motor Neurone Disease being autoimmune was a bit sketchy, circumstantial only at the current time. Have I missed something important? We lost my husband's mum to MND, and I tend to try and keep an eye on the research, but I've had my eye off the ball the last 12 months or so. If I've missed something important, I'd really appreciate any heads up you can give. Thanks.
@@katbairwell So sorry to hear that. I lost my mom to ALS so I only really keep up with that specific MND, but you're right - it's still debated whether it's an autoimmune disease. Saying that, sometime last year there was a study that suggested that ALS patients may benefit from a therapy that targets autoimmune inflammation. Either way, it's wild how little we know about such devastating diseases.
@@danriddick914 I'm sorry, my friend, you put it precisely when you say it's a devastating disease. It's telling that almost everyone we've talked too, that has lost a loved one to it, has become a keen watcher of the science, hoping that other families will get better outcomes one day soon. Much love
Idk why I first interpreted the « that one we don’t really understand » as referring to males and not ALS to which I was gonna say Amen 😭 I do have lots of questions to take up with my Y chromosome like why can’t I just sit around in peace and think of nothing 😂 why am I preparing in my head for a scenario where I may or may not have to fight a bear? I’ve never even lived in bear country before wtf
@@dreammaker9642 Until I was adult diagnosed with ADHD, I had no idea that when most people talk about letting their brain go "silent", they meant they could actually think of nothing, just, like, empty peaceful quietude. Mine has always squealed and screamed at me like a sugar-overdosed child at a theme park!
i am a man living with psoriasis and hashimoto's thyroiditis. my mother and sister also have hashimoto's.
How does it feel to be part of the 5%? /lh
Dang, that's some tough luck!
Did you have any issues getting it diagnosed correctly because of your sex (I can imagine unconscious bias on a doctor's part) or did things go alright?
I hope your conditions are well managed - all the best!
@@cexilady3333 what's with mocking a person who has a serious disease
Next time have empathy.
@@blazer9547 You aren't edgy sweetheart.
@@blazer9547 the /lh at the end of the statement indicates that what they said was light hearted...if you don't know something, look it up before berating others for your lack of context. Please read this as a neutral tone and good advice.
Just a woman here, grateful not to suffer from an autoimmune disorder
Lucky you
It should be noted that males and those with Turner’s syndrome also have a waning immune strength against pathogens as we age. This difference in higher rates of autoimmunity in females vs age-associated waning pathogen resistance in males fits into the paradigm of the immune system having to strike a balance between being strong enough to be protective but not so strong as to attack the self.
This video makes a lot of sense. Woman who have babies go through drastic immune system responses while bring pregnant. Just look into how chaotic pregnancy is on the human body.
Not to mention breastfeeding. Growing and feeding a small human does some interesting stuff to the female body.
also interesting that autoimmune symptoms will often be suppressed during pregnancy and then come roaring back after delivery.
My hashimotos is directly related to the birth of my son, there's apparently a correlation.
Yep, I was placed on a drug used in transplant patients because my body treated my pregnancy as a virus, but even that did not work. I have only gotten to 8 months on 3 of my many pregnancies and they ended in being stillborn I won’t say how many pregnancies that never got past the first trimester it’s just to heartbreaking. The Drs at the IVF programme never could work out why my body kept treating each pregnancy as a virus. In many cases I never made it past the first 6 weeks of my pregnancy. I never told family if and when I was pregnant anymore simply because I knew that by the time the family were told I had already lost my baby.
I use to give blood every month in my 20’s early 30’s and because of an oddity in my blood each time I went in to donate extra blood was taken and sent to the UNI for their special tests and experiments they were running. After my 2nd blood transfusion I was no longer allowed to donate blood which I was only doing because I was on the bone marrow donor listing.
