Gene Editing: How CRISPR Will Change EVERYTHING & Create Designer Babies
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- čas přidán 27. 08. 2024
- Patrick Bet-David explains why the FDA has officially approved CRISPR gene editing as a treatment for Sickle Cell Disease, marking a historic milestone in medical science. The science behind CRISPR-Cas9, a revolutionary gene-editing tool has transformed biomedical research. Understand how it can precisely alter DNA to correct genetic defects, potentially treating a range of illnesses. As CRISPR technology advances, so does the debate over its ethical use. PBD also discusses the controversial topic of designer babies, examining the moral implications and potential societal impacts of gene editing for non-therapeutic purposes.
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Patrick Bet-David is the founder and CEO of Valuetainment Media. He is the author of the #1 Wall Street Journal Bestseller “Your Next Five Moves” (Simon & Schuster) and a father of 2 boys and 2 girls. He currently resides in Ft. Lauderdale, Florida.
![BREAKTHROUGH: Scientists Reverse Blindness [CRISPR Technology]](http://i.ytimg.com/vi/rbVvu_104Pg/mqdefault.jpg)
It always starts with a good cause, then it devolves into vanity.
Such an underrated comment. (Edit: the comment was like 5 minutes old when I posted this one). It would completely revolutionize the plastic surgery industry, to include (if they could) transgender people.
@@kevinlucas9905…
This is the comment.
That’s a sin.Literally.
Then military technology. No public discourse, voting, or consent over era changing technology.
There are several scifi books that deal with designer babies. The author did make sure to note that most were only available to those who could afford it.
Which book specifically?
exactly! reminds me of the movie GATTACA. I can think of one book somewhat similar that I have, Upgrade by Blake Crouch.. haven't read it yet but will soon. What are some of the books you are referring to? I'd love to add some to my TBR! SciFi//Horror is truly horrifying!
@@ZukoTheShinigami The Octagonal Raven follows a character from one of the pre-select families that use nanites to enhance mental and physical traits. L. E. Modesitt Jr. I would have to go home and dig more to find the other scifi books. Heinlein has a few where there was gene manipulation.
@@the_eerie_faerie_tales Gattaca comes up if you Google about it, so I def need to go read it. The Octagonal Raven by L. E. Modesitt Jr. and just go browse Heinlein and similar authors. Anne McCaffrey's Petaybee series touched on a combination of gene manipulation by one family in conjunction with the planet actually altering the colonist DNA to adapt to it.
Gundam seed Anime has a whole story about this. Also, the film Gattaca is pretty good and talks about this issue.
Gundam seed Plot
The series is the first of the Gundam franchise set in the "Cosmic Era" in which humankind is divided between normal Earth dwelling humans, known as "Naturals", and the genetically altered super-humans known as "Coordinators". The primary conflict of the story plot derives from jealous hatred by Naturals of the abilities of Coordinators, leading to hate crimes, and eventually the emigration of almost all Coordinators who flee into space to live idyllic lives on giant orbital space colonies called PLANTS of their own design. War eventually breaks out between Earth and the PLANTS. The Earth is divided between two major factions, the Earth Forces formed from most of the natural born human nations, primarily the Eurasians and the Atlantic Federation, and a natural human supremacist group known as Blue Cosmos with its slogan, "For the preservation of our blue and pure world". The Earth Forces are not a unified alliance, and infighting and mistrust exist between their various nation states. The second major Earth nation is the Orb Union, a staunchly politically neutral and isolationist nation located on small Pacific Ocean islands ruled by a hereditary monarchy and still contains Coordinator citizens.
Gattaca Plot
In the "not-too-distant" future, eugenics is common. A genetic registry database uses biometrics to classify those so created as "valids" while those conceived naturally and more susceptible to genetic disorders are known as "in-valids". Genetic discrimination is illegal, but in practice genotype profiling is used to identify valids to qualify for professional employment while in-valids are relegated to menial jobs.
sounds good on the outside but messing with dna cant have a good outcome. billions of years of evolution and some scientist with maybe 20 years experience thinks he knows better... i dont think so
Counterpoint: We no longer allow natural selection to maintain functional genes; for the entirety of human history up until the last century certain genetic expressions were an automatic death sentence. One of the most obvious every day ones is hips for women - if your hips were too narrow, you would most likely die in childbirth. Now that we have safe C-sections women with narrow hips and men carrying that gene for narrow hips are able to put their genetics forward to the next generation. If it is possible to tweak the human genome to allow for hips wide enough to readily accommodate childbirth, that would be a reasonable use of gene editing software. Preventing certain genetic disorders, such as down syndrome would also be a reasonable use of this technology. Technology is neutral it is how mankind uses or abuses it that matters.
