Steady state concentration and dosage regimens - Lect 15 - Pharmacology
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- čas přidán 21. 07. 2024
- Lecture 15: Steady state concentration, dosage regimens, loading dose, continuous infusions, and maintenance dose. These are lectures I gave on pharmacology and pharmacokinetics at University of California - Irvine School of Medicine.
Give a thumbs up and leave a comment. More to come thanks.
View the rest of my pharmacology videos below:
(1) Pharmacokinetics & ADME: • Pharmacokinetics for S...
DRUG ABSORPTION Videos:
(2) Drug Absorption Overview: • Absorption of Drugs - ...
(3) Bioavailability: • Drug Bioavailability O...
DRUG DISTRIBUTION Videos:
(4) Drug Distribution Overview: • Distribution - Pharmac...
(5) Volume of Distribution: • Volume of Distribution...
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DRUG METABOLISM Videos:
(6) First Pass Metabolism: • First Pass Metabolism ...
(7) Phase I Metabolism: • Phase I Metabolism - P...
(8) Phase II Metabolism: • Phase II Metabolism - ...
(9) First Order and Zero Order Kinetics: • First Order & Zero Ord...
(10) Drug Half-life: • Drug Half-life | An Ov...
(11) First-order elimination rate constant and half-life-details: • First Order Eliminatio...
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DRUG ELIMINATION / EXCRETION
(12) Drug Clearance: • Clearance and Rate of ...
(13) Renal Excretion of Drugs: • Renal Excretion of Dru...
(14) Ion Trapping: [Note Yet Posted]
(15) Dosage Regimens: • Steady state concentra...
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Factors That Affect Drug Metabolism:
(16) Enzyme Induction: • Enzyme Induction - Pha...
(17) Competitive Inhibition Overview: • Competitive Inhibition...
(18) Competitive Inhibition of Statins: • Competitive Inhibition...
(19) Acetaminophen toxicity (Clinical Correlate): • Acetaminophen or Tylen...
(20) Pharmacogenomics Overview: • Pharmacogenomics | Asi...
(21) Slow Acetylators - Pharmacogenomics: [not yet posted]
Help us caption & translate this video!
But where is lecture 14? I could not find it anywhere.
So happy you posted again ! You are a great teacher, please continue!
This video was very helpful, thanks!
Thanks for posting again!!!
For the MD ( maintenance dose ) , dont we neeed to take into account the time intervals in which the designated drug is given in order to calculate the dose rate ?
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These videos are FANTASTIC. Wonderfully helpful for my doctorate level pharmacology material!! Thank you so much!
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Thank god!! Hurrah a new vedios... I really REALLY admire the way u teach... So CLEARLY, PRECISELY, INDEPTH CONCEPTS IN UNDERSTANDABLE WAY!!!
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Is there even a video for ORAL dosage regimens (DIGOXIN) in particular; calculating steady state peaks and troughs and time to steady state. Using Ka (absorption RC) and K (elimination RC)? If not, someone please help me.
Well done...!
With respect to fluoxetine, it has a half-life of 5-7 days and is therefore eliminated between 25 - 35 days after the last dose. From this video it would take 25 - 35 days to reach steady-state concentration.
If the patient then starts taking 20 mg/day, does it take another 25 - 35 days to reach the next steady-state concentration? If not, what is the way of calculating that?
Also, there’s inflammation that after steady-state with fluoxetine, because of the long half-life, then dosing can occur every third day.
Good bless you
Thank you for the video. It was great! One small question though. When calculating volume of distribution, aren't we suppose to take the volume or weight of fluid which is 60% of total body weight 60% of 80 = 48 kg or 48 L than the body weight itself?
I think 60% of total body weight is total body water...
Here they have already given Vd in the unit of L/kg so you just need the total body weight for calculating Vd
very helpful thank you so much ^-^
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With fluoxetine that has a half-life of 5 days, why does the patient take it every day? It would seem the patient is given more drug than s/he can eliminate and the the plasma concentration will just continue increasing with each daily dose. What am I not understanding?
How come certain drugs can be loaded while others cannot
Sir,can you please upload the lecture 14 on ion trapping..It's missing
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Steady state should be 94% after 4 half lives and 97% after 5 half lives
Sir make many more videos as you can
Sir , Loading dose is always given as Iv ? Nd what about Maintenance dose,it will also be given as IV always or can be given as orally?
He said if IV is used we can use 1 as bioavailability, any route can be used but they have different bioavailability.
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I've understood all your previous videos very well and they were very helpful. But this video I just don't understand as well. Please bring back the previous teacher.
lol is the same person
4.32 half lives are required to achieve 95% ss
I understand that you want future doctors to know that 4 - 5 half-lives are required to reach steady-state, but I want to know why. Every video that I watch says the same thing without any explanation and it is extremely frustrating because I'd like to get the big picture rather than memorizing an arbitrary number.
nombla1111 yes yes and yes! I've been looking for a video like that I love learning conceptually