I am 61 now, but they never could find the answers as to why my body did what it did. I have no idea if there are other women out there who have never been able to go full term with the same issues as me. The Drs never said if they had other patients like me. During those years of disaster I only had one Dr no matter where I moved around the Sydney Bowl I always went to my family GP since I was 16 years of age, before that I use to live in the UK.
lol I just worked it, from the time I was born to my present day I have only ever had 6 family Dr’s in my 61 years, and only one of them I have ever refused to see again because he’s a jerk. The 2 best Drs I have ever had in my life were old school Drs, the first one was my last Dr in the UK, he was 92 when we left and he was still practicing Dr he was also one of the Drs who was training the next generation of Drs. The 2nd Dr is my current GP he is 84 and was one of the Drs who created the “Flying Drs” service in Australia he now only works Mornings and he said as long as he still sharp he will keep working.
Funny how the best Drs are also our oldest Drs.
@@deedrole5296 broadly speaking, estrogen ramps up the immune system while progesterone dampens immune response.
Very good reporting here, you gave a great sense of the research!!!
Welcome to SciShow Niba, I love your expressive presentation style. With autoimmune diseases, the complexities of our genetics and the immune system combine into mindboggling complexity squared. Fascinating!
Thank you SciShow. Welcome to SciShow Niba - you are a very skilled communicator - my Internet-weakened attention span allowed me to watch the entire video! This information about the genetic sex chromosome component of autoimmune diseases is also part of the explanation for the large variety of hetero, homo, trans and every other human sexual behaviour. I wish those of us humans who think anything other than hetero sexual desire is a sin or somehow wrong could instead try to learn and understand their fellow humans before condemning them. I am optimistic, but won't live to see it.
i think you might've misspoke a bit, trans isn't a sexual behavior
@@nerdywolverine8640 he's a little confused, but he's got the spirit 😂
Early detection? I’d settle for doctors believing us when we come in with all the symptoms and a family history asking specifically about the disease we have!
"...y is much smaller than x..."
784+ dislikes: "and i took that personally."
I'm a 32 years old man who got diagnosed with MS at 18, an age where it's pretty uncommon for men to be diagnosed and way more common for women. I absolutely can't argue with this video. When it comes to MS women get diagnosed more often than men and, on average, at a starkly younger age
Great video as always
"Xist" sounds like the name of some sort of health-focused tech start-up lol.
Sounds like a gamer name.
Ahh so informative video! Thanks! 👍
OMG, you mentioned Hashimoto's Thyroiditis! That's my autoimmune disease!
Trisomy 21 is fatal in utero in about 50% of affected fetuses. A few more die during the early newborn period. Life expectancy is reduced even with optimal supportive care.
Ive always found it fascinating how each sex is disproportionately affected by different kinds of genetically based illnesses. It really goes to show that despite how amazing the capabilities of our genes are, there are still massive flaws to be found in them as well.
Especially ones on sex based chromosomes.
Evolution don't care.
They are not inherently flaws per se. Your genes make sense for the environment they have developed for. If we do not live in that environment any longer - which most of us don't, in "the modern" world - then the interaction of your genes with the new conditions can go awry.
@@TV-xm4psThey are actually flaws. You can't justify being born blind or missing your hearing. Our bodies are not perfect. They are far from it. They are as bad as evolution could get away with. Genetic issues are totally useless and mostly don't have a "hidden meaning".
Love your cardigan!! 😊❤
I definitely believe this... all of the women in my family have at least 1 autoimmune disorder, but most have 2 or more; I have 3.
I know exactly what you're talking about, yet still curious
If Autoimmune Disease are more prevelant in animals that have two or sets of Sex-Chromosomes, does that mean the disease in animals where the males have the two sets, like with birds, are mire prevelant to the males?
That would be a very interesting question and could help people learn a lot about autoimmune disease!
here for the guys who didn't realize the title is a joke
Thank you for this.
