We're Shockingly Close To A Cure For Aging | Answers With Joe
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- Äas pĆidĂĄn 20. 05. 2024
- Aging, and the chronic diseases that come with it, is considered just an inevitable part of life. But what if it wasn't? What if aging itself was a disease - a disease that can be treated? Many scientists are doing just that, and the results are nothing short of shocking. Just how close are we to a cure for aging?
By the way, be sure to check out David Sinclair's podcast where he goes into much greater detail on all these concepts here: / davidsinclairpodcast
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TIMESTAMPS:
0:00 - Intro
1:04 - What Is Aging?
2:44 - The Disease of Aging
4:44 - The Information Theory of Aging
5:52 - Longevity Genes
10:07 - Intermittent Fasting
10:53 - Cold Temperatures
11:33 - Exercise
12:15 - Supplements
13:56 - What's Coming In The Future
15:49 - Final Thoughts - VÄda a technologie
I've always said that they'll find a cure for aging about the time I'm 80 and I'll have to live forever as an 80 year old man.
GodâŠimagine being the elderly when they first discover aging.
Depending on my personal condition, I might just decide to go. Finish my bucket list and then go.
Or you could be a twelve year old Highlander. Which is worse?
Look at east Asians, particularly the Chinese and Japanese. They are quite able and self reliant even at 80, and it's just for one simple reason: activity. You can be a healthy, mobile 80 year old if you work to be healthy and mobile now. Go on regular walks, take up dancing, don't let sedentarism take over. You're right, it's not the same being a healthy 30 something and a healthy 80 something, one is clearly objectively lesser. But that doesn't mean it needs to be terrible.
@@troywilliams9688 was she 10? I thought she was like 4.
@@Fernando-ek8jp can you point me to the academic study that shows that East Asians are shown to be active in their 80s in a statistically relevant way as compared to other nationalities?
I've seen what dementia does to people, it robbed my grandmother, grandfather, and great-aunt of their minds in their old age. It's an utterly horrible fate for everyone involved, so if anti-aging tech can prevent or even reverse it, it would be the single biggest boon for human dignity in the history of mankind. No one deserves to be reduced to a shell of their former self like that.
True it Robb my grandma and great grandma
So true. A cousin, aunt, uncle and a dear family friend all were taken by this horrible disease.đ
it would be nice
Maybe she just had menopause. Here in Ontario Canada many middle aged women with menopause and other hormonal déficiences are being wrongly diagnosed with dementia and are being placed in nursing homes. The Ontario government is ultimately responsible.
Most of my ancestors died in a Genocide, so I never knew them. A Lot of my female relatives got Fatal Cancers. One First Degree relative DID make it to Ninety, but slowed down, mentally and physically, the last three years.
Mortality has been a subject that has put me in great sadness many times. The idea that "experiencing" will end someday, and just the realization that the fact that we "experience" in the first place is so complex and so unexplicable... It makes me feel very fragile if that makes sense.
Reverse aging and immortality any relations?
I think mortality is a good thing. You don't want to live with your regrets for ever. I'm glad that I won't have to last longer than 80.
Just remember what good ol mark twain says "I do not fear death. I had been dead for billions and billions of years before I was born, and had not suffered the slightest inconvenience from it."
Always makes me feel better đ
If we werenât mortal we wouldnât cherish the âexperiencingâ.
You hit the nail on the end with your closing speech. I'm getting tired of those selfish people not worrying about the future because of "not living long enough to see it". It kinda shows you that these people literally screwed future generations and would rather Kamikaze themselves than face the consequences of what they did.
17:38
But how dare they be YOUNG while we are OLD. I think it's fair. They laugh at us being frail and having lose skin... so let them stew in our waste in return.
They say respect your elders and then donât do anything worth respecting lmao
@@royzlatanestevez9843 admitting youâre stupid and selfish should be embarrassing not a brag đ
@@mikeximenez5285 You are too young to understand. Soon you will be old and understand that aging and death are necessary parts of the circle of life that produce justice.
I'm 48 at 46 I was diagnosed with stage 4a cancer. Physically I feel about 90 and mentally about 12. Can't help the cancer but the way I live with it. I'm not dying from it I'm living with it. Only way to go. #hereforagoodtimenotalongtime
Amen!
â€ïž
Since it's pretty ubiquitous in my family I've got a slim chance of NOT getting it. How does it affect your mind?? Do the chemo drugs take away your learning??
Wishing you well dear; the power of a positive mind is unbelievably helpful. Try whatever possible to not feel physically 90 at age 48; fight this horrible disease with all your mighty mind and determination.
May the grace of Our Almighty in every Form and Way help you đđœ
Hell yeah! This is a person who wants to talk about their car warranty! What do you say?
35 yr old man: "Age reversal is unnatural!"
75 yr old man: "How's that age reversal thing going?"
300 yr old man: "Get off my asteroid!"
500 yr old post human cyborg: beep bop boop
700 yr old man: De do do do de da da da.
Cabages are unnatural as well! They are a pure Human invention! The original plant that the cabbage descends from is nothing like the modern cabbage. It's only due to Human intervention that it exists
900 year old man: *incoherent babble*
It's taken me 50 years to shed the fears installed by my parents, and the world. I feel I'm just starting life after decades of mental illness.
Then I hope you make the best of what you have left here and truly enjoy what you can
Thatâs the journey it doesnât mean we should live an extra 200 years just because we see ourselves as unfortunate
@@djzip9231 If it were a real thing... My body my choice.
How long did Moses live?
@@Necro2Juggalo Thanks! You are very kind.
Longevity would be a great equaliser. Iâm putting myself through medical school right now in the hope of branching the gap between the science and the medical community. Your not alone. So many get a bum start in life and take decades to work out the mess their parents did to them. Iâm the same, a few years older than my fellow students. I want to give everyone enough time to reach their full potential, regardless of their start in life. People who are against that donât know how difficult and unfair things can truly be. I hope you continue to enjoy your life moving forward and I hope you can see this technology come about. We canât get the past but we can strive for a better future.
This is actually precisely what I'm working on! Already have some human data to show a decrease in the age of individuals DNA with a specific protocol!! Sinclair has definitely done some great research
Got any of that cool research you can share?
Good luck on your expansion!!
@@abcrasshadow9341 I too would like to read any relavent papers.
As someone hoping to transition into this field soon, I will happily read anything and everything you produce!
Aging means two things to me:
1- INJURIES from long ago come back to remind me they happened.
2- GRAVITY really starts to be an obstacle.
3- UV radiation from the sun (and other things)destroying your genes.
4- Chemicals destroying your tissue (like oxygen).
5- Indigestible trash piling up in the cells, and around them.
The elderly (me-getting there đ) aught to be sent to the Moon in the future to aid their health whilst doing important medical research đđŒ.
3- the floor gets very far away.
@@iniquity123 and be extremely overpaid for no apparent reason at all. I am all for it!
F-K Gravity
I think what Sinclair's lab is doing is, hands down, one of the most fascinating stuff out there. The fact they managed to rejuvenate an old mouse to become a "teenager" is just astonishing.
As I remember exactly, they had two mice of the same age. Then they olden one mouse(gray falling out hair, no energy, losing vision) measured it's results on a treadmill, and then rejuvenated it back to being young and measured again. I remember Sinclair said this "new young" mouse ran so long on a treadmill that their testing program stopped measuring because they didn't expect any mouse to run that long :)
They also managed to tumorize an eye of a mouse(I think) and then cure it back to full health.
Yeah, next 20 or 30 years looks quite promising, if we manage not to kill ourselves in nuclear war that looms on the horizon..
Rejuvenate/ rebuild an eye, I'm all for that! Maybe an "antibiotic" to combat the set of "stupid emotion" genes that have us constantly dancing with nuclear war... Vladimir, take your đ!
We managed not to kill everyone in the first wars, it's not going to happen now, probably...
That nuclear war can't come fast enough. And we already are killing ourselves, albeit slowly. Nuclear bombs would just speed it up.
Is this the same guy who made a super soldier mouse? Mouse was like equivalent to 70 year old and ran on a treadmill like...forever. I can't find video. Think it was on vertasium. I think down side was the caloric intake needed was insane and woukd die rapid.
@@bedhead4728 y, that's the one.
CGP gray had a really good video on the psychological barrier you referred to as "aging Stockholm syndrome". People that say aging gives life meaning have a perverse definition for the meaning of life. No one would say to the Grim Reaper "Hey could you cripple my son so the time he spent before being crippled is more meaningful"? Yet that's basically what people seem to think with regard to aging
The death of a toddler carries more weight than that of a 90 year old for a singular reason "they had so much more life to live". Increasing lifespan actually increases the value of each individual life.
No it carries more weight because people are hypocrites, they preach about equality, but in reality they are the opposite of it. No one has more life to live after it is dead.
Your two sentences contradict each other. In my brain.
@@mrlarrybobjr Not at all. If value of a life is decided by its potential future length, every life increases in value.
