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Lonza
Switzerland
Registrace 3. 11. 2011
At Lonza, we enable #AHealthierWorld by supporting our healthcare customers on the path to commercialization. Our community of over 17,000 talented employees work across a global network of more than 30 sites to deliver for our customers across the pharma, biotech and nutrition markets.
A View On the History of Capsule Manufacturing
Tracing the Evolution and Future of Capsule Manufacturing
In this episode, we are joined by Ljiljana Palangetic, Associate Director of Hard Capsules R&D, and Bram Baert, Senior Director of Regulatory Affairs from Lonza, to delve into the intricacies of capsule manufacturing and the evolution of drug delivery technologies.
Your grandmother might have told you to “just swallow your medicine,” suggesting that you may have to endure something unpleasant but necessary. Today, however, this old saying might not ring true, as capsules have become ubiquitous in modern medicine. Favored by 44% of consumers, capsules simplify medication intake with their ease of swallowing and ability to mask unpleasant tastes. From ancient Egyptian leather pouches to modern high-tech production lines, capsules have undergone significant transformations, seamlessly integrating into our daily lives. Swallowing one’s medicine has never been so easy.
Yet the role of capsules has expanded far beyond taste masking. Today, they are engineered to deliver drugs to specific parts of the intestine, dissolve at controlled rates, and even contain multiple medications in one unit. This adaptability not only improves patient compliance but also caters to a myriad of medical needs. As we look toward the future, the potential for capsules in drug delivery is boundless, driven by continuous innovation and a deep understanding of materials science.
As mentioned in the podcast, if you haven’t already listened to episode 9 of this season, you can find out more about targeted drug delivery using capsules here.
Curious to Know More?
Join us in this conversation hosted by Martina Hestericova with Lonza's Ljiljana Palangetic and Bram Baert as they unveil the advancements in capsule manufacturing technologies and their impact on modern drug delivery systems.
KEY TERMS IN CONTEXT:
Regulatory Affairs are crucial for ensuring that all pharmaceutical products, including capsules, adhere to legal and regulatory standards. Professionals in regulatory affairs navigate the complex landscape of pharmaceutical manufacturing, particularly focusing on consumer and patient safety, by collaborating with health authorities to establish and update regulations that ensure the safety and efficacy of capsules.
Two-piece Capsules consist of a cap and a body that fit together, making them a versatile choice for different types of medication delivery. The design innovations of two-piece capsules have evolved significantly since their inception in the mid-19th century. They accommodate a multitude of materials such as powders or granules and playing a crucial role in modern automated manufacturing processes.
Designed to pass through the stomach intact and dissolve in the intestines, enteric capsules are crucial for drugs that can be deactivated by stomach acid or may cause irritation to the stomach lining. This technology ensures that medication is released in the part of the gastrointestinal tract where its absorption is optimized, thereby enhancing both the drug's effectiveness and patient comfort.
The use of polymer solutions is integral to forming the shells of capsules, particularly in technologies where a capsule is dipped into the solution, allowing the polymer to dry and harden. The choice of polymer affects the capsule's dissolution rate and stability, which is critical for ensuring that the drug is released at the correct rate and location in the body.
Made from thin membranes derived from the small intestines of sheep, SAPARIS capsules are an early form of specialized drug delivery technology. They were designed to allow for a slow dissolution rate, aiming to improve the timing of drug release within the body. This technology showcases the evolution of capsule materials from organic origins to today's synthetic and semi-synthetic materials used in capsule manufacturing.
In this episode, we are joined by Ljiljana Palangetic, Associate Director of Hard Capsules R&D, and Bram Baert, Senior Director of Regulatory Affairs from Lonza, to delve into the intricacies of capsule manufacturing and the evolution of drug delivery technologies.
Your grandmother might have told you to “just swallow your medicine,” suggesting that you may have to endure something unpleasant but necessary. Today, however, this old saying might not ring true, as capsules have become ubiquitous in modern medicine. Favored by 44% of consumers, capsules simplify medication intake with their ease of swallowing and ability to mask unpleasant tastes. From ancient Egyptian leather pouches to modern high-tech production lines, capsules have undergone significant transformations, seamlessly integrating into our daily lives. Swallowing one’s medicine has never been so easy.
Yet the role of capsules has expanded far beyond taste masking. Today, they are engineered to deliver drugs to specific parts of the intestine, dissolve at controlled rates, and even contain multiple medications in one unit. This adaptability not only improves patient compliance but also caters to a myriad of medical needs. As we look toward the future, the potential for capsules in drug delivery is boundless, driven by continuous innovation and a deep understanding of materials science.
As mentioned in the podcast, if you haven’t already listened to episode 9 of this season, you can find out more about targeted drug delivery using capsules here.
Curious to Know More?
Join us in this conversation hosted by Martina Hestericova with Lonza's Ljiljana Palangetic and Bram Baert as they unveil the advancements in capsule manufacturing technologies and their impact on modern drug delivery systems.
KEY TERMS IN CONTEXT:
Regulatory Affairs are crucial for ensuring that all pharmaceutical products, including capsules, adhere to legal and regulatory standards. Professionals in regulatory affairs navigate the complex landscape of pharmaceutical manufacturing, particularly focusing on consumer and patient safety, by collaborating with health authorities to establish and update regulations that ensure the safety and efficacy of capsules.
Two-piece Capsules consist of a cap and a body that fit together, making them a versatile choice for different types of medication delivery. The design innovations of two-piece capsules have evolved significantly since their inception in the mid-19th century. They accommodate a multitude of materials such as powders or granules and playing a crucial role in modern automated manufacturing processes.
