Mast Cell Activation Syndrome (MCAS)
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- čas přidán 11. 09. 2022
- July 26, 2022
Bateman Horne Center has partnered with the University of Utah Health to conduct a Long COVID and Post-Viral Syndromes ECHO (Project ECHO). This series delivers information to healthcare professionals utilizing short didactics and case-based learning to enhance their ability to manage patients with long COVID, ME/CFS, FM, and related comorbid conditions.
Brayden Yellman, MD, addresses the assessment & management of mast cell activation syndrome (MCAS):
- Review of mast cells and their function
- Mast cell mediators and associated symptoms
- Mast cell activation/hypersensitivity triggers
- Symptoms of MCAS
- Clinical criteria for MCAS
- Relevance of MCAS to Long COVID and/or ME/CFS
- MCAS treatments
Note to community members: We advise viewers to always speak with their medical care team prior to making any adjustments or changes to their current regimen.
Bateman Horne Center’s involvement in this program is made possible with the additional support of the Open Medicine Foundation.
If only the drs were subscribed to your channel
This channel is a treasure trove. What the hell. A lot was not taught when I was at uni. Love it!
Wow, this talk explains so much of my symptoms: fibromyalgia, severe allergies, exercise-induced asthma, migraines, sun rashes, IBS, heat sensitivity, food issues, concussion/neck whiplash … I need to try some of those treatments he listed!
No wonder my decade plus of allergy shots haven’t worked out for me. I’ve only experienced minor decreases in allergies and have had new ones pop up.
Spot On Dr. Bateman. Well stated.
Dr. Yelling you did a wonderful job of explaining in terms that were very clear and concise. I was diagnosed with Mastocytosis 12 years ago. I see mcad symptoms in people who have had Covid in my family, and others.
To add to my last comment as a Mast Cell Activation patient - the commented medications have changed my life! Especially compounded ketotifen, cromolyn sodium, and Xolair. I literally take almost every single med. in the slides. But if I miss taking my ketotifen I have severe stomach pain no Gi doc can fix., plus too many issues to list.
Xolair - My GI doc tried to get me Xolair for years. But it was only prescribed to me when my very knowledgeable Dermatologist saw the massive hives caused by a simple scratch on my back when looking for moles.
I fully support the use of Xolair to treat mast cell issues. It made my life go from almost unbearable to Pain that can be handled.
A pain free existence for those with this issue may not be a possibility.
Does it help Skelton pain
@@Truerealism747
Look into Vit D3, K2 and Electrolytes Magnesium, Calcium and Potassium
This is an excellent series, comprehensive, digestible, without controversy. Bravo!
Agree - alcohol intolerance in the tiniest amount is a no-no. Also, caffeine intolerance. These two together are an MCAS diagnosis on their own. They deplete vitamin B1 - see alcoholism. Large group of MCAS patients using high dose vitamin B1 for improvement and claimed cure. Start very slowly (important) with more-natural vitamin B1 (Eg. thiamine hydrochloride) before the less powerful synthetic analogues (eg. Benfotiamine) and only then the very powerful analogues (eg. Thiamine Tetrahydrofurfuryl Disulphide TTFD, or Sulbutiamine). Must be taken with a standard vitamin B complex of all the B vitamins. All of these are widely available vitamin B1 supplements. If you initially react badly to ordinary B1 high dose then scale it back until you can cope. Move forward by increasing dose/analogues if improvements ensue. Lots of info videos on CZcams.
Nonsense
100%
Thank you so much for posting this video! I think this helps explain my illness and relevant issues. And why I am concerned with getting COVID. There has been a lot of research for other minor illnesses causing CHS, fibromyalgia, etc. that are virus connected.
Most physicians in the past 20 years did not know what caused severe and debilitating pain and other issues for many that ended up being a Mast Cell issue. I am very thankful for the progression and understanding of Mast Cell illnesses.
Thank you!
It's related to hypomobility.i have fybromyalgia symptoms CFS before this decades but mist are in the spectrum for which I have found out last week Asperger's after my son's diagnosis the role of pyroles in this.i had covid did not effect me.
I stumbled upon this syndrome while doing research on another syndrome, something that I whole heartedly believe my siblings, myself and my kiddo have. I do my nails at home about every week to 2 weeks. Anytime I use my nail drill on my cuticles, the next day I end up with extremely itchy, swollen, red, painful blotches that most often than not blister! It hurts to wash my hands in anything warmer than luke warm water. The whole area by the first knuckle on almost each finger will have this occur. Knowing that the syndrome I've been doing research on and this syndrome are connected....the pieces just seem to fit very well together! Thank you for the information, I will be doing more research about this and documenting anything that happens to my hands for my doctor to see.
Thank you for the detailed information. If we could put it into a pill to open the minds of so many healthcare professionals. I would love to visit one day for treatment. Happy holidays.
Great talk!
Thank you for posting this video!
Excellent synopsis!
You can have both issues regarding too many mast cells AND mast cell activation syndrome at the same time. If I just had the clonal issues and no inappropriate reactions I’d have a super power. I have Systemic Mastocytosis and I started reacting to laundry fragrances very poorly. The reason is my spindle shaped mast cells activate inappropriately which then imprint on the healthy mast cells and now over time I’ve become chemical intolerant. I’m 49 and only ever started reacting to fragrances at 48.
Alcohol destroys me entirely.
