The SINAPPS2 Clinical Trial - Treating psychosis with immunotherapy ?
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- čas přidán 8. 07. 2024
- To find out more about the SINAPPS2 Trial please click here:
www.psych.ox.ac.uk/research/a...
Psychotic illnesses like schizophrenia and bipolar disorder are serious mental illnesses of unknown cause. There is an urgent need to discover the basis of these disorders, and to develop new treatments. There are many lines of evidence to suggest that a proportion of psychosis has an immune basis. We are a multidisciplinary group of clinicians and researchers who are exploring this possibility, using a range of approaches.P
We have found that some people with psychosis have particular antibodies that are known to cause another serious brain disorder - encephalitis. It is possible that these same antibodies are also causing psychosis in some people, and we are undertaking research to establish whether this is the case.
We undertake clinical trials of immune therapies in people with psychosis, and experimental medicine studies to examine the interaction between the immune system and the brain.
We propose that in some patients the cause of psychosis may be antibodies binding to neuronal membrane targets (NMDAR, LGI1, GABA-A and other), especially NMDA receptors, in the brain. The hypothesis underlying the SINAPPS2 trial is that these antibodies may be pathogenic and responsible for isolated psychosis (antibody-mediated psychosis).
We are currently conducting the SINAPPS2 trial to test whether immunotherapy is an effective treatment for antibody-associated psychosis. It is a randomised phase II double-blinded placebo-controlled trial of intravenous immunoglobulin and rituximab in patients with antibody-associated psychosis. Adult patients (16-60 years old) with antibody-associated psychosis are invited to one of the NHS hospitals participating in the study, where they are assessed and assisted by a team of SINAPPS2 clinicians and researchers. Eligible patients are randomly allocated to receive either intravenous immunoglobulin combined with rituximab or placebo treatment and they will be followed for at least 12 months - Věda a technologie
I wish I could be one of these patients, my life is over
Markers of chronic low grade inflammation are raised across neuropsychiatric disorders. Immunotherapy is a good next step in addressing the treatment gaps prevalent in neuropsychiatric care. I use minocycline in my practice in India to Rx negative symptoms. It targets astrocytes. Hopefully, we get to use MABs and IVIGs in psychosis.
Hello doctor Kulkarni
I am trying to find a doctor in India that understands immune system's role in schizophrenia and can treat it from this angle. How can I reach you?
@@yogeshsoni4558first of all he dont know how to treat with that new treatment because he said so although all tools required are in india and the guidlines of the new treatment is available online. if he neglected to answer you 3 months or he is ignorant to know he has a notification (iliterate about technology ) then he is a harmfull doctor. His comment is just a social small talk with a little man time waster who have been denied to give him a word in responce
I hope you Realize this is Not a regular Psychosis?!
This artical is misleading!
This is Not a psychosis trestment!
Its against auto immune psychosis Not many have that.
And minocycline has alot of sideffekts!!! Betten use ulotaront and xanomeline next year.
@@classic2620 thanks for your words.
What is the exact bloodwork test to have done? In the US
Update
What about people with long term chronic psychosis that meds have not helped ? If in USA how could we get tested to see if this may be helpful ?
Would you please give the name of the blood test that would determine the presence of the antibodies. I'm in the US.
I would love to participate with in it Please let me know how this is possible since I live in another country. Could I contact you and talk about it Please . It is hard with this type of illness.Thank you
What about skitzophrenia
I am curious to know how Ed is doing now?
Hi,
Ed is doing well.
Best wishes,
SINAPPS Research team
What type of treatment is given? Whats the basis of it? The science behind it?
Dear Leslie,
Apologies for taking us long to reply. The SINAPPS2 clinical trial is testing efficacy of IVIG and Rituximab for people with antibody associated psychosis. You can find more info on our clinical trial and scientific background on our website www.sinapps.org.uk The list of relevant published papers is available in Resources.
Best wishes,
SINAPPS2 Research Group
Is this trial still going?
HI,
The trial is still ongoing.
Best wishes,
SINAPPS Research team
@@sinappsgroup7418 one year has passed, is the trial done?