@@MedicosisPerfectionalis at the minute 24:08 , gastric acid secretion is by Gs coupled ? Should not be by muscarinic receptor M3 Gq coupled ?! I am confused with Histamine functions!
ı never have the tolerance to listen to my professors for 20 mnts😂 but ı can sit the whole day watching and listening to your vedios, hilarious and gifted😊
Perfectly explained. I've been rereading my textbook for ages, but it only clicked when I could visualise the processes through your drawings. Many thanks!
diction and voice 100% Explanation and simplification of the information 100% writing, drawings and colors 100% sense of humor 😂 100% Great Thank to you good luck Keep up 👌👍
I’ve been trying to restudy physiology, patho and pharmacology (for an embarrassing amount of time) and been working for a while to get all the G-protein receptors down because I know they are so key. You just did it so well and made it so simplified. Bravo to you! I will likely be subscribing to your content. Thank you!
The reason your content is so amazing is because although it gets really specific, so we can understand in a reasonably deep way these biochemical mechanisms, it doesn't go unnecessarily deep, like what we can find by reading Goodman and Gilman's (I mean I love it but the text is just too long), you give exactly what I need to study for the masters entry exam I'm preparing for. Thank you so much!
Coming here to learn abt GPCR’s after I have been dealing w hellish Long Covid for 16 months now..some think GPCR’s are involved in this and there’s a clinical trial using an aptamer to act on GPCR’s. Hoping for the best
@@MedicosisPerfectionalis thank you so much your videos they are very helpful, here is the feed back of last semester i got "A" in microbiology and "A" in biochemisrty because of your Toutorials. again thank you so much and be blessed...😊😊😊
Hi! Thank you so much for your amazing content! What is a good source of information for categorizing drugs that act on Gq vs Gs vs Gi receptors? I appreciate the ones you mentioned, but I was wondering where I could find more. Thank you!
Hey, thank you for your awesome videos i have a question, hope you can help me: 1. β1 stimulation :: Gs :: ⭡ cAMP & PKA :: ⭡ Ca in myocytes :: ⭡ Contractility of (cardiac) muscle Q1. so as β receptor stimulate Gs, does it mean all β receptors (β1,β2,β3) would ⭡ Ca in the effected tissue? for instance, due to Gs pathway, β1 stimulation makes ⭡ Ca in myocytes. so does β2 stimulation makes ⭡ Ca in vascular smooth muscle too, as it use the same Gs pathway? in the video you had written β2 stimulation would "inhibit myosin light chain" in VSMCs. i know the fact that β1 is dominant receptor in heart & β2 is dominant receptor in VSMCs, but my question is when they (β1&β2) both use Gs::cAMP::PKA, how does one receptor knows to make "⭡Ca" and another knows to "inhibit myosin light chain" in the cell? Do their Gs differ or do their PKA differ from each other? i hope you can help me to know what i am missing here best regards
Thank you so much for your video! This makes so much sense! I was wondering if @19:52 you meant to write M2 and M4 are Gi --> which inhibit the sympathetic system because in the video it says that it inhibits the parasympathetic system?
thanks for real life saver professional better than school professor's goddess on youtuber make textbook into less than half hr vdo and immediately connecting whole pic that helps us get connected with all the critical concepts! thanks for make everything so clear! watching your vdo once is saving me reading my teachers books for days and still messy not sure what they try to deliver as key point or larger scope concept! and btw 15:32 the GDP was replaced by whole GTP not just Pi.
btw thanks a lot, I have a question about gastric acid secretion, of course, Gs is a cause of vasodilation and also smooth muscle relaxation then it means the mechanism of H2 cannot contract the smooth muscle of the gland which releases gastric acid now how to release gastric acid without contraction of the smooth muscle
Thank You for the great well explained videos .I was looking for a video that explains G-Proteins. Can you please make a video on Arsenic poising and how it affects the TCA cycle?also on mercury poisoning and its affects on the enzymes? Can you also please make a video that revises TCA cycle and Glycolysis and gluconeogenesis?
From my PhD experience in Biochemistry Yes that’s true. Ribozymes , Ribonuclease P are example of enzymatic RNAs that are made of RNA and there are very few non proteinous enzymes like this the majority of enzymes are made of proteins after translation.
🐳 Kidney Physiology: www.medicosisperfectionalis.com/
Wish there were Nobel prizes for breakthroughs in using YT as an educational platform for science. You, Sir MP, would be a shoo-in!