I had a phlebotomist trying to get an IV started at WashU wearing fragrance, dump my BP, sending me into shock. It’s fragrance free…..
Gotta love healthcare people wearing fragrances.
This is such great information on MCAS. Thank you BHC. Xolair has cured my MCAS about 80%. My life was pretty miserable before Xolair. Now I can eat anything I want and rarely react.
Did Xolair fix your fatigue? Was it because of respiratory problems?
@@mamajennie do you have pain with your mcas what's xloir
There’s no cure for mcas.
@@lauriekline178 you can get it in full remission my.main problem now is fybromyalgia symptoms
But how wise to mask symptoms?
Very good presentation.
Had asthma for decades, which is now thankfully in remission, after addressing deficiencies and deliberately inducing detoxification... Mucus excretion in sinusses, and brochospasm with wheezing were mainly triggered by grass pollen, and house dust, but was also sensitive to secondary nearby smoke, and to some preservatives - especially when in combination with sugar.
Pay attention to your bodys alarm systems. It makes me wonder if someone was malnourished, their liver had NAFLD ( from sugar and HFCS) and was disfunctional from seed oils, heavy metals, actyaldahydes (from candida and mold exposures), and lipopolysacrides ( from latent dental root canal and other infections) and their kidneys were overloaded with toxins as well would the body act in such a way that a person would be hypersensitive? I am still learning about what helps and what hurts. Thank god for supplements that work.
Natural support? not add more chemicals.
💯 Detoxify from unnatural chemical exposures, and look into rectifying deficiencies.
Important to note that Vit C is a natural anti-histamin, working alongside, and sparing Glutathione. For proper absorption of C (for example in both gut and brain) Sodium should be present. Receptors for Vit C and Glucose are similar, with sugar-uptake favoured. Towards preventing symptoms associated with Scurvy, less Vit C is needed when one is on a LCHF keto/carnivore type diet.
@@maricamaas2326 lemons / hence vit. C triggers release of histamine.
No elevated IgE is needed to get Xolair approved for chronic idiopathic hives, only for asthma and nasal polyps.
I have MCAS since I had an allergic reaction to a flu shot in 2013. Ketotifen has helped me the most as well as antihistamines. I became allergic to benadryl after taking it so often, symptom was a burning tongue for two hours after taking it. Also became allergic to Xolair after the ninth month injection but I was doing fine without it, the ketotifen caused a calming down of my symptoms. I was off and on Prednisone since 2013 just recently got off it five months ago, my allergist wanted me off of it. Doing well, watch what I eat. Have allergic reactions still sometimes to unexpected things , sometimes to things I should have avoided. I think vitamin D3 has helped me my level is at 65 now. Also probiotics, IBS probiotics, lactose intolerance probiotics . Also take some of the B vitamins for fatigue helps greatly. Take other vitamins too for osteoporosis / Penia have it the worst in my wrists. I'm writing this in case it might help others who are going through the same thing. And I never got covid luckily. My husband didn't either and he worked through covid and got the shots.
Believe many (if not most) are developing this condition due to interfering with the body's natural immunity; by introducing pathogens, toxic substances and foreign dna directly into the body; this without any proper trials supporting safety... It's criminal what's being done to humanity (to vulnerable babies, growing children and the elderly especially) under the guise of supposed health care... 😢
You might want to look into the work of MD Judson Somerville ('The Optimum Dose')... He had found a level of D in the blood of 100-140ng/ml to be optimum; for this daily administration if 30 000 IU's of D3. Be sure to alongside D3, also take K2, and enough Magnesium.
Had myself also been taking B Vits, towards supporting the liver and nervous system; as well as Vit C, which is a natural anti-histamin - working alongside and sparing Glutathione (for women the dose is 70mg and for men 90mg p.kg. bodyweight - spread out through the day).
Do you see out of state patients? I’ve been with Cleveland clinic for 22 months since my vax day. I need help. I have high tryptase. Having episodes.
There is a connection between intense exercise and intestinal permeability/ leaky gut.
Yes it’s called post exertional malaise.
how long does cromolyn take to work?
Dr does MCAS get better with time when treated properly? Or does it get worse regardless of treatment?
🌟🗽
Are you treating this condition? My son was left with this disorder after suffering COVID 20 months ago.
Either contact the Bateman Horne Center or try to get referred to a mast cell disease expert would be my advice.
Look into liquid Cromolyn.
Hey! You seem young and still have questions.
Want to talk sometime about a treatment that has been working to eliminate MCAS/allergies?
Do we have any data or indication of MCAS as related to pregnancy/breastfeeding? Could it exacerbate symptoms? And which of these treatments mentioned would be safe during that period?
Benadryl made me ill and so did taking DAO. Would I be right in thinking other mediators are causing my MCAS?
I like the natural route in resolving it.
Active Mast Cell dysfunction
What are your symptoms
@@Truerealism747 I have digestive health issues. Feel drained of energy and ache in all parts of my body. Fibromyalgia was the diagnosis in 1992. I continue on working and getting my health issues taken care of like Asthma and heart condition with electric system of my heart. I wonder if all this is from paraquat or something else in chemistry.
To hear about a drug with a 'black box warning' that's being prescribed, is causing emotional stress - contributing towards setting me up for sympathetic overdrive, and is additionally upsetting my mast cells 🤦
Plus I am in my 7th decade now and sensitive to many meds.