ANTIHISTAMINES by Professor Fink
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- čas přidán 10. 06. 2013
- In this video lecture, Professor Fink reviews the actions of Histamine and both H-1 and H-2 Histamine Receptor Sites. Professor Fink then describes the actions and uses of H-1 Antihistamines [including diphenhydramine (Benadryl) & cetirizine (Zyrtec)]. Professor Fink then describes the actions and uses of H-2 Antihistamines [including famotidine (Pepcid) & ranitidine (Zantac)] and also the related Proton-Pump Inhibitors [including esomeprazole (Nexium) & omeprazole (Prilosec).
Check-out professor fink's web-site for additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.com
Down-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: wlac.redshelf.com/
“Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: onlinestore.wlac.edu/fink.asp
You are asking a Question that comes-up ALL the time! Let me try to address it as simply as I can:
Any drug that works by blocking the "muscarinic" ACh Receptor sites will block the parasympathetic actions on the visceral organs. This allows the sympathetic autonomic motorneurons to exert the dominant effect ON THE VISCERAL ORGANS.
IN ADDITION, any drug that works by blocking the "muscarinic" ACh Receptor sites will ALSO BLOCK THE ACTION OF ACh IN THE CNS (BRAIN). In the CNS, ACh is primarily EXCITATORY. This causes an overall decrease in electrical activity in the Brain, causing drowsiness & lethargy.
YES; on the surface it looks a paradox: "Stress state" on the VISCERAL ORGANS (peripheral action), but drowsiness in the Brain (central action)!
BUT it is all based on blocking the muscarinic ACh Receptor sites: (1) on the visceral organs and (2), in the Brain.
Thus, drugs that block muscarinic ACh Receptor sites, like atropine, or many drugs with "atropine-like" actions (including Antihistamines) cause CENTRAL sedation (drowsiness) and are even used to slow-down electrical activity in the Vestibular (Balance) Reflex Center and Vomiting Reflex Center and are prescribed to reduce "motion sickness" (such as meclizine & cyclizine.)
Good Question!
What are the 5 common antihistamine drugs with sedatory properties?
You are a true Champion! I think you have 5 dislikes from other professors who wish they could be doing what you are doing
You helped me get through my pharmacology back in 2013, God bless!!
Professor Fink your lectures are amazing! I watch them for fun, they are very informative.
Thank you Professor Fink, your lectures are helping me prepare for the provincial Nursing Exam (Canada). Youre a great teacher, and you explain concepts very well.
Thank you for your kind words.
Best Wishes for your SUCCESS!
Thank you very much professor FInk the lecture was very beautiful organized really helped me a lot to clear my concepts.
This is a great professor ! i learned so much from you than from my university god bless you
I say: Professor Fink, you are the best.
Professor Fink say: I don't know what you are talking about.
I Said: In page A378, where I talk about "all the greatest teachers ever", your name is number one in that list.
Thanks for sharing your presentation with public, you are the best professor in my life ! !
Ohh I love professor fink ❤God bless your heart 😊
love your lectures sir ! you are awesome !!! people live you raise the standard for teachers .. you are truly 'GURU"..
You are inspiring, if all lecturers where like you then students will be willing to continue their education. I am currently revising for my preregistration Pharmacy exam :)
Professor Fink, you're the man! Your fine lecture is helping me out with a writing assignment and I sure ain't no scientist.
May god bless you. You have taught very well❤
Thank you very much from your neighborhood pharmacist. I appreciate your impressive presentation and passion in teaching...way better than many of pharmacy school professors...Please keep up the good work. You are the reason my explanations (to sick patients) are friendlier and easier to understand.
I really enjoy pharmacology thanks to you
Captivated me for the whole video. Histamine/Antihistamine made easy.
Great stuff! Thank you Professor.
Great lecture you make reviewing so easy. THANK U
i really enjoyed this!!
Thank you Professor Fink.
Professor Fink is the Best.
Very nice lectures. Have benefited alot❤
Fantastic lecture sir, you are a good teacher
Great professor!
Thank you for your lectures professor Fink, you are a very good professor. Is there a way that I could get your lecture notes. They are very helpful and very informative.