If we "evolved" over billions of years, then this is just removing the randomness of the process in order to "move us forward". If we were actual created however, then this may actually be messing with a design (any time it focuses on something other than fixing diseases and disorders, and potentially even if it does attempt to focus on those things)
Your point isn’t as good as you thought it was lmao
With respect, I do not believe we need the wisdom of billions of years of evolution to understand how two well-functioning and completely formed arms would generally be vastly more preferrable to the alternative. Or two well-functioning and completely formed eyes.
Errors in biology happen very frequently, and modern medicine has allowed an astronomically greater rise in fully functioning people with defects to remain well past their previous life expectancies. I do not loathe these people so much that I would not wish for them to at least have the opportunity at a life more to their liking, were the science and research at that point.
For example, seeing children born deaf or blind to some degree finally being able to more properly hear or see their parents through the assistance of electronic devices is, in my humble opinion, a net positive to denying them even the possibility in its entirety, because it would be "playing god".
Your grammar proves why maybe it’s not a bad idea.
I did a essay on this at uni. Its crazy to me the how powerful the people who have this technology could become
what's scary also is the DNA printers that the public will have at some point.
Yeah but cancer treatment still "doesnt exist". People keep dying and getting sicker and sicker
They already clone people without their consent
I just wanna get rid of ssa
Likewise, “Designer Babies.” Was the essay.
In life, I will forever be grateful for health, wealth and a great professional whose help has been great for my finances.
What’s most terrifying is the idea of humanity as a whole being at war with an enemy like AI and their gene edited clones
They only go to war for money! 😂😂😂
Truth
WW3 is gonna be wild
Na thats a rad idea for a movie. Give it to an AI to write the script. XD
@@vladimirpastukhov7538😂😂😂😂
I notice that most of the people actually discussing CRISPR in this context have no first-hand experience with using it, and don't realize how long it takes to actually implement a single base pair alteration (e.g. for a virus or bacteria being researched) using CRISPR on even a small number of cells. Aside from the fact that CRISPR technology is at least 15 years old (if we could somehow get "designer babies" from it we would have done so by now), the process of gene editing itself is nowhere near instantaneous (and there is no way to increase its speed, as this is largely subject to hard physical limitations on molecular transport) and therefore highly inconvenient as a method of broad genetic modification and used quite sparingly in research labs.
The FDA approval for HbS works only because in the vast majority of cases of sickle cell trait/disease the cause is a well-known *single* nucleotide/base pair mutation, and thus CRISPR is sufficient to make this single edit in utero/in vivo. It should also be noted that sickle cell trait (not full-blown disease) is protective against malaria, which is believed to be the reason why it has persisted in those whose ancestry is rooted in places where malaria is/was historically endemic, e.g. sub-Saharan Africa, the eastern Mediterranean/the Levant, and the Indian subcontinent. Nearly all other traits or diseases are nowhere near as simple and are often controlled by several genes of many base pairs (in some cases hundreds) each, and thus not practical or appropriate targets for CRISPR gene editing.
EDIT: The FDA-approved treatment involves the modification of a patient's own stem cells via CRISPR and then re-transfusion back into the patient. Note that the approval is for patients *12 years and older*, i.e. not babies or fetuses. Again, the reason why this works is probably because this is likely a single-nucleotide modification and therefore not a multi-gene edit (which prior research has shown to be problematic).
Any patients receiving this treatment will be monitored for years to come, for obvious reasons (the side effect profile includes immunosuppression), and as a result despite FDA approval I suspect that the number of patients actually receiving this treatment over the next decade will be relatively limited compared to the total number of people who have sickle cell disease/trait.
People need to keep in mind that the "designer baby" idea is ancient. The Spartans discarded babies that did not meet certain criteria. Every time a potentially-viable baby is aborted today, he/she is being sorted out of existence. It is immoral, but people and societies have been sorting babies for a very long time. Fortunately it does not appear that CRISPR will be a precision tool for this end.
The way you've explained it lessens the potential negative impact of it. I hope you're right.
Why do you say crispr only for editing single base? If it can edit one it can edit more than one right.
@@nigelbhebhe2805 Germline modifications via CRISPR were already attempted in China a decade ago (~2014/5), and the published results from those trials (which were failures in attempting to correct a mutation causing beta thalassemia and to make embryos HIV-resistant) specifically noted that CRISPR was not ready/sufficient for genome editing of the sort people are imagining right now.
EDIT: Reports also indicate that CRISPR-edited human cells have a high (~40%) risk of not being able to properly repair DNA damage (we sustain DNA damage all the time from things such as cosmic radiation, and our bodies are constantly repairing this damage), and thus have a dramatically-increased risk of developing cancer (i.e. accumulation of unrepaired mutations).
