Plasma Half Life || Elimination Half Life

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Video Summary:
Plasma half life is time required for plasma concentration of drug to fall by 50% of it's initial value. When the drug is first time given, it's concentration in plasma falls rapidly due to distribution on body compartments other than blood. Half life measured during this distribution is called distribution half life. With elimination, there is gradual fall in plasma concertation. Half life for this elimination is called elimination half life. Elimination half life is constant in first order kinetic and varies in zero order kinetic.
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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorized websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

[@jd123-]

You deserve a million dollars!
I've lost 4 hours of my day trying to understand this concept, and you just did it in minutes

[@hopedream7749]

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[@ybear1975]

great videos and unique way of expalinning thing!

[@bryanmuchiri1998]

Our local Indian saving our semesters. Thanks mate

[@NonstopNeuron]

Happy to help

[@hasnimhima3184]

Wow, you cleared my basic in this short time. Really helpful. Keep uploading.

[@NonstopNeuron]

Thank you, I will

[@sujaysaha9691]

Nice... A major concept is cleared in this short video 😊😊

[@NonstopNeuron]

Glad to hear that!

[@giridharkarnam8495]

wonderful explanation, Such simple way. Thanks

[@NonstopNeuron]

You are welcome!

[@mardiarahman2167]

If plasma half life time is for any drug 2-6 hours then what can we say about this drugs action???

[@maimwatenga9895]

Well explained 🎉

[@tanjimahsan6424]

Thank you thank you.. Tomorrow is my pharmacology viva.. And this video helped me a lot

[@NonstopNeuron]

Best of luck!

[@Chineseiseasy265]

Thank you so much

[@queenbeequeenb9]

Thank you

[@Guidance2799]

Thank you sir ...topic is cleared in just half time🙂

[@NonstopNeuron]

Hahaha....😄😄. Good one...

[@fariyazahan5934]

Fabulous 👌

[@heartmindvloggs-bp1ye]

Thanks

[@sharyanazir9850]

Amazing.

[@mr.beastfanclubs]

Complete pharmacology is available sir?

[@NonstopNeuron]

No we haven't completed the entire pharmacology yet. But we have covered so many topics. You can browse them more easily from our website. I hope it helps. Thank you.

[@noclick]

i'm only here because youtube decided to recommend me real ''Half Life'' content

[@SahilKumar-if5zn]

Helpful👍

[@NonstopNeuron]

Glad it helped😊

[@Pranab396]

Super

[@user-sp1gd4tx6j]

Is plasma excreted from urine as you are saying plasma concentration decreases

[@NonstopNeuron]

By "plasma concentration" here I mean concentration of any substance in plasma.

[@zaifurrahman1257]

Amazing

[@NonstopNeuron]

Thanks

[@nareshkumar.v6207]

Half-life of extravascular tissue bound drug is relatively high ? Why

[@NonstopNeuron]

Because they are bound to extravascular tissue (where they are not degraded)

[@aswanikalash8159]

Very nice

[@NonstopNeuron]

Thanks

[@thesp1r1twalk3r]

Half life not constant so emptying varies over time

[@hariharans7101]

🔥

[@user-uj9tr1wz5y]

If a drug is highly lipophlic can we say that plasma half-life of that drug is large compared to a less lipophlic drug since lipophlic drugs can distribute more and are harder to excrete ?

[@NonstopNeuron]

Yes

[@user-uj9tr1wz5y]

@@NonstopNeuron but what makes me confused is that since it is highly lipophilic, shouldn't its concentration in the plasma decrease so does the plasma half life of that drug?

[@user-uj9tr1wz5y]

@@NonstopNeuron also thank you so much for this quick reply

[@NonstopNeuron]

Distribution half-life and elimination half life are two different half lives that we can find for a drug. I think you are confused between them. Distribution half life is usually shorter due to rapid initial distribution. You know what...! The thing you asked in the first comment has also got a special name, termination half life. Depending on the pharmacokinetic profile of the drug, these half lives may vary. I hope it helps.

[@user-uj9tr1wz5y]

@@NonstopNeuron I just watched your terminal half life video and understood it better. Thank you so much.

[@Somethingsm2u]

Can you pls make a video on half life vs duration of action of a drug

[@NonstopNeuron]

it's s very straight forward relationship. The longer the half life the longer the drug works.!!! unless of course it's a hit and run drug in which case the duration of action would be longer than what is predicted based on half life. humm... I see, we can compile multiple such examples. Will note down this suggestion.

[@nehameghwal5040]

👌👌