Tysabri, Ocrevus and Lemtrada! Oh MY! 2019 Updates
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- čas přidán 26. 08. 2024
- In this video I teach you about the most effective medicines to treat Multiple Sclerosis in 2019. If you want to up your understanding of Tysabri, Ocrevus and Lemtrada, then start watching this vid right now!
This video footage was originally recored during a 1.2 hr long live stream on MS disease modifying therapies. Based on viewer suggestions, I've chopped up the content into two "easily digestible" videos.
Tysabri, Ocrevus and Lemtrada! Oh MY! 2019 Updates. The Boster Center for Multiple Sclerosis accepts all major insurance carriers and accepts consults from around the globe, both in office and via telemedicine. www.BosterMS.com or call 614-304-3444 to schedule!
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COMMENT with your thoughts and questions below! I look forward to reading and responding!
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SHARE this vid: • Tysabri, Ocrevus and L...
Here's a link to the original livestream: • LIVE STREAM: LEMTRADA,...
SHARE vid "WHY BOTHER WITH MS MEDS?" video: • Why Bother With MS Meds?
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NOTE: Make sure to talk to your provider before ANY treatment decision. We hope to educate, empower and energize those impacted by Multiple Sclerosis. This channel consists of a collection of formal lectures and informal video clips about MS to help education others. These videos do not provide medical advice and are for informational/educational purposes only. The videos are not intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of a qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read or seen in any of our videos. They are just to help educate you about the condition guys!
This is a really, REALLY fantastic video on the “top shelf” medications for MS. It’s extremely informative and presented in such a way as to help people decipher all the sometimes confusing medical jargon that comes with treating MS. Thank you for your time and passion, Dr. B. You truly are making a difference well beyond your clinic walls!
Thank you for the kind words Megan! I aim to help educate, empower and energize folks impacted by MS! #WeHaveMS
Infallibly so...
🍊💓✊
@@AaronBosterMD Dr.Boster, I was infused with Tysabri once a week for 64 weeks. It was at Borges Medical Center in Kalamazoo, Michigan. Though my tribe and military SSDI paid for the 2k a week drug, I believe that it doesn't work for everyone. I mean no disrespect, 2 weeks after stopping the infusions, I started getting insane cluster headaches. Which surprisingly enough, Bare, Tylenol and even Advin didn't help. Only drug that killed the paid was BC powder. Simple asprin powder! Just an update and the name Tysabri sparked some memory's.
Thank you for all that you do. Knowledge stops confusion which stops stress, which you have helped do.
Thank you again Aaron!
I'm newly diagnosed and this is hands-down the most helpful channel I could have possibly found. Thanks Dr. Boster!!! :)
Great to hear!
It makes me crazy I have learned more about my treatment and disease from your channel than I have from the 4 different neurologists who've treated me. Thank you for making this complicated topic comprehensible. I visit your channel to find a little sanity - you are wonderful!
👍🏼🙏🏼😊
I totally agree.
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Lemtrada all day it's been like a cure for me.
1. Gait Improvement
2. Feeling back underneath my feet
3. I can withstand the heat
4. EDSS improved 75%
5. No risk of PML
6. No longer use a cane or walker
7. Walking speed has increased
8. I can walk upstairs and down.
9. I can maintain an erection again
10. Vision has improved greatly 20/25
All things that Lemtrada has done for me.
Con- I have hypothyroidism but managed with meds. No further issues.
MATT Z Wow, that is incredible! Maybe I need to switch DMTs!
That is great to hear!! Were you on anything prior to Lem?
@@beverly9885 Always consult with your Neurologist. This is my case not anyone else's. With that said it's HIGHLY EFFECTIVE. The other thing i want to touch on is to make sure you do your own reseach on the medication understand it know it that's your job as well not only the doctors. Now I just mentioned Doctor make sure he/she knows everything there is to know about Lemtrada i mean everything. There is a specific protocol and duration of time to follow prior to infusing with pre meds to help mitigate side effects. All things to make sure you're comfortable during and after. You found the perfect place to learn and that's here on this channel with Dr B. Best of luck to you. Don't ever hesitate to ask questions or challenge your doctor RESPECTFULLY if you're not sure about something or need it explained in detail that's your right.
@@Just4Kicks1234 Yes Tecfidera then Lemtrada
No risk of PML?
