This Lab-Grown Brain Made a Muscle TWITCH, Here’s How
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- čas přidán 3. 06. 2024
- Growing brains can be a tricky process, but growing ones that can make muscles move? That's an incredible feat. Here's how scientists did it.
How Close Are We to Farming Human Body Parts? - • How Close Are We to Fa...
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Cerebral organoids at the air-liquid interface generate nerve tracts with functional output
www2.mrc-lmb.cam.ac.uk/cerebr...
"The capacity for this model to be used to investigate the way in which neurons connect up within the brain and with the spinal cord could have important implications for our understanding of a range of diseases. In particular defects in neuronal connectivity are thought to underlie various psychiatric illnesses, including schizophrenia, autism, and depression. "
Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output
www.readcube.com/articles/10....
"Finally, through electrophysiological and co-culture studies, we demonstrate functionality of these tracts, which are even capable of eliciting coordinated muscle contractions in co-cultured mouse spinal cord-muscle explants. This approach is likely to be a useful new tool, not only because of its ease, but also due to its util-ity in studying axon guidance, tract formation, and connectivity in a human system"
What's Wrong With Growing Blobs of Brain Tissue?
www.theatlantic.com/science/a...
"The stuff we really care about in the brain, like consciousness, are emergent phenomena-they arise from the collective workings of individual neurons, which create a whole that’s greater than the sum of its parts. The problem is that we don’t know at what level these phenomena emerge. A neuron is not conscious. A person is. What about all the steps in the middle? What about 2 million neurons? 20 million? 200 million?"
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![Are Brain Organoids Conscious? AI? Christof Koch on Consciousness vs. Intelligence in IIT [Clip 4]](/img/n.gif)
The argument "It's just Science-Fiction." is now officially a dead argument.
you would think, unfortunately, people dont care about proof, they just want to be right " . Just ask the UFO community
@@CstriderNNS Or a flat earther.
So technically, before 'now'. Anyone that claim 'its not just a science-fiction' are a fool becuz they just happen to pick the right answer before the 'non-fiction' even happening
So is it to be considered a living human child?
0451 Shodan Not doing anything useful, bro what did you type that stupid comment on? That's right, a piece of former science fiction, now science fact. Nothing useful, what the hell.
So, that mini brain starts a streaming channel for your muscle
Is it a problem?
Growing Faster GPUs and CPUs...
I'm just waiting for the mini brain to say rate and subscribe to his mini streaming channel
After few years it names itself ninja
Jeremy Daugherty
No, subscribe to Pewdiepie.
As a stem cell researcher, I am thrilled to see the development in cerebral organoids - This might be our big chance to develop effective drugs for dementia related diseases such as Alzheimer's!
Or start some zombie apocalypse
@fllamber If you send me some skin cells, sure - will only make your muscles twitch though
Can fix trump dementia??
TBH I've got a weird question for if we develop full cures to mental disorders that reverse all the effects: will people like me with disorders such as Autism, which can have some benefits like very specific skills, want to cure that disorder and lose one thing to gain back another? I'm scared that if I ever "cured" my Asperger's Syndrome, I might not be skilled enough in subjects like Math to do the things I love anymore since that aspect of my thought process would likely be gone. I'd rather stay like this if it means I get to keep being great at the stuff I'm great at, I'm an introvert anyway so it doesn't matter all that much to me how well I socialize.
@@baconsandwich1887Unfortunately, I am not a neurologist or psychologist and therefore do not feel entitled to give you a scientific answer about mental disorders. From a personal standpoint, however, one of my best friends has Asperger's syndrome. When we first met, he was introverted but after some weeks of sitting next to each other in class, we started talking (and he was unbelievably funny). I know that he has obstacles from time to time in regards to socialising but he is unbelievably smart. I would not like him to change and he would not either. Many people, however, suffer from neurodegenerative diseases, which are often deadly/or destroy the lives of the patients. Over 45 Million people in the world suffer from dementia, half of which are diagnosed with Alzheimer's disease. There are no current cures for Alzheimer's which makes it a very tragic disease (Coincidentally, I just made some videos about Alzheimer's). Although Multiple Sclerosis itself is not deadly, over 50% of patients develop cognitive dyfunction, depression is 3 times more common and divorce rates are 9 times higher. These are diseases in which we urgently need to develop cures. If you are interested in such topics, you can subscribe to me and we discuss them in the future.
Her: Why we want to make brains ??
Me: In case of zombie outbreak, we could feed them.
yes
Domesticated zombies
the new pet
Science Fiction
Science Fictio
Science Ficti
Science Fict
Science Fic
Science Fi
Science F
Science
That's how I see things working out currently and the future.
