A Needle So Tiny It Injects Into A Single Cell
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- čas přidán 17. 05. 2023
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It may be possible to create a needle so small it can inject a vaccine into a single cell. But it's not the product of a medical device company. It's part of something we often think of as making us sick.
Hosted by: Reid Reimers
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Sources:
www.cell.com/trends/microbiol...
www.ncbi.nlm.nih.gov/pmc/arti...
www.tandfonline.com/doi/full/...
www.ncbi.nlm.nih.gov/pmc/arti...
www.nature.com/articles/nrmic...
www.cdc.gov/vaccines/hcp/conv...
www.britannica.com/science/an...
www.ncbi.nlm.nih.gov/pmc/arti...
www.ncbi.nlm.nih.gov/pmc/arti...
www.mayoclinic.org/diseases-c...
www.frontiersin.org/articles/...
www.frontiersin.org/articles/...
study.com/academy/lesson/what...
pubmed.ncbi.nlm.nih.gov/23531...
pubmed.ncbi.nlm.nih.gov/28035...
www.nature.com/articles/s4158...
www.nature.com/articles/d4158...
pubmed.ncbi.nlm.nih.gov/16824...
www.ncbi.nlm.nih.gov/pmc/arti...
www.frontiersin.org/articles/...
journals.asm.org/doi/10.1128/...
bmcinfectdis.biomedcentral.co...
www.britannica.com/science/li...
www.cdc.gov/listeria/risk.html
breast-cancer-research.biomed...
clinicaltrials.gov/ct2/show/N...
www.ncbi.nlm.nih.gov/pmc/arti...
journals.asm.org/doi/10.1128/...
www.cdc.gov/foodsafety/commun...
Images:
www.gettyimages.com
commons.wikimedia.org/wiki/Fi...
commons.wikimedia.org/wiki/Fi...
www.mdpi.com/2079-6382/8/4/162
commons.wikimedia.org/wiki/Fi...
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this is just a reply
Muy buen video, se acercan a igualar o superar tecnología alien de expedientes secretos x, junto virus y bacterias qué muten o alteren a la gente desde dentro, también usar esta tecnología en servicio secreto para intervenir especies inteligentes biológicas, sus civilizaciónes junto con alterar e intervenir su evolución biológica para que no sean una amenaza para la humanidad como encontrar predadores en la edad de los metales y alterar secretamente sus civiles machos y hembras, así como militares para obligarlos a seguir caminos tecnologicos, religiosos, culturales etc etc.
Hasta experimentos de virus y bacterias manipulando óvulos a travez de varios para fecundar óvulos con bacterias y virus para manipular la religión de especies inteligentes biológicas mamíferos y hacerles su buda o Jesús que nace espontáneo para conquistar y controlar otras especies inteligentes biológicas mamíferos por el universo, método de conquista e intervenciones en la historia de civilizaciones menores al tipo 1.
the needle is pretty average i think, maybe even a little big
I'd say it's quite large actually
Yep, looks normal to me.
"Not an actual accurate depiction".
In court.
Comment of the Day
I love how this is the most upvoted comment on a science video 😂
But will they make a “micro-butterfly needle” for those cells who are afraid of shots?
Lol
This is the most wholesome comment
I actually worked in a lab that studies this exactly with francisella bacteria it was extremely insightful and was run by some truly brilliant and dedicated people
This sounds like a very powerful technology. Hope it gets the funding it deserves.
It won't. CEOs need to increase their salaries by another million the next 2 quarters so they can afford their vacation spending spree. Life's hard yo.
@Razgrits it'll get funded right before a stock meeting and then left without
Cool! For my PhD I inject proteins into isolated neuronal cells, the technique is called microinjection. You have to make a tiny needle and be quite careful where you inject the cell, I use a needle less than 500nm in size. Tiny is relative however especially compared to this approach.
What kind of instrument do you use to inject the cell?
How many things could never go wrong......
whoa I'm reading Andy Weir's book "Hail Mary" where I just learned about nanoneedles, and now SciShow releases this video
I once had an experimental rig that could inject a single GMO created cell with small proteins.
In 1992!