I'll be getting my third infusion of Ocrevus in April. After both of the split first dose infusions, I got a bad headache starting about four hours after I finished up the infusion. It was like a combination of sinus, migraine, dehydration, and stress headaches combined. It went away about twelve hours after it started, but I also was very fatigued, and slept most of the 24 hours after the headaches started. But then, I felt pretty damn good, compared to how I felt before starting treatment. After my last infusion, I still had the headache, but both it and the fatigue were greatly reduced. Dr. B brought up the possibility of Ocrevus "wearing off" the closer you got to the next infusion, and I experienced something similar. In the last 4-6 weeks, I experienced a slow and subtle return of symptoms that had mostly dissipated. Most notably, the brain fog, and a return of "the hug". I ended up on the phone for a couple hours with the Ocrevus reps, detailing all my symptoms before treatment, after the initial dose infusions, and what had changed in the last several weeks. I'm approaching that several week period again, as my next infusion approaches, I've not yet noticed a return or increase of symptoms. This was something we, the entire team, had hoped for. The only changes I've noticed can easily be attributed with the weather this winter. I'm only a couple hours from Dr. B, so I'm sure he will understand what I mean.
Well, maybe one thing is coming back, I've noticed the need to correct more and more typos. Still, I think I've made improvement overall.
Dr. Booster thank you so much for all of your videos. I was just officially diagnosed last week at age 62 and my doc said my MS is rare and aggressive I will hopefully be starting Ocrevus in a few weeks. I have spent the summer viewing your videos and am so grateful I have found you on CZcams! My husband who has CLL took my diagnosis hard and I showed him one of your videos to help explain what I was going through. You are an awesome human!
Hi Wanda, hope you are doing well, would like to hear from you on how Ocrevus worked out for you?
Watching whilst being infused with Tysabri! 🧡
I watched as I was getting ready to head out to my Ocrevus i fusion!
I'm trying to decide between these 2
@@NERVE-DAMAGE I just had my 4th Tysabri Infusion 3 days ago. God bless and ❤️ all
@@ArmoredDangerousEph6-11 any progress is it good because im searching about tysabri before i get it
Excellent, thorough explanation. Glad I found Dr. Booster on the web, sad I live in NJ and finding his depth of knowledge after living with MS for 40 years.
I am starting Ocrevus on Monday. Unfortunately Tysabri led to positive JC Virus and aubagio led to larger brain lesions in only 6 months of therapy... hoping Ocrevus is the winner!!!
Thank you for taking the time to make these videos. Really informative and helpful for the MS community, much appreciated. Really.
Doc, I was wondering- when you get a chance...
Could you go over some of the more frequent psychological related issues that come with MS. Hitting on the grief process ( as I find we go through this more frequently, whenever we lose a certain function) positive coping mechanisms. Ect.. emphasizing counseling. If I’m missing a video you did on this- 🙏🏻 let me know please. Thank you. I believe people overlook the emotional/psychological aspects of MS
I really appreciate all your videos! I’m newly diagnosed with MS and finding your channel has been a such a stress reliever! I tell everyone about your channel and hope you keep making many more videos! I have learned sooo much! You have a lifetime follower!
Thanks so much for sharing your time and knowledge. You have given me a greater understanding of MS and how my medicine works. Love the fight behind the school with your friends analogy!
Thankyou from Perth Western Australia! Your Chanel has been a god send for myself, family and my friends. 💖
Our daughter is 43 and just diagnosed with MS . Your channel is very educational and we've taken notes. Since most Children can't wait for their independence from parents, they often tend to withhold important information from them, especially concerning their health. This knowledge on your channel means it won't be necessary for us to put her Neurologist through the third degree torchur treatment--tactics that most parents tend to use on their child's physician--which also embarrasses our grown-up babies. We can now remain silent, but with the knowledge we need, in order to be helpful in her treatment. So thank you kindly for empowering us. Sincerely yours, a couple of neurotic parent's, living somewhere in Utah.🖐️
Hi Dr Boster, thank you for this video, your timing is fab as I'm hopefully due to start my first treatment with Ocrevus - just need my lymphocytes to start playing ball! Very informative and I like your analogies. Wish you were here in the UK & at my local hospital. We are left to find out about these drugs from a booklet, which is never great & leaves you with so many questions. Many thanks and keep doing what you are doing. Jane
You asked once what my personal goal was. I think as my daughter has this at 25 I would just like her to have better day not in pain where she can see and have continual hope. Thank you for being a wonderful source of hope for me.
Thank you for doing these recordings. I live in Gibraltar, in Europe and we do not have a neurologist. We have one doctor who deals with local MS patients but sadly he has much to learn. Thanks to you, things are explained now 😊
Hi, I came across your video on progression independent from relapse activity when someone from one of the MS groups posted it on there. Admittedly, I cried my eyes out. I’m doing everything I can to slow the progression of this disease, following strict diets, taking very invasive drugs that come with a loooong list of side affects but I am still going to end up being disabled. It made me feel hopeless. But, I’ve continued to watch your videos, yes they’re hard to watch but neurologists and nurses just don’t have the time to go over all this information with patients.
