Learning to design mini-proteins that bind to specific protein targets

Presented on October 6th 2021 by Brian Coventry, hosted by Chris Bahl
Abstract:
Antibodies have no trouble binding specifically to nearly any protein, but how do they do it? We set out to discover the principle necessary to design mini-proteins that bind to arbitrary protein targets using only the target apo-crystal-structure as our guide. While we certainly can't match the broad spectrum binding of antibodies, for a certain class of protein targets (those with rigid, exposed hydrophobics), we've learned quite a bit and have found binders to 30+ targets so far.
doi.org/10.1101/2021.09.04.45...

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Very helpful!

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absolutely beautiful

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