If technology allows human beings to consistently live well beyond 90 years old, I think we as a species will be confronted with some pretty uncomfortable decisions. The Earth can simply not sustain current birth rates AND increased life expectancy. So do we demand 100+ years of life for every human being around the world, as a matter of right? Or do we consciously limit access to this technology, so as to prevent ecological collapse? Perhaps new methods of population control would be implemented. Itâs an interesting thought: for the first time in history the population of the younger generations would be curbed so as to sustain the extended life of existing generations.
@@Thelango99 I see your angle, but when grandpa dies we get his actual value to put in the bank. When a baby dies you only get funeral expenses. Grand dad was worth way more. But also itâs harder when a baby or small child dies because itâs out of the natural order, your children are not supposed to die before you, so itâs hard on the brain. Witch Carrieâs more weight. I donât know anything though , just some quick thoughts hereâŠ
I remember being a kid, looking at my great grandma in pain, getting cancer, breaking bones easily, and thinking that aging is to blame. That it's the disease we all have. It's super exciting thats being explored and worked against.
I remember my great grandmother, and how she lived to 96. All the while saying she has lived long enough and is ready for it to be over. Quite frankly I dont blame her
@@LordHarv if you're in pain all the time and prone to illness for sure, but I believe I'd be willing to live 1000s of years or more if I could stay "young".
@@Ishykai exactly. I think there might be a point though where I'd be like "yeah I've had enough" then just die lol
@@gotworc I think the world is expanding so fast and developing in so many interesting ways that you will never get bored. Even boredom will probably be cured in the next 1000 years.
@gotworc the real question is, which will come first, us becoming cyborgs due to the ai becoming smarter and smarter, or us fixing aging. Or, we have both, what then? If you already donât age will you still want a mechanical hand just because youâll be able to carry more? Idk but I personally donât think these will happen within my lifetime, and Iâm only 22. People used to think weâd have flying cars by now 100âs of years ago. Who knows though, maybe aging will be fixed by the time I die, but than the problem with cost comes in, will only rich people be able to live forever?
Iâm in my teen years and this is the best news of my short life. Imagine the technological advancements in 70 years or so!
They talked about fusion energy 70 years ago and it is still not here. Stopping biological aging is probably even harder, so don't get your hopes up too much. The best you can do is to work in the anti-aging industry in any sort of role. At least then you help increase the chances. You have to work someplace, so why not in the anti-aging industry.
"What if we had to live with our decision?"
Well considering I've been getting worse health for the last 10 years and I keep telling myself I'll work out eventually, I think I know that people won't change things until they face their consequences and then they will wish they did something sooner but never actually do something than prevent it from getting worse, repeating the cycle.
Itâs weird, but due to the pandemic and staying in Iâm in the best shape Iâve been in in a really long time. 20 minute video between Firas Zahabi and Joe Rogan about âhow to workout smarterâ made me change the way I was working out. I donât believe in being sore at all during the workout process anymore, lol. Then I started following another CZcams channel called ACHV peak that had these pre built month long workouts that are awesome, and I just keep re-using those. Best wishes! Getting started is the hardest part.
@@derpatwerknsubbers1680 hell yeah, I'm happy for you. I know I need to do something but I'll use excuses like due to a traumatic childhood I developed "learned helplessness" but my main problem like in the video by Breadsword "Gurren Lagann and Getting It" you have to get angry at your situation to change it. But I've rarely ever gotten angry about any ever in my life enough to do anything, I just lay in bed and practice escapism through CZcams videos.
That was me. 57, and in lousy shape (although better than many of my age-peers). But various health problems Iâve had for 15 years (blood pressure and low potassium, mostly) were diagnosed as a hormonal issue. Surgery (one of my adrenal glands was removed) completely cured just about everything wrong with me that wasnât being 57 and out of shape, and I feel a million times better. This has prompted me to work hard on improving my overall health, changing my diet and exercising daily. In five months since I started (and four since I got serious), Iâve lost 20 pounds, improved my cardio health and strength, and most importantly, created sustainable habits. Iâm looking at a 50-70 pound weight loss on top of strength, flexibility, and endurance improvements. Life is getting a LOT better.
Monster-Girl Lover Weâre entering the age of A.I... after a pandemic shut down most of the world for the better part of a two years. From what Iâve seen? Everyone is (for the most part) doing the same thing: stay in, watch videos and reflecting. As far as learned helplessness? Been there, itâs rough... keep asking yourself âWhyâ and then âHowâ long enough and often enough and trust me: youâll start finding reasons to get mad.
I think it's interesting how people see this and other type of scientific discoveries as unnatural when, technically, there's no such thing. One of my favorite quotes is from Sapiens: "Whatever is possible is by definition so natural. A truly unnatural behaviour, one that goes against the laws of nature, simply cannot exist, so it would need no prohibition.â
Unnatural/natural is the stupidest construct that people put an insane amount of value in
A more useful distinction is manmade vs naturally occuring.
And in that framework things like clothes, houses, cabbages and dogs are manmade and not naturally occuring.
@@PyrusFlameborn Yeah, but man-made constructs, and indeed man, are naturally occurring as they... occur in nature. _That's the whole point._
Maybe intelligently designed vs. not intelligently designed might be closer to the more proper distinction, but then again most people who confuse "natural" for "good" usually think "natural" is part of some divine plan, so maybe that isn't ideal either.
i feel like that is a stupid quote, no offense. What do you say to the experiments done on people by nazi scientist? Do you call em natural? nothing is black and white. So grouping everything we do as natural is unnatural.
@@eleonarcrimson858 Don't worry, I'm not offended. I guess what I was trying to say with this quote is that "natural" and "unnatural" are human constructs. The definition of natural is "caused by nature, not humankind" but humans are a part of nature, just like monkeys, pigs, mushrooms, etc. People usually think "natural" means good and "unnatural" as bad, when in reality they mean neither. Because of this people usually defend things by saying it's "natural" and when calling something "unnatural" it's usually in opposition of something. I'm kind of bad at explaining things, but what I mean to say is that everything is a part of nature therefore everything is natural. But that doesn't mean everything is "good" or "meant to be", it just is.
I think when it comes to anti-aging research you should always credit Dr. Aubrey De Grey who basically pushed for this research and pioneered it for two decades before anyone like Dr. Sinclair (big props to him) could've touch the subject and leave his career intact.
These days, everything that De Grey Advocated for decades is actually happening. Surely he deserves at least a shout out.
As much as Eric K Drexler is I guess treated as kind of a joke these days, he was the one who first sparked my imagination to begin pondering the possibility and implications of anti-aging and transhumanist technology when I was in my late teens (in the late 90's). And I'm no scientist so that maybe doesn't matter much, but that was what led me on the path to knowing about figures like De Grey, and spreading awareness about that side of science and seeding enthusiasm to others.
@@salmongod9115 Great observation, you are absolutely right. It totally slipped my mind. Drexler wrote and spoke about this ages ago. He's not called Father of Nanotech for no reason.
Yes! A million times yes! He's always been in the frontline and many people just say he's crazy. He'll be remembered someday
Sure credit him to. Thanks De Grey. Its very possible(And close)
De Grey is basically the Tesla of anti-aging research and as you said should be remembered as such. I stumbled on the guy like 15 years ago when I got deep into researching the plausibility of science fiction concepts and the fact that his then "bleeding edge of research" is now a not too distant horizon is astounding.
I feel approximately the same as I did at twenty-five. I did get COVID which had a long recovery but none of the complaints that are normally associated with aging. Good genetics - long lived ancestors. Good diet - a choice. Good environment - a choice post childhood. Good mental & physical exercise - a choice and lifestyle. I hope to benefit from the good science that is coming too us in a not too distant future. (Added: I am 60 years old.)
This doesn't matter if you might be YOUNG. How old are you, it's not clear. You might be 26... no wonder you feel 25.
The hardest part in implementing new habits is those first few days to weeks of torture where the body's cravings fight you the entire way. It's much easier for people once they get married to simply let themselves go, gain weight, get the dad bod, stop exercising, and the body is a "use it or lose it" mechanism. If you want to maintain function of say your bladder capacity or ability to read text close up, you need to exercise these skills. Same goes for maintaining muscle mass through basic compound movements... bench presses, trap bar squats/deadlifts, and pull ups. These and a good diet keep a person in good shape, but they are uncomfortable to do, at least until the habit is formed.
I recall reading an article once by Dr. Tom Rainbow about how we were on the verge of eliminating aging, and that he might be a member of the first generation for whom lifespan was not bounded by aging, as we were "at most 20 years" from eliminating it. The year was 1984. Dr. Rainbow died later that year from cancer.
Iâm in my early 20s, I just had a brain MRI done and apparently my brain is that of a 70-90 year old physically speaking. I definitely feel that way lol, and my body is falling apart due to genetics⊠but this is fascinating! If they couldnât fix my health issues I wouldnât live any longer than I have to đ„Č life is hell for us chronic pain/illness people, but I definitely donât want to miss out on life (I already am). So if they can make my quality of life better and delay aging so I can enjoy myself, it would be amazing!
lol
Doctors treat women like old men-- if the problem isn't obvious, we are expected to live with it.
