Diagnosis of serotonin syndrome

Pathophys: increase in serotonin at the synaptic cleft
Etiology: typically result of combining medications that increase serotonin
Signs / symptoms:
Neuromuscular excitability: myoclonus, hyperreflexia, tremor, seizure
Autonomic dysfunction: diaphoresis, hyperthermia, mydriasis, hemodynamic instability, n/v/d
Altered mental status: delirium, psychomotor agitation
Malignant hyperthermia has NO hyperreflexia
Differentiate from acute dystonia, which has oculogyric crisis and torticollis
Differentiate from neuroleptic malignant syndrome, which has lead-pipe rigidity

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