Renal Tubular Acidosis - made easy.

In this lecture we will understand Renal Tubular Acidosis. RTAs are complicated group of disorders and the different etiologies have quite a bit of overlap, thus making it hard to understand and use.
References
1. Hypokalemic Distal Renal Tubular Acidosis. Patricia G. Valles. Adv Chronic Kidney Dis. 2018;25(4):303-320.
2. Distal renal tubular acidosis: a systematic approach from diagnosis
to treatment. Sabrina Giglio. Journal of Nephrology (2021) 34:2073-2083
3. Renal Tubular Acidosis: H+/Base and Ammonia Transport Abnormalities and Clinical Syndromes. Ira Kurtz. Adv Chronic Kidney Dis. 2018 July ; 25(4): 334-350
4. Distal Convoluted Tubule. Arohan R. Subramanya. Clin J Am Soc Nephrol 9: 2147-2163, 2014
5. Up to date - 5/31/2023
6. Renal Tubular Acidosis. Mustaqeem R, Arif A. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023
7. Palmer BF, Kelepouris E, Clegg DJ. Renal Tubular Acidosis and Management Strategies: A Narrative Review. Adv Ther. 2021 Feb;38(2):949-968
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Unless otherwise specified, these lectures are intended only for adult population and may not apply to pediatric/neonates.

[@user-uk3so1jw3t]

Very hard topic. You made a complete video without making it complicated. Thanks a lot

[@angelicamaedelacruz616]

Thank you so much for making this topic so chewable. This really made me understand the topic instead of memorizing the table of the difference in RTA type II vs Type I. 🎉

[@gagankumarMD]

Glad it was helpful!

[@kaze123ckr]

5:51 In here, you mentioned Na reaching DCT and proximal collecting duct stimulates RAAS, and subsequently causing hypokalemia.
However, RAAS actually turned off if macula densa sensed larged sodium (increased GFR).
The reason why RAAS was activated is that loss of Na in NaHCO3 would lead to intracascular depletion, and subsequently activate RAAS, and further causing potassium loss.

[@kaze123ckr]

So in a state where RAAS is activated, if you supply with NaHCO3 load, Na will be reabsorbded and potassium will lose more.

[@glksivakaran]

Thank so much sir from uk 🇬🇧

[@imageofwish]

Thanks

[@Rares462]

If you want a goob mnemonic think about type 1 - one - H+/ type 2 - two - BIcarbonate, type 4 - 4 looks like an A - Aldosterone

[@gagankumarMD]

thanks.. that is cool . . .that is going to stick in my memory forever. ....