As someone else whoâs been on the chronic pain track, I completely understand this. Things have gotten a little bit better with some donated stem cell treatments, but every day is a slog to get through.
I'm so sorry to hear this! This isn't right. Do you have issues with your memory?
I also have genetic neurological disease and connective tissue disorder. It is a hellish life, we must make people aware of these problems :)
The most compelling argument for anti-aging to me is as follows: Imagine if we could have some of history's brightest minds contributing to science for ~500 years each instead of ~50 each.
Conversely, imagine history's worst tyrants living that long.
One of the most compelling arguments are, the brain doesn't stay malleable and it's highly likely brilliant peoples cant keep making advancements. Also, I'm pretty sure people who life hundreds of years would eventually get depressed or go insane.
No, just no. This assumes that people want to live that long and be contributing to society for all those years. It also assumes that we won't have similar geniuses appear after them, and ignores the circumstances that led to their apparent genius. Everyone likes to remember the people who won the Nobel prize, but ignore the enormous body of literature and community which contributed to that genius.
Weâd be a type 9 civilisation if they were all still here today
but think about how human societal structures aren't perfect
including science
so many times, for science to advanced people had to literally sit down and wait to older generations to die out, because they were too stubborn to even consider anything else
imagine the stagnation we'd reach with the ''owners of what's right'' never dying
Thanks! Great video. Just watching it added several years to my life. I feel it!
Something cool: 4 years ago, at the age of 55, I noticed that my hair was actually growing out black instead of gray, along with being full and silky. I found this odd since I have been a brunette most my life, and my siblings were all getting white hair including my sister who is a year younger than me. Even now, at 59, 99% is still growing in black with barely any white hairs (my younger sister is now completely white). Everyone pegs me at 10 years younger than my actual age. My body, however is a completely different story... đ
Talking with my doctor, we came to the conclusion that it was possibly due to the steroid shot that I have been getting in my right eye, four times a year, for the last 18 years to stave off blindness due to retinal disease (I'm already blind in my left eye). So my hair, technically, doesn't seem to be aging at all. So yes, I'd like a drug that would do the same thing to the rest of my body. đđ
"You're still slowly dying, but good news, you hair will live forever!
I'd like that drug too!!!
There is testosterone injection
Start working out seriously also maybe even talk to your doctor about testosterone replacement therapy. I knew a guy coming to my gym the man is 59 and was in crazy good shape started exercising in his early 50 and weighed like 235 with abs being only 5â7â
@@draggy6544 But the testosterone will make any cancer accelerate from what my dr told me...
I've worked in nursing homes for 7 years and I often has gotten me thinking about aging. Yes, those I take care of tend to live a fairly long life, but their lives are usually lived in poor health towards the end. It seems like it is just suffering
Extreme longevity runs in my father's family. For well over 150 years, if they survived infancy, no one died under 100, including a great uncle who literally drank a bottle of whisky and smoked two packs of cigarettes a day.
One of the things I've noticed is that, where eating is a social highlight for most people, none of the people on the long-living side of the family cares one bit about food. They all will often forget to eat if they get too busy with something.
Perhaps it ties into the longevity benefits of fasting.
There are a lot of people who donât get enough food. Doesnât help them live to 100. Likely itâs genetics. Few can drink and smoke and make it to 100.
Sounds like they were prime candidates for the Howard Foundation. Invented by Robert Heinlein the foundation was started by a billionaire who died of old age in his fifties? His foundation approaches people who had all four grandparents living and offered them a trust fund if they married someone from a list of people with all four grandparents alive. The intent to breed longevity into the human race.
@@thebigpicture2032 I think he meant âintermittentâ fasting. When they were hungry, these people ate. Being constantly malnourished is a whole other thing that certainly does not lead to a long life.
I watched a doc on aging where it said that there is a genetic marker that is common in families with many centurions. There were many examples showing bad life style choices didn't affect their longevity!
@@thebigpicture2032 not necesarily eating less, but maybe not forcing yourself on a strict schedule makes things easier on the body, i know that if i dont force myself i rarely sleep and eat at the normal hours, but i do still sleep and eat in the same amounts and it tends to feel better
My whole lab's hypothesis is that AMPK promotes tumor growth in breast cancer (with published work). This video speaks about one side of AMPK, however we might be too fast to regard AMPK as a silver bullet. AMPK is also acts as a stress sensor in cells. But a very good video about the topic indeed.
If such medication was truly implemented one day I would take it without hesitation. I'm already trying to make the world we live in better everyday and I would like to be able to do this as long as I possibly can. I honestly wouldn't mind living 500 years if this was possible.
But is this good for society? A few hundred years ago we thought slavery was ok and even the people who didn't like slavery were an average super racist. How many people back then could be influenced to accept modern standards?
Is there a point at which older people just refuse to change and cause major conflicts with younger generations? Also if you had a never aging population wouldn't this contribute to the worsening wealth gap.
@@fluffybunny7089 Why would it be older people causing major conflict? You don't think younger people cause major conflict? What about younger people refusing to change?
I've been exercising several times a week for 20 years and started intermittent fasting 3 years ago. I am going to do everything in my power to catch the reverse aging train.
Same with trying to catch that train!
Iâve been doing extreme IF (36/12) with CRON for 15yrs. It works wonders!
i call it skipping breakfast
â@@vbgvbg1133 Well yeah, but you won't make as much money by saying that lol.
Basically you've gone back to the life of a peasant in the Middle Ages. With a life expectancy 35yrs old you should certainly beat that aging problem.
"learn to live with your pain" is what I usually hear. I just turned 51... I look about 55 and feel about 80.
I'm about to turn 55, and I feel like I'm 35.
My 36 year old GF actually thought I was the same age as her when we met (and she's slim and hot).
@@SeanClarke good for you đ
I suspect my liver will kill me or I'll overdose on painkillers by accident someday, better than living with the pain.
@@SeanClarke Interesting, I'm actually 80 and feel about 30. When I met my 25 year old GF she thought I was 20
@@rambi1072 do you have problems with sunlight?
i love you. your analysis is always spot on. no one makes me wanna be a patreon member. you are worth it
if i could live 150 healthy years instead of 50-60 I definitely would. I'm in no rush to kick the bucket and its an exciting time of human history, while i may just live long enough to see the important breakthroughs, i would like to live long enough to also see them implemented worldwide. id be more at ease closing the door on my life and leaving my children in that world.
I am heading to the front of aging research. I want to create a world where everyone can decide for themselves how long they want to live. It is really sad to see most of my friends and family not understanding the implications of the fact that the top killers are only symptoms of aging and that a cure can be created within their livetimes. Often they even think it is a bad thing and should not be done. But I hope they will understand and i am proud to be participating in fighting the biggest source of suffering.
Are you a scientist for this type of research đ€......
I donât understand the mindset of those people. Seriously wanting to die? It would be like WANTING someone to barge into your house and bludgeon you to death slowly. Obviously we should do everything in our effort to prevent that from happening
For some people, LIVING is suffering
I wish you the best of luck! I'm routing for you and your fellow researchers! I think it's sad too, that people think of aging as something we'll have to deal with.
I fear my own death but I don't think it's the biggest source of suffering, not even close
i remember reading a popular science magazine back in 2008 on this very subject. they cited three factors for aging. 1) DNA degradation(ie damaged DNA), 2) debris building up in cells due to leftovers from cell division, 3) free radicals. the article covered research into cell debris. basically every time a cell splits, there's left over material that just sit inside the cells afterwards. the cells have the ability to expel these debris, but don't for some reason. overtime the debris builds up to the point that cells can no longer function properly, halting cell division, so no new cells are formed, or if they are they are defective. they found a chemical treatment that would cause the cells to expel the debris, freeing up the space for cell growth and division once more. they tested it on mice. mice have a life span of roughly 2 years. mice treated with this drug regularly, lived to be about 6 years, tripling their life span. they were also healthier for much longer and took much longer to show aging. the left over aging was due to there DNA still getting damaged over time. they tested older mice that were graying and saw surprising results. over time the gray hair went away and they started acting like younger mice. the treatment actually reversed the aging that had already happened. the mice have a relative known as the naked mole rat. unlike most other members of the rodent family, they live about 30 years. so they have 15 times the life span of mice or rats. this is due to them having a special protective coating on special DNA that cells use for error checking when making DNA copies for new cells. over time most animals special DNA gets damaged, errors start compounding, leading to aging and eventually death. since naked mole rats have this coating on their DNA they suffer far less aging effects, they almost never get cancer as a bonus. their DNA is extremely stable. if treated with the previously mentioned drug, they'd likely live longer than your average human. if you could modify human genes to have this coating like the naked mole rat DNA does, and if treated with this drug, you could see human life spans increased to a thousand years or more. it's weird im only hearing about this stuff again after 14 years.
