HRT Reduces Heart Risk When Given EARLY in Menopause - Clinical Trial
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- čas přidán 25. 07. 2024
- The 2016 Early vs. Late Intervention Trial with Estradiol (ELITE) looked at women given estradiol early in menopause (less than 6 years) and late in menopause (over 10 years). This video explains the results of that randomized clinical trial.
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Here’s a link to read the clinical trial results:
www.nejm.org/doi/full/10.1056...
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Thanks Steve, can you post a link for this stub please?
@homaw Thanks for the reminder. I remembered after I posted that I neglected to include that link. www.nejm.org/doi/full/10.1056/nejmoa1505241
Thanks for sharing this. Great info!
You’re so welcome!
Love your videos. You always have great information! I’m 63 y.o. Been menopausal about 11 yrs now. Kaiser refuses to RX HRT they say I’m too old and high risk of breast cancer, blood clots and heart disease due to my arteries and vessels are aged, and hx of migraines makes more of risk for blood clots. I’m not overweight just elevated cholesterol and do have hx of migraines for yrs now.
Thanks, always love your work. How about hormones in creams?
@cf9250 You’re so welcome. Ahhh . . . your second question is a lot more involved. Hormones in creams are almost always completely different than hormones taken orally. Every dosage form has its advantages and drawbacks. The next trial I plan to cover involved estradiol transdermal patches.
My sister is 62. Unfortunately this year she’s had two surgeries on both the large arteries in her neck. They were 95% blocked. Not only has she not been on any hormones, but she’s a sugar refined carb eater. In other words, she’s not the best eater. I worry about her because her MRI has already shown she’s had three mini strokes. She said she’s going to change her ways before it’s too late.
I am 80yo and was taking estratest until about 4 years ago when my doctor won't prescribe any longer. I have really gotten fatter and weaker and no endurance. Where can I get these hormones to start taking again??
Thank you for this info! What was the dose of estradiol they used?
@adriapeet3943 They used estradiol 1MG for all hormone patients. I didn’t see anything about whether they asked patients about symptoms.
I apply estrogen and progesterone at low level since many years ( quantity for a day lasts for 4 days), then I tried to increase the quantities a little bit and my pulse got higher and because of that -I think- my insomnia got worse (I have no uterus). Does that mean what I already apply is enough?
I wish you would say the percentage of estradiol is needed to make a difference. I have the .025% patch and wonder if it’s strong enough.
Are there studies for estradiol patch?
@seven471 Yes . . . but the evidence is not nearly as strong about estradiol patches improving cardiovascular risk. I’m planning another video about the KEEPS study, which used transdermal estradiol.
Yes, absolutely patches help in the same way if not better as oral increases blood clot risk, hence heart ....transdermal does not and absolutely helps our hearts by unclogging arteries and making them more supple.
@@pamw3238 I'm sorry, I strongly do not agree. I am a major hormone provider in Central Florida and I have a Masters Degree from the University of South Florida in Metabolic and Nutritional Medicine. To my (very well read) knowledge, there does not exist a study on the planet that in a prospective manner has ever shown that Oral Estradiol increases the risk of blood clots. Now if you want to talk about Premarin and Provera, well, then I will agree 100%. But in terms of estradiol, there is no research showing an increased risk of blood clots
In addition, transdermal or pellet therapy does not affords the same cardiac protection. Estradiol taken orally increases estradiol esters and those little guys are like lubrication on the artery wall. E2 Esters reduce dangerous cholesterol accumulation against the vessel wall and thus directly reduces the build up of plaque. Transdermal estradiol does not go thru the liver, does not produce substantial esters and therefore does not give the same degree of cardiac protection. both oral and transdermal reduce the risk of clot formation in advanced disease, but only oral E2 reduces plaque build up
Hi, Steve, why do I keep hearing some hormone doctors said that the oral route estradiol may carry the risk of blood clot. Is it true with some scientific evidences?
I value your research. Thank you for the information.❤️
Oral estradiol? I read from more than one source that estrogens should not be taken by mouth anymore. Hasn't it been well known since the 1960's that oral estrogen increases the risk of clotting and can cause heart attacks or strokes (hence the Nurses' Health Study)? Who still prescribes oral estrogens? Are there exceptions to the general rule? I'm confused.
@jackidalseme3138 That’s an excellent question. YES! There are providers who still prescribe oral estradiol. There’s definitely a perspective that says, “estrogens should never be taken by mouth.” But it’s not that simple. There are major advantages to oral estradiol. The evidence that estradiol increases blood clots is actually not that strong. I want to post a whole video about estradiol and blood clots. Still need to do more research though.