Back then it was the size of a small car, a bespoke build. The injection system was controlled by a brand new Apple Mac with a stunning 1GB removable optical storage disk, to record what happened. I’d hand make a set of needles on a micro-lathe each morning so yes we could make a practical micro-mechanical syringing system like this 30 years ago.
With a microscope & TV camera I’d target each cell. If I succeeded with a dozen cells in a week it was a good month. Sometimes it would be 28 days of straight failure and it felt more like witchcraft than science.
Nice that times move on and what we learnt back then fed into how to manipulate biological structures into living bio-nanomachines to create a dependable medical technique 😸
Super cool. Thank you for sharing 😊
In my old lab we also had a microinjection system, with glass needles. A bit easier setup than what you describe; was mostly used to inject fluorescently labelled proteins and see where they would go in the cell. But it was still a skill to be able to inject successfully; lot's of broken cells and needles.
Getting poked with a syringe only to get injected with more syringes lol
It's like Inception but with needles instead of dreams
@@grimacethehutt4671 Goat movie.
nah they be in yoghurt ;)
I learned about viral vectors back in about 1984. Since then I've wondered why they weren't studied to develop medicines or vaccines into cancer cells directly.
More immediately in the 1980's AIDS epidemic, I wondered why they weren't used to deliver anti-AIDS RNA inside cells since that was where AIDS hid and what made it impossible to fight.
Oddly enough our information on viruses is not as thorough as it is on bacteria. And because viruses are basically packets of dna they are harder to rid. But honestly once the hiv virus gets into the cell it’s game over you gotta get it before hand. Until we have a way to exercise dna out of the cell with out damaging the cell that’s won’t happen or if we can id those cells that have the dna then we could just target them but otherwise our efforts have been solely based on prevention of hiv entering the cell
They used different viral vectors, but everyone got its downsides. The Problem stems from the vector itself most of the time. Back in the days they used different retroviral vectors with apparent succes, however they later discovered that these retroviral vectors had unidentified rna/dna sequenzes that caused cancer in the test subjects. Other vectors like many adenoviruses caused alot of problems with the liver or just didnt have a lasting effect and thus where way too expensive. The most promising viral vector i think to this day is the adeno associated virus. It works very well and shows very promising results in testsubjects, with the big downside that it is simply too small. So scientists are limited in what they can pack into these :/ Nowadays we try to stray away from actual natural viral vectors and rather design human made lipid nano particles or stuff like that, tha resembles a virus to have more control over it.
I thought they were going to talk about In vitro fertilization. I see so many clips of needles injecting into an egg cell. And that blows my mind. I was so excited to see them talk on that
This is incredibly cool. Probably every generation thinks this, but despite everything, this is an amazing time to be alive.
AKSHUALLY I bet those living during the black plague didn't think that
Scary times if you live in Florida.
And also horrible times neo colonialism is growing each day many horrors such as child labor in cacao farm are treated as normal or hidden and stuff like war between ukraine and russia happened there is war zones present in africa that are in no way getting better and middle east is being middle east do I need to say more about them?
Yeah clot shots are awesome💪
Isn't invitro fertilization exactly what the title says? I think that bacteria or virus injecting stuff count as different drug delivery system than syringe. Generally drug delivery systems are interesting topic, it's nice to see it covered.
Yep, that's where I thought the video was going based on the thumbnail. IVF doesn't require a needle to puncture the ovum, what you're thinking of is intracytoplasmic sperm injection (ICSI). Ova are the largest - excluding neurons - cells in the human body, so it's possible to puncture them with a needle which is large enough to fit a spermatozoon completely inside it. Wild, right?!?! The needles shown in the video are very different - the payload is just a handful of molecules, and they would be assembled spontaneously rather than shaped out of glass.
Eggs are 200x times bigger than normal cells
@@ChemEDan Thanks for a nice explanation. I wouldn't call method presented in the explanation a syringe, although on a microscopical level it is similar. On a macro, human level, you gotta make up lots of actual organisms, then somehow inject them, so they can inject the pay load. It's a very cool concept, but I found the description a bit misleading. Thanks again for patching up my knowledge about IVF and human cells. Have a good one.
Its made by a kind of organism we often think of making us sick.