You could go to Mexico about 10’years ago and get genetically modified babies. They approved it here in the USA now but it’s a technology that has existed a long time. They also already can enhance humans they’ve done trials on actual adults with illness. Only 1 died. They definitely have the technology. I’m chronically ill and I have high hopes for it. I am very scared of the consequences though. The fact that they can also create something lethal is scary.
@@whitebroccoli694 No. Each enzyme used can only target a single sequence/nucleotide. If you want to target another sequence, you need to develop a new enzyme for the new sequence (which so far has taken years for each enzyme, not to mention the fact that we still haven't discovered the target sequences for most genes/diseases), and then run CRISPR again (depending on the number of cells you're trying to modify, a single CRISPR run can take days).
You can, however, use CRISPR to transplant entire sections or segments of sequences, if the section/segment is bound/capped on both ends by the same sequence.
I remember reading about this twenty years ago. There’s a book called Remaking Eden, already discussing how we were headed this way to the point where we will eventually have two separate species
I don't understand how people try to use fiction as valid support for reality.
@@KimChi-wz7mk Its called thinking through the possibilities and even though its fiction it is a possibility.
the thing is fiction has always been something that someway tured into reality for example phone was a fiction at one point in time at one point going to space was a fiction as well fiction and reality are connected the things that are fiction now might turn out to be reality at one point in time so there no saying fiction can be reality
How about lightsabers, or ships that can travel faster than the speed of light? Will those things become reality anytime soon?
@@Justajawnie I don't think you understand how logic works. A possibility is not support for facts.
Patrick, check out the 1997 film “Gattaca” (if you haven’t yet), starting Eathan Hawke, Uma Thurman, and Jude Law. Good story, and the director/writer pretty much summed up your monologue into a 1hr and 40min long flick that’s actually a pretty decent watch (definitely quality above what Hollywood peddles nowadays).
Amazing movie, may the truly human spirit triumph !
Great "movie"....lol . Hollywood prepped us all for this 😢
This video didn’t mention the most impactful dynamic that this tech will create. The dynamic of people with gene edited babies vs non-edited babies. It’ll be an arms race of sorts. I highly recommend for Pat to invite Jean Francois Gariepy to talk about this. JFG is also a commentator plus a former scientist at Yale and he can walk them through it all
Upvote and a reply so hopefully Pat or someone on the team will see this. I think you should X this to him, as well.
it will be all the rage for a few years then people will want and value non gmo organic super greens fed babies grown in high nutrient free range wombs
Pat please see this.
Eventually there will be two species that are unable to mate with each other
I hope he does!
There's a great Kurzgezagt video about this exact subject that came out a few years ago that gives the deets on the physiology and social impact. Good coverage PBD
I'm from South Africa and I remember my Life science(biology) teacher telling the same story when we were doing the {genetic engineering} topic and we all said he was telling lies, and now I'm shocked😅
I worked in a CRISPR lab. Doesn't go as quick as you think. Still too many variables we don't understand and off-target effects that make positive results coincidental
Studies have shown that women under 35 have success rates of around 20% per cycle with artificial insemination; however, this success rate decreases as women age. Women over 35 have success rates of approximately 10% per cycle, and women over 40 have success rates of around 5% per cycle.
Who is going to blow 200k per a go when you have a 80 to 95% failure rate.... Then look at how many of these children come out as expected...
So, you have a 80% chance of failure, then who knows what percentage actually develop as expected after birth...
I’d argue that the tech is much like computers back in the 1950’s and 1960’s. They were the size of a room and could only perform basic calculations. It wasn’t until the 1970’s that they shrunk down significantly and became more user friendly for the average person. Right now CRISPR is too clunky to perform complex genetic modifications and it isn’t very user friendly, but give the tech 10-20 years and a couple more breakthroughs and it will revolutionize the way we live.
Just because you work in a CRISPR lab doesn't mean you understand how the technology evolves on a societal scale. Discovering CRISPR was the hard part, scaling it is easy.
Hey i want to ask you something can crispr change skin color?
Hello, i wanna ask you something, could CRISPR Technology be a solution for clinefertel syndrome (47 xxy)?
I have Follicular Lymphoma, a slow growing cancer that is manageable but not curable. Doctors say it’s in my “Gene’s,” so this could be big help for me and others. There will always be bad stuff people do with different technologies, but don’t let fear keep us locked out from reaching our full potential as humans.
God didn’t give us wings, but gave us ability to fly. God didn’t give us 4 legs, but gave us dominion over animals. God didn’t give us, language, but gave us a tongue. God didn’t give us a house, but gave us the means to build it.
Have faith.
Mate, I am a medical scientist who has worked heavily in cancer diagnostics. I've lost a mother, father in law, an many friends to cancer which is a different beast to genetic diseases. Most FL express multiple mutations (around 4) unlike SC which is one. Single hereditary genetic mutations are the low hanging fruit using this type of tech. Its use in cancers are decades away. There is more promise in killer T cell-like therapies for leukemias and lymphomas. Have faith brother, 2 Corinthians 12:9, all will happen according to His will.
