Addiction specialist answers your Trintellix questions! Learn the side effects, pros and cons
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- čas přidán 29. 07. 2024
- What is Trintellix!?!?!?!?
In this Q&A Video with Founder of the Alternative to Meds Center, Lyle Murphy, the questions about this drug are answered. Watch as popular questions listed below from subscribers are answered.
00:00 - Intro
00:21 - What is Trintellix like, compared to Zoloft?
02:31 - Does Trintellix target receptors other than serotonin (adrenaline, dopamine) and how is Trintellix different from other antidepressants?
04:07 - How do I know if a Trintellix dosage is too high? What symptoms are notable?
04:53 - Is Trintellix a better option than Viibryd?
05:48 - What happens if you stop Trintellix cold turkey?
06:51 - In your opinion is Trintellix easier to come off of than Celexa and Lexapro?
08:08 - Trintellix causes anger outburst but is that really a serious concern or fake news?
09:20 - I smoke marijuana and know that it interferes with some antidepressants. Is there research to say if marijuana affects Trintellix?
10:58 - My Bi-Polar spouse spends all day in bed. Is this the illness or the Trintellix and Seroquel?
11:57 - What can I do to relieve a severe itching side effect after starting Trintellix? Is it possible this side effect will be resolved? I have taken antidepressants for 20 years. I have survived weaning off of Effexor to transition to Trintellix.
13:41 - Is it okay to take CBD with trintellix and mirtazapine?
14:45 - Is trintellix a common backup if Zoloft doesn't work for anxiety?
16:36 - ATMC
Is Trintellix Good for Major Depression? Trintellix Pros and Cons
For most people, experiencing loneliness or sadness is a normal reaction to dealing with life struggles or losses. Unfortunately, sometimes those feelings fail to resolve themselves and become overwhelming. They may produce physical symptoms that interfere with handling daily activities and enjoying life. When these conditions persist for more than two weeks, you may be dealing with a common but serious mood disorder known as depression. Depression is a treatable mental health disorder. Mental health care providers often use a combination of therapy and medication to alleviate the symptoms of depression and help people develop the coping skills they need to enjoy life.
Trintellix: Pros and Cons
Pros
● Trintellix has a similar rate of efficiency as other SSRIs in treating major depression.
● It has shown a lower risk of weight gain than other antidepressant medications.
● In comparison with other antidepressants, Trintellix has a reduced risk of sexual dysfunction.
● Trintellix has similar side effects compared with other SSRI antidepressants.
Cons
● Trintellix, like other antidepressants, poses a risk of increased suicidal thoughts in users under the age of 24.
● Trintellix users typically report higher rates of nausea than those taking other antidepressants.
● Using Trintellix combined with other medications or herbal supplements that increase serotonin levels can result in a dangerous condition known as serotonin syndrome. The condition includes fever, seizures, and muscle rigidity.
● Trintellix can increase your risk for bleeding issues or hyponatremia (low sodium).
● Using Trintellix or any antidepressant medication can cause a physical dependence on the medication.
Side-Effects of Using Trintellix to Treat Depression
Like any other medication, Trintellix comes with side effects. The most common are:
● Decreased sex drive
● Heartburn
● Gas and constipation
● Dry mouth
● Blurred vision
● Spinning sensation
● Change in taste sensations
● Nausea and vomiting
More severe side effects that require a call to your doctor are:
● Coordination issues
● Agitation
● Muscle twitching
● Increased thirst
● Breathing issues
● Vomiting blood
● Seizures
● Black stools
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Here's a detailed list of the neurotransmitters affected by Trintellix:
Serotonin (5-HT):
Inhibits serotonin reuptake by blocking the serotonin transporter (SERT)
Acts as an agonist at the 5-HT1A receptor
Acts as a partial agonist at the 5-HT1B receptor
Acts as an antagonist at the 5-HT3 receptor
Acts as an antagonist at the 5-HT1D receptor
Acts as an antagonist at the 5-HT7 receptor
Norepinephrine (Noradrenaline):
May indirectly increase norepinephrine levels in the prefrontal cortex through its actions on serotonin receptors
Dopamine:
May indirectly increase dopamine levels in the prefrontal cortex through its actions on serotonin receptors
Acetylcholine:
May indirectly increase acetylcholine levels in the prefrontal cortex through its actions on serotonin receptors
Histamine:
May indirectly increase histamine levels in the prefrontal cortex through its actions on serotonin receptors
Glutamate:
May indirectly affect glutamate release through its actions on serotonin receptors
GABA:
May indirectly affect GABA release through its actions on serotonin receptors
It's important to note that while Trintellix primarily affects serotonin directly, its effects on other neurotransmitters (norepinephrine, dopamine, acetylcholine, and histamine) are thought to be indirect, resulting from its actions on various serotonin receptors
After 2 years of 10 mg, I am tapering it down to 5 mg. Is gonna be my second week. The withdrawal symptoms are painful as feel very much more tired, more emotional, very dizzy, loss of motivation and focus, experiencing brain fog and lot of headache. When I was on my usual 10 mg, it did help with concentration and low mood, but was feeling a lot anxious, felt angry and ready to fight all the time and impulsive. After a while I got to a stage where I couldn't feel joy or happiness, also lack of enjoyment regardless I was doing things what normally I would enjoy. .That is very frustrating! And still was struggling with not being depressed.