As a biologist I can tell you if you haven't heard of it for so long either it was way oversold or they were unexpected issues. Unfortunately aging is a holistic issue so it's very hard to foresee what's going to happend with any treatment in a species or across species. Do you remember the name of the compound by any chance?
What if it was legal for scientists to experiment on criminals on death row? I mean they're already going to die so like why not test this stuff out?
@@danklegosi6084 Most biologists are against the death penalty to begin with so no. It is absolutely inhumane.
@@kalidwapur but the criminals themselves have done inhumane things to get there in the first place. Why not do something to benefit humanity when there bodies will basically go to the equivalent of a human dump? Why not recycle?
Want to help your cells now? Do Sun Chlorella. It penetrates the cell walls to detox them
I was thinking about this in 2016 or so when I read some news about this potential. I think people would really start buying only the most durable products. If a house is designed to last about 100 years, and a person has outlasted 2 of those houses, I bet they would start looking at how to get a house that lasts 500 years, or maybe even 1000 years.
It seems that human psychology has generally caused a self-limitation of over-population. Of course, some births will still be necessary, since there would still some deaths by unnatural causes.
It would also be interesting to see how people realize that they have plenty of time to solve the big problems of the world. Without the impending deadline to build a retirement before being too old to work, people could be more free to take risks on big projects to solve problems. Hey, if I can live 1000 years, why not spend 50 years developing farmland in starving countries? I can always work in an office later, or work in an office now, and still be young enough to join the peace corp after 50 years of this.
Weâve been doing suspended animation for surgeries for over 25 years. We can cool a personâs temperature and stop their circulation for approximately 1 hr while vital structures are repaired. Then, using machines to re-engage circulation and initiate gradual warming, the heart can then be restarted. Itâs a big operation and complex process anesthesiologists can make possible. Impractical unless it is the only option for a surgical problem too risky to undertake otherwise.
I wonder how much of the pushback against this type of research comes directly out of religiosity. It seems that religion has long existed as a way to answer questions about our own mortality. I canât imagine how hard it would be to see the benefits of anti-aging science when you view aging as some long/painful/necessary road towards your mansion in the sky (obviously this isnât how everyone views the afterlife, but that isnât the point).
Do you really think that if people lived forever that they would fix things such as earthquakes, famine, racism, hate, war... how about fear, can we just take a pill to stop fearing or phobias? God doesn't let us just live forever - he fixes everything.
@@BryanDoesCinema I have no idea what would happen to earthquakes, famines, or war. What I do know is that scientific progress has made far more progress on those fronts in the last hundred years than any other practices weâve observed in human history.
I think that believing there is a god who will one day make all things right is a very powerful message that is extremely helpful for a lot of people. What I donât think, is that such a claim could possibly be substantiated. Believing a thing will happen one day doesnât make it so, and every single generation as far back as we can see thought that that day was upon them, in their lifetime.
Can I ask you honestly, how many thousands of years would have to pass with no signs of a returning deity, before we should start looking elsewhere for answers? Because weâre over 2000 years in now and not much has happened. Iâm not trying to provoke you or be argumentative, I just genuinely donât think humanity can afford to hold onto false hopes with no evidence for much longer.
@@BryanDoesCinema â I actually think it would, to an extent. The longer we live, and the healthier we are while we do it, the more exposure we get to other people⊠including different races and sexualities and all of the above. Studies show more exposure leads to less racism, so that would help⊠plus weâd be a bit less stressed about getting older which would lead to better moods, less anxiety and depression. Plus we would be able to accrue much more information and retain that information over a longer lifespan with more health in typically elder years. Obviously things like earthquakes and famine could still be issues just due to that theyâre natural processes⊠tectonic activity for earthquakes and drought or flooding for famine, but because weâd be living longer and better able to obtain and pass on information we could mitigate them easier. Now, Iâm not saying itâd be some miraculous change in intelligence or whatever, but it seems to follow that having more time to learn and pass on information would benefit us in virtually every way, even if itâs just a few percentage points.
@@BryanDoesCinema some of us want to live longer because we don't feel that we have accomplished enough. It won't stop evil, but it also won't stop good. There is more good than evil even if it's just over 50% good. Also, scientists are figuring out how to stop earthquakes and famine by using innovation via artificial intelligence, or super intelligence computers.
You're probably right, some idea this isn't God's plan or men stepping into gods role but ironically abrahamic religions should believe this is exactly God's original plan any way.
Several years ago, I read about a study in Norway for a drug that targeted and destroyed senescent cells. It had worked in rats and appeared to make them Iâll for a short time as the cells died off, then the vital cells grew back to fill in the blanks. Human trials were supposed to be starting when I read about it but Iâve never heard anything else. Might be a great subject for a video!
I would imagine your body having to support all those senescent cells that aren't doing anything anymore is just like supporting deadweight (or maybe live weight đ) that doesn't really benefit you.
I don't have any litterature to share off the top of my head, but this study failed or at least did not produce any promising results. The last thing I heard was that it ended. (Norwegian healthcare worker)
Everyone up vote this so Joe can see it!!
Its really eerie how I'd been writing a sci-fi script for a while where anti-hero character invents DNA editing software that essentially "peels back" all the junk DNA &removes the perfections etc &in the story the side effect was you'd be deathly ill akin to a a heavy flu as the DNA bots did their work.. then once it's done &you've lost alot of bodyweight &your teeth &hair have all fallen out.. you'd slowly start developing your "new &improved" physique/phenotype etc.. differences in bone strength/structure your teeth regrowing perfectly uniform (or to your specifications) from scratch etc
Science isn't really my background but I just figured from casual knowledge that this would be a unique way to visualise that process instead of the typical "drinks vial with blue liquid &hulks out"
Then it turns out my thoughts were closer to reality than I... Uh.. thought
@@Strideo1 Those cells are still functional, just less functional. If they were completely non-functional, they would typically get shut down.
"Word salad" - I like that! I shall have to use it. :) :D
I work as a care aide in an assisted living facility here in Canada, and I first worked as a care aide in the '90s. I took a long time off from this work. I have noticed differences in people's lives as they get older in the past three decades. People are living healthier longer, and this includes physical and mental healthiness. People are able to stay in their homes longer, and they don't have to succumb to things like diabetes and heart disease and other typical aging conditions nearly as early.
Yet like you said, Joe, a lot of focus on life extension is making sure that people live longer as elderly people, despite all the things that happen to our health at that time. Yes, there are people who continue to live fairly healthily a lot longer than others, but even with all our advancements in modern medicine and healthcare, there are still a lot of people who end up with major health issues that make it more difficult for them to continue living as well as they could have. I don't know if I'm making sense here.
While it's great to see people living longer and the like, I would love to see a focus on life extension happen more for young adults and those of us in our middle age years. I'm not saying that we shouldn't still care for our elderly folk - we should - but why not focus on having people live with as good health as possible while we're younger instead of focusing on maintaining life when we're older? Why not extend the years when we're physically able to do more and the like?
Also, why not focus on trying to find ways to eradicate, or at least lessen a great deal, mental decline and try to work on getting rid of dementia? It's heartbreaking to see people's mental faculties leave them and to see people so confused.
I hadn't thought about this topic in the way you're talking about it here until this video. Thanks for giving me and everyone else watching this some much needed food for thought.đ€
Using batteries as a metaphor, the 'cure' for aging would essentially change us from being like NiMH batteries which degrade over time, to being like Alkaline or Li-On batteries which maintain a constant power output until the end if its life cycle. I'm down for that.
I read "Ageless" by Andrew Steele recently which covers most of the same ground as this video, and I have to say it was the first time I ever really concidered quitting my job, going back to college and studying biology so I could get into gerontology.
Do it
Go for it!! As they sayâŠâLife is shortâ, so go make everyoneâs longer!đđ»ââïž
Do it đ
Do It!!!
I love it that you addressed quiality of life, not just years. This is happening. Cant wait to find out how the fundamentalists handle it.
The people who are against radical life extension will just use it and pretend they were never against it. If given the option, no one chooses to die tomorrow. Most will change their mind when death starts getting really close
Oh they'll love to hang around a bit longer to keep making others peoples lives miserable. It's their sport
And they'll even credit the longer life to jesus
@@Suprm_Lord_E There's a different breed of zealot these days. The heretic-burning mobs aren't spilling out of churches anymore. They're praying to an image of a white dove on a blue background.
Well, they cannot whine about it, the Bible says people will "live as long as trees" in the future so it's on God if we discover how to live for centuries.
I'm sure that their ultra-rich pastors are already doing everything they can to extend their lifespans so that they can continue living in the lap of luxury. Can't be dying and letting anyone else have the mansion, cars and Learjet, can we?
Hey Joe, I just restumbled upon your video. It's so awesome and informative! I look forward to you doing another banger video on longevity + life extension, especially with all the recent news. :)
I see two possible futures with anti-aging: either medical companies are going to make even more obscene amounts of money selling it at exorbitant markups, or some kind of governing body will step in and provide this technology to anyone who wants it either for free or a reasonably low cost. I desperately hope for the latter but fully expect the former.