Me... mosquitos 😅😆
Anyone getting some wonderful 'Journey to the Microcosmos' vibes here? 🥰
"How? Why can't you die?"
" -Nanites- bacteria, son."
Great video! This guy has a great voice too!
Hi Reid!
This is better than space!
That's smol
I thought this was going to actually be about microinjections and not bacterial vectors lol
Same xD
The problem I can see with this would be a random mutation that turns these bacteria into a super infection.
Call that a needle!? This is a needle!
Ive seen lots of footage of micro-needles that pierce oocytes to swap out nuclei and other organelles so the title confused me
Whoa that's tiny!😱
...that's what she said? 🤔😏
Smol
@@Aragorn7884 dmn you.
@@Aragorn7884 stop it xDD
Its always good to hear new advancements in medicine but knowing this probably never going to be spread out to the public without costing a lot for the use of it, does dampen that feeling. And yes, I do believe all medicine should be subsidized so everyone can get it no matter the amount of money they have.
I don't feel that way living in a country with universal healthcare.
I'm sure the US will eventually switch with all the political pressure.
They'll keep saying there's no way, but it just takes creating a base insurance by the government and all insurers need to send money to that org, or force all insurers to be complete non profits with price minimums to offset the cost of expensive meds that have to be price capped. I think these two versions are pretty achievable
@ayo I think you should feel that way. If I develop seizures or get cancer and don't have a job, I'm just going to be in debt until i die. There are 2 for profit dialysis clinics across the street from eachother on my way to work. Not very cool.
Nanofabrication for integrated circuits or for biochemistry requires isolation from extraneous effects such as how dust, vibration, and slight electrostatic fields would cause havoc for such microstructures to not endure for long outside a cleanroom air shower bunker.
...we should use bacteria as an energy source
Feels weird to hear Reid outside of SciShow Space
This looks a lot more like a super weapon if you ask me, lets hope it wont be used that way.
it will
Right!!! Breed a batch of the virus/bacteria that injects botulam into the heart, brain, lungs, or really any necessary body parts cells needed for life. Make it transmissible by mosquitoes. Or make it a one time use by sterility for assassination/target removal. Use a bacteria that targets particular genes from ethnic, racial, gender, or really any genes from those for blue or brown eyes to those that code for short or tall.
Deadly as hell and limited only by ones own imagination, money, and knowledge.
We already have thousands of ways of killing people that are easier, faster and cheaper than this. No point worrying about this one
You can bet it will!
I love this man's voice
what about mutations of the bacteria or the payload they generate?
This is absolutely genius
If you could directly target individual immune cells, could you use this tech to do the opposite of what you're saying? Like treat/cure autoimmune diseases that target healthy tissue.
I wish I could like it way more than just once. There needs to be a spectrum! From kinda-like to oh-my-god-this-is-the-best-thing ever!
Must have a very steady hand
I fainted during the injection scene, but I'm okay now
That’s the size of needle I need.
I would think EUV photolithography would be able to make such a needle.
You know, the way we modify bacteria to help us fight off pathogens and develop medicines could be considered the latest evolution of how we domesticated animals to help us hunt and to use as food, except this time it's on a microscopic scale.
Wow
Cool thanks
I have to subscribe to this channel because I love how you act effortlessly. You are so talented
And in NO WAY any government will use that as weapon, NOT AT ALL... :)
The needle depicted does not accurately represent anything more. Than that.
I asked a lawyer.
Until I saw his face, I thought that SciShow had tapped Rob Gavagan XD
Hi, I have a question to your video about feline's roaring and purring: You talked a lot about the length and pads of the vocal chords. Is meowing high-pitch-roaring then? Or is the sound produced in a totaly different manner?
I reckon this is more than possible. We have tiny glass fibres that can transmit 20KW of DUV Lasers to cut 10cm of steel so a tiny needle is attainable. But really that is something my mwdicltech sister might work on...
I've seen this movie before. Will Smith's gonna have to sacrifice himself after he discovers the cure.
Finally, a fix for my Trypanophobia
That's a lot of effort to make a dirty joke... Proud of u Scishow
How do these bacteria needles compare in size to the needles they use for doing IVF? I thought this video would say something about those.
