Using ultrasound to open the blood-brain barrier holds potential for dementia
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- čas přidán 29. 01. 2017
- Queensland Brain Institute | www.qbi.uq.edu.au
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This must be the most beautiful accent ever ! The voice is fantastic too. The actual content is amazing !
Thanks for the video it explains the process more clearly about how this treatment will hopefully work. It was reported that trails on humans were starting this year 2019 after tests had been completed on sheep. Originally reports stated that trails would take about 10yrs & that was 4yrs ago. It also stated that you were doing trails on patients that weren’t showing symptoms & I was wondered why chose those patients? I hope it is successful so many people are depending on this break through treatment our family being one of them. Wishing you all good results. Thanks for your commitment.
Very exciting non pharmaceutical treatment. Thank you. No porn music needed.
Not enough views for this video. Implications are MASSIVE. Wonderful video. Great effort.
BIG question how long before it becomes generally available to the public ?
Thanks Steve. Our researchers' current work is still in mice which have a very thin skull. In order to apply our work to human skull they encounter two problems: The first is that the human skull is much larger; the second, has to do with the properties of the cancellous bone of the human skull that blocks the ultrasound waves and causes skull heating. Both issues need to be solved.
The ultrasound project team is currently focussed on the development of an ultrasound device suitable for the use in people. Our researchers are working with an engineering company to develop equipment for the measurement and analysis of ultrasound waves through thicker skulls.
So while the research so far is promising, it will unfortunately take a few years until the device will be available and clinical trials can begin.
So you haven't got it going even in Sheep yet? Oh drat ! So you dont use ultra sonic paste for good conducive contact as in the norm with ultrasonics? I thought you might have a sort ofultrasonic headset or something.And the sound power is sufficient to cause heating. What a surprise.Do we know what frequency is best for going thru thick headed people yet?
The research methods for using ultrasound devices in this way on animal models and humans are still being investigated, so we are not able to give any further details at this time.
Wow!
wonder if this could be used in conjunction with the g127v homotype prion variant to transport it through the blood brain barrier through some type of spinal or jugular catheter? Im not sure if the microbubble agents would denaturize it though. I saw on some site that theoretically the g127v might have trouble making it to the brain on its own or something like that
Maybe it can use againts rabies when the virus is in the brain
Could this method be combined with a Nanoparticle mechanism? For example, the first method here, could be used to open the BBB and the Nanoparticles might provide greater precision when dealing with such conditions. The University of Boston has also used an approach using Nanoparticles for this very thing.
Opening the blood-brain-barrier is, in itself, a method that could be used to better deliver other targeted drugs to the brain. We aren't currently studying this with nanoparticles, but that may be a future area to look at.
Would not be possible to use this method for DIPG?
I've been doing scalp massage and skull tapping on the crown of my head when I feel the itchy and headaches that occur in the am and after exercise. I think it might be releasing the clogging in my BBB and slowing the Multiple Sclerosis onslaught?
Are you working with Sunnybrook Hospital in Toronto at this time? I know they were looking into a similar approach.
We aren't working with any other organisation at this time, other than a company that is building the ultrasound device.
@@qldbraininstitute Is it possible to use this treatment to patients with PSP disease?
Has anyone tried this method and is there any improvement.
Couldn't DMSO be used?
Hm.