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Words cannot describe how thankful I am for this channel!!
I am thankful for your comment!
My great Dr... you truly deserve Medical-Science Teaching Award . Bravo
Thank you so much, dear!
I swear to God you deserve more . You are just great phenomenon .
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@@MedicosisPerfectionalis at the minute 24:08 , gastric acid secretion is by Gs coupled ? Should not be by muscarinic receptor M3 Gq coupled ?! I am confused with Histamine functions!
@@ThatsWhy- I think H2 receptor by histamine and M3 by Ach both causes gastric acid secretion and they are Gs and Gq coupled respectively.
Now, that's a quote, "the best pneumonic is understanding." Best explanation yet. Thank you for all you do
Thank you :)
ı never have the tolerance to listen to my professors for 20 mnts😂 but ı can sit the whole day watching and listening to your vedios, hilarious and gifted😊
I appreciate you so much!
No way u just explained that in 5 minutes at 2x speed and when i go to class, my professor doesnt explain it that easily. Bless you and your lineage
Thank you so much for watching!
Please help me by sharing my videos with others!
Perfectly explained. I've been rereading my textbook for ages, but it only clicked when I could visualise the processes through your drawings. Many thanks!
You’re very welcome 😊
Thank you so much for watching!
diction and voice 100% Explanation and simplification of the information 100%
writing, drawings and colors 100%
sense of humor 😂 100%
Great Thank to you
good luck
Keep up 👌👍
Thank you!
Great 💜❤️❤️❤️
I understood what the Flip You were Talking about 🤣
Amazing!
I’ve been trying to restudy physiology, patho and pharmacology (for an embarrassing amount of time) and been working for a while to get all the G-protein receptors down because I know they are so key. You just did it so well and made it so simplified. Bravo to you! I will likely be subscribing to your content. Thank you!
I appreciate you!
The reason your content is so amazing is because although it gets really specific, so we can understand in a reasonably deep way these biochemical mechanisms, it doesn't go unnecessarily deep, like what we can find by reading Goodman and Gilman's (I mean I love it but the text is just too long), you give exactly what I need to study for the masters entry exam I'm preparing for. Thank you so much!
You’re very welcome 😊
I appreciate you, Darlan!
Good luck 🍀
Coming here to learn abt GPCR’s after I have been dealing w hellish Long Covid for 16 months now..some think GPCR’s are involved in this and there’s a clinical trial using an aptamer to act on GPCR’s. Hoping for the best
I came after a long time again ........
And still loved it...❤❤❤❤
Thank you!
One of the greatest videos on youtube!
Thank you so much, Zainab!
I always appreciate your comments!
when i stuck at school , the first thing comes in my mind is to vist your tutorials, i really appreciate them they are amaizing...!
I am so happy to help!
@@MedicosisPerfectionalis thank you so much your videos they are very helpful, here is the feed back of last semester i got "A" in microbiology and "A" in biochemisrty because of your Toutorials. again thank you so much and be blessed...😊😊😊
its really amazing lecture.
القدع متالق كالعادة في الشرح 🇪🇬 🇱🇾❤️🔥❗️
This realy is the basic medicine Will never find like this teaching, thanks
Glad it was helpful!
I hear your voice in my head when I study. This is good. ❤
Wow 🤩
what an amazing teacher you are. you are excellent
perfectly explained every step thank you so much
My pleasure 😇
You're right!!!! my professor can not teach this!
Thank you for watching my videos! I wish you success!
i highly appreciate your videos
I appreciate you too!
Best explanation ❤
Thank you so much, Helia!
Finally
I understood G protein
Thanks a lot
My pleasure!
I have a lot of love for this channel. Thank you so much for all that you do and continue to do!!
You are so welcome!
I love your videos. Learn and laugh at the same time :D THank you
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Pure gold✨
Thank you!
you r my Professor
I just can say: I LOVE YOU !!!! thank you so much !
Thank you for supporting my channel by being a member!
"It is a very simple concept but it is just that your work professor can't teach" that hit me badly lol
Hi! Thank you so much for your amazing content! What is a good source of information for categorizing drugs that act on Gq vs Gs vs Gi receptors? I appreciate the ones you mentioned, but I was wondering where I could find more. Thank you!
you are a great teacher.Thank you,Sir.
My pleasure 😇
🙏 thank you your video saved me
Thank you 😊
The best ever
Thank you!