Yes part of the problem for women is that our pain (and other symptoms) are just not treated seriously. I'm post menopause now. I love it!!!! Kind of wish I had been diagnosed with endometriosis. At least they would stop fobbing me off with "you'll be fine once you've had a baby / past menopause. "
"It's never lupus"
I have a unspecific arthritic diagnosis including the genetic testing for HLA-B27, which was positive. I thought it was also related to sex, but I just read on wikipedia that HLA-B27 is coded on chromosome 6 though... it still associated with sex or was that a misunderstanding on my part?
I read that trans women (who are XY) sometimes develop autoimmune diseases when they start on oestrogen. Maybe there's a hormonal component to the sex discrepancy as well. Unfortunately I can't remember where I read this
schishow actually did another video on autoimmune disorders that discusses this, a few years ago i believe
I remember another video on autoimmune disorders here and how it was noted that the trend even occurs among trans women, which wouldn’t normally be expected. Which does make me think Estrogen is likely involved too tbh. (Yes, one can be trans without HRT but I believe the study cited did look only at trans women on HRT so yeah. :V)
Hi Niba!!❤❤
Y'all, the title isn't clickbait - it's a pun. "Sexist" is actually a play on the issue being related to X chromosomes (aka the long-standing idea that this is an issue in "women") and Xist (the stuff that wraps around the extra X and silences it).
"Autoimmune disorders are Xist. Here's why."
I don't think so.
Ikr, NPC is reaching hard.
@@blazer9547I hope you experience joy one day! Good luck!
@@justaregularguy115 do you have a counter argument based on facts and data?
I have already stated this a few times already but the title of the video is clearly tongue-in-cheek, think of the headlines from a few years ago the “Covid-19 is homophobic” article titles were clearly not meant to be taken literally and are just using a jokey description of the actual problem.
No, by definition it’s still clickbait. Clickbait is everywhere, not all of it is bad. If this video was titled “Why women get autoimmune diseases more” less people would click. There’s also nothing related to sexism in this video, if they wanted it to be less clickbait-y, they should’ve called it “Why Autoimmune Diseases are SeXIST” Or something. This is still very much clickbait.
Can you do a video on Mallen streaks or poliosis?
I have lupus and always thought it was induced by hormones, since triggers are puberty, UV rays, and other stress.
My brother has Hashimoto's thyreoiditis, my second cousin (a female) has lupus. My brother also thinks her daughter has lupus.
New presenter is great! 👏 👏
Still not sure about the recent use of multiple camera angles 😛
I recently started suspecting I have systemic lupus (tons of symptoms + family history), so this is right on time 💀
Good stuff
From my wife: "I KNEW IT!! I knew it!! Dammit! Life is unfair!"
Then she said some unmentionable things along these same lines.
That second camera angle in the intro was super unexpected
As a sufferer of Hashimoto's I'm thrilled you're talking about autoimmune disease and I think you should do so as often as possible. However, maybe refrain from the (perfectly comprehensible) puns because people are media illiterate and the sexist culture war weirdos who hate women come out of the woodwork. (They'll do that anyway.)
Eh, we can't let the no fun, media illiterate weirdos win. If you can't tell it's a silly joke you're doing something wrong.
(Unless English isn't your first language or you have some sort of learning disorder obviously).
Can we test for this? I want to be tested! I have multiple autoimmune diseases and want to know if my chromosomes are faulty!
My family have a bunch autoimmune disorders that are expressed differently among us. We all have primary clubbed fingers, my grandmother had AIED, and my mother has psoriasis and rheumatoid arthritis. I myself, a male, have vitiligo and HSP. There is still much research to be done on why autoimmune disorders are expressed differently among the global population.
I have health problems that got worse the last couple years, especially since COVID. My gynecologist said to me I should get checked by my GP, because my symptoms sound like an immune issue. I don't like that... 😅
As a woman who has hoshomitos, this was very interesting
I wonder how this affects the few XX males with an SRY on one of their X chromosomes.
I have 5 autoimmune diseases. Possibly a 6th which I am being tested for, all related to the Type 1 Diabetes I was diagnosed with in my teen years. I am now in my 70's. This is a very interesting video and would like to find out more.about this theory.