You can expect this technology only to be available to the 1% elitists of the world. They'll monopolize it and make it available only for them and their constituents.
The rich will live long lives and the working class will live age normally.
It will get to the point where the rich are like how we see vampires in popular culture just without the bloodsucking, Maybe.
Or the third possibility: We don't solve it. Though I like your optimism. I'd enjoy living a good couple thousand years if I could.
Or it will depend on where you live. In most of the rich democracies anti-aging will most likely be a part of universal health care.
If you're in the US chances are that you're gonna get the latter. Yall don't even have basic Healthcare and have a median life span of 77 years old, while the rest of the developed world has universal health care and a median life span above 80.
I've been an anti aging advocate for most of my adult life. I became fascinated with it during high school and took a course in anti aging realted biochemistry and cytology when I studied biology in university. Not only is there the benefit of having people live healthy for longer times, wich in itself is great, but for me the biggest draw would be that a person can benefit society for far longer. Just think about it, we spent so much time learning until we're proficient in our work or even just hobbies. For my field, you study til your mid 20s to get a M.sc., at leat three more years for a PhD. That's about the same time you then got to contribute to the field AND train the next generation already. And when you retire, or eventually die, your expertise is lost forever and someone else needs to step up. It's highly inefficient. Imagine all the brightest minds in a field, be it scientists, artisans, or even contemporary witnesses, who together with their knowledge, we lose every day. If we could extend the time we could dedicate to the problems in science and society, we might get a lot better results. Just doubling the time we have would be a huge win already.
that, and perspective is really important. imagine if we had 300 year old people alive today, who look 30-50, maybe we could avoid fighting a lot of wars & making the same stupid mistakes over & over if we have more perspective. then again, there might also be echo chamber communities of pepople who are mentally very stubborn & stuck in the past, who just get more & more ignorant as time goes on.
@@kvidal88 on the other hand, you could have immortal dictators calling themselves god kings.
That all sounds great, but the whole âcontributing longer to societyâ sounds like it would be exploited in ways we canât yet imagine.
@@samchoate1719 maybe workers will have to actually stand up for themselves & stop accepting unsustainably bad wages/conditions
@@TwitchyTopHat1 that's going to happen if this is possible at all. you can't stop rich people & large states from doing their own r&d. may as well let some decent people do it too.
"Mortality Stockholm Syndrome" that's a very good way to put it, and yes it's crazy there's so much pushback on living longer
I only have a problem with it for one reason: population growth and the limited resources of the earth/environment.
@@autohmae Population isn't growing - it's now coasting. We're in for a crash in the coming century. This also will have positive effects on the Earth/environment angle. It's amazing how most people don't even know this.
Population increase is caused by *births*, not length of life. And birth rates are tumbling everywhere now, even in traditionally high-birth rate nations. Population crash is fare more likely to be our concern, and longevity science will be a crucial part of dealing with that.
@@Fredjoe5 it's still growing, but in Africa, we'll get to just shy of 10 Billion. If you want to see how it will go, check out the video: "Hans Rosling: Global population growth, box by box" or more recent: video "Population Growth. Is it out of control?" by Just Have a Think
@@autohmae Even Africa's replacement rate is falling into the toilet, and that's only going to increase even more as attitudes related to women and families continue to change there.
Hans Rosling has done excellent work in highlighting this. If you've got the Ehrlich's criticizing you (as he has) then you're probably correct! LOL
It was a really good description of it. For hundreds of thousands of years weâve had to put up with the pants-shitting terror of knowing weâll die. Weâve tried to pretend weâre ok with it and at peace, calling it natural as if that makes it ok. Weâve even invented religions to try to ease the pain. Thereâs a big wall around that part of our lives, and I donât think most people are willing to open that part of themselves up. Cuz if the therapy doesnât pan out, then theyâre right back in pants-shitting terror territory, and theyâll think itâs better to just die in relatively stable peace.
Also that one bloke was right, population growth will be a huuuuuge problem. People are entirely too invested in making their kids their legacy instead of making their works their legacy, and thatâs gonna bite us all in the ass unless we seriously switch our thinking.
I'm sitting her wondering what comment I should put about, "is it really a good thing to drastically extend life?" the Joe drops the bomb about how we would act if we had to live with our consequences. That's such a good question. I don't know the answer and I don't know the answer to how we can sustain life if everyone can maintain whatever age the want, but it's such an interesting discussion. Thanks for pointing out an angle I hadn't considered!
When Joe asked, "What if ppl didn't have to live with the consequences of their lifestyles", I assumed he meant indulging in poor diet and lack of exercise. Which is what a lot of folks would do with their de-aged bodies.
I disagree with the notion that we live longer now a days with the years being added at the end of our life. I think a lot of people (including myself) are gaining years in our 20s 30s and 40s. Iâm 37 and everyone thinks Iâm 25. people are looking alot healthier in their 50s then they used to. I think itâs more like we are gaining an extra couple years for every 10 year increments
Humbling, as always. Whenever you start going into biology (I'm a grad student of immunogenetics), I start out cringing, expecting all the unavoidable inaccuracies of a complex subject broken down into a 20 min video - only to get a few new ideas for the next semesters TA job I'll be doing. Thanks, man, you rule.
Buying the book?
@Andrew Blucher Which book? The parts I'm most inspired by are Joes "word mess explained" moments. Oh, and the zombie thing. Great way to wake a class right up.
@@CatSingerB _Lifespan: Why We Age - and Why We Don't Have To_
by David Sinclair
Be careful of his site, my antivirus software didn't like it.
@Andrew Blucher Oh, no. I rely on scientific papers in my work; they tend to be a much more reliable and much less biased source of information. Or at least much easier to screen for reliability and biases.
That is great praise for Joe and the work he puts into the vids...while still having fun along the way.
*In 500 Years;*
Concerned mother: "You're 102 years old, why don't I have any grandchildren yet?"
Son : mum are you living in past ?
Children are made in lab from 100 years đ
Great vid, keep us updated!
The sad thing about consequences-induced behaviour change in light of living much longer, is I don't think that will be enough to induce wise decision making. I always thought that existential threat would motivate people. However the pandemic opened my eyes to this assumption. Denial is incredibly strong, even to the point of one's own demise. Several people even in my family denied Covid-19, and died of it. They inevitably spread it to others too.
Covid wasn't and existential threat, not even close, it didn't even affected total death rate.
Suspended animation, life extension, and a growing population that needs to go somewhere. Getting major long-term space travel vibes and i'm here for it
Seeing the Earth is suffering an overpopulation problem, if everyone doubled their life span, then the population would also double. Causing starvation and poverty. So, if we create people who can live much, much longer, they need to go somewhere else! Space travel could greatly benefit from these longer living beings.
@@alphagt62 If people life longer, you'd probably find less kids being born. The thing is, there are enough resources for everyone at the moment. It's just not distributed well.
population might be growing
but for sure not everywhere
its quite common to see declining birthrate in well developped countries
more and more of such keep saying the only way to keep their population productive is immigration
well, what if there would be another way?
@@alphagt62 The Earth is suffering a climate problem, not an overpopulation problem. The Earth could easily handle at least 12 billion people with current tech, it'll just struggle to handle 3 billion if we don't get a grip on carbon production.
@@alphagt62 global population is in estagnation few more decades will go down until it stables
I did hospice care for both my grandparents. It was an experience I never want to repeat. Nor do I ever want someone to go through that for me.
I know what you mean! Itâs not only excruciating to watch but also for the person in hospice care. Can be just horrible at the end. It is hell on earth and we can make this so much better
Bingo, you nailed it again, Joe... "Life wants to survive", and yes, those genes responsible for bringing an organism into being in the first place, will do everything in their power to return that body or organism to homeostasis if injured, ill and diseased, and live on until it is physically impossible to do otherwise. This is the power and nature of life. We collectively know this because life can be found literally everywhere on the planet, no matter how cold or hot or unforgiving the environment; life has always found a way to exist and to thrive because of lifeâs fortitude and resilience to simply be. Life, in some shape, form, or fashion shall always thrive on our planet long after mankind has obliterated ourselves via senseless wars and environmental destruction.
The power of life on this planet is in fact, pound for pound the most powerful force in nature and in the entire universe. âLifeâ is precisely what gave rise to everything known in our universe⊠and that force, in truth and fact, lives within each of us.
The problem is that Western modern society, cultures, and civilizations are designed to be the antithesis of sustaining normal life, mostly political to pit us against each other, which has come to fruition now in America, and around the world can be seen in all the civil unrest, wars, and population displacement around the world. All of these violent, biased, judgmental, and prejudicial forces that have been unleashed against its populations are antithetical to life and harmonious living, where nurturing, living, life, and homeostasis cannot take place or be maintained or sustained, which is why our world is dying in real time every second of every day. The catastrophes that we are witnessing take place around the world shall befall the U.S. sooner than we think, and more powerful than we can defend against. There are zero winners in this deadly and catastrophic game of tug-o-war that nations are playing with one another.
