How Particle Accelerators Are Used to Cure Cancer - with Simon Jolly
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- čas přidán 1. 06. 2024
- Could particle accelerators like the Large Hadron Collider really help to cure cancer?
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An advanced form of radiotherapy, proton beam therapy enables tumours to be targeted with greater precision, reducing the collateral damage to surrounding healthy tissue. With two NHS proton beam centres set to open this year, physicist Simon Jolly sheds light on this cutting-edge technique and the technology needed to deliver it.
Watch the Q&A: • Q&A: How Particle Acce...
Simon Jolly is currently the leader of the UCL High Energy Physics proton therapy research group where his research focuses on high precision detectors for proton beam Quality Assurance to ensure the treatment is delivered safely. The NHS is building two proton therapy facilities in Manchester and London, to complement the existing ocular facility at the Clatterbridge Cancer Centre. He is also a member of the international AWAKE collaboration that is seeking to develop proton driven plasma wakefield accelerators. He is leading the development of the AWAKE spectrometer to measure the energy of these plasma accelerated electrons.
Simon has played American Football for Great Britain, captaining them in 1996, and also won national titles with Farnham in 1996, Oxford in 2001 and London in 2005. He also made a number of appearances on radio, television and at popular science events.
This talk and Q&A was filmed in the Ri on 12 October 2018.
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Thank you for posting this. I have cancer and have had two bouts of Radiotherapy and I am taking part in a drug trial of a new chemotherapy which I take in pill form everyday at home.
I love to watch documentaries and this is one of the best, most clear and beautifully delivered lectures I have ever seen.
Terrific stuff and understandable by most people.
Stay strong!
stay strong
I hope ypu're doing well, Kindle.
I just started chemo last week and radiation today. I found this excellent lecture after searching for the VMAT and IMRT machine made by Varian. The 50 second Varian video is informative, for being a shorty.
All the neato tech involved in those machines is amazing, and hopefully obsolete in a few more years.
I worked in Hospital years ago, and one day found me conducting an inventory in the Proton Room, as we called it.
Pretty much standard stuff, until I found a piece of 22k gold chain-mail!
It was used as a beam-stopper drape of sorts; put the material over parts you don't want zapped.
The links in this fabric were a bit bigger than 1mm in diameter, and beside the chain-link weave, there were tiny scales of gold worked into the mesh, covering the holes in the cloth.
Very much like an Edwardian metallic mesh purse, Whiting and Davis weave to be specific.
It weighed a little over 400 grams and was about 25cm on a side.
Part of the inventory process for this item was to take it to the Histology lab where it got weighed! Gotta make sure no one is shaving the thing...
Fabulous information; thank you.
All these kids in HS and college looking to get MBA's and be millionaires selling crap and being business magnets.....you want to be truly rich. Become a scientist, engineer, etc and help develop these technologies and become a modern day hero.
This was absolutely brilliant.
I got to meet Simon today and he's a legend. Lovely person.
Hurrah for experts, international expertise!! Admirable in every way!
video reply to those who wonder "Why LHC" when people are dying of cancer...
🎯😎👍
Curing cancer is nice and all, but it's nowhere near as important as Particle physics or Cosmology.
The most inspiring lecture I´ve watched.
Wonderful lecture, both content and style were top notch. Such a big contrast with the previous 2.
I am in Heidelberg in the Gantry right now with who guessed it, a embryonic rhabdomyosarcome like the young girl snowy.
I am blown away of how such complicated machines and research by thousands of absolute madmen try to save my life in an effort I cannot cope.
Thank you for this great video explaining the details!
Great presentation. Thanks, Simon, for putting your depth of knowledge across in an interesting and easily understandable way.
The best explanation of how particle accelerators work I have seen 👍
We need more of these!
Beautiful presentation
such an amazing video, it was breathtaking
He's an excellent teacher.
thanks for sharing!
Great talk, thank you
Brilliant speaker!
This is amazing. Go science!
Wow....how awesome is science?!
Well, nice to see an RI video about something I do. Though considering I usually watch these to try and keep up with real physics it feels kind of weird. Lol
Well this blew me away!
Me too dude !🎯 Science RocK ,,🤘
17:38 - Fucking brilliant, maybe cancer won't be so scary by the time I'm old enough to be high risk for it.
God Bless him and the children he saved and will saved. I needed a moral and charitable story, a true heroic story. thanks lord, and Dr. Simon Jolly. the world is less, messed up since you solved cancer. lord bless the sick children, praise the hero. Dr. Jolly.
That's a great presentation Dr. Jelly, thank you.
It's a shame that enlightening videos like this get only tens of thousands of views and useless ones get millions.
Why build one in the most expensive place in Britain? It'd be much cheaper to build it, and a hotel, above ground somewhere which would benefit from the investment , say South Wales or East Anglia. Much easier to move the patient - which begs another question: why not just move the patient instead of the beam ? perhaps use low energy x ray to locate the target marker as the patient is moved.
The first is an excellent question, which probably has more to do with politics than anything else.
However as to the second point there are a number of ways in which the patient is repositioned instead of the the beam. The trouble with moving the patient during the treatment is that they can become nauseated or move independently of the immobilization. So basically the gantry is to improve patient comfort and treatment accuracy, with the latter point probably being debatable.
@@Biga101011 yes he made this point in the q and a , but i wonder how much could be achieved with the patient in a chair rotating (and elevating) in front of a horizontal beam , and how this would differ from the rotating scanner.
@@wktodd I should probably watch the q and a sections. There was a doctor I formerly worked with, who will remain anonymous, that was really excited about that exact idea. I think they built a chair and started testing out how they could set people up to it. Apparently there where guidelines on how quickly treatment devices should rotate around patients to be considered safe, but none for how quickly patients could rotate.