N0616JC Productions Sci-fi is contemporary and the future might as well be magic.
This could be cool for brain damage.
Soo true... Science fiction questions the scientific fraternity as to why an ideology cant work
There was a time where watches with a radio that went both ways where found to be pulp science fiction
i.imgur.com/78WKgfB.jpg
Science
Science F
Science Fa
Science Fac
Science Fact
Reminds me of the God of the Gaps fallacy. Like how religious people keep having to give up the whole "God did it" idea. Once we find solid scientific explanations for how the universe works, that's one more thing that religion still can't explain.
We are our brain. The brain grows "us" around it to feel, see, and interact with the world. This is so amazing!!
Its somehow like a spacecraft. The brain ia the pilot and the body is the spacecraft.. Intresting.
@@yajhernandez7096 and you are the... Damn
@@yajhernandez7096 yeah the brain is the pilot, we are the controls and the body is the spacecraft
Scientist: "I wonder what it's thinking"
Brain: "Bub bub buda bub. Talking away....Takkeee onnn meeee, take on me, i'll beee goooonnnee, in a day or TWWWOOOOOOOOOOO!"
This is probably the funniest comment I've seen in a long time 😂
As someone with TBI this might one day be key to fixing my broken brain. Please keep growing them as it might turn people like me into more normal, functional human beings one day.
Aleksander Wit I don’t think he means to literally take the lab grown brain and replace his. I’m pretty sure he meant to study it and use that knowledge to help people like him.
Master Boss or maybe even take parts of the lab-grown brain and replace parts of his/her brain that correlates to his condition
Aleksander Wit well if we had the technology to locate where specific memories are located in the brain and the transplant is precisely done that would lower the risk, all you had to do after all is replace the part of the brain where it had the memory that caused the trauma with brand new artificial neurons
Or maybe even replace some parts of the brain to reduce the chance of getting traumatize after a traumatic injury
If you'd replace your brain you wouldn't be yourself.
In case of a zombie apocalypse...
Scientists: *We got this covered*
If the brain develops a consciousness? Yeah, but who is the brain? How does it comprehend existence as just a brain? I say carry on, it's for a better cause.
Attach it to the internet. Imagine a powerful A.I. connected to the internet. Eventually it will become so powerful it will be aware of everything at the same time. 😱
@@prem_tamilsiddha8987 and that's how the terminator timeline was carried out
@@prem_tamilsiddha8987 Basically SCP-079 but organic
@@prem_tamilsiddha8987 That's what I thought. Connect me to the cloud.
Consciousness is the illusion of senory experiences
imagine.... an organic brain powered computer
"Coming soon to a missile near you" knowing where all the cutting-edge technology goes first.
that was the original idea of the matrix.
That would be slavery from the consious bio computer's perspective.
@Bazzralic I think this is a bit beyond Black Mirror ... Anyway good show!
bad computer, gets distracted by all the porn
Will vegan and vegetarian zombies eat lab grown brain?
Huh?
*_Mr. Person Humanson Only if they ask nicely... maybe._*
😂😂
BWAHAHAHA
No that would mean it was artificially cultured like meat, vegan zombies would be like the normal ones eating organic brains i.e Humans
This is the coolest thing I've seen in a long time. This will hopefully change the world.
Well done scientist's, we'll done.
👏👏👏👏
Brains grow to seek a control interface is what I got from this.
Absolutely to advance our health and understanding of our brains the research is invaluable
So damn exciting yet Black mirror levels of terrifying
What could possibly go wrong here 🤔
@@osmosisjones4912 I don't think there is an answer to that yet, I think more research is needed.
So if this us an active brain. What should we consider an unborn child's brain?
Yonatan Avhar Nothing, soon no medical illnesses will exist and we can live forever.
I assume it can develop way more effectively than our brains, since it doesn't have to care about all the muscles and senses we have
Is this the beggining of biocomputing?
People being outraged about imperfect results.
That is fascinating! Also happy you talked about consciousness as I was wondering about that. It would be too unfair to let it get that far, but I am sure that won't stop them in the end.
This is amazing, mind blown.
I wish I had some nutritious solution.
Try a banana.
Sperm
@@cyberavenger8668 Mmmmm bro-gurt
Whyyyyy
I have Congenital Anosmia ( meaning i lack the ability to smell, in my case because i lack both olfactory bulbs ) and hope this is a step in the right direction to maybe fix in in 30 years or so
Xander vM if you from cali you ain't missing out on much, man
@@flyboy5229 man, no joke: id pay 500 euro to smell a fart
Can you smell through your tongue?
So humans need to grow partial babies so you can get to smell.