But this doesn't mean that everyone will experience the same!
I stopped trintellix cold turkey because of the nausea. I still am throwing up every day and am sick of nausea. I can wake up and have 200 mg of diphenhydramine and still throw up an hr and a half later. Literally now have cavities from it. I dislike depression but am neither depressed nor anxious with a benzo but they dont want you to be addicted to those but do want you addicted to ssris. I just don't take anything now and am hoping nausea stops soon. Opiate withdrawal nausea is only a few days but ssri nausea lasts weeks and weeks!!
I had to get off trintellix yesterday, my Dr. Put me on pristiq. No weaning needed. I was on for 7 weeks, super agro, very emotional, nausea. I had a gene test and the trin was on the list off low interaction. I'm sure the drug works fine for other people. I just wanted others to know that irritability can be an issue for some people
I have tried this for about a week and a half left side of mouth is numb, slight nausea but biggest disturbing symptom is dizziness. Its a matter of safety, dude Im getting off it.
This drug sucks as much as the other SSRIs!
BTW how are you now off of it
I was on trintillix 3 weeks at 5mg for stress and anxiety. It didn't do much. I tapered off. Day 3 of tapering. Some anxiety, but I'm going to the gym and burning it off. It's not easy, but not terrible. The ice pick zaps hurt but only lasted a day.
I was on it for 8 it did nothing for me and came w a lot of shit side effects.
@@garysimone4977 I'm done w ssris. These doc seem to not understand side effects.
@@garysimone4977 I agree I'm trying all natural stuff to see if it helps at all. Hope you feel better soon.
Pls speak about clozapine tapering and vitamins to support receptors effected
Clozapine Withdrawal, Tapering, and Clozapine Alternatives. Alternative to Meds Clozapine Help Video czcams.com/video/NhNLN3osB4o/video.html
Trintillix best time to use morning night please reply
Can you please speak about withdrawing from Clozapine.
We Did Make A Video About Clozapine, Check It Out Here: About czcams.com/video/NhNLN3osB4o/video.html
This morning I woke up from a nightmare incredibly disoriented. It might’ve been a result of Trintellix since it’s the only medication I’m taking & im new to it.
Yes it causes weird dreams
This medication gave me way too much mental energy which made my anxiety worse
I gave this med 8 weeks. It never helped. Also made me feel wiped out during the day until about 7 pm. Worse part being I couldn't nap, could not sleep until late at night and then waking up at 4 am every morning. What garbage.
I’ve taken celexa, Lexapro, Zoloft, Prozac, Viibryd, Paxil, and Wellbutrin and Trintellix has the worst withdrawal symptoms I’ve ever experienced. If I forget to take one dose, I have such severe dizziness that I can’t stand up at all. If it weren’t for getting zaps with it, I wouldn’t have connected the two.
Trintellix has helped me out in so many ways, no side effects did try other meds like zoloft and buspar only made sick or worse off so the mechanism of action is different to person to person, and i recommend first doing natural approaches and therapy before dabling into medication
Btw the video wasn't useful, a bunch of wrong information
Do not smoke weed while on antidepressants people. 2nd, why are you smoking if your on antidepressants anyway? Seems counterproductive. Just my opinion
w języku polskim
Poisoning it with medications lol
Painful to watch. Stop coughing / fix your phlegm
The absolute worst to come off of
Oh lord, this was the worst "information" video on Trintellix/Brintellix I have seen on youtube. To answer questions you also have the knowledge to do that