In any case he was only the for a sort time and I don't think they ever came close to treating someone with it. It's a great idea though, and you are certainly in good company with thinking outside the box. Maybe we will see that one day.
regarding the first question, I think it is important to notice that the people that work and service this are highly skilled and it is much easier and cheaper to find these people in a big center. This centre most likely will be used (as it should) for a lot of research and not only treatment, so you kind need an Uni as well...
Not saying that's completely justified, but it kind of makes sense to build it in London and Manchester.
@@Cotonetefilmmaker You also don't want to move the patient far from their emotional support network. The best way to do that for as many patients as possible is to locate the treatment center near a large population center. Patients are not mechanical devices that can be shipped off to be fixed in a center located as a jobs project where the local populace can be trained quickly in repair procedures.
Any more Suzie Sheehy? 😊 She's awesome, very excellent presentation BTW , keep it up guys
18:45 Really? Isnt your margin about the same taking into account the breathing of the patient, and the fact that small changes in the contour of the patient (losing / gaining weight / rotation and breathing) is going to change how deep your peak is being deposited?
Also how much dose are you putting down in the spinal cord?
Scan the tumer with one single jet xray only to eliminate the timer directing just one x ray.
We have a particle accellerator like that in Austria, in the city where I live
Just for reference, 1GeV in calories is about 5 trillionth of a sandwich worth of energy.
That is the reason why some people are obese. 😉
The Medical accellerators remind me of particle weapon system I was working on in the 1990's we built a linear accelerator called a Radio Frequency Quadrupole, which is used in muon cancer treatment The Prototype flew into space as part of Bem Experiment Aboard Rocket (B.E.A.R.) It has pages on both the CERN and Smithsonian websties.
"Other than that Mrs. Lincoln, how was the play?"
I "see" what you did there.
Very informative video.
Science!!!
21:45 Looks great doesnt it?
Does your patient breath at all? That tumor would be moving up and down, and as you put your pencil beam down, are you hitting a part that has already been scanned by the beam and doubling dose - or are you going to miss a part of the tumor that is constantly breathing away from the beam and missing it?
When radiating tumors that move - you need to have a beam that - as evenly as possible - puts down dose across the path the tumor moves as the patient breaths.
Or fix that issue, but tracking the tumor up and down - or have the patient hold their breath as you treat them.
I'm due for surgery on tue 11th december, in 5 days..at Aintree hospital..I'm getting a permanent stoma . :( ....any chance you can try it on me?..
I'm taking an AP Biology course and I just took a test on cell division. Cancer is such a terrifying thing. All it takes is just one cancerous cell to ruin somebody's life... I greatly respect people like him who are working to eradicate such a disease.
Wow !⛑️
27:10 Why is the energy of collision double?
Because there are two energetic protons making each collision :)
I'm almost sure it's because 2 beams travel in opposite directions, then the beams cross over each other - 'shine through' each other and the particles collide head-on.
I'm almost sure.
The Trevor you are correct, that’s exactly why ;)
Because both particles are moving at high speed in opposite directions so the energy adds up. Two cars travelling at 60mph crash into each other from opposite directions the energy of the crash will be the same as one car travelling at 120mph into a brick wall
Timestamp (In Progress)
What is cancer? 00:00
Healing Method 08:00
how X-Ray generation work 10:38
The Bragg Peak 14:12
thanks for moving the cancer cells to death. curing the sick kids, make you Angel like. you have made humankind, progress forward. the world will be looking forward and futuristic.
as a matter of interest the bbc made a horizon programme titled ‘the 25 million pound cancer cure’ but it’s off the 30 day iplayer availability but might well be back
I don't understand why the proton beam, as it becomes slower, manages to do the most damage at the tumour site, when it will be at the slowest and least energetic.
I am guessing that as it becomes slower it means that body tissue stops it more easily, so radiation is more concentrated over a very small area rathe than whizzing straight through ……. I think
I always prayed for a day like this to when I will be able to get rid of cancer all thanks to dr gboya on CZcams for making that happen 😊...
What a terribly quiet audience! some half reasonable jokes in there :-)
I recall reading that the Ri use highly directional microphones that don't pick up a lot of extraneous noise (e. g. audience response), so that may be what causes the effect.
@@jonrutherford6852 Again, GREAT info ... even rational thought!
Why not rotate the patient?
It is a lot harder to move a patient with millimetre accuracy that it is a beam
19:42 Very bad comparison! WHO IN THEIR RIGHT MIND DOES THAT TREATMENT ANYMORE??? Of course we spin around the body fully, suppressing the entering / exiting dose at those vital organs. 70% dose on the heart ---- are you insane????
Its like comparing a horse to a sports car - compare a car to a car!
This is what ALL proton treatment facilities do. They are NOT up to date on their knowledge of radiotherapy treatments, because often, because of uncertainty and variation in patients, their need to expand margins to be as effective (because the peak dose is so narrow) often, on average, is the same as standard of care x ray therapies.
First!
"Dose deposition" sounds wrong. You're really implanting these protons and not depositing them. Maybe dose implantation is a better phrase?
29:55🤓 Where is Hydrogen?
Boron therapy
We can 3D print radiation burns now!
Nice to see...
A..science achievements moving into practical use to improve live...
B...that the NHS spends their money for something useful rather than spending it on drug and alcohol addicts recovery treatments people choose to throw their lives away wreaklessly.
wow the timing- Bush's funeral happening now- The youth's ideas have room to grow b/c we die. Evoluton is emergence flowin. I love this page a lot
Click-bait, and for those of you with cancer, well, Ha-Ha.
Give cancer a chance ( to cure human Ego )
Why not rotate the patient?