Are there solutions and means to prevent these foreseen catastrophes? Oh, you betcha, will they be employed in time to save these nations in conflict around the world, including our own? Not likely, for unfortunately, hate is more powerful than love, history has proven this biological disorder in human genomes since mankind first set foot on Earth. This desire for war and bloodshed against our neighbors is a feature, not a bug, of human evolution that shall never be fully contained nor controlled, for it is eternally buried deep within our DNA/RNA. The most we can do is monitor it and mitigate it when and where we can, if not unleashed for too long. In the case of Israel and Palestine, it has been unleashed for too long to mitigate or control now.
Sadly, mankindâs prognosis is not promising; the end of times does indeed appear to be upon us, so live, love, and prosper while we can.
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Wonderful. Inspiring! Thank you for sharing!
My favorite joke about aging is:
âOh my leg hurts when I wake upâ
Doc âwell, just stretch it out in the morning for about 30 minutesâ
âOkay, how long will I do thatâ
Doc âoh, noâŠyou just do that from now on.â
Why is this a joke, exercising is healthy at all ages. I really don't get what's funny about that
@@PavltheRobot The joke is that he needs to do it now when earlier he didn't
@@PavltheRobot It's Louis CK, the delivery matters
Doctors are getting better when it comes to curing diseases, and recovering patients from emergency scenarios, but when it comes to the most common ailments of "why does this hurt?", "Why am I constantly aware of this part of my body when I never was before?", "Why do I occasionally fall on my face while trying to stand up?" .etc, they're about as useful as rubbing dogsh*t on an open wound..
@@whimsinator2982 No it's not, the joke is that patient thinks exercising will only be a temporary treatment. Reluctance to healthy movement is just being lazy and I really don't find anything funny in that. Despicable attitude.
It's amazing how things come full circle. I'm 62 and I still remember a BBC documentary I saw when I was young claiming that the main cause of ageing is food. I remembered it into adulthood and decided to only eat when I'm hungry. That turned out to be between 11 am and 8 pm. Still do.
How do you feel at 62?
as always, a wonderfully-engaging presentation!!!
Your closing question is golden. Makes me reflect.
As a graduate student pursuing aging research as a career, I love to see the excitement from the general public about aging research. But oh boy, thereâs a lot of things in covered that are either misleading or just plain wrong. The basic biology behind this stuff is probably too complicated to explain in 20 minutes, but I would expect joe to do enough research to know that mTOR doesnât repair DNA. It doesnât have any interactions with DNA. It is a kinase that controls growth. The effects of intermittent fasting on health are almost completely attributed to the caloric restriction it induces. And letâs not get started about NAD precursors and resveratrol. I know the Sinclair book was exciting, I read it too and it got me more interested in aging research as a career path. But honestly, itâs very clear that the knowledge protrayed in this video is almost completely from the book. If you see this joe, please consider doing a follow up on this video after spending more time listening to the space beyond that book. Peter attia, brand stanfield, Matt kaeberlein, layne Norton and others will point you in the right direction without hyping up snake oil and over interpreting animal studies and saying itâll all work in humans.
Do we really want to live to 90 or 100 no matter what? Being very sick after say 87? But living through strokes...loss of sight... falls ..strokes?
Seems science/meds already extend life...but worsen quality of life. No thanks I will pass.
everything interacts with DNA. however, RNA has long been recognized as having more immediate effects on living organisms. you'd know that if you were studying as you claimed.
What degree did you get?? I'm very interested into going into this field and any advice you have
@@nigelwest5776 in high school (age 14-18) we learn about DNA and RNA. You may want to study there first.
@@kidkarate420 lol what. Saying âeverything interacts with DNAâ means literally nothing. Want to clarify what you mean? mTOR is a kinase, which adds phosphate groups to target proteins. It does not bind to, or modify DNA. It forms a complex with other proteins (forming mTORC1 or mTORC2) which in response to nutrients, activates/inactivates other target proteins. It does not interact with the genome. It doesnât form complexes in the nucleus. Therefore it doesnât interact with DNA. If you studied what you pretend to be knowledgeable in, you would know that.
I have tried Metformin twice when doctors prescribed it, and both times I was convinced I was going to die.
It felt as if my chest was about to explode. It was prescribed for pre-diabetes, which went away as I lost some weight, but I was planning to keep renewing the recipe as I knew the substance had anti-aging properties. I probably should have tried the substance for a third time by micro dosing and then keeping on increasing until I reached a normal dose, but I got spooked because it didn't only feel like I was dying; it really had me convinced that I was done with living.
I feel like a lot of people find the meaning in their life by the fact that their life is limited and every moment counts. The moment you take that away is the moment they lose meaning in their life.
Anti-aging doesn't mean eternal life, unfortunately or not. Life is still limited by the fact that eventually, you're gonna trip and take a deadly fall, get caught up in a natural disaster, mauled by a bear, or get some other fatal bit of bad luck.
Hey, this is sort of off topic, but when you mentioned Metformin I did a little research and realised my endocrinologist is not giving me the right treatment for my insulin resistance, and I wanted to thank you, thanks Joe âïž
Edit: it occurs to me some people are stupid, so I'd like to say google is a tool, not a doctor, it can help you ask your doctor questions, and if you're like me and have struggled for a diagnosis only for doctors to tell you "lose weight", that's not okay, keep digging, challenge them, get a second opinion if you feel you're being dismissed because there are better doctors out there.
Oh, you figured out with a little googling what your endocrinologist couldn't after about 11 years of training?
@@turdferguson3400 Sometimes patients know the disease better than the doctor. A doctor has a thousand diseases and several years to study them. The patient has one disease and all life time to study it.
Although the study should be carried out strictly by reading scientific publications on topic in a good medical journals. Not sure if this a case.
@@turdferguson3400 yes
@@rainbowhyena1354 thank you. And it's not like I'm going to go to my doctor and say "you're wrong, google told me", I am going to open a dialogue with him, it has given me questions to ask.
That's cool that it prompted you to have a more detailed discussion with your endocrinologist.
I'm sure they have many things to consider balancing the pros and cons of many different drugs and treatments for a variety of patients.
just because you do a little research doesn't lead directly to asking for Ivermectin đ
Some people are happy just taking the doctor's advice, some would rather have a more detailed dialogue.
Good luck in your treatment.
It's quite uncanny how sci-fi is quickly becoming our reality in this century. I hope they manage to figure out this "cure" for aging during what's left of my lifetime. As Freddie Mercury sang: "I want to live forever"...
Pretty damn close actually they are making rapid advancements towards eliminating aging
He was gone way too soon. Stupid Reagan and ignoring a pandemic because it only killed gay people at the time...
????
He sang 'Who wants to live forever?'
it was from the 1986 movie Highlander - and stands as a warning of the sadness and perils of immortaility
@@bbbf09 talk about missing the point by mile
@@bbbf09 Oops! Well, I do. Always thought it was "I". In my defense, english isn't my native tongue and I never paid much attention to the song's lyrics.
That said, "a warning of the sadness and perils of immortality"? Only people who either lack imagination or don't know how to enjoy life would think that! There's just too much to experience in this universe for a billion lifetimes, let alone just one...
Thanks for yet another stimulating video
Hey Joe, awesome video! Thanks for covering Longevity. â€
The way I've been taught to think about aging is this: nobody dies of old age. everyone dies of some disease.
So yeah, aging is a disease.
well the older you get the more free readioactivity also influences your whole structure. The older you get the more likely you will become something like the vampire from Nosferatu. hf!
Disease implies something is going wrong. Atrophy is unavoidable though - but thatâs why we reproduce and make shiny new copies.
@@Flaschenteufel The problem isn't the "free radioactivity". The problem is biological systems that at 20 years old could fix it can no longer do so at 80 years old. It's a biology issue, not a temporal one.
i would argue it is more of an acquired immune and cellular function difeciency syndrome
âwe've managed to slip evolution's leash now, haven't we? We can cure any disease, keep even the weakest of us alive, and, you know, one fine day perhaps we shall even resurrect the dead. Call forth Lazarus from his cave. Do you know what that means? It means that we're done. That this is as good as we're going to get.â ~ Robert Ford (Westworld Season 1)
The first season of Westworld is and will always be a masterpiece.
Can't wait for season 4
Sounds cool, it's obviously wrong though. A bit arrogant to think we aren't evolving anymore
imo we're far from finished with evolution. The main issue is we have made earth functionally too small to diverge into different species due to the ease of travel mainly but also the connection of information too. just wait till we get among the stars, that will be the next genesis of human evolution assuming we're not all androids. even then some divergence in thought can happen.
@@syntra2388 I agree, assuming we don't annihilate ourselves first.
I think much of the resistance to anti aging comes from the fact that so many cultures romanticise aging, associating physical aging with wisdom and knowledge.
Maybe you are just disillusioned with your local elderly home also known as the government?
People who lived their life fully generally do not miss living forever but there are not so many of these people these days as people often choose between family life and fulfilling their career dreams thus always wanting more time to catch on the department they did not prioritize if they did not manage to live a balanced life.
