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Prof. Suresh Bada Math
India
Registrace 26. 11. 2011
I, Prof. Suresh Bada Math, am deeply committed to the profound wisdom of the 'Karmanye Vadhikaraste' Sloka from the Bhagavad Gita. It reminds us that while we have the right to perform our duties (Karma), we should not be attached to the outcomes. As intellectuals, we have a sacred duty to disseminate knowledge, uphold justice, and promote a healthy lifestyle. I passionately believe in the ideals of Education, Health, and Justice for all, which are not just ideals but a way of life for me. I am dedicated to making these principles a reality, to think of them, & to live by them every single day. I aim to empower healthcare professionals to reach those who are underserved, ensuring that the benefits of education, health, and justice are accessible to all. I also firmly embrace the principle of “Vasudhaiva Kutumbakam” (A Sanskrit phrase of Maha Upanishad) - which means "The World Is One Family,” highlighting our shared responsibility to make our planet a better place for everyone.
Long-acting Injection Flupentixol Decanoate
Long-acting Injection Flupentixol Decanoate
Flupentixol Decanoate is a prodrug, derived from the compound Flupentixol, which is a first-generation antipsychotic. The decanoate ester serves as a depot, allowing for a slow release of the active compound, Flupentixol, once administered intramuscularly. This pharmacokinetic feature ensures a prolonged duration of action, distinct from the rapid peaks and troughs seen with oral antipsychotics.
The following are some key pharmacological properties of Flupentixol Decanoate:
Slow and Steady Release: Flupentixol Decanoate exhibits a slow, steady release of the drug, with minimal fluctuations in plasma concentration over time. This property ensures a consistent therapeutic effect and reduces the need for frequent dosing.
Half-Life: The half-life of Flupentixol Decanoate typically ranges from 12 to 19 days, depending on individual factors, including metabolism and dosage. This extended half-life contributes to its prolonged therapeutic effect.
Metabolism: The decanoate ester undergoes hydrolysis to release the active Flupentixol. Once released, Flupentixol exerts its antipsychotic effects by antagonizing dopamine D2 receptors in the brain, among other mechanisms.
Administration and Frequency
Flupentixol Decanoate is administered as an intramuscular injection, typically into the gluteal muscle. The frequency of administration varies depending on the specific clinical indication and the patient's response to the medication. Common dosing schedules for Flupentixol Decanoate include:
Initial Loading Dose: A loading dose is often administered to establish a therapeutic level of the medication quickly. This loading dose typically ranges from 20 to 40 mg, although specific dosing may vary based on the patient's condition and previous antipsychotic exposure.
Maintenance Dosing: Following the loading dose, maintenance injections are given at regular intervals. Common dosing schedules include every two weeks, every three weeks, or monthly. The choice of dosing frequency is based on the patient's clinical response, side effect profile, and clinician's judgment.
Individualization of Treatment: It's important to individualize the treatment plan for each patient. Factors such as the patient's response to the medication, side effects, and clinical need should guide the choice of dosing schedule. Some patients may require more frequent injections, while others may benefit from less frequent administration.
Response Assessment: Clinicians should monitor the patient's clinical response and side effects regularly. Dosing adjustments can be made to optimize the therapeutic effect while minimizing side effects. Flexibility in dosing frequency is a significant advantage of long-acting antipsychotic medications like Flupentixol Decanoate.
Dosing and Titration
The optimal dose of Flupentixol Decanoate can vary from patient to patient, and clinicians should consider several factors when determining the appropriate dosage. The following dosing considerations are important:
Severity of Symptoms: Patients with severe or acute psychotic symptoms may require a higher initial loading dose to achieve a rapid therapeutic effect. Once symptoms are controlled, the maintenance dose can be adjusted accordingly.
Previous Antipsychotic Exposure: Patients transitioning from other antipsychotic medications to Flupentixol Decanoate may require specific dosing adjustments based on their previous treatment and the need for cross-titration.
Individual Response: Patient-specific factors, including metabolism, drug sensitivity, and the presence of comorbid conditions, can influence the optimal dose. Some individuals may respond well to lower doses, while others may require higher doses to achieve therapeutic benefit.
Weight and Body Mass: The patient's weight and body mass can influence the appropriate dosage. In some cases, a higher body mass may necessitate a slightly higher dose to maintain therapeutic plasma levels.
It is important for clinicians to titrate the dose carefully based on the patient's individual needs and to consider the risk-benefit profile. Over time, adjustments can be made as the patient's clinical condition and response to treatment evolve.
