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# APPLES OR APPLE SLICES!!!!!!!!!!!!!

For those who say the video is too fast, it can be slowed down. Try 0.75 speed.

I lost you on "1 of 2 smokers dies from smoking "

Indeed the clearest and simplest explanation about Mendelian randomisation studies that I have come across. Thank you very much for this! 👍✌

los epidemiologos etan interesados en entender factores relacionados a la salud y a la enfermedad los fumadores tienden a morir antes que los no fumadores, eso pareceria cierto. pero desenredando causa-efecto puede ser dificil los fumadores son diferentes en general que los no fumadores, son propensos a tomar mucho alcohol y tienen una dieta menos saludable, pero aunque fueramos a medir estos factores, podriamos no medirlos perfectamente, o puede haber otros que no medimos tambien como cuando la gente se enferma pueden reducir o dejar de fumar, lo que puede erroneamente sugerir que la reduccion en el fumar apunta a peor salud podriamos asignar aleatoriamente 50000 personas a fumar y 50000 personas a no fumar y seguirlos y monitorear su salud, esto remueve la posibilidad que otro factor cualquiera peude ser responsable por cualquier diferencia que podemos ver en su salud a largo plazo, pero esto no es ni etico ni practico por fortuna todos hemos sido recrutados para un experimento sin saber. cuando hemos nacido, nuestro genes que pasaron al azar de generacion en generacion influencian cuando comemos tomamos, fumamos y mas. estas influencias geneticas no son afectadas por nada que vos elijas o no hacer en tu vida no estan relacionadas a los factores confusos. podemos usar este conocimiento para aprender acerca de causa y efecto. agrupando gente de acuerdo a su codigo genetico. este metodo es llamado aleatorización Mendeliana Por ejemplo fumadores que tienen una version de un gen llamado CH RNA 5 tienden a fumar mucho menos que fumadores que tienen una diferente version. cuando agrupamos gente de acuerdo a que version de este gen ellos tienen encontramos que gente con la version del gen asociado con fumar mucho suelen morir mas jovenes pero es el gen el que influencia que tanto vivimos, de otra manera:No lo pensamos. cuadno miramos al mismo gene en no fumadores, no hay efecto en la expectativa de vida. Entonces, el efecto debe ser impulsado por el fumar. usando este metodo puedes mostrar que fumar causa cancer de pulmon, enfermedades de corazon y respiratorias y muchas otras enfermedades pero no parece influenciar el choque o la ansiedad, La aleatorizacion Mendeliana ha empezado a decirnos sobre factores que influencian nuestro riesgo de enfermar. Ahora estamos usando el mismo enfoque en otros caminos, para mirar a muchos factores de riesgo agrupados y a ver que progresion de enfermedad influencia lo que nos puede ayudar a desarrollar nuevos tratamientos

the metaphor and animation of a balance is fantastic!!! very easy to understand

an app only half the population can use lol. Sorry Android Alcoholics! Your device isn't as monetizable so we don't care about you!

Nice art 🎨

Y'all need to delete and redo this,delete this,or just stop.

Wonderful explanation, thank you!

What is this style of animation called? (infographic?) I would like to use this technique for a university project assignment. Many thanks.

fashinating method!

lol if so then vapers would not have depression or anxiety it’s the nicotine which is the killer of mental health and tobacco for physical health

8 weeks and its a hell! I struggle with depression and concentration. Sometimes I think to my self, why The F did i quit?! But I know it was the right thing to do

Uhhgfv

Doesn't this really amount to a population-level survey of an incident phenotype, which you then correlate (severity or incidence) with the inheritance of known or random-panel variants? Not sure how this differs from standard GWAS.

Smoking ruined my life i started to feel depressed for no reason and my metal heath was really bad i was happier before now life became boring because i started smoking more

Went 8 months and then started going through some stuff. Now I’m back to square 1.

Am I the only one who finds the flat tone coupled with lightning speed extremely annoying? If you're gonna read off a script, why don't you just post the script instead for people to understand better?

Does anyone’s else’s heart beat fast after smoking , and gives them anxiety ?

Nicotine is definitely harmful

Thanks md for this link

False nicotine causes genetic breaks. Which cause cancer. It’s not harmless.