I think that this may be mostly a mental limitations issue, there are limitations in the brain department on how much information we can cope with without cleaning too much of our life memories for new ones or making your brain too cluttered to be fast, also fact that you have always something to chase giving you a purpose that may be lost if you with sufficient persistence and lifespan can achieve what you wanted and suddenly lack purpose in life, many lottery winners rock bottom as the purpose of their life is suddenly lost if they did not need to work or even do housekeeping with all the money that can cover for these perceptually boring activities that give many people reason to wake up. For content creators, scientists, artists or people interested in tech, there is always something to do or to be excited about, but what if you don't have such interests and your boring hospitality job of serving to people was keeping you alive by giving you purpose which will be no longer available if people do not need to be replaced as they won't age anywhere as fast or they will be displaced by machines that can be through parts replacement or nanites which may one day also helping humans from inside become truly immortal.
What can be a blessing for some may be a curse for others, I do not think that long life is necessarily something to be excited about for everybody but curious people certainly have a reason for excitement especially if they aspire to be the first to visit new solar systems or do other long term projects currently requiring multiple generations to finish.
As a caregiver familiar with ageing firsthand, I personally believe it would be humanity's greatest achievement to lessen this terrible suffering.
A world where people stopped ageing or aged less wouldn't mean that people will stop dying. People will always die regardless. What it means is, say, you lived until eighty, instead of the last ten, twenty or more years of your life living disabled or in pain, you could live that entire eighty years in a healthier more capable body. You would maintain dignity and independence, and you'd be a lot happier as a result. What's the point of living longer if it means that you will be "old" and sick for longer? No one wants that, really. People want to live longer so that they can extend their experiences, but wouldn't those experiences be better if they didn't involve you watching the people you love grow old and fall apart before your eyes, not to mention you? More time young = more quality time. Let's aim for eighty years in a forty, or thirty year old body! 4:44
Joe! I loved this video, this is the sort of thing that got me to sub in the first place, neat science stuff with a dash of clever and charisma. Much better than the disaster stuff that (unfortunately) gets you more views. I know you gotta play the game homie, but this is the kind of video I love your content for.
I've been going down this rabbit hole for a few years now and still learned a lot from this video! I'm so glad you covered this. I hope it gets more views because I love your story videos (like that dead Australian beach guy) and deep dives over the doom and gloom!
"a slight state of stress at all times"
well good to know that my need for a certain amount of stress at work is actually a good thing. besides that it gives me the opportunity to get the amount of energy I have out of my system.
yes, I have ADHD and moving around a lot not just helps to fall asleep before 3am, but also helps me focus. besides my medication besides producing dopamine to help me calm my head down produce adrenalin on the side and also kill your appetite for a couple of hours.
I guess it has some benefits to be a neurodivergent hyperenergized bouncy ball if people continue to guess my age to be 5 to 7 years younger than it actually is --- or it's just my height. who knows?
edit: tbh I feel like my time of living is way too short. I mean I'm not even 30 yet but imagining that in around 60 years or earlier this vessel will be decayed so much, that it's completely useless is terrifying. like that's just a fraction of time and it's mostly wasted on decaying.
I feel like I would've barely seen anything of this world or the universe, how things move and change over time in just 100 years. a 1000 years seem more practical to actually see things evolve and change, yet still quite short.
maybe I'm weird, but I really want to know and see what the future beyond one millennium will look like. will humans manage to stop or even reverse climate change at some point or find another solution to save the environment or just end up going extinct due to own selfish greed? I know I will probably be long dead before expanding your lifespan becomes a possibility.
Wow loved the way you ended that with that last question. Nice.
My grandfather was Curtis Henderson, a pioneer in cryogenic science and also was extremely interested in life extension. I donât know if this part is true but I heard from my dad he was apart of an experiment that kept mice alive almost indefinitely. Their immune system became extremely limited and they had to live in a sterilized environment with their food regulated
This is partly true. The immune system is designed to keep you alive in harsh conditions. And it leaves collateral damage, that undesirable in milder conditions. But removing it won't make you immortal, it will only extend your life by 10% or so, cause it is not a major mechanism of aging
Cryogenics is legitimate scientific study of ultra cold and low energy states in physics.
Cryonics is the busineess or 'art' of freezing human meat long term using cryogenic engineering means in the extremely likely bogus belief that it will be somehow resurrected as a functioning human consciousness one day.
With due respect, from what I see Curtis Henderson was a lawyer, businessman and interested in life everlasting. He never appeared to pioneer or produce any fruitful discovery or invention in the field of cryogenics - or in any legitimate scientific endeavour.
3:00 my mom is a vet and she says to people ALL the time- âage is not a diseaseâ. people get worried about their older pets and she constantly tells people that being old isnât a death sentence. i have a 17 year old cat and whenever i ask how heâs doing, she tells me he doesnât have a disease, heâs just geriatric. very reassuring.
I also have a 17 year old cat, but I've noticed she's been getting very weak and i haven't seen her in 2d since she went outside. I'm guessing she's gone now.
So you mom doesn't understand science? Weird. Age is literally a disease.
@@RedboneUnincorporated age isn't "literally" a disease because there's no widely adopted technical convention for what a disease is. But it certainly can be made to fit most definitions.
I understand your Mom is just trying to reassure people that their pets aren't ill and don't need unnecessary treatments, but there is an actual scientific study looking at ways to help dogs live longer lives. CZcams doesn't like it when I post links in comments, but it can be found by Googling "dog aging project"
@@renato360a Facts disagree, how about you actually watch the vid, or at least do a google search bc you are WRONG!
Great information! Thanks!
CGP Grey has a video called "Why Die". It is extremely good and I recommend that anyone that liked this, have a look at it, really changed my views.I use to sit around, "waiting" for science to finally make us immortal, stop aging, etc. However, it was just moving really slow, and I never understood why until I saw that video, and how are view that death is "needed" just holds back the research. He also has another video "fable of the dragon - tyrant" that perfectly illustrates why the whole dying is needed thing is just causing more death
Iâve been following Dr. Sinclairâs work for some time now, and started taking NMN (an NAD+ booster) 3 years ago when I was 38. Itâs a fantastic supplement. I feel less creaky, lighter on my feet, have more energy and my sex drive is higher than ever. Iâm about 10-15 pounds lighter and currently chasing my high school 5k time. I can workout longer and harder in the gym. I take 500-1000mg per day. I also take resveratrol, but would attribute most of the positive effects to NMN.
That sounds really interesting! Any source you can particularly recommend to get into this topic? The book maybe?
So what happens what you stop taking it lol
@@Pony341 I guess I age normally lol! Iâve stopped using it for a week or so at a time, and I definitely notice a difference in energy level and motivation.
Nice Add
I just began taking NMN so i hope it is effective. As WC Fields quipped while reading the Bible in the hospital, "Lookin' for loopholes...."
"Aging research is still in its infancy" is kind of a full-sentence oxymoron, am I wrong?
Anyway, the Stockholm Syndrome thing reminded me of a Greg Egan story called "Border Guards" where one character who's lived for untold eons by the time of the story goes on a huge rant about how people used to glorify death with all sorts of insane rationalizations about how it makes us noble or makes our time more precious or whatever.
I just realized the whole thing is on the author's website. I'll just copypasta a relevant snippet:
âIt was the naturalistic fallacy at its most extreme - and its most transparent, but that didnât stop anyone. Since any child could tell you that death was meaningless, contingent, unjust, and abhorrent beyond words, it was a hallmark of sophistication to believe otherwise. Writers had consoled themselves for centuries with smug puritanical fables about immortals whoâd long for death - whoâd _beg_ for death. It would have been too much to expect all those who were suddenly faced with the reality of its banishment to confess that theyâd been whistling in the dark. And would-be moral philosophers - mostly those whoâd experienced no greater inconvenience in their lives than a late train or a surly waiter - began wailing about the destruction of the human spirit by this hideous blight. We needed death and suffering, to put steel into our souls! Not horrible, horrible _freedom_ _and_ _safety_ !â
Sorry but life gets tiring at a certain point. Not the same point for everyone, but allowed to live ling enough everyone will experience a disaffection with life. Itâs exhausting. And we are built for death- no organism anywhere lives forever. We die to make room for the new, and for change that is necessary to our species. I mean, the other option is eternal stagnation. Just look what happens when a bunch of geriatrics who are set in their ways are governing a country- they no longer represent the majority of societal beliefs and are out of touch with actual modern problems.
@@juliejanesmith57 Life is tiring at every point. It's a constant struggle and unending tug of war with death. It's only through life that you eventually learn to abhor death. Because it takes time to make progress. The last laugh of the universe is to just strike you down when you're finally starting to get life figured out. All of medicine exists to cure this ultimate plague once and for all.