Flupentixol Decanoate is a prodrug, derived from the compound Flupentixol, which is a first-generation antipsychotic. The decanoate ester serves as a depot, allowing for a slow release of the active compound, Flupentixol, once administered intramuscularly. This pharmacokinetic feature ensures a prolonged duration of action, distinct from the rapid peaks and troughs seen with oral antipsychotics.
The following are some key pharmacological properties of Flupentixol Decanoate:
Slow and Steady Release: Flupentixol Decanoate exhibits a slow, steady release of the drug, with minimal fluctuations in plasma concentration over time. This property ensures a consistent therapeutic effect and reduces the need for frequent dosing.
Half-Life: The half-life of Flupentixol Decanoate typically ranges from 12 to 19 days, depending on individual factors, including metabolism and dosage. This extended half-life contributes to its prolonged therapeutic effect.
Metabolism: The decanoate ester undergoes hydrolysis to release the active Flupentixol. Once released, Flupentixol exerts its antipsychotic effects by antagonizing dopamine D2 receptors in the brain, among other mechanisms.
Administration and Frequency
Flupentixol Decanoate is administered as an intramuscular injection, typically into the gluteal muscle. The frequency of administration varies depending on the specific clinical indication and the patient's response to the medication. Common dosing schedules for Flupentixol Decanoate include:
Initial Loading Dose: A loading dose is often administered to establish a therapeutic level of the medication quickly. This loading dose typically ranges from 20 to 40 mg, although specific dosing may vary based on the patient's condition and previous antipsychotic exposure.
Maintenance Dosing: Following the loading dose, maintenance injections are given at regular intervals. Common dosing schedules include every two weeks, every three weeks, or monthly. The choice of dosing frequency is based on the patient's clinical response, side effect profile, and clinician's judgment.
Individualization of Treatment: It's important to individualize the treatment plan for each patient. Factors such as the patient's response to the medication, side effects, and clinical need should guide the choice of dosing schedule. Some patients may require more frequent injections, while others may benefit from less frequent administration.
Response Assessment: Clinicians should monitor the patient's clinical response and side effects regularly. Dosing adjustments can be made to optimize the therapeutic effect while minimizing side effects. Flexibility in dosing frequency is a significant advantage of long-acting antipsychotic medications like Flupentixol Decanoate.
Dosing and Titration
The optimal dose of Flupentixol Decanoate can vary from patient to patient, and clinicians should consider several factors when determining the appropriate dosage. The following dosing considerations are important:
Severity of Symptoms: Patients with severe or acute psychotic symptoms may require a higher initial loading dose to achieve a rapid therapeutic effect. Once symptoms are controlled, the maintenance dose can be adjusted accordingly.
Previous Antipsychotic Exposure: Patients transitioning from other antipsychotic medications to Flupentixol Decanoate may require specific dosing adjustments based on their previous treatment and the need for cross-titration.
Individual Response: Patient-specific factors, including metabolism, drug sensitivity, and the presence of comorbid conditions, can influence the optimal dose. Some individuals may respond well to lower doses, while others may require higher doses to achieve therapeutic benefit.
Weight and Body Mass: The patient's weight and body mass can influence the appropriate dosage. In some cases, a higher body mass may necessitate a slightly higher dose to maintain therapeutic plasma levels.
It is important for clinicians to titrate the dose carefully based on the patient's individual needs and to consider the risk-benefit profile. Over time, adjustments can be made as the patient's clinical condition and response to treatment evolve.
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Sir Flupentixol Decanoate is very effective in psychosis and less side effects
Are there any repurposed drug that could be used for clozapine resistant schizophrenia along with clozapine pls ?
I'm suffering from major depressive disorder with major psychotic symptoms from 7 long years. I've been taking treatment in abhaya hospital, Bangalore under Dr.jagadeesh. Im still suffering every day, I had dropped out of engineering College in 2022 , im still not able to go to college, im already 22 years of age, my career got ruined, i cant even step out of my bedroom , im under social withdrawal, my medication is not working at all , im extremely suicidal, i would like to consult you online. How can i get ur contact? Kindly reply
Please consult your doctor in-person at the earliest.
Sir...I am Jonah. A bsc psychology student sir... Sir... I am happy to leaen from you sir...