Good chance this industry lies about cancer being genetic. As cancer is down to cells being destroyed by shite diets and has increased over the year’s without cure then these people are using cancer to slip in this tech.
Personally this is going to happen whether we like it or not. Very similar to the internet, it is going to come down in cost to perform gene editing. If one country bans it, there will always be another country that allows it. It is good to raise awareness about the bad effects of this technology but banning it outright wouldn't be the solution and won't be successful.
Don’t think for one minute The baby factory that we saw from the WEF won’t be implementing this technology
💯
Those (franken)babies weren't (or wouldn't be, assuming they haven't yet tried this technique) even created from a sperm and egg cell. They're trying to create soulless humans.
Can’t wait first of all I won’t have to rip my vagina in half giving birth now I can make sure my babies don’t get my big nostrils and thick brain ? Amazing
Revelation 9:6
And in those days shall men seek death, and shall not find it and shall desire to die, and death shall flee from them.
Revelation 18:23
23 And the light of a candle shall shine no more at all in thee; and the voice of the bridegroom and of the bride shall be heard no more at all in thee: for thy merchants were the great men of the earth; for by thy sorceries were all nations deceived.
Sorceries ➡️ pharmakia ➡️ magic = mark of the Beast 🧬 abomination that causes desolation
Repent !!! Altering your DNA 🧬 will make you unredeemable. Because now you have transitioned to a post human state. Only humans are granted salvation. So be very careful on what you do.
Jesus Christ is the way, truth, and Life . Repent and call on Jesus.
We are coming to the End .. as it was in the days of Noah so also will it be in the coming of the son of man. Humans were altering 🧬 in those days too. Read genesis 6:4 KJV
Many Christians and believers and people that are worldly will take this abomination and be doomed.
pdf.cgg.org/T1613c.pdf
From the WEF? Do you mean Ectolife.
Citizens pay taxes to the goverment....who gives money to the college....who uses money to develop a product....that gets sold to the citizens.
Kinda feels like the citizens pay twice.
Now you’re catching on.
Government is good at fronting the money for the initial R&D since they don’t have to worry about turning a profit. The initial colonization of the new world and the first wave of satellites in orbit are a perfect example. There was no practical reason why anyone in the private sector would dare to fund these ventures since there was almost no chance for a return on investment to occur, but government, for better and for worse, doesn’t need to worry about that. It was only once these ventures were proven to be commercially viable that private enterprise stepped in and funded the operation (read the East India trading company or Boeing/United Launch Alliance).
Free healthcare?
My newborn great niece born in Colorado had a rare genetic disorder called SMA spinal muscular Atrophy. Similar to muscular dystrophy although some newborns die within the first year.They were able to use some new gene therapy to correct the bad gene. It was a $4 million dollar treatment with a team of 16 doctors. I suspect it was some form of Crispr although no one in my family is really able to explain to me exactly what the gene therapy was.
They are on their way to helping with a functional cure for type 1 diabetes as well
I have a similar condition and I don't think everyone understands the benefit it would give people like us! @@user-xf3cu4le5z
$4 million treatment
did it work?
@@user-xf3cu4le5zat what cost I wonder. And it may never show up before years later.
You went off the rails with this one, if your kids had genetic disorders you will do it in millisecond. This is a major breakthrough for human health. I agree that we should be careful but millions of people are suffering from genetic diseases
Millions of people don't have enough food, water and medicine either. It will be for the rich.
This will be for me regardless of the cost, and if it isn't sold/given to me and people like me, we will take it for ourselves.
@@b.shes.2643cringe, that’s what the poor people said and look at them now: still poor. The rich will never allow a peasant like you to join their community and benefits.
Millions have diseases caused by our toxic lifestyles, prior to conception, during gestation, and post birth. They call them "genetic" diseases but for most its only predisposition. The environment (on multiple levels) pulls the trigger. Genetics simply load the gun. Much truth out there by real experts, MDs, PhDs, you name it.
As just one example, look at what Dr Stephanie Seneff from MIT says about Glyphosate, what it does, and it's on vast majority of our food in the USA. Also what she says about vaccines. Quack? Or honest researcher whom the controlled fake news won't allow to be heard? Endless examples of these fyi.
@@slinkye254I totally agree with your comment, except from the timeline. I think this will be fully matured and available in less than 20 years, probably 15.