Thank for your time and dedication.
great lesson
Awesome..Thank you sooooooooooooooo much !!
i wish you were my teacher in every subject
tk u sir for the video lecture
helped alot
So for. whole body skin itch burning "crawly" and prickling and even numbness will a H1 and H2 (ranitidine and certrizine) taken help this?
Tnx Doctor👍❤️
How do they cause drowsiness/sleepiness?
Which Anti-histamine, or combinations of, can be or are known to enhance or potentiate the effects or longevity of Opioids for drugs like Oxycodone?
And is their a min MG threshold of the Anti-histamine one must take for this enhancement to be achieved ?? Thanks.
Professor,which university do you taught during this lecture ?
is it possible to get the handouts you have to make notes on while we watch your videos?
Check-out professor fink's web-site for additional resources in Biology, Anatomy, Physiology & Pharmacology: www.professorfink.comDown-loadable e-Books of the Lecture Outlines by Professor Fink can be purchased from the WLAC Bookstore at: wlac.redshelf.com/“Hard Copy” Lecture Outlines can be purchased from the WLAC Bookstore at: onlinestore.wlac.edu/fink.asp
its 2020...Are you still monitoring the communication during user viewing of your video lectures?
YES, I am! -- professor fink
About the so-called "Second-generation" H1-antihistamines such as Zyrtec:
In the written out lecture you write that it *does not cross* the Blood-Brain-Barrier. But when you talk about it at around 18:40, you say that they are "less able to to cross the Blood-Brain-Barrier". That's a huge difference.
Personally, I have bad experiences taking even half a pill of Zyrtec (for the purpose of reducing allergic rhinitis): even this small amount makes me sleepy, it slows me down both physically and mentally, so I stopped using it.
It's simply not true that this "Second-generation" drugs does not produce anti-cholinergic side-effects.
can benadryl destroys the liver if taken once a day in one week.. thanks
Professor Fink where are your based? In Canada or America?
i have a question professor. i have almost watched all of your lectures... and you said that parasympathoLYTIC drugs causes the brain to go to a SYMPATHETIC response by DEFAULT... and in a sympathetic response there is CNS STIMULATION... i hope you could answer this. have you just made a small error in explanation or is my analyzation wrong?
You are asking a Question that comes-up ALL the time! Let me try to address it as simply as I can:
Any drug that works by blocking the "muscarinic" ACh Receptor sites will block the parasympathetic actions on the visceral organs. This allows the sympathetic autonomic motorneurons to exert the dominant effect ON THE VISCERAL ORGANS.
IN ADDITION, any drug that works by blocking the "muscarinic" ACh Receptor sites will ALSO BLOCK THE ACTION OF ACh IN THE CNS (BRAIN). In the CNS, ACh is primarily EXCITATORY. This causes an overall decrease in electrical activity in the Brain, causing drowsiness & lethargy.
YES; on the surface it looks a paradox: "Stress state" on the VISCERAL ORGANS (peripheral action), but drowsiness in the Brain (central action)!
BUT it is all based on blocking the muscarinic ACh Receptor sites: (1) on the visceral organs and (2), in the Brain.
Thus, drugs that block muscarinic ACh Receptor sites, like atropine, or many drugs with "atropine-like" actions (including Antihistamines) cause CENTRAL sedation (drowsiness) and are even used to slow-down electrical activity in the Vestibular (Balance) Reflex Center and Vomiting Reflex Center and are prescribed to reduce "motion sickness" (such as meclizine & cyclizine.)
Good Question!
thank you very much professor. This made my day
When you say when you can take antihistamines for sleep, shouldn't you mention that this works only with 1st generation antihistamines because these cross the BBB?
even with the second generation we could have somnolence (around 8%)
What are the use of Anti-Histamin in normal patients? :(
How could i make it about 5/6 page for an assignment ?
Thank You :)
what a great lesson, you know here in my country (portugal) teachers are always telling us how worthless we are, how we can't compare to british and american med students and etc, but honestly most of the british and american teachers also give much better lessons and have a great attitude too!
I'm anti-antihistamines.....