I’m doing the best I’ve been in years while being on tysabri. Just today I walked all over hospital with my cane, no wheelchair! Also today was pretty amazing because I found out my MRI is STABLE! I’ve been breaking out into “woohoos” since 2pm.
I don’t know where to put this doctor, but it is because of you that I will give Ocrevus a try. I often felt embarassed, even a bit angry, with your ‘are you 4 on 4’, because 3 of them I did, but medication - the only thing I can’t decide myself - I did not. I’m 50 and my condition worsened a lot over the last 5 years. Hence I felt sad, even a bit embittered, that my neurologist first wanted to start siponimod, hence not one of the ‘big guns’. But I sent her a lenghty mail and she finally decided that we should give Ocrevus a try. And that thanks to the guy who doesn’t want you to turn away before the end of his videos. Thanks!
I appreciate the comedy in these videos as well as the information
Best DMT video I have ever seen! And I watch your videos A LOT. This was very concise but also EXTREMELY thorough and informative. I loved your analogies and explanations. This video made it super easy to understand 3 drugs that can be very complicated to learn about and compare. I know I have been a successful Lemtrada patient, but I'm ALWAYS looking to be more informed and be able to assist others I come in contact with. I KNOW this video will be an amazing tool I will forward to anyone wanting to improve thier lives living with MS. THANK YOU SO MUCH DR. B!🙌🏼🙏🏻
Interesting video on O.That’ said, I think it’s really important that you discuss O’s impact on PPMS. That appears to be the biggest controversy of this drug.Thank you for addressing this, if you will.
Thank you Dr Boster - this is absolutely brilliant- such a fantastic explanation of how these DMTs work! Just awesome 😁 🔥🔥🔥🔥🔥
Thanks a lot doing this for us!!! Great explanations as always! Greetings from Serbia.. :)
Excellent! Excellent!Excellent! I feel so much better informed about these meds. And thanks for the news about breast cancer. I was very concerned about that.
I'm thinking of Pac-man eating my adult B cells. Very Cool.
I'm trying to decide between the first 2. And I wanna say thanks for THIS video. Seeing as tho my 2 "choices" are in this video. My neurologist hasn't suggested the 3rd one you talked about (sorry I didnt wanna have to spell them out lol. I just went by the order that you talked about the 3 in THIS video)
Just dx this week myself. I'm very scared and dont know what my future will hold. Hope ur doing well with ur battle, from a fellow 9ers fan with MS
You can't go wrong when you have Dr.B demystifying the top 3 drugs on the market. Thanks for taking almost an hour to share,you quantify the value you have in our MS!!!
Doctor Boster the themes you reffer are fascinating. Since my diagnose I've been thinking so much in the nature of my treatment and related drugs. Now I´m glad I found your channel with themes I might discuss with my neurologist.
Brilliant video, thank you so much for this information, you are truly helping people all over the world. I am about to start my 2nd course of Lemtrada and this is really helping relieve some of the anxiety. Thank you again. UK Wales
Thank you for making the time to educate us Dr Boster. Having started Lemtrada in Feb of this year, I am immensely interested in any information regarding it. I found your explanation of how it works very easy to understand.
Started out on Tecfidera and got seriously sick from side effects. Got started on Vumerity and then started having bad side effects as well. Finally got the courage to tell my dr that the meds were not working for me and that I needed something more effective. I should be starting Tysabri soon. Thanks for all you do for the MS community!
Thank you for you clear explanations. You were very clear that Ocrevus can increase the chance of respiratory system infections. How can we protect ourselves in the Covid19 era? Should we avoid it as a potential treatment?
Thank you so much for this video and your channel! I Love how educational you are and how you add humor to it too!
THANKS DOC!💝
Thank You Dr. Boster for the very educational time you have spent for the village.
What would we do without you.
Thank you for this great video! Best regards from Germany!
Doctor you are amazing. Thank you for the time you take to teach your patients and others
Thank you! Explaining it so we can understand!
Glad it was helpful!
Amazing information. I was dx in 1991, was then hospitalized for a month and given Solumedrol and sent home. never treated, I am now 75. now getting lots of spasticity. I am wondering if you treat older patients?
I love the pac man shirt!
Another super informative session! I know these videos are a ton of work even though they appear simple. Much appreciated!