*Smoking cessation medications (especially prescribed ones) can cause serious problems.* I recently quit smoking "cold turkey" and just went through the withdrawal like an adult (crying in the bathtub only a few times). I had to do it this way because *nicotine patches sent me to the ER with sky-high elevated blood pressure and the worst panic attack of my life. I thought I was suffocating while breathing, for crying out loud. And the ER thought I was going to have a heart attack.* It is critically important to stress that everybody's body is different when you talk about things like this. It is highly irresponsible and misleading to claim smoking cessation aids are completely safe, as a quick search on any engine will tell you what I have already, just with actual data to back it up. I'd like to stop others from potentially harming themselves with those things. They do still release nicotine into your body and *have been proven to increase your reliance on it.* Please be more careful with your information and check everything. The lozenges and gum (OTC, unlike the patches) gave me headaches, which can lead to other *very serious problems.* No, they were not used at the same time. They were tried at different times over these past 2 years, that includes the patches. It is tough, but just stopping is the best way to approach it. Symptoms usually peak within the first 72 hours, and when you've been using cessation products to try and wean but still feel miserable after 3 days, well those are 3 days you could have spent completely stopping and you would be *so much further along* with your commitment to quit, and the worst will be over, or just about. Need a way to make sure you don't give in? Look up every possible health issue. You'd be surprised what smoking has the potential to cause. Too lazy to do that but like the idea of being scared with facts anyway? Try using openai chat. The AI is incredibly accurate and influenced by real data. It'll do the trick easily. It can also, believe it or not, provide support to you by telling you things like "You can do it!" and it remembers your conversation and progress better than your best friend could. It can also reassure you and encourage you if you do slip up during your detox. It does it with facts based on data, but the devs did put a surprising bit of human-looking compassion into its code. It won't judge you, either. It's there to help. ANYWAY! What about THC or CBD smoke? This applies to THC and CBD as well; while not as deadly as nicotine, if you are smoking it then you are still building tar up in your lungs. Assuming it is legal where you are either medically or recreationally, I have 2 ways to ingest it for you that will save your lungs (and heart, and stomach). It's better to ingest THC/CBD, which can be done by steeping it in tea for 10 minutes, or if you have a slow-cooker/crock pot, you can simmer peanut butter and chocolate (needs to be fatty and something like butter for the THC to bind to it) with your THC/CBD, pour everything out onto pastry sheets and arrange them like chocolate bars or nuggets and let sit in the fridge overnight. Bam. I just told you 2 easy ways to drink or eat your THC/CBD to help you avoid smoking it. But, to be honest? If you ARE going to quit cigarettes cold turkey as I have, it would help to have CBD or THC to smoke every 2 or 4 hours for the first 2 days. You should find yourself able to only "need" one or two hits of your THC/CBD product to feel satisfied enough. It won't help much with restless leg syndrome, which can be felt in the back as well, specifically the upper spine. If that's what your withdrawal feels like, then you may need to heed the things I've said as that signifies your body has some similar responses to this thing as mine does. (NOTE!!! It is POISONOUS to boil tobacco and ingest it. That is how you make homemade pesticides for your garden plants. Please do not ever drink tobacco water!!) Be aware that quitting cold you will experience mood swings, heartburn, dizziness, a restless night or two, sweating, etc. Don't be afraid of these sensations or emotions. You are fine. You are safe. It will pass. Here are some food suggestions that might help with some withdrawal issues: Fruits and vegetables: Incorporating fresh fruits and vegetables into your diet can provide essential vitamins, minerals, and antioxidants that support your overall well-being during withdrawal. Whole grains: Opt for whole grains like oats, brown rice, quinoa, and whole wheat bread. These foods provide sustained energy and can help stabilize blood sugar levels, which may help with mood swings. Protein-rich foods: Include protein sources such as lean meats, poultry, fish, eggs, beans, and nuts in your meals. Protein can help stabilize blood sugar levels and provide a feeling of satiety. Yogurt is also acceptable. Water: Staying hydrated is crucial during withdrawal. Drinking plenty of water helps flush toxins from your system and can help alleviate some withdrawal symptoms. It's important to note that while these foods may support your overall well-being during withdrawal, they won't directly alleviate nicotine withdrawal symptoms. However, maintaining a balanced diet can contribute to your overall health and may indirectly help you cope with the challenges of withdrawal. You can also spend the first 2 days just walking. It helps, it really does.

Its a nasty one to get rid of. I finally got off of them after so many tries............The best is (Obviously feeling better) to not mentally obsess over the nest hit/drag/fix of nicotine..........Its terrible when your in it knowing its killing you.......I could feel my heart getting weaker and weaker.......I had no energy........I would get exhausted midday.....Now I am up at 5am and am active until 10pm........its wild how much more energy I have..........Its incredible...!!