@@Hamsterbytes Pretty much. Only more like, partial baby clones of me, since implanting foreign cells into a body doesn't really work that well ( there is a chance of rejection ). But since they are clones of me, i can talk for myself and say its okay to make clones of me to harvest parts of other me's to put in me, if that makes sense.
That moment when a 4 day video upload gap from seeker feels like a lifetime!
I am so impressed by humanity at times!!!
Do you understand how amazing this is? This could heal all types of encephalopathies.
year:3000 AD
Q:where were you born?
A: in a lab!
B:same here!
some are already born in a lab due to complications
Sounds like thing you can implant into person who is paralyzed, implant where the damage was done maybe this thing can create new connections and reverse the damage.
Just a crazy idea but I that could be a good use if that can happen.
@Adriel Ramos that's actually really interesting! Because if you could implant a working brain into a braindead person, the electrical signals would branch out into the patients brain. I wonder if it could work as a Kickstarter?
We need more of this!!
Imagine just waking up your first time existing and there's just nothing but you can do this weird thing that you have no idea what it does
You could almost say there is a DISCORD between the neurons
_silence_ the discord...
@everyone this pun is epic
@@YeppyNope
I'm guessing that's his, mine was an obscure game reference
All it needs now is some breast tissue.
connect a brain to a robotic body.... to create the ultimate humanoid.
@Blake Pinette * Cough, you can have computer programs that repair themselves. It's called restoring from backup.
Well explained, thanks
Absolutely amazing!
You guys said that it has twice as many connections as a cockroach, does that mean that it’s twice as smart? And does that mean that cockroaches don’t have consciousness? This is actually fascinating to me!
Edit - I’m totally gonna have to follow this program to see what they do in the future because this is super cool :D
I'm sure cockroaches have experiences but are cometely incapable of being aware of any of them
@@asloii_1749 I pretty sure a cockroach has more awareness than you think just try and stomp one and it will run.
Consciousness or awareness is not an all or nothing kinda thing you have different levels of it.
To run from danger requires the awareness to know I am in danger so I should run.
No. of neurons =/= Smart. A cockroach’s brain has structures and regions designed to process specific information but this is just a blob of neurons
can I have a new brain pls
I would love to hear more about brain organoids and in vitro neurons used for calculation. For example, Dishbrain from Cortical Labs in Australia. There are a number of university research groups also using neurons either in organoid form or in vitro to perform calculations and solve problems. Please cover this topic
Yes we should and it could be the key factor in finding a way of transference of the conscious.
Just now was reading your last story about it and video on same topic, it eventually came. I was like What the freak is this 😅
I wonder where we would be if ethic were forgotten and scientists just focused on continuous advancements.
Destroyed, maybe. Better? for some time, definitely.
We’d get Alma Wade.
They would use your first unborn child.
Imagine criminals being experimented upon sans consent and normal people getting placebo surgeries real time. Continuous advancement may sound good at one point but does it to everyone or is it in the future? What if you are the one chosen would you be happy? You're experimenting for a good outcome out of series of unethical and bad decisions.
@@Hamsterbytes lol...
Finally a brain/human physiology video after a long space videos.
Cool topic!
The medical benefits of this could be huge, but I agree the ethical side to this needs to be addressed ASAP so that we can move forward safely with reasonable regulations and avoid looking back on this as the start of horrific experimentation. It may all seem fine now, but when you ignore the ethics you get the Tuskegee trials.
I agree with you 💯💯
vvhat is tuskegee trials
God: Am I a joke to you?
Logic: you don't exist
Jesus these people take a meme too seriously
@@dannydjduc99 well it is a science channel i suppose, we're all INTELLECTUALS OF 401 IQ HERE
God doesn't exist.........
@@NightcorEDM and you now this from your vast experiences at life a?
I'm enjoying the music in the background.
In general, I think it is important to perform research on this topic to understand the underlying mechanisms for the brain. The next step is the ethical part. Which spices does the cells come from? Depending on how advanced the research is we might have to go through ethical committees. But in my opinion, go for it and make the research!
Me: We now live in a world where scientists are basically creating life...
God: Am I a joke to you?...
but they are still using existing materials to do so thus manipulating life.
they need to create the materials from nothing first before its creating life.
@@Kittsuera a woman's egg and a man's sperm exists... They create another life. Sooo...? You can't, in any way, call it manipulating life.
@@bis9817 ... unless i were to call the introduction of one organism to another also a form of manipulation.
but fine, if they were to use the raw material and form it into a biological one and then get it to form an organism then that would be creating life.
@@Kittsuera actually that happen a lot.