Designed to pass through the stomach intact and dissolve in the intestines, enteric capsules are crucial for drugs that can be deactivated by stomach acid or may cause irritation to the stomach lining. This technology ensures that medication is released in the part of the gastrointestinal tract where its absorption is optimized, thereby enhancing both the drug's effectiveness and patient comfort.
The use of polymer solutions is integral to forming the shells of capsules, particularly in technologies where a capsule is dipped into the solution, allowing the polymer to dry and harden. The choice of polymer affects the capsule's dissolution rate and stability, which is critical for ensuring that the drug is released at the correct rate and location in the body.
Made from thin membranes derived from the small intestines of sheep, SAPARIS capsules are an early form of specialized drug delivery technology. They were designed to allow for a slow dissolution rate, aiming to improve the timing of drug release within the body. This technology showcases the evolution of capsule materials from organic origins to today's synthetic and semi-synthetic materials used in capsule manufacturing.
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3069 Lubowitz Path
259 Rowe Courts
2480 Krajcik Light
797 Kunde Ford
5952 Colt Extensions
Now this!!✅️🫶💯🎊
Wow this is amazing. I would love to join the team too😊
😊
Eure marketing bzw Viedeoabteilung braucht dringend ein besseres team.
Please hire me i have a masters degree in industrial automation
LGKHG is amazing like this rapidly
In a city with less than 10k people. I’ll pass 😂
❤
Total Bullshit. Lonza, Visp is a notoriously racist place [thats why they brought out this video] . Many of my Muslim colleagues can testify. Racism was wholesale during my time working for these hostile people. Do avoid. Also the amount of cover ups and mistakes in the production of biological medicine is absolutely astonishing. Terrible Site to work at. Ask anyone on Lindkn .
Vídeo só para quem estudou inglês. Para mim, inútil 😢
Vielen Dank
Water
A View On
Stay in India
For someone who has COPD, and use a CPAP device with humidifier, there MUST be some substance that can be added to the water to deliver some healing directly to the lungs. I've used my device every single night for over a year. I feel it's wasted time when it could be delivering actually good, easy to use, lung healing medications. I would even sit for a short period of time with a nebulizer if the liquid had some serious healing effects. If one can vape nicotine, there MUST be some other drug that will take advantage of such a device . Many come with prefilled, sealed capsules. Surely we should be able to get medicines delivered that way.
Bardo Ramos is going to spread HIV TO WOMEN AT LONZA HOUSTON. HE SMOKES WEED. HE IS A CONVICT. HE SEXUALLY HARRASSED ME AT LONZA. HE HAS SEX WITH MANY WOMEN AT LONZA.
Loves
Excellent
wow Nice vice video
Thank You For vaccine
Wonderful!!!
YOU'RE DONESKY 😊 🖕🤙
Logistik Erwachsenen guten guten Sparniss............
Nice 👍
Hello. I am a filmmaker and photographer located in Sierre, 20 min by train to Visp. In video industry around 4 years. I filmed interviews, tutorials, music clips, social media content and ads. I would like to create content for you. I can send you my portfolio if needed.
MURATORE TUTTO FARE, disponibile da subito!
Wondering why the use of the peptides is STILL not being used when it's been clearly effective for 40 years. I'm never giving money to cancer research ever again. Neither should you, sounds harsh but you're fueling the fire of corruption.
czcams.com/video/rmxUsAI29fw/video.html is this the same thing ?
Scary in the wrong hands...
Really enjoyed the conversation. Thank you for sharing
Proud to be part of Lonza….💐
😘 Pᵣₒmₒˢᵐ
Could it treat blood cancer?
Oncolytic viruses are viruses that have been modified to selectively target and kill cancer cells. These viruses can be naturally occurring or engineered in the laboratory to specifically infect and destroy cancer cells while sparing normal healthy cells. Oncolytic viruses work by replicating inside cancer cells and causing them to rupture and die, releasing new virus particles that can then infect and kill other cancer cells. One of the advantages of oncolytic viruses is their ability to not only directly kill cancer cells but also activate the immune system to attack the cancer. When cancer cells are killed by the virus, they release cancer-specific antigens that can be recognized by the immune system. This triggers an immune response that targets and kills remaining cancer cells throughout the body, even those that were not directly infected by the virus. Several different types of viruses have been studied as potential oncolytic agents, including herpes simplex virus, adenovirus, and measles virus. In recent years, the U.S. Food and Drug Administration (FDA) has approved several oncolytic viruses for the treatment of certain types of cancer, including talimogene laherparepvec (T-VEC) for advanced melanoma and Imlygic (also known as T-VEC) for inoperable melanoma lesions in the skin and lymph nodes. Oncolytic viruses are a promising area of cancer research, but they are still being evaluated in clinical trials to determine their safety and efficacy in different types of cancer.
Dr Obulor has broader my heart, i will always remember your efforts for helping me get rid of my cancer virus. what else can I say than thank you #Drobulor.
Dr Obulor has broader my heart, i will always remember your efforts for helping me get rid of my cancer virus. what else can I say than thank you #Drobulor.
Im gonna keep an eye on this company.
Would love to learn about this in regular words
Are y'all doing cryogenics?
Can't get more ambiguous than this. Is there any back story this? So weird.
Please,create real individual cartilages,bones,skin.. for reconstruction of NOSE!nobody thinking about it,but it’s so important! I’m dreaming to have my nose like it was before
Dr itepu on CZcams always keeps his words to the letter that is why is a doctor with a different, an inherited doctor his words can never go back in void without being accomplished. Thank you doctor for putting an end to my ailments called herpes virus. Thank you once again doctor
Covid calling
So should you be able to move certain exosomes from one area of the body and repair another? Isn't that also chemistry in your body too?