I inherited Hashimoto's from my mom, but I guess I'll take that over inheritance of her schizophrenia and epilepsy.
I really wasted a significant amount of time in my teens wondering if I was under a counter waiting for my mental capacity to decline. The Hashimoto's wasnt on my radar at all.
I have Grave's disease just like my father. Thankfully mine went into remission before having to have my thyroid removed.
autoimmune disorders run in my family, for us both men & women get them pretty equally since almost everybody has something. though i've noticed that specifically crohn's & ankylosing spondylitis are most common in my male relatives vs lupus, hashimoto's, & sjogren's which only affect my female relatives (as far as i know)
I'm a type 1 diabetic and a cisgender woman. How common is that compared with other autoimmune disorders? I've met several type 1 diabetic men and I wonder what the statistic is for xy vs xx in diabetes.
Also wondering how common is it to have more than 1 autoimmune disorder since I also have Hashimotos.
i know the reason T2 is more common in men is because estrogen increases insulin sensitivity... but of course that's a very different thing from T1
looking it up, it seems the ratio for T1 is slightly under 2:1, and, considering it usually develops in childhood, is probably caused by genetic differences rather than hormonal ones, so trans people would be affected similarly to their AGAB (although maybe it is still partially hormonal? so specifically trans men going on hormones could be more likely to develop it in adulthood, which does also happen for cis people but is relatively rare)
It‘s very common to have more than one autoimmune disease sadly.
My husband has MS and we know a lady with MS. Lupus runs in my husband's biological family on his father's side.
One set of experiences does not offset statistical facts.
What I was always wondering, as far as I have learned before, pre-menopausal women are on average less susceptible to infectious diseases.
Could part of this question also be that this is the downside of a more active immune system? And the more active immune system being an evolutionary adaptation to traditionally being the one who cares for children (who are more likely to go through many diseases quickly, and also a good way to come in contact with poop and bodily fluids) and the ill?
another thing about this: the immune system's function is severely reduced during pregnancy (so as to not attack the fetus), the heightened sensitivity could be to make up for that in between pregnancies (also remember that pregnancy used to be a lot more common in the past)
but yeah, sex hormones affect immune function, it would be wholly unsurprising if say, trans women going on estrogen were more likely to develop autoimmune diseases, but probably not quite on the level of those with XX
@fghsgh that's another good point, one hypothesis is that the rise of autoimmune disorders is as internal parasites dampen the immune system, and without them we essentially all have a somewhat overly alert immune system. Maybe fewer pregnancies also means our immune system doesn’t get downregulated enough
Another idea, I saw in another video that it’s random which x in each cell gets activated, it’s like the pattern on a calico cat. What if female bodies are more likely to get immune cells that are confused because of this? Perhaps the immune cells in the thyroid are more exposed to the proteins of one x rather than the other and sees the other x as a threat.
Where’s Hank
I expected this to discuss Polyvagal theory
I tested positive for autoimmune disease, specifically what type not known yet
Gotta love the sexism from the people who very obviously posted without watching the video. 🙄
When it's over 7 mins long, 4 mins old, and you posted your factually incorrect comment 30 seconds ago...
Title is inappropriate. nature don't discriminate
@@blazer9547 It's obviously just fun word play... calm down
Bots I assume
Where would that be "factually incorrect" tell me please
@@scalpingsnakeNo, it's not "obviously word play." That's the mistake. Assuming everyone is "in on the joke." They're not. Normalizing terms like sexist is the real problem.
I may just be more tired than usual, but I had a hard time following this video. I did listen to it at a slower speed, which helped some, but the concepts are multi-faceted and I needed the facets laid out one at a time and more of the connections between them explained a bit more. But fascinating topic. I'll keep an eye out for more information on it.
I found it hard to follow because there were no pauses in the script. It seems that @SciShow *deliberately* edited out the pauses between sentences, which just made everything feel chaotic!