Particle do pop in and out of existence all the time.
We already created life from scratch in 2010.
Boston Dynamics has entered chat:
This is the coolest thing i heard today.
Yes. I'm all for it. It can be used to help injured brains.
U can’t replace a brain of a living human
Never thought we could build Brain
Isn't it becomes rivals to AI
instead of engineering mechanic brains, we simply give cyborgs human brains. its much easier and faster.
@@keylanoslokj1806 idk if that would work but if someday it would, I don't think we should give anything that is physically much stronger than a human a brain. Seems like it would be hard to control.
@@dangerdan2592 The advantage of an AI is that it is a free worker, if you give them consciousness then it is just an slave and you pretty much ended without the advantage gained, unless... we start being ok again with slavery, but then why even bother with developing AI or lab grown life.
yh but what if its super confused or in chronic pain..
I doubt it has the ability to feel pain as it's never experienced it.
Human brains dont have the neuron paths to feel pain. That's why open brain surgery is possible while the patient is awake.
Now I just feel bad for Mr brain
Having ADHD I would love to see more development towards understanding how the brain works, hopefully to develop more treatments (and for other conditions too such as Alzheimer’s)
I think we don't yet understand consciousness ,for what it truly is .
And as for the experiment ,its great discovery , but I somehow think it might be used in future for every other purposes than medicinal ones , just like so many before ,and even today.
We better figure out what "alive" actually means to us and fast. Neural tissue connected to a spinal cord and muscle tissue that then twitches sounds very similar to "a detectable heartbeat" in a fetus.
That barely means much to pro choice people. According to them something’s only alive if it is born
Hey Max i'm Tonou from Emel Quantum Energy inc..here's what i know and can tell you..Every living thing happens to be alived, and can only survives in our Dimension under one order..The magnetic field spectrum..that's right.. the magnetic field travelling across oceans of galaxies..and the Magnetic field will only respond to us only within the magnetic spectrum..Well in order for us to quickly find out what ALIVE means and how to replicate the physical brain and the 100 billions neurons and 1000+ quadrillion connections..Well i am the guy currently working on it. Email me EMEL.QE@GMAIL.COM
How about out of body brain backup?
Andrew Walker That's more biotech than this, still interesting, the prospect of being able to live forever and having clones of yourself for use, especially genetically modified ones is very riveting.
@@fatguy6153 I bet you're the only guy in the world who took his comment seriously.
Naked Squirtle I bet you're the only one who didn't, not everything is sarcastic like your memes.
@@fatguy6153 its a joke dude and you dont need clones to harvest from them we can do it with pigs today and it Will become mainstream on Labs tomorrow
Latioswar R I'm talking about clones for individual use, not to harvest, we can modify ourselves to our own desires, and if one body dies we can always have another. Humanity can reach true perfection and do away with genetic defects without the need of primitive ideas such as eugenics. Immortality will soon be feasible.
Fascinating
Really like that background .
What is the number of neurons and/or neural connections that are required to produce consciousness? Where is the line? The truth is nobody knows.
The researchers statement, that their mini brain is far from reaching consciousness, is a convenient conjecture - not a fact.
They should just be honest and say it’s possible that the mini brain is conscious to some degree and that they are ok with that.
is a bacteria conscious? should we ban petri dishes and research on bacteria because they may be conscious?
Brain size relative to body mass is another huge factor. Maybe a mouse sized brain with no body could be equivalent to a dog's conciousness. You're right in that we have no idea what consciousness is and the thought of experimenting with consciousness like this is slightly disturbing
When it is able to interact and observe its outer environment. Otherwise it is just a processing unit.
@@albejaine So if we put someone in a sensory deprivation chamber they're no longer sentient? The Human brain is, technically speaking, a massive processing unit. How do we know when a processing unit becomes sentient? I recommend that you try a game called "The Talos Principle", it's quite insightful.
Do it! If all goes well, I might be reincarnated as a petri-baby.
As long as it doesnt feel pain, I totally support this
This would be a huge breakthrough in the field of robotics!
These is also breakthrough for curing brain related disease.. maybe Alzheimer will just be a history.. Human can increase their lifespan through cyborg technology and also dementia will be a thing from past.
OK so we are 80000 times smarter than roaches, good to know.
I wish I was a roach
frankesteinnnnnn
PICKLE RICK is becoming more and more possible and i love it
Totally! I support this research. The first time we are getting a proper way to truly learn the connection between consciousness and the brain.
I'm very pro-science but this bothers me. For exactly the reasons mentioned at the end of the video. We don't know at what point we've made a *being*.