Everytime Pat says/insinuates/ something is "very weird" i get super intrigued and know it's gonna be a great segment!❤
I found a lucrative English teaching job online in China and it turns out I was working for the boss of a certain Chinese mafia. He had 8 kids: a girl, a boy, by his wife; twin boys by another woman; genetically-altered triplet boys by a third woman. He had so many children because the first sets of children weren't "good enough". He wanted a male to carry out his legacy. Two of the three triplets (and perhaps the third, as well) were violent little sociopaths, just like daddy wanted. I say this because the kids were in a bizarrely strict study schedule (they basically wanted them in structured learning 24/7) and when the eldest boy just wanted a few minutes away to play with legos, his father immediately saw that on the app that had all the house cameras and kicked the boy into a fetal position. He leaves the room and then two of the three triplets come and kick their (barely) older brother in the back as well. When I saw this, stabilized the situation, then went to the bathroom and ended up crying (for less time than it takes to go to the bathroom), and then got fired for not continuing to discipline the eldest.
this is crazy. you should submit this story to a news paper with some evidence
@@samuraijosh1595 Triads have reach.
I've been following CRISPR for years and I'm all for it. They need to use it as a cure for the autism epidemic, in particular. That's not playing God, that's helping the less fortunate like a good Christian.
Always enjoy your content PBD
TY Pat for covering CRISPR! Are you a fan of / excited for future longevity health technology?
You need to interview Dr. David Martin to discuss this topic.
I’m visually impaired legally blind
Gene therapy seems to be some hope
But gene editing is not a joke
If a minor thing goes wrong in the editing it mess up the person life
We can end up creating a race of super geniuses !!!
One of my favorite movies, Gattaca, is based on in this. How the world becomes divided between designer humans and natural humans
@Valuetainment Happy to connect with your team and discuss
Designer babies will not happen any time soon. But curing diseases and potentially cancer absolutely. I think by 2030 we will have a couple of approved CRISPR therapies. First cancer treated probably comes in by 2030 I suspect. CRISPR technology is for real, and I've covered the companies in this space for years now. Welcome to the CRISPR community.🧬
It’s happening now.
Can you respond to Jerry's claim ?
He's talking about the report from China. China imprisoned the scientist who was found to do something like this. CRISPR edits from therapeutics do not modify the germline, so even if you are cured from SCD, you still can pass it on to your children.@@mml3140
The designer baby has already been done by the Chinese Scientist. So you statement “will not happen any time soon” is a false statement. Do not under estimate the pace of technological advancement. I think you are thinking way too linearly instead of exponentially.
All roads to Hell are paved with good intentions
This will be no different
Why?
I would love to go to hell. Hopefully there is a god and send me to hell. 😊😅❤
I’m 34.. when I was in like 6 grade AT SCHOOL here in America our teachers made us watch this video on basically designing yourbaby. To be smarter, athletic, eye color hair color etc. the documentary we watched was as if it was already being done. This was over 15 years ago. I would not be surprised if they were preprogramming of some sort
They talk about visible characteristics like eye color or something and then they secretly modify things like willpower and integrity
I'm thinking the Pope was the first crispr baby
We can’t modify things like that because we don’t know what gene combinations factor into personality. It’s also known that at least 40% of a person’s personality is formed through life experiences so gene editing won’t change too much on that front. Phenotype editing like eye color, height, etc is easier to modify since we already have a rough idea of which genes control for them.
Besides, I think it would be in the best interest of insurance companies and other organizations to help people for the simple reason that they want you to work for as long as possible without you having to use their services. The majority of a person’s medical expenses occur near the end of their lives, so these companies have an enormous incentive to make you as healthy as possible for as long as possible because it’s more money in their pockets and less being payed out to hospitals and drug companies
You should interview the main leaders in this industry to talk about the latest research and where they are heading. Netflix Unnatural selection documentary was the open door to the public to understand the timeline of all of these advances. Please do the same.
Gattaca! If you haven’t seen it, please do. Thats exactly how I see this playing out.
I loved Gattica. I see it playing out as well.
The gene editing stock to watch include: CRSP, NTLA, EDIT, VRTX, etc.
I am a PhD student and in Fall 2023, one of the questions in final semester exam was on applications of CRISPR in management of bacterial disease . Its a good technology if you study it
DNA editing companies and AI tech companies are the internet and social media of the early 90s-2000s.
Damn near will be bigger
@@sagefromthe6551 It would be God
AI is more like the natural conclusion of the internet revolution, much like how the jet engine eases for aviation. There have been more advancements since then, but few seemed to have really had an impact on civilian life after this point. AI, in my opinion, will be the last major breakthrough from Silicon Valley.
Gene editing on the other hand is more like the personal computer in the 1970’s prior to Apple getting their hands on the tech from IBM. Apple was able to make the product cheaper and more user friendly for everyone. Gene editing tech is more or less ready for public use, but it doesn’t have the proper user interface to make it practical yet
It only is speeding us to the END of all. Super bad aay....@@LDM_podcas
Advancements in science and technology are always good when treated responsibly.
Meaning when a small group of people control it... That is essentially what you are saying....
