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- čas přidán 14. 10. 2023
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0:12 Building Blocks for Treatment Plan
0:42 Who is the lecture for?
0:51 Advanced Cancer outside the Prostate
1:03 What is the problem?
1:27 Oversimplification?
1:49 Too many diagnostic options?
1:59 Multiplicity of practice and business models?
2:24 Misunderstood terms and concepts?
2:40 Outdated perceptions?
3:04 Too much information
3:30 Goals of this presentation
4:02 The Basics of Advanced Prostate Cancer
6:13 "Updated" Biology of Advanced Prostate Cancer
6:38 "Clonal" theory of Cancer
6:45 The Heterogeneity of Prostate Cancer Cells
10:20 Systemic treatments as of 2023
10:48 What is a systemic therapy?
11:28 Suppressive therapies
13:05 Cytotoxic therapies
14:12 Mechanism of Action (MOA)
14:52 Testosterone promotes prostate cancer growth
16:01 GnRH Hormone Therapy
16:27 Anti-Androgen Hormone Therapy
16:58 Hormone (Castrate) Resistant Prostate Cancer
17:28 ARPI Hormone Therapy
18:55 Chemotherapy
19:55 Immunotherapy
20:37 Radioligand Therapy
21:40 What's the best way to create a treatment plan?
25:03 Abbreviations pertaining to forms of therapy
25:46 Case study: Newly diagnosed Advanced Prostate Cancer
27:39 Triple therapy
28:51 What if you didn't start with Triple Therapy?
29:48 Case 1: Failing HT?
32:51 Chemotherapy first
34:12 Case 2: Failing HT + ARPI?
38:50 Less differentiated = more aggressive cancer = LESS PSA & PSMA
39:36 PSA Zero
40:24 Case 3: Failing HT + prior CHtx?
42:19 Case 4: Failing HT + ARPI + prior CHtx?
45:35 Proper "care and feeding" of your treatment plan
46:00 Regular and comprehensive follow up is key
47:13 Prior genetic testing
49:36 Updating genetic testing
50:43 Mutations relevant to PARPi
52:13 Mutations relevant to immunotherapy
54:07 Mutations relevant to PARPi or immunotherapy
57:05 Regular and comprehensive follow summary
57:24 Direct treatments as of 2023
58:15 DIY Combat Manual for Beating Prostate Cancer Videos
59:02 Multiple ways that residual disease can be eliminated
59:21 Chest surgery example
59:47 Radiation therapy example
1:01:25 Minimal invasive procedures
1:02:33 Misunderstood concepts
1:03:18 Stand-of-Care
1:05:11 Guidlines
1:05:58 Clinical trials
1:09:43 Oversimplified view of disease
1:10:08 List to bring to with you to physician meetings
1:10:48 Dr. Kwon's Team
Don't know your stage? Take the quiz: visit www.prostatecancerstaging.org
To learn more about prostate cancer, visit www.pcri.org
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Who we are:
The Prostate Cancer Research Institute (PCRI) is a 501(c)(3) not-for-profit organization that is dedicated to helping you research your treatment options. We understand that you have many questions, and we can help you find the answers that are specific to your case. All of our resources are designed by a multidisciplinary team of advocates and expert physicians, for patients. We believe that by educating yourself about the disease, you will have more productive interactions with your medical professionals and receive better-individualized care. Feel free to explore our website at pcri.org or contact our free helpline with any questions that you have at pcri.org/helpline. Our Federal Tax ID # is 95-4617875 and qualifies for maximum charitable gift deductions by individual donors.
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I have prostate cancer Gleason 3+3=6, I'm 62 and have been watching this channel for a week or so. My father, died this year, age 93. He had his prostate removed in the 1980's (age~ 58) surgically from the rear (at that time this was state of the art and promised less side effects). Then a few months later, he had radiation for three or four months. The cancer returned and his PSA was over twenty in around ten years. He was put on hormone therapy every time his psa would go up very quickly to the upper teens or over twenty. Anyway, his prostate cancer was in his bones ect.. The last three year of his life he began taking some sort of chemo tablets, two per day. This was a last resort by an oncologist and he lived a few more years and was fairly happy despite having to run to the mens room often. Let's hope we can all live to our nineties cancer be darned.