In my experience, I have noticed that a patient, with a general sense of sadness on acount of academic failure, was prescribed fluoxetine but became dangerously suicidal, homicidal and psychotic with visual hallucination. Accordingly, the patient was labeled bipolar and prescribed an anti-psychotic and mood stabilizer (olanzapine and valproate). The patient became lethargic and developed hypothyroidism and fatty liver disease and now also required treatment for dyslipidemia with atorvastatin. Aripiprazol was then prescribed as a replacement for olanzapine to 'minimise metabolic side effects of treatment'. Clonazepam and propranolol were additionally prescribed. The patient, however, became hypersexual and began experiencing unusual involuntary movement that appeared to the patient as if his bed was shaking during the night. The patient was admitted on account of a relapse and subjected to unconsented drug trials with clozapine. The drug trial, however, caused hypersalivation and tachycardia. ANC and WBC counts were not monitored while administrating Clozapine. The trial drug was swiftly withdrawn and replaced with lithium carbonate, the first line of treatment for bipolar disorder and the patient discharged. Inability to comprehend written information forced the patient to quit prescribed medication. The patient has now been off psychiatric drugs, stable for the last 5 years but still requires treatment for hypothyroidism and dyslipdemia and experiences chronic sinusitis with difficulty breathing from his right nostril. Can someone decipher this conundrum?
Sir i have a doubt...do levy body dementia have cure?..like is it reversible to back to normal?
Thank you sir 🙏
Short videos are very interesting sir .sir kindly make video on acute transient psychotic disorder especially management ..always have a confusion..
Thank you 🙏🏻 very much for your suggestion
Sir, can anyone with dyslexia persue mbbs with PwD reservation?
🙏⬜💐Excellent Professor Dr.Suresh BadaMath,Flupentixol Decanoate is very potent anti psychotic but with EPS. So, parasympathomimetic(agonist) drug is adjunct Rx is required. I highly respect your passionate mind, insight and wide spectrum knowledge in medical studies in our Bharat Barsha. Please stay safe and healthy and happy with your beautiful family and all yours NIMHANS colleagues. 💐⬜🙏
Prof. Suresh Bada Math, This is fantastic! I subscribed because I love it!
what happen when the father is indian and the mother from other country?
hindi vidio pleawswe
an informative, educative and indeed insightful Thank you Mwalimu
Thank you sir 🙏
Thanks a lot sir very informative lecture
Good standing certificate later... Wow great new laws 🎉
Thankyou so much sir...
Thanks sir 🙏
excellent class sir
Thank you doctor, it was a very informative session.
Hello sir, i have schezoprenia disorder from last many years. I have been taking medicine of olanzapine tablet. Sir i want to give UPSC exam. Will i be able to receive mental illness certificate for reservation?
thank you so much sir
amazing lecture, thank you doctor
Thank you sir, nicely elaborated ❤
Thank you sir.
Can OCD qualify for permanent disabilty certification?
Very informative
Dear Sir how can i contact with you can you please mention your email ID
Sir plz develop video on Global Burden of Disease
It's great that every video is evidence based
Good information
Iam suffering from depression sir
AVAILABILITY OF LONG ACTIVE HALOPERIDOL IS ALMOST NEGLIGIBLE NOW DAYS SIR
Sir I'm a student suffering from extreme social phobia ,are these services free, from tele Manas either mental health professionals or non-professionals
My experience with Akathesia: It felt, physically, like an electric motor was implanted at the base of my spine, where the tail bone meets. Because the motor kept running I could not sit still at all. *Torture*. I wanted so badly to relax and sleep but I could not. I tried alcohol - didn't work. I tried a strong Benzo - it too wouldn't stop the damn motor from running. This lasted for 48 hours plus, then started wearing off. It was awful and can't forget it, even though it was decades ago. It was precipitated by me taking 2 Navane tablets, recreationally. Because I was young and stupid. I never, ever want to go through Akathesia hell again.
Thank you so much sir
thank you so much sir
Sir is this curable
I took notes
Life saving information my friend. How can one know what one doesn’t know??? So much conflict of interest for the recipient.
I ask clarifying questions- inquisitive, also because it is important I understand what I’m consenting to!!! They provide no direct answers. I’m so greatly, this is one way that the Internet is useful and proactive!!! God is good. The truth wins, everything will be ok. Stay strong.
WOW. Thank you.
🌹⬜💐Very nice Hon’ble Ģreat prof.Dr.Suresh BadaMath. I highly respect your passion. Please stay safe and healthy and happy with your beautiful family. 💐⬜🌹
Sir where can I get this topic in which book can I refer sir I have a seminar please help me
Always have confusion in injectable dosage sir when read from book...but this video regarding haloperidol is very helpful.. kindly sir continue these videos discussing individual injectables
Sir, is brexpiprazole comparitively safe and available in Indian markets easily /prescribed likewise ?
excellent talk
Very important video thank you so much sir
Hello sir. Can you please make videos on tic disorder and tourette syndrome?? And also the role of antipsychotics in that? Thank you
Thank you sir for your wonderful lecture. Really helping