Thank god this is finally making it to bigger audiences…
As a parent of a child who lives with SCD and its devastations I'm excited for this therapy to cure genetic conditions.
And why would the pharmaceutical industry want to give anyone a "cure"? And lose money? Not likely.
You'll be more excited to see the price of the therapy at 1million+ dollars
No one ponders why GOD'S Wrath will be unleashed upon the Earth.
This is exactly why.
Ever since the Fallen ones past forbidden knowledge unto mankind,
humanity has taken it upon themselves to re design what GOD has
already made perfect.
But...I Digress !!!!
God would of come down ages ago if he was real the worlds all kind of sick
This is evidence of just how vanity obsessed or vain mankind is…
Nothing wrong with it
As someone with CIRS… I hope that they can figure out how to modify the HLA-DR gene to save us from constant suffering.
If you believe in god it seems unclear why this process would be “playing god”. If god has created you and your potential god gave you this ability.
So your not playing god, you are using the capabilities god has bestowed upon the people.
We are definitely headed to “create a character” in real life.
Hitler will be laughing his ass off with the results. An Aryan race just how he wanted it...
“As it was in the days of Noah, so it will be at the coming of the Son of Man. For in the days before the flood, people were eating and drinking, marrying and giving in marriage, up to the day Noah entered the ark;”
Matthew 24:37-38 NIV
People forget that the reason for the flood was the corruption of DNA.
“The Nephilim were on the earth in those days-and also afterward-when the sons of God went to the daughters of humans and had children by them. They were the heroes of old, men of renown. The Lord saw how great the wickedness of the human race had become on the earth, and that every inclination of the thoughts of the human heart was only evil all the time. The Lord regretted that he had made human beings on the earth, and his heart was deeply troubled. So the Lord said, “I will wipe from the face of the earth the human race I have created-and with them the animals, the birds and the creatures that move along the ground-for I regret that I have made them.””
Genesis 6:4-7 NIV
@travelrs1491 great nugget of information!
Gene editting should ONLY be about medical issues NEVER commercial use. This type of science needs to be nationalized to restrict misuse.
what's most important is to know that overexpression of CAS9 causes defects in the chromosomes...
And cancer
@@plaiche indeed cancer. what most don't realise is that defective chromosomes = no babies, opening the way for integration with Ai - cyborg humans. I foresee this happening, followed by the event that the majority won't see coming...the quickening! sending out the love ❤️
They've been wanting this for a century, Patrick. Have your ever read Brave New World by Aldous Huxley? It's eugenics.
You’re committing eugenics when you chose a mate to have sex with and reject the other because they’re not good looking enough. Get off the high horse.
Love videos like this. I send one to my family and friends and boom! I got PBD in their algorithm. 😊
🎞 Funny how he didn’t mention 'Gattaca' (1997), the quintessential film about a genetic dystopia.
📺 But I would like to add the two 'The Outer Limits' episodes, 'Unnatural Selection' starring Alan Ruck and its sequel, 'Criminal Nature' starring Gary Cole, also delve into the topic.
Fun fact in the early 00's Gundam Series had a story that revolved around teenagers getting caught on a space war between Modified and Natural Humans and how they subtly tackled of gene modified humans (coordinators) and the general reaction of the majority(naturals) how it severely causes unfair situations for people who honed their skills and abilities only to be outdone by modified geniuses which is decades younger than them; Which in term caused a very deep hatred towards these modified humans causing decades of chaos and bloodshed. The two that broke the camel's back for the coordinators was when Coordinator Jesus got brutally murdered causing most to flee on multiple artificial space cities He single-handedly made and a Nuclear bomb was sent by the world government struck one of these innocent cities. It may be "Anime" but damn......
TLDR: future war started between natural born humans and genetically modified humans (coordinators).
Protagonist is secretly coordinator with no choice but to fight for Earth "Army"
This was literally pure fiction back then, never expect for this to be slowly becoming a reality.....
So yeah if this becomes normalized then expect some people literally gonna abuse this......
The sad part is, as much good as could come out from this...we all know they'll use it for the most horrific government mandates imaginable.
This technology is amazing. I'm glad you're sharing this tech. It will absolutely change the world in ways we've never seen before. AI is getting all the hype, but this is an equally if not more amazing technology.
imagine if they use AI in this field who knows what could happen
AI is already being used for genetic engineering
This is satanic.
This is more important than AI. Suffering will decrease significantly.
you think so ? look at how mrna worked ??@@CaliDraco
Problem is we just don’t know enough of the longer term effects and the “epigenetics” of what happens when we do this and then pass those modified genes down to offspring
A.I. Is already kicking this into high gear. Companies like Ginkgo Bioworks are using Crisper and many other editing tools like Alpha Fold 2 A.I. This Tech is going to move fast in the next few years.
