#67 - Limitations to VO2 max with Professor Jose Calbet
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- čas přidán 5. 08. 2024
- Dr Glenn McConell chats with Professor José Calbet from the University of Las Palmas de Gran, Canary Islands, Spain. José has a very strong research record and is a global leader in his field. He has done amazing invasive exercise studies in humans to determine the limiting factor(s) to VO2 max. We talked about what is VO2 max, the factors determining VO2 max, the limits to VO2 max, the effects of VO2 max on exercise performance, pseudoanemia, VO2 max in females, VO2 max in masters athletes etc. In general he is finding the oxygen delivery is the main limiting factor to VO2 max. A very interesting, long chat. Twitter: @GRHEFS_ULPGC
0:00. Introduction and how José got into exercise research
4:55. Links with Bengt Saltin and University of Copenhagen
9:12. What is VO2 max?
10:59. Cardiac output and blood pressure
14:15. Blood pressure can drop near VO2 max
15:30. Maximum heart rate/ stroke volume
17:50. Submaximal exercise in trained vs untrained
19:06. Oxygen extraction during exercise
24:40. Main limiting factor to VO2 max
27:41. Capillaries and muscle mitochondria
30:31. Hemoglobin concentration and oxygen delivery
32:40. Athletes limited by oxygen delivery/temptation of EPO
34:35. VO2 max in women: lower hemoglobin
38:19. Pseudoanemia in endurance athletes
45:42. How does high Hb mass improve submax performance?
49:42. Role of genetics and ex training in VO2 max
56:18. Responders and non responded to exercise training?
58:50. Blood flow restraint to maintain blood pressure
1:05:35. Masters athletes vs young untrained
1:12:43. Ex training can slow the decease in max HR with age
1:17:51. Does life long exercise slow the reduction in VO2 max?
1:21:19. Loss of mitochondria with age vs inactivity
1:24:40. David Costill. 70 ml/kg/min VO2 max enough?
1:31:50. Sex differences in metabolism during exercise
1:36:00. How does creatine supplementation reduce VO2 max?
1:37:29. How know how close to VO2 max potential you are at?
1:42:38. Hyperthermia, ventilation and blood flow
1:45:41. Can increase VO2 max by giving vasodilators?
1:48:05. Hypoxia doesn’t increase VO2 max
1:49:44. Takeaway messages
1:50:40. VO2 max and life expectancy
1:53:00. José feels lucky/Bengt Saltin/University of Copenhagen
1:54:32. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (link.springer.com/book/10.100....
Connect with Inside Exercise and Glenn McConell at:
Twitter: @Inside_exercise and @GlennMcConell1
Instagram: insideexercise
Facebook: Glenn McConell
LinkedIn: Glenn McConell / glenn-mcconell-83475460
ResearchGate: Glenn McConell
Email: glenn.mcconell@gmail.com
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Not medical advice - Věda a technologie
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The take home message is....
Be active, avoid being sedentary at all costs.
So if you are going listen to this upload, do so by being active.
Thank you for uploading and sharing.
That episode was a banger. :-D
Very interesting, my favourite interview you have done - please keep them coming. I also discovered your chapters so one can dip into certain topics which is very useful too. Thanks for doing these.
Great to hear you liked this one so much. Jose is great!
Good to hear the time stamps/chapters are useful for you too.
My pleasure. I love talking with all these experts so I plan to keep it up 👍
Thanks!
great insights
This was awesome! Both of you are legends!
If VO2max depends on body weight (ml/min/kg) I'd expect that creatine supplementation decreases VO2max alone by the fact that bodyweight increases.
Bodyweight only increases with creatine supplementation due to increaser cellular hydration. Vo2 max will only decrease with higher body weight if the extra weight is due to muscle mass or body fat. This is because muscle and fat have blood vessels which will use more oxygen. The extra water from creatine obviously is just water, it's not metabolically active therefore won't impact vo2 max.
What do you think of Muscle Oxygen Measurement products, like the MOXY product, as a reliable way to measure and monitor muscle oxygenation during training and racing?
Nice to know what percentage of VO2 we should be training for longevity and is it a pace or HR.
It also depends greatly on whether you prefer easy workouts, HIT, or SIT.
@@PerryScanlon don't they say HIIT gives the most bang for your bucks but I do race marathons so it's intervals and the long runs I do.
@@alanshrimpton6787 maybe for stroke volume. For skeletal muscle adaptations the Gillen/Gibala 3 x 20 sec protocol has impressive results. But for long distance races it seems that volume is most important.
Very interesting stuff, especially hearing percentages of oxygen extraction. Regarding current EPO in sports, I did a lot of sleuthing into the science and policies over last winter and spring. I'll see if CZcams lets me post a link...
The link wasn't allowed. In short the newest WADA EPO document references the 2021 Laurent Martin paper which extends detection window of microdosing to 48 to 72 hours, but this requires out-of-competition testing that surprises the athletes. A 2011 review paper said it was only 12 to 18 hours. The biological passport document unfortunately does not reference the improved biomarkers in the Holly Cox 2021 paper which can use dried blood spots (no refrigeration and longer time for transport) or other proposed biomarkers.
Related: WADA developed improved tests for AICAR in research papers, but they are not mentioned in the technical documents, so the tests are not required, and a positive test may not hold up in court because there's no decision limit in the threshold document.
On a positive note, boron supplementation appears to increase free testosterone by a similar amount as microdosing to a point that is on the threshold of detection.
@@PerryScanlon Thanks. Not sure I totally follow what you are saying.
@@PerryScanlon Thanks. Glad you liked the podcast. Not sure I totally follow what you are saying re detecting microdosing. Didn’t realise AICAR was being used by athletes and is banned. And why is boron positive news?
@@insideexercise it means you're right that EPO is not just a thing of the past, but that might change if the ABP includes more biomarkers proposed in the scientific papers.
Unfortunately I think the podcast failed to address big issue: vo2 max vs strength/endurance. So if you didn't even know that vo2 max existed, wouldn't simply measuring your strength and endurance be as good to predict longevity?
Wouldn’t say as good. How would you measure endurance without measuring VO2max?
@@tasosmakris1 easy. There are huge datasets for how fast ppl run 1, 3, 5 km... you can try and see where you are in % distribution of your age group.