We need the natural speech pauses to give our brains a break!
@@marmar90000 Maybe that was the problem. Because when I slowed it down, there were still no pauses. Interesting how important that can be!
I am a man and I get hemiplegic migraines, which are FAR more common in women. Is that why I love when my daughters paint my nails?
I have the hlab27 type that is linked to ankylosing spondylitis in more men, but I keep stumping the rheumatologists because I only have eye issues and no spinal problems. For some reason it seems being female is protecting me from the worst of this specific disease.
As a man with an autoimmune disease I concur.
i like her style very mych thanks for the videooooooooooooooooooooooooooooooo
It's overbearing, a verital verbal assault - does she breathe through her ears?
Cancel autoimmune diseases!
Tell that to my Crohn's who has taken most of my bowels from me.
Yes, please!
Yes lets do that please and thank you lol.
I have a condition called Immunodysregulation polyendocrinopathy enteropathy X-linked (IPEX) syndrome which is the root cause of NUMEROUS auto-immune disorders because of the mutation of the FOXP3 gene that messes with the production and normal function of regulatory T-cells. And regulatory T-cells work to tone-down an immune response, preventing auto-immune attacks.
The FOXP3 gene is present on the X-chromosome, like the other auto-immune conditions. The big difference with IPEX however, is it, affects men a LOT more than women. This is because, to my understanding, the mutated FOXP3 gene is a recessive trait that requires the mutation be present on BOTH X-chromosomes, otherwise the dominant, non-mutated copy prevents it from being expressed. However, since men have only 1 X-chromosome, they don't have that copy of the correct gene to silence the mutated copy.
The other auto-immune disorders are, again to my understanding, connected to dominant genes and thus only need 1 copy to be expressed. Am I getting that right?
Narator "People born with two or more x chromosomes"
Me: "OR MORE HERE TO REPRESENT!!!" also got extra autoimmune shenanigans for added spice.
I have lupus and now i wanna get my genome sequenced
TL;DR - Excesses of Xs's cause a lot of messes
Living a life full of messes caused by my excess x's (and exes) xD I love this rhyme
OK, the first 2.5m of this video leads me to posit that, because of Barr Bodies, where cells turn off one of the X chromosomes, and it's basically never ALL one parent's that gets turned off (most notably visible in Calico cats where they are a patchwork of both parents colorations)... if there is some minor conflict between this where the Mother's X chromosomes are entirely in charge of the Immune system's detection apparatus and it sees another cell with the father's X expressing, it triggers an overactive defense response. It would also seem that certain systems are more susceptible to these issues... now to unpause and see if I'm in the general vicinity.
Hrm, right path, slightly different path... but the compound that turns off the chromosome getting loose and messing with other genes seems like a good, plausible theory that I hadn't thought of.
Wait- cells...explode when they die?
That would explain the way hangovers feel.
Also this video should include autoimmune disease due to michrochimerism
So that just means I am extra unlucky to be a man with autoimmune issues? T-T
I didn’t see a mention of what I’ve read quite a bit, the link between auto immune diseases and CPTSD. Off to read my life away… 🤣
… the what now? 🙃🙃🥲
It's never Lupus.
WE LOVE DIANA aka PHYSICS GIRL!! ❤
XXY people are still screwed? How would we know if we have that? 🤔
Usually symptoms of XXY appear during puberty, but not always. Recently saw a video of a man who didn't find out till his 30s, after testing for less specific symptoms like fatigue and heart or lung issues, IIRC.
A miracle that this was discovered?
Is it the same chromosome silenced across the body, or does the body have a sort of mosaicism ?
it is mosaicism! i believe scishow already has a video about that (it is also the reason why 99%+ of calico cats are female, the spots _are_ the mosaicism)
Glad I watched this, I actually thought women were less susceptible do to their bodies needing to suppress the immune response due the foreign cells from pregnancy. Thank you 🙂