"Can you imagine if you can do that!?"
You can do that today Pat - if your partner is taller, darker, skinnier, etc. Your child is more likely to inherit those genes.
My question for you is what % are you comfortable with. My challenge is taking the randomness out of it actuallly endangers humans because we may all become too similar
Is there a danger in being too similar?
A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution
Book by Jennifer Doudna and Samuel H. Sternberg
Great read, easy to understand for non microbio students/people (though it helps).
My biggest colony is a Duchenne study. I have been here 17 years. This group is not one bit closer.
I learned about biohacking in 2011. I graduated high school shortly after writing my capstone on the gene editing capability and ethics. I went on to get my bachelors in biomedical engineering technology. This is something that is very close to me. 90 percent of my family suffer from type 1 diabetes, a genetic disease that can be eradicated with the CRISPR method. We’ve had the capability to eradicate all genetic diseases for almost a decade. University of Pennsylvania has recently published there study The playing god argument has prevented us from preventing millions of genetic diseases and disorders. I am an ordained minister and don’t want to dismiss the religious concerns. I truly believe we can pass legislature to only use the technology for genetic diseases and disorders. God loves his children and us finding a way to prevent human suffering is not playing god, it’s helping our fellow man.
It would be messed up if A.I decides to create a new entity. Something we could never imagine
Or bring back the Niphillim 😢
@@LuxuryArchived that's the vibe im geting. I think the A.i. has us setting up a system to control us. Now it can modify us.
@@LuxuryArchived Hell starts at mars, we need the doom Guy
Forget about designer babies, I want to edit my genes NOW at 47.
This is an active discussion in which ethically, CRISPR and other even more advanced gene editing biotechnology can only be applied to somatic cells (cells which can’t be passed down to future generations) vs Germ line cells (cells which can be passed down to future generations like eye color, height etc).
In case someone at Valuetainment sees this, I would like to make a suggestion about your 2nd camera angle. The side profile looks weird and it loses audience engagement. It's much better to stack the two cameras next to each other, one being a WS & the other a CU
Can't believe i just heard Patrick explaining me the technique i am learning of in school😂
My son has Duchenne Muscular Dystrophy. This gives me some hope for him.
Your videos are always the best. Thank you! Happy holidays!
Most of the cannabis sold in dispensaries has been edited with crisper tech to reach such high thc levels and is totally unlabeled here in Canada.
You can pick any development topic.. literally anything, and bring out the ugly. Internet, AI, transportation, ect.
You can definitely tell this was narrated by someone who has no first hand experience of a loved one suffering from one of the handful of horrific terminal genetic diseases where the number one cause of death is actually suicide due to the outlook and affect on daily life.
This will enable people even further into their poor habits. Genetics load the gun, but diet and lifestyle pulls the trigger.
Doctors need to tell you to cut out alcohol, drugs, processed foods, add clean organic foods, exercise daily and many of these issues would go away.
That won't happen because The FDA ( Food and Drug Administration) work together to make eachother profitable.
They can't stop me from goung to Turkey or something 😂
Let’s give them time to get things right ❤ For those who lost and missed out on life . Those with second chances will definitely make a change in society
Can you do a quick talk on multi level marketing?
Make designer babies and no cure for cancer!? This world is so F'd up...
This might be the cure for cancer….for future generation tho
Funny.. I was just listening now to Walter Isaacson who shadowed the creator of crisp and wrote a book about it all... get him on as a guest
Everybody into this topic should read the book “Change Agent” by Daniel Suarez. It’s fiction, but go read the synopsis. It’s insane. He’s way ahead of his time with the things he writes about and he writes them in a way where they could totally come true and some already have.
Since our world currently seems to directed by multiple movie scripts, I’m gonna presume that this is how the Resident Evil script gets started. The zombie apocalypse is just over the next hill now.
The movie Gattaca predicted this
Was looking for this comment. I said the same thing. No doubt it will divide society just like in the movie. Bc people like me will have kids the natural way.
Brave New World was first.
Remember when Crisper was a good a snack, the good old days, how we miss you
Difference between Crispr/biological and nuclear weapons is most cannot get weapons grade nuclear material like uranium or plutonium but Crispr is a smallish machine controlled by a AI programme that would be infinitely easier to get your hands on.
Bro We did Gene editing since like 7 years ago I've become skilled in this this is old tech by now .
The people playing God are going to cause a lot of damage with that tech.
U mean playing with what God gave us? Technology is the natural evolution of nature. If anything, God started this all.
@@cybrdelic
It will be weaponized. When that weapon grows beyond the control of the Malthusians that deployed it we'll all pay the price for their folly.