Trying vapes again

The irony of it is that heavy cigarette-smoking is often a sign of mental illness (or at least relatively poor mental health). People with bipolar disorder or serious depression often have a hard time staying away from the vices of alcoholism, cocaine addiction, heroin use or chain-smoking. No-one smokes cigarettes more than a psychiatric patient who’s just been released from the ward.

That was really cool. Thanks for that!

What if the SNP in question is associated with phenotypic differences that significantly affects the environment of the patient? I.e. the SNP causing sickle cell anemia, which is overrepresented among Black Americans. Would it not be possible for a SNP like that to lead to spurious associations between exposures and outcomes? I.e., you could think that the sickle cell anemia SNP leads to higher rates of Diabetes - but it's not the SNP in itself which is the cause of that, but a complex series of socioeconomic factors associated with being Black in the US?

Tabex - Sopharma if people are struggling. NRT keeps your nicotine habit! You're addicted to nicotine not smoke! WTH is the point in replacing nicotine with nicotine...duh!

great animation!

Day 13 on patches. Only time I've wanted one is at the times I normally would have had one (in the morning with coffee, after food, boredom) so I've changed my routine a bit and I don't miss smoking at all. Probably will when I drop to a lower dose of patches but that's a few weeks away yet

“Changing environments instead of minds might be the best way to change behavior”, in other words manipulation. My question is, who decides proper behaviors? If a person understands the risk and benefits of any given decision, yet they decide to go against the prevailing thought, then who are we as a society to disregard their decision. Even worse, you then abuse data to coerce and manipulate that person to bend to the prevailing view with no concern of the consequential harm you may have brought to this person. Forget being sneaky or wrongheaded, this way of thinking is flat out immoral and disrespectful. Furthermore, these manipulative methods could be used against any one of us at any given time. Think twice before participating in any rewards schemes that requires you giving up large amounts of person data! Its liable to end up bitting you in the ass!

Awesome explaination. Super clear. Thankyou! I'm sure that 2 minute clip of genius took a lot longer than 2 minutes to put together

Im on exactly a month, I have felt low to no cravings the last week, I decided to celebrate with my homie with a J, but we put a cig in it, just for the taste… godDAMN that was a mistake, the taste is horrible it ruined some perfectly fine Zaza, but ye I’m back on day 1 I guess?..

Day 56 of not having a ciggie am using a vape instead have saved a lot of money by just buying vapes really it's still addictive but you aren't getting all the crap with tobacco.

What a great video. I gonna break this down in a video! I hope you will like it. + 1 sub 🚭🚭🚭

Thank you for making this video!

Smoking provides the brain with carbon monoxide which prevents your brain from having enough oxygen also heavy metals like lead and arsenic are well known that destroy brain cells and cause payments IQ loss from smoking this is why smoking is well known for increasing stroke risk of which further causes more brain damage and toxic chemicals like radiative toxins in cigars and ciggectre Increase risk for being tumours and cancers

Drawing is so small.. unable to see it in portrait mode ... New Drawing should be in new slide.. You will get more views if it is more easy to see

2:10 did u say “smoking tobacco is dangerous not nicotine”? Nicotine is in tobacco

Damn! I got lost in the doodles. This is great way of explaining any information. I am wondering is there any app / software to do it.

great short and clear compared to the 1h long others vids... thanks!

I want to quit however its not worth the trouble or the pain I inflict on others when I do make the attempt, I don't like how I become without nicotene however I live in reality, I have lost too many friends and upset too many people shame no help exists for people like me.

This has to be the most useless video I have ever seen, I myself have schitzophreania and yes I am on medication I have searched so many videos how to deal with abusive or violent outbursts I have when I ever attempt to quit. I am not interested in being drugged up either through the withdrawals I gave up quitting nicotene I have had enough I am better with it than without it.

For me the withdrawal symptoms of giving up nicotene are terrible my personality changes, I get very aggresive and people can't handle being around me why I won't be giving up nicotene.

This video is not what I expected I myself become abusive verbally towards others without nicotene and can lash out physically I have tried quitting many times I vape now only reason I got off cigarettes this video was not the least bit helpful to me.

I wish this video wasn't at such a hyper speed. Makes it difficult to absorb the info!

I've realised noone can help you but yourself I've smoked weed and tobacco combined since I was 13 yr old for 20 years everyday of my life ...I'm 20 days clear now and have saved 550 quid by the end of the month !

Meanwhile me watching this video while smoking a cigarette 😀😀😀😀😀