@@juliejanesmith57 , we won't have to stagnate if we have enough (extraterrestrial) resources to propagate and expand civilization beyond our home planet. This will be a realm where life extension is critical for long term survival, principally because it's difficult to shield our bodies from the much high levels of radiation anywhere outside of Earth's magnetic field. There's no guarantee that we'll gear up soon enough to make the move, but if we can suppress the worst effects of global warming (with sulfur particles in the stratosphere) we'll buy enough time to make it a reality.
Tnx @eyedunno for the suggestion on Egan and Border Guards! I found the story online. Very interesting way to approach the topic of life and death. I think life gives meaning to life!
@@juliejanesmith57 Your data appears to be incomplete.
1)Turritopsis Nutricula ("Immortal jellyfish") is not built for death; it regularly reverses the age of its cells.
You can kill it - it is not *invulnerable* - but it will not die on its own.
2) Ennui can onset at any age, but it has a treatment; find something new and interesting.
You should find something that engages you to care about living.
LOVE the final question, Joe!
Metformin is also used to help with PCOs. I've been using it for years and had no idea there was that much to it. Thanks for the info!
I exercise 6 days a week for about 40 minutes. I've been doing this since 2019 and I love it. I'm 41 and I feel like I'm 20 something.
I love the topic, but I would suggest looking at the newer research papers (conducted by unbiased researchers) about the ineffectiveness and in some instances adverse effects of healthy people taking Metformin and Resveratrol. Unfortunately, other research labs have been unable to replicate the results from Dr Sinclair's research on Resveratrol.
I've been digging a large project by hand. I'm 52. The ground is rock hard. I use a digging bar to chip thru the rock hard earth. Yesterday I got 50lbs sacks of feed for the farm. I'm swearing the sacks are not 50lbs. I can straight arm them. I think the physical work made me younger.
When you mentioned Mortality Stokholm Syndrome, it makes me think about all the literature and media written over the past few thousand years, talking about how life can only have meaning through death. It's always struck me as a bunch of terrified people trying to make themselves feel better about something awful, that's out of their control, by saying "No, it's good actually!" Colour me unconvinced.
I'm sure theyâll figure this all out right after I die đ
Have the same feeling tbh
even if they figured it out tomorrow its not like regular people would have access to it
Joe, thank you. I've been having a ton of exams this week and I come back home at the end of the day to watch your videos. I feel informed and entertained. Thank you Joe
I've been taking NAD for some time now and as a 49 year old it gives me increased energy four workouts it Focuses my mind so I strongly recommend it.
This is so interesting.. I actually got a prescription of metformin because I have a history of spikes jn my blood sugar, and I got a prescription for tretinoin due to acne.
Both metformin and tretinoin have anti aging properties no wonder people never guess my age right, I'm in my early 30s and I still get carded
I'm sure many of us don't actually care to live forever. I don't think "mortality" disturbs a lot of people - contrary to what psychoanalysts and writers constantly go on about. What disturbs us is that we have SO LOW quality of life for the MAJORITY of our lives. Think how shortly we are young - and I don't even mean being a kid or teenager, but 30s (which is old to children). Most of our lives, we are OLD - unable to do the things we got used to doing as a kid and still love, tortured by constant pain, getting ugly, getting sick... and this continues from 30s for 40-60 YEARS. I am sure most people would be fine with the lifespan they have if we could live well. 80 years WELL LIVED would be so precious and amazing. I'm sure "mortality" is okay for most people if we actually got to enjoy life and not just get a few minutes of yard time at the beginning of life. Excuse my language, I'm an ex con, did 6 yrs in the pen in my relative "youth".
I think most people either donât think about it or are actually disturbed. Itâs pretty bullshit to be born, with no say in the matter, just to suffer and toil to try to find the things that make your life worth living only to inevitably have them all ripped away regardless of anything you could possibly hope to do about it. Itâs kinda a scam honestly
I agree. personally, I think the 3 things that must be fought tooth and nail is aging(inevitability of death), depuration(self destruction), and physicals limitation(space travail/flying/tools).
Yes because if thereâs one thing we need is a population that never ages or dies. That will fix the issues of housing, young people paying social security for an old population, and overconsumption of resources.
@@Sillyhands1 Yep, the last thing we really want is a population that can live much longer. We have enough issues as it is. I wonder how people would react to forced sterilization because there's too many people that can't be provided for adequately?
@@Sillyhands1 if we ever get there, humanity will find its place in other planets or in space.
but I always thread in caution for anything extremes, like removing aging/death completely. It can get dystopian real quick.
Wow, the cynics showed up in force, here.
Firstly, people who age and remain *healthy* just keep working until they've achieved financial security. That means they either reach a point where they *don't need* Social Security or other aging pensions, or they just keep working, because they can, until they die of accident or misfortune. The young won't support them, because they'll support themselves.
Secondly, more than 80 percent of medical expenses accumulate in the last two years of life. What happens if that can gets kicked down the road for three or four decades, and the aged person has that much more time to accumulate the wealth needed for when that long-delayed end draws nigh?
Finally, we see a pretty solid pattern of declining birth rates in a society, as that society industrializes and grows more affluent, thereby. If people know they can work for a century before they have to quit due to age-related problems, how many children will they feel the need to have? One, or maybe two at the most?
So, tiny families of long-lived people who accumulate wealth, through work and then investments, many of whom have minimal health-care costs because they die in auto accidents or lightning strikes or something, as the odds just catch up with them.
I mean, the notion of dying instantly after 120-140 years of healthy life seems pretty good, to me.
I've long held that if humanity has a purpose, as, as far as we can tell, the only beings born of the universe while also able to study and understand that universe, we should be looking into this whole "inevitable" heat death of the universe stuff. Kinda hits all three of your tenets.
Ive just turned 60, and only having potentially 20 years left is horrifying.
I'm only 36 and ready to go.
Extending a life with a good quality of life sounds great! I have to say that I definitely don't want to dictate who dies and who doesn't. But I do know that some societal progress does happen when the "from a different time" holdouts pass on of old age. I think we can find a way to adjust to it, but I do see that as a negative of longer lifespans. We need actual change at a quicker rate right now, but we're moving at a glacial pace, and sometimes even taking a step back.
Counter-question: how much do you think biological aging contributes to a person's resistance to change, and would being able to stay young for longer help us as a society become more open-minded and willing to try new things?
Professor Sinclair actually talks about it in his book. And it has some interesting points. For instance take some of the career politicians or supreme court members in the US that stay in it for life. If they don't pass on because of aging, will they feel like changing their mind on certain topics. Will you keep voting for that one "old" politician that has been representing your state/country because in general he has been doing a good job even though he has aspects that are just a bit outdated.
On the other hand, an older society might be more stable. Societal change can be a very disruptive, and even dangerous, process. Whilst something like the French Revolution might have produced a 'better' society, the Terror is called that for a reason, and it spawned a Napoleon hell-bent on conquering Europe.
What you ideally want is a society that can change and progress in a somewhat more stable manner, as a consequence of debate not whoever was angriest killing those who were in charge before them.
@Tech Priestess Micaela that's a good point, it'll make a problem that seems for some to be the future's problem, a more pressing issue. It could have that effect, I think he even mentioned that as a counterpoint. And I want to be that optimistic that'll it'll be helpful.
@@d.b.4671 I haven't even thought about that. I think it's a relevant point that changes how I should think about it.
I enjoy almost every minute of my life. Why wouldn't I want to have more. I hope if we discover how to stop aging we could also youthen 80 year olds.
Love your videos. I watched most on my TV, so could not subscribe before.
Great summary of the antiaging movement. Recently, the Saudi government has said they're devoting a billion dollars a year to longevity research. Calico, a branch of Google, has been quietly working on longevity treatment for years. You can get Metformin from an online doctor - I take it every day. I started my longevity journey at 50, and now I'm 59, the rubber is meeting the road, as they say, and I feel great. But it's never going to be just one thing - you have to eat smart, sleep smart, exercise every day, control stress, etc., as well as take supplements. I find it fascinating. If my friends of a similar age are the control group, then I'd say what I'm doing is definitely working. I have a lot I want to do. I would love to live for hundreds of years.
Interesting stuff. I'm in for doing anything I can to slow down aging and be healthier. I'm going to be 61 in August. I still look very young for my age. Most people are surprised. But with high blood pressure and a few other issues. I need to focus on some of these things contained in this video
Side note: "Intermittent fasting" is literally how most poor families eat daily. One meal, portioned for size and age. Caloric restrictions from day 1
Nah
Define poor.
I know true poverty can and does exist in the first world, but i donât think your description is what first world poverty looks like overall.
@@michaelgriffiths4498 this also isnât true lol
What is with people these days? Itâs like they are too busy getting all their information about the world from their phones that they canât even talk to people to figure out what their lives are actually likeâŠ
I was in food stamps for a while. $250 a month for a family of 3. That is enough to get by, but you arenât getting obese on that.
That's not Intermittent fasting that's malnourishment. If you don't get enough nutrients every day in your meals with fasting, you'll develop various diseases and even won't live that long. Fasting is not just "not eating".
It's not ebt that causes obesity, its cheap comfort food. America has a comfort food disorder