Dr Bostor you are a gift to the MS community!! Thank you!!!🙏🏻
PS my daughters family are all ABs too lol. Dr Aaron B, Alexa B, Asher B, Avery B (3 weeks old). 👨👩👧👦
I have experienced the opposite - becoming JC-negative after 2 years on Tysabri, having tested JC-positive (0.38) at the start.
Being JC-negative was an argument of my MS-neurologist why I should stay on Tysabri, despite having tons of trouble, including MRI-spots.
I love your videos - i'm early in my ms diagnosis and are trying to figure out what drugs to go with ..leaning towards ocrevus
I enjoy your videos. They are so informative and you break things down to understand easier. Thank you! I just started Ocrevus, 2nd infusion 7/28. I’m excited to see how this all goes.
This has been so enlightening. Thank you for your simple yet thorough explanations.
Thank you Dr. Boster! I truly appreciate you and your tips
I have had a good response on Lemtrada with no new or active lesions for over 5 years. I was not kept on acyclovir after my Lemtrada infusions and did develop Shingles about 28 months post treatment. I have also had several bouts of mild skin cancer but had some removed prior to treatment and have pasty white Northern European skin AND live in Texas so I'm not really surprised at that. Having been on different DMTs prior to Lemtrada I can say I am thrilled to have had a chance to have this treatment.
I get Tysabri every 4 weeks. One difference in my experience is that I recieve Tysabri and then get infused with a solution that gives the nurses about another hour to observe how I’m doing. I’m usually at the hospital two to three hours.
Thank you for the excellent education! Your videos have been a really helpful resource.
You're very welcome!
excellent video. thank you for this. i have an allergy to tysabri. when i got my first infusion i had hives and thought i had other symptoms no need to mention. this is very interesting.
Very very good video as don’t have an hour with neurologist (who is a brilliant professor and got me on tysabri right at the beginning because it was aggressive) however after a decade with no replapses now wanting to change to ocrevus. I’m slightly JC positive. However given my success I’m scared of changing and this has helped a bit. Keep up good work
Thank you so much for this channel Doc. Extremely helpful.
I'm kind of late to the game, this being 2 years old, but what an amazing explanation! I may need to change my DMT in the near future & my neurologist is thinking that Ocrevus or Tysabri would be the two to chose from. Thanks for giving me more real information on these amazing medications.
THANK YOU for being an awesome teacher and doctor (and NOT a nakey doctor). :)
Thank you so much for all the information!
Dr B. LOVE your analogies it explains complicated science in a non doctor understanding. Question: If after a full treatment of Lemtrada, ( year 1 and 2) and a person had gotten ITP, then later on had an attack or 2 new spots on MRI. What is the risk percentage of getting ITP attack again if a 3 round of Lemtrada is given?
Great analogies!
thank you!
I took your advice Aaron. I am getting my ocrevus early and I saw my old MRI’s.
Dope shirt 👕 Dr!!! 😎
I'm sorry Dr.Boston for not tuning in.I HAVE A UTI INFECTION WHICH MAKES ME LAZY.
So glad you posted this. My husband has been on Ocrevus for 1 year as of next month. He continues to get worse and has PPMS. He has had a reduction in his lung capacity down to 60% and continues to have upper respiratory issues. When we mentioned this to his Neuro- they said the infection is only at the actual time of the infusion so they disregarded this as related. Any ideas on how we can get him to review this problem again for us? We really like his Neuro but he feels it isn't related to Ocrevus.
I'm sorry I meant he has SPMS
Thanks so much for making this video. Very helpful.
Glad it was helpful!
Do I remember you saying it really takes a year for full protection after starting a monoclonal antibody?
I’m one week post lemtrada, the rashes was so bad from day 2 of lemtrada until 2 days after completing the first round! My vision gotten worse during lemtrada but now it is better. Other than that i’m feeling completely the same as before lemtrada. I didn’t know what to expect bcs i’m the first one to do lemtrada in my hospital and fourth one in my country as Ms is a pretty rare disease in Malaysia 😂 this video helps to clarify a lot of things 👍🏻👍🏻
Right on Allah!
With Ocrevus, how much of the function of the T cells remains for other important jobs in the body?
Very good and informative video, to the point where I'm thinking of getting my partner to watch it. I'm currently on ocrevus, coming up to my second full dose, and I'm feeling so much better already 😁 I was on copaxone from 2015 to 2019, then I went on tysabri for one dose before they found I'm JCV positive, so went back on copaxone, and started ocrevus in June 2020, after I had a very bad relapse mid-April where I had 2 generalised seizures in an hour (I think), and had my post-ictal state in hospital, where I got IV steroids and a monitoring period.