I found the presentation on the topic of prostate cancer to be the most amazing and comprehensive one I've seen to date. I would like to express gratitude to Dr. Kwon and the PCRI (Prostate Cancer Research Institute) for the presentation and for sharing. I am 66-year-old individual with prostate cancer, specifically a Gleason Score (GS) of 9, and have undergone a prostate operation (2017), hormone therapy, and salvage radiotherapy (2021). My PSA (Prostate-Specific Antigen) has risen to 0.12 ng/mL. I am in a stage of contemplating their next steps in treatment and found the information session to be educational and helpful in providing guidance for their future treatment plan.
I'm 60 and had a radical robot prostatectomy 7 months ago. I just had a PSA .10 and I am now on Androgen and started 48 radiation treatments as we think the cancer is in my Lymphatic near operation site nothing showed on bone scan or other scans, but we believe this treatment plan should be done anyway as one of my nodes that was removed had cancer. I only had 5 radiation treatments so fare and only had talked to doctor about my treatment plans for only 5 minutes, so I know very little about my condition and treatments at this time. Thank you for helping me get up to speed. I'm so hungry for info that I hit up all sites to learn all I can, and this site was the most informative by far.
There can be no better lucid and indepth explanation all about prostate cancer and it's ramifications. I am an advance prostste cancer with metastatis..but the way this dr is pressenting so passionately and qualitatively , at 72 I wish I was a dr like this dr ..I have forgotten about my cancer after listening this dr .great..i am from India
Dr Kwon has been my Doctor for over 3 years the guy knows what he’s doing so listen to him. I started with stage 4 and a PSA of 93 and a Gleason 8. My first doctor started me with 44 radiation treatments. After that luckily my wife got me into Dr Kwon. I have had several different treatments that helped but always came back.I have done 5 of 6 treatments called Lutitium 177. So far my PSA is undetectable nothing new and nothing showing. I am hoping for a remission to last for longer 6 months. I’m very fortunate to have Dr Kwon and once he gets ahold of you he doesn’t let go. Thanks for all he has done.
Dr. Kwon and his team and associates are national treasures. I remember sitting on a chair for my first visit and the APRN introduced herself and asked me if I wasted to pursue containment or cure. I was speechless. Cure was not on the radar. Cure is not guaranteed. An associate said I had a 14 percent chance of not being cured. Meeting Dr Kwon was one of the most awesome moments of my life. I have trouble believing he is human and not angelic. Humility, compassion, empathy and caring do not always accompany genius. May God and the real angels protect and bless Dr. Kwon as he is a National treasure and his team sent by God to battle for our lives. Hopefully his understanding of Prostate cancer will spread across the world. God bless the Kwon Team. Thank you.
As usual, Dr, Kwon is articulate and to the point. Best presenter out there!
Thank you so much for this clear and informative video!
Thanks! You folks are appreciated!
This is the best summary I have ever seen -- excellent information, clearly organised and presented!
Thank you once again Dr. Kwon.
Probably the most concise and informative video I have seen since I was diagnosed with prostate cancer in 2018. wish I saw back then.
Great video that covers all the important points of advanced prostate cancer treatment in plain English. If you want a detailed overview and you are new to this disease, start with this video.
Dr. Kwon, this presentation was excellent and extremely informative. I will be meeting with my doctor shortly and plan to discuss some of your points presented here. Thank you again.
Clear, calm and thought provoking thank you .
Thank you very much Dr.Kwon.
Thank you for a great presentation it was very helpful
thanks for having a sense of humor! and adding new words to the vocabulary. I have 4 + 3 and I'm trying to get HiFU but what a wait.
Very thankful for pcri also glad u all get together to share info,my situation below ,next message