You’d think with all the movies we’ve made we’d know playing god never works out
@@TheAngelOfTheBottomlessPit yeah? and what else?
no there isnt, nobody will be harmed@@TheAngelOfTheBottomlessPit
IEMK they’ll probably start growing humans and putting these into actual humans and when they develop free will they’ll take over
just shoot them @@crabosity
Guys this video is fake! They just took the brain from me!
The ethic question is less of whether it will become conscious, and more about defining what is consciousness. Therefore bringing the question can it ever be considered conscious in the first place. I dont know personally but those are the direction of questions that need answering.
So long as this helps get us closer to the creation of cyberbrains, I'm all for it.
We're so close to being on track for the Ghost in the Shell timeline.
Imagine if that brain was conscious
first year:
WHERE THE FRICK AM I?
WHAT THE FRICK AM I?
WHO THE FRICK AM I?
*WHY* AM I?
*scientists connect brain to mouse*
HOOOOOOOLY WHAT THE FRICK IS GOING ON AHHHHHHHH!
Mewtwo. ;D
In 2059
"Oh what a creation of God.."
"Oh it's not his..it's ours.."
Deep blue see jpg.
2019?
@@zacharyhandy9606 no no..i mean 40yrs from now 2059
hee, you right.. that dialog is the main things gonna happen if they success working it.
Can you do a video on how brains reach consciousness?
And also to understand how the brain works so that we can recreate the information system in a different substrate.
Sooo....basically they grew the brain of Trump?
Yes keep growing brains .... !!!
Very very interesting
Some people need to grow a brain. This is a step in the right direction.
Awesome !
Så spiser roboten kjøtt og bruker energien fra mat til og fungere?
Hell yeah keep growing them brains
Precisely what field of research des this whole neuronal and nerve stuff fall into? I need to apply for university within the next two months and this is hella interesting to me.
Should we? Absolutely! Forward, ever!
How about regeneration of severed spinal cords?
In one of my weirder dreams you could go to an electronic parts store and buy artificial chicken brains complete with some electronic interfaces and a reverse fuel cell to give it nutrients, all conveniently encapsulated in a small metal shell, guaranteed to work for 10 years in proper working conditions and sold with a small battery attached so it won't die during shipping and storage. Trying to program the thing was definitely not fun though, but imagine the possibilities!
Could you use this to help peralized people by reconnecting stuff
What if you apply that method for spinal chord injury? Since it has shown in proof of concept it can attach to spinal chord, if you do the same procedure for a paralyzed person /mouse with spinal chord injury, could it help?
Could we upload any algorithms to that mini brain?
2:12 agree
Straight up sci fi... amazing
Yes, grow a brain inside a brain to shed memories and live forever.
It's not about "let's attach a brain on a limb and see what happens". Starfishes already done that.
"What/Who's brain was it?" If it twitches, yes it is alive. The big question is "Who/What". Who/What does that brain identify itself. The brain contains awareness. Even a simple brain structure like an earthworm's brain can pick itself out of a million like worm around them. "I think, therefore, I am".
I just imagined a worm saying "I think, therefore I am" in a baritone echoing voice, it was fun thx
Omg stfu, no ones saying its not alive
@@sasdasdasd4728umad bro
maybe this could also help explain the theory of the beginning of life?
I can see why they are doing this.. "immortal desire".. yeah one of the biggest point.
I don't thing it would develop intelligence without sensing things and without ability to manipulate surrounding. I would say yeas, we definitely should explore this.
How about cloning body parts, in my case, a pancreas (islans of langerhans ) to get insulin without rejection? For all diabetics.
what a great times to be a nerd
Great now i can horsing around with myself.. Literally
Without sensory organs to input environmental stimuli and sensory information from the "body" that this hypothetical "Self" would inhabit, there really shouldn't be any meaningful consciousness. Without those sensory organs, there wouldn't be any notable language learned and therefore, conceptual ideas about the "Self" in that cluster of random neurons wouldn't exist. Also, the proliferation of the human (and by extension, many mammalian) brain(s) undergoes a complex system of enrichment and pruning that determines which neuron networks need to stay for the well-being of the organism, and without that environmental stimuli to determine what things need to stay, any random proliferation of neurons in a "mini-brain" will not have a meaningful pattern due to lack of pruning to facilitate any kind of consciousness or awareness. Once we start /that/ process, then I would imagine that ethical implications would need to be discussed, but until then, we're talking about a cluster of cells with no awareness/consciousness, and specifically, no pain receptors(!), that just fire random electrochemical signals to anything that will accept them.
Huh interesting wish I could study this
Cool. All we need now is to give it a mouth and ears and eyes and see how it works
This is the song, "one", by metallica. Whoa.