Thank you
Hi Aaron, great video (and Videos you are producing). I am keep thinking and wondering what would it be like if one would mix Tysabri with Ocrevus? (To have a great wall of China as well as no major part of B cells). Are there any data available about combining DMT therapies? Best regards, Ted
s51ta
Yes! I wondered the same thing!
I’ve been on all three. Just got first dose of ocrevus. Went 11.5 years on lemtrada. Seems to have expiration date of 5 years for me, so at this point, 5 years from last lemtrada dose, I have new lesion. Nero wants me to give ocrevus a shot. I’ll take whatever to be able to keep walking
hello dr.aron thank you Sooo much for every thing ⚘
- Can i take ocrevus if i have (Hypothyroidism) ؟
There is a hypothesis that the autoimmunity caused by Lemtrada is due to the B-cells repopulating quicker than T cells and above baseline (most of the autoimmunity issues are B-cell driven). So, why haven’t doctors looked at low dose rituximab at 6-months post last infusion to see if it reduces the secondary autoimmunity. Why hasn’t this study been conducted?
thank you
I also agree about the remission statement.
Thanks for this, Dr. B!
While taking my first dose of Tysabri, I could feel the sensation returning in my feet about 30 minutes into the infusion. I came off of Tysabri because my neurologist said my risk of PML was too high. I am no on Ocrevus and haven't had any of these miraculous feelings. I really wish there was a way to bring down the JCV titer. I really miss Tysabri.
Nata means cream!.
Sorry, I'm spanish. I couldn't help myself.
Great job!
So helpful! Thank you! 🤗
No new lesions since my diagnosis due to TECFIDERA.🤘🎼🤘
I was diagnosed 4 years ago.
Me too! 5 years ago
This was only one worked good for me
I have been told I am too old for any of the DMT’s, that was in my 60’s. I am now 76 yo so is it still too late with all of the new DMT’s is that still true. I started with RRMS, it is now SPMS and no longer walking.
Thank you!
Hopefully we will find a sponsor for ocrevus with me since the BTK inhibitor as kind of been ruled out so far
It’s making my hair fall out Ocrevus is for myself I’m under weight and I don’t feel it’s helping me. I have secondary progressive multiple sclerosis though and I was diagnosed with the JC virus in January 2016! I’m wondering why my neurologist hasn’t started me on the new May something I forgot what it’s called but it’s the first med approved for secondary progressive multiple sclerosis.
13:07 this makes me so depressed. Poor guy.
Im JCV positive at some 4.2 whatevers so like suuuuper positive so we went with lemtrada - best decision ever!!
Christine Arrand:
Dr. Aaron Boster: QUESTION- Would it be safe for someone that has this high of an immunity to JCV to try Ocrelizumab? Have a similar JCV & had new disease activity (physically & on MRI) six months after R2 of Lemtrada....
I will be starting Ocrevus treatment on Monday! Unfortunately my brain lesions got bigger with a pill called a Baggio
Ms diagnosed 2019 thanks
#MSWarrior
Thank you for all your work to help us to understand about MS disease. I am 58 yers old I got my first relapse at age 49 where I diagnosed to have MS. I was put in steroid then I recovered. Because of my lack of information about the disease I thought I am off the disease, but I got another relapse after 3 years which was stronger than the first one. Again I was put on steroid the my doctor has put me in interferon Avonex injection. Since then I did not have any activity of the disease, but I fed up with these injection and I wold like to change. I listened to you program about Ocrevus and Lemtrada medication. For my age 58 years old which in your opinion would work better for me?
It's 4 years later are this drug's still good or are there better.
Thank you so much
Any time
I having a terrible time with Tysabri. The nausea was bad and pain.
Any suggestions.
My 20 year old niece has just been diagnosed a week before Christmas 2020 with MS. She lost sight in one eye and then two weeks later lost the use of her legs. 2 relapses. Her Neurologist wants to start her on Tysabri every month but we are terrified of PML. Do you have any advice? We are so lost and desperate. Thanks in advance.
How about natalizumab, cervical dysplasia and encephalitis? I already have cervical dysplasia and been through viral encephalitis at the age of 4...I am 39 now
Dr Boster - I just commented on an older video but I'm curious what your thoughts are on taking Ocrevus if we want to conceive a child. My current neurologist says it's okay to take, wait 4 months and then try to conceive for 2 months before the re-infusion at 6 months. Do you agree with this course of treatment?
Have you heard of feakal transplant? Do you think gut Bio improvement can help ms symptoms. Isn't the gut the most important key to health improvements?
Super-thumbs-up!
Hello doctor. I have MS for 20 years. I have a question about stem cell therapy. Can you make a video about that please. Thank you.