Ova are much larger than most cells. You don't need to manually inject a million cells.
Where do they get the tiny cartoon bandaids?
We've got something that's close! ICSI (intracytoplasmic sperm injection) can be used as a part of IVF (in vitro fertilization) treatments for infertility to inject a single sperm (the smallest cell in the human body) into a single egg (the largest cell in the human body).
I swear vaccines don't hurt nearly as much as when I was growing up
But wouldn’t it require many many injections, with huge precision
I think you misunderstood the video. All this would be happening on a microscopic level
And after this it's editing plant leaves chlorophyll cells to produce others medicines along side it so all we have to do is grow and harvest leaves instead of chemical manufacturing them
i do like how they rebranded CRISPR to mdnra.
Interesting
Cellectra elevtropulse frequency opens the cell. Look it up.
Could anyone tell me where in America this guy's accent is from please?
It's really nice and quite distinct.
Editing genes with micro organisms is next level, hopefully we stabilize mutations so a "smart" virus doesn't hack our shiz.
I have Multiple Myeloma, so this is potentially good news!
Havent they got these already when doing IVF?
So, should we call these new antigen delivery microorganisms "baccines," or "vacteria?"
Cool
Of course we could also completely wipe out humanity with this also
But that just means we have two customers now instead of one
That's still pretty big
So nah I'm good
More dinosaur videos!
Neat
❤
Nanobots? Nah, wetware nanobots!
Anybody seen “I Am Legend?”
wow
this might allow for full body and permanent genetic modifications.
This is incredible technology. I hope it gets vaccines to historically inaccessible places someday.
Don't we already have needles that small, like what they use for fertilisation? Can't they inject a sperm into an ovum?
Those are much larger cells. Bacteria are usually several times smaller than Eukaryotes
@@Demonic_Tang But he was talking about injecting into human immune cells.
Tldr: raw chicken cures cancer.
*sees title of video*
In vitro fertilization: *am I joke to you?*
As cells go eggs are huge though like yeah it's impressive
You sound like neil and hank
This tech is very very smart. I just don't understand why not to use some bacteria we already have as buddies in our bodies. We have dozens of those in our guts, noses, mouth... everywhere. Why not them?
Many of those bacteria would cause an infection if we don't attenuate them first. A lot of commensurate bacteria are "opportunistic pathogens", which are fine when balanced but alone cause disease.
If we have to attenuate it regardless, might as well use a bacteria that is easier to work with in the lab, like E. Coli.
I thought this was going to be about revolutionary tech, not CRISPR stuff we’ve been doing for decades…
Casually steals your mitochondria
"A Needle So Tiny It Injects Into A Single Cell"
Isn't that how IFV is done?
Eggs are by far the largest human cells. They're even visible to the naked human eye! Multiple times larger than the next largest human cell.
True, more specifically ICSI, a form of IVF, uses a needle to directly inject a sperm cell into an egg cell
John Travolta
So handsome ❤❤❤
Most bacteria are already "not infectious;" why not use one of them?
Because they don’t interfere with DNA 🧬 😅
Narashige of from by Japan has had microinjectors since the 1980s so this is nothing new.
This guys voice is going places for sure
We seemed to have not found retroviruses useful. This research is useful for researchers. Not for Joe Blow. Not for 40 years anyway.
İt's like GMOs for bacteria 😹 come on homosapiens you're really planning to own this world 😂
Dude sounds like an AI
Great potential for medicine ... and bioweapons ... and side effects ... and devastating bacterial mutations. I can't help but think and feel that the biotech I'm gonna see developed in my lifetime will have the potential for good, evil, and error that nuclear power did for past generations.
Wait a minute... Don't you belong on SciShow Space?
comment
Lot of comments here.
reply
you make a good point, can't believe they didn't mention that once in the video!
Like kill individual cancer cells
The antigens look like underpants
NEEDLES ARE BADD, AHHHHHH!!!!!!!
Not really but also I have a phobia of them so I feel this
@@baileyjerman5573 yeah I mean, they are good and I’m fine talking about them, but if I see one go into the skin I feel not good
That's how the " DARKSEEKERS " were created in " I AM LEGEND " We don't need that apocalypse!!!!
Virus needle