Applying a closed, modular, semi automated system to CAR T cell therapy manufacturing

Presented By:
Yongchang Ji, PhD.
Speaker Biography:
Yongchang Ji, PhD. is a process development manager in the Cell and Gene Therapy Group at Thermo Fisher Scientific in Carlsbad, CA. Yongchang currently working on development of closed, modular and semi-automatic workflow solutions for viral and non-viral cell therapy. Dr. Ji received his Ph.D. in Cell Biology and Anatomy from SUNY Upstate Medical University, NY and his undergraduate degree from Xiamen University, China.
Webinar:
Applying a closed, modular, semi-automated system to CAR T cell therapy manufacturing
Webinar Abstract:
Cell-based chimeric antigen receptor (CAR) T cell therapies have rapidly advanced in recent years, with a variety of targets in clinical research and several FDA approved products already on the market. There has been tremendous effort to make CAR T cells more effective, safe, and persistent when treating patients. On the manufacturing side, however, errors, lot-to-lot variation, and contamination can be associated with open processes and manual handling of CAR T cells. In this talk, we will discuss a closed cell therapy manufacturing workflow developed by Thermo Fisher Scientific. This GMP compliant, semi-automated manufacturing platform, which when used in combination with Gibco™ Cell Therapy System™ (CTS™) reagents, protocols, and analytics, can result in efficient, consistent, regulatory-compliant manufacture of CAR T cell product. Taken together with instrument modularity, digital connectivity, and cGMP compatibility, the manufacturing of therapeutic CAR T cells using this workflow will help enable a lower rate of contamination, less product failure, and higher product consistency. Please join us to learn more about various solutions that Thermo Fisher Scientific can offer to support customers who plan to manufacture of CAR T cells for clinical use.
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