@travelrs1491 when did it become unnatural? When life first spouted on this planet? When we discovered fire? When we made the internet? We've been on this path since the moment God, or whatever u believe in, put us here - no matter how you look at it. Technology is as natural as anything else. We went from single celled organisms, to complex organisms, to organisms with brains , to organisms with big frontal lobes, to technology. How can it not be natural if it's operating by the laws of nature? And it's also been provided by nature.
This is something that should not be rolled out without consent from the public. I am tired of invasive technologies.
# ElderMaxonWasn'tWrong
Do you know what the average IQ of the “public” is? Why do you think dim-witted people should be given the power to make decisions that steer the course of human history? Do you think they are even remotely educated enough? Do you think they remotely think rationally enough?
Fertility doctors no longer transfer more than 2 embryos, most commonly 1 at a time. The statement of having 3 children at the time same is not factual. This is because of chromosomal tests done prior, which increase the chance of implantation and only embryos with high chance of implantation get transferred. Many doctors will not transfer chromosomaly incorrect embryos. More than 1 baby is a risk to the mother and baby, and it’s considered unethical to bring that risk.
Designer babies aren't as simple as picking from a menu and you get those traits. Epigenetics matters at least as much as genetics. Epigenetics: "the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself."
This is a fallacy that a lot of people have - genetics is not a blueprint, it's a recipe. Different environmental factors can cause completely different outcomes with the same genes.
And we haven't even touched on how the child is raised. Nature vs nurture.
We now control both the environment and the genes. It’s a no brainer. People keep using “the environment” as if it is a variable that we can’t control and will throw a complete wrench into gene editing. No.
Is this the process where they send a cancer patient's bone marrow to the lab to be "trained" to go after the particular cancer the patient is fighting and then the marrow is reinstalled into the patient?
Let's not forget the movie Gattaca
Very underrated movie. That is exactly where we are heading
Getting flashbacks to Power Ranger’s TimeForce…and Gundam Seed; coordinators (designer babies) vs the naturals
correction: That leaves 40% the 21% are part of the 60% that showed positive response to the treatment.
Transhumanism. I've been thinking a lot about this for a long time. And somepeople will have purple skin. Purple eyes and grow gills.
I'm glad I'm old. It's hard to keep pace with this advancing technology that I hardly understand. I won't be around to see designer humans and the effects of this science fiction, for the good and for the bad. The idea of editing out severe disease sounds really good but what's the flip side? Is there a flip side? Who knows? Good luck humans
Or maybe lots of people won't suffer horribly. A lot of us alive today are suffering seriously because we have genetic mutations that cannot be fixed and it is a lifelong sentence. All tools can be used for good or bad. We should not shun things for good because bad can try to use it too.
I have been doing this for 7 years not always successfully and because I'm doing it on my own independently Gaining access to equipment and funds has been difficult but this has more potential than just about anything I have ever studied And if Americans don't participate in this for whatever reason all the other countries will and the possibilities are endless
If this technology can be used on people who are already born, this could revolutionize the cosmetic surgery industry. Instead of going under the knife for a rhinoplasty, just use CRISPR to change your nose. Going bald? Use Crispr. Crooked teeth? Use Crispr. Short legs? Love handles? Small calves? Turkey neck? Small chest? Weak jawline? Ingrown toenails? Low arches? Droopy eyelids? Excessive body hair? Just use Crispr. Also, maybe Crispr could replace steroids. Yes, this is all an oversimplification, but still fun to imagine it for good outcomes.
They have done it for decades if they are telling you .
As Tucker said, This isn’t a fight for politics. This is a religious fight. Those who believe in god and those who believe they are god.
If JCDenton is capitalized, I'm pretty sure God should be capitalized.
Of course it's exciting and has more potential for good it's very ahead if it's time so we naturally fear the risks of it because we don't understand it enough, but yeah as a way for having an advantage militarily then obviously it is of course useful, besides that there are many cool things it can be as long as people work to mitigate the risks of it that's important and cannot be overlooked, it is somewhat questionable like what would be considered competition if the genes can be selected everyone can play the piano everyone can be made to run fast the risk would then be everyone and everything being exactly the same or something like that and that's risky but it is cool to think of being able to personally customize your body new sports will be created or is it all a means to an end, when automobiles came into existence people felt the same way about these things though so and I ultimately feel that just because we can do something doesn't mean we should and there are many examples today of this tread carefully with this tech and consider all problems
You should've covered crispr a long time ago. Good job
As someone who works with this technology, CRISPR is another tool. How you use it is the important part.
We are definitely living in the end times
It's the mark. Our DNA is signed by the hand of God.
Both of you need enlightenment.
Gattaca (1997) starring Ethan Hawke and Uma Thurman written and directed by Andrew Niccol (who wrote and directed Lord of War)
Stock symbol is CRSP :us should be a great stock to buy and hold long term. This is just the start of many cures. Should be worth 200$ a share. Very undervalued.