I always appreciate a little dopamine from time to time. Is it true that insulin can (will) put glucose into an adipose cell?
Yes, it’s true!
Hey, thank you for your awesome videos
i have a question, hope you can help me:
1. β1 stimulation :: Gs :: ⭡ cAMP & PKA :: ⭡ Ca in myocytes :: ⭡ Contractility of (cardiac) muscle
Q1. so as β receptor stimulate Gs, does it mean all β receptors (β1,β2,β3) would ⭡ Ca in the effected tissue? for instance, due to Gs pathway, β1 stimulation makes ⭡ Ca in myocytes. so does β2 stimulation makes ⭡ Ca in vascular smooth muscle too, as it use the same Gs pathway?
in the video you had written β2 stimulation would "inhibit myosin light chain" in VSMCs. i know the fact that β1 is dominant receptor in heart & β2 is dominant receptor in VSMCs, but my question is when they (β1&β2) both use Gs::cAMP::PKA, how does one receptor knows to make "⭡Ca" and another knows to "inhibit myosin light chain" in the cell? Do their Gs differ or do their PKA differ from each other?
i hope you can help me to know what i am missing here
best regards
You are the absolute best!!!!!!!!!!
Solid video yet again!!
I appreciate you!
Thank you so much for this!
Awesome presentation
Thank you 😊
You are a genius guy, ty
you are a genius wow
Thank you ☺️
I really can’t thank you enough ❤
My pleasure 😇
Thank you so much for your video! This makes so much sense!
I was wondering if @19:52 you meant to write M2 and M4 are Gi --> which inhibit the sympathetic system because in the video it says that it inhibits the parasympathetic system?
thanks for real life saver professional better than school professor's goddess on youtuber make textbook into less than half hr vdo and immediately connecting whole pic that helps us get connected with all the critical concepts! thanks for make everything so clear! watching your vdo once is saving me reading my teachers books for days and still messy not sure what they try to deliver as key point or larger scope concept! and btw 15:32 the GDP was replaced by whole GTP not just Pi.
Dr I really addicted to your way in teaching, do you have pathophysiology videos? 💜💜🦋
Thank you so much 😊
What specific topics in Pathophysiology?
Wow thank you!!
My pleasure 😇
btw thanks a lot, I have a question about gastric acid secretion, of course, Gs is a cause of vasodilation and also smooth muscle relaxation then it means the mechanism of H2 cannot contract the smooth muscle of the gland which releases gastric acid now how to release gastric acid without contraction of the smooth muscle
Al or nothing
this lecture was really entertaining
Thank you 😊
Amazing 👌👌👌
Thank you 🙏
Thank You for the great well explained videos .I was looking for a video that explains G-Proteins.
Can you please make a video on Arsenic poising and how it affects the TCA cycle?also on mercury poisoning and its affects on the enzymes?
Can you also please make a video that revises TCA cycle and Glycolysis and gluconeogenesis?
Thank you so much for letting me know!
THE BEST!
Thank you so much ☺️
No surprise , another class 👏🔥
Thank you 😊
Great video as always. Never Disappoint
Thank you 😊
Thanks 💗:)
You’re always welcome 🙏
Thanks 🙏 💕 ❤️
My pleasure 😇
Pro level
Thank you!
Hey ❤️,Can you please make a video on "Ovarian Cancer"
Thank you for letting me know!
You have done it again! Made my day. “G-protein, why not F-protein for ”F me.” Hahaha!
19:55 Gi-inhibition of parasympathetic function??? Bradycardia is not characteristic of para action. ty
I meant to say that Gi is responsible for the inhibitory functions of parasympathetic actions.
You said that "all enzymes are proteins" I have learnt that some RNAs are also enzymes! So is that wrong?
I have not heard this before. Where did you learn this?
@@ZahdShah from my biochemistry lecturer !
From my PhD experience in Biochemistry Yes that’s true. Ribozymes , Ribonuclease P are example of enzymatic RNAs that are made of RNA and there are very few non proteinous enzymes like this the majority of enzymes are made of proteins after translation.
13.50
❤❤❤
Thank you 😊
Waaaauw!!!!
Perez Brian Hall Eric Hall Helen
🙌🏼
Thank you 🙏
Moore Ruth Williams Michelle Williams Dorothy
Quite simplistic and incomplete
🤦🏻
Can you please tell me relationship or difference between gpcr amd adenosine receptors