Insilico Medicine
Insilico Medicine
  • 57
  • 126 696
Accelerating AI-driven Molecular Modeling with COSMIC
Researchers at Insilico Medicine, a clinical stage AI-driven drug discovery company, have developed a new adversarial generative framework for molecular conformation space modeling called COSMIC (molecular conformation space modeling in internal coordinates) that can provide important insights into the 3D positioning and activity of molecules to help drive decisions about drug design.
Published in the Journal of Chemical Information and Modeling, COSMIC provides accurate conformation space modeling more quickly than recent state-of-the-art diffusion models. The framework relies on a two-step process that involves constructing a conformation through internal coordinates and then predicting the distances between neighboring atoms to quickly refine the initial conformation.
COSMIC also introduces a new energy-based metric called RED (Relative Energy Difference) which evaluates the physical plausibility of generated conformations by accounting for conformation energy. This metric allows for large-scale, quantitative comparisons of energetic performance.
Learn more: www.eurekalert.org/news-releases/1042863
zhlédnutí: 117

Video

From Generative AI to Human Clinical Trials: A story of Insilico Medicine's TNIK Program
zhlédnutí 2,4KPřed 2 měsíci
Please do read the original paper here: Ren, et al. A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models. Nat Biotechnol (2024). doi.org/10.1038/s41587-024-02143-0 www.nature.com/articles/s41587-024-02143-0 This is our first take on a documentary video explaining the story behind our novel antifibrotic program where target discovery and disease modeling AI (Biolog...
Precious3GPT - Multimodal Omics Transformer from Insilico Medicine
zhlédnutí 801Před 2 měsíci
Precious3GPT is a genuinely multimodal transformer-based model trained to emulate the workflow of case-control studies, with an emphasis on chemical pertrubations. We have tokenized multiple data types and have trained one global model to perform multiple tasks in drug discovery, aging research, and synthetic data generation We plan to collaborate on Precious3GPT with multiple groups and then r...
Insilico Medicine - 10 Years of AI Drug Discovery Innovation
zhlédnutí 2KPřed 3 měsíci
Insilico Medicine was born at the Emerging Technology Centers in Baltimore in 2014 where founder and co-CEO Alex Zhavoronkov first began exploring combining bioinformatics with deep learning. He announced the company in 2015 at the NVIDIA GTC conference. The Company published our first proof-of-concept studies in 2016 in Nature Communications on a new method to uncover disease pathways using de...
Swan Lab - a Roballet (aka, "Robot Ballet")
zhlédnutí 750Před 6 měsíci
Insilico Medicine's AI-powered robotics lab is capable of performing all sorts of experiments in support of the Company's AI drug discovery efforts including cell culture, high throughput screening, next generation sequencing, cell imaging, and genomics analysis and prediction. In fact, these AI-powered autonomous guided vehicles are so advanced, they can even be trained to perform a ballet.
Training AI Robots with a Human Coach
zhlédnutí 382Před 6 měsíci
Insilico's AI-powered robotics lab is a key part of the Company's end-to-end Pharma.AI platform for drug discovery and development. The lab is capable of performing cell culture, high throughput screening, next generation sequencing, cell imaging, and genomics analysis and prediction autonomously. Here, Insilico Medicine founder and CEO Alex Zhavoronkov, PhD, shows how these "smart" robots can ...
Quick Tour of Insilico Medicine's AI-Powered Autonomous Robotics Lab
zhlédnutí 954Před 7 měsíci
Get a quick tour of Insilico Medicine's state-of-the-art AI-powered robotics lab in Suzhou, China. The 6th generation Life Star Lab is helping to accelerate our AI-powered drug discovery. In the lab, robots perform cell culture, high throughput screening, next-generation sequencing, cell imaging and genomics analysis and prediction - and all the data they generate feeds back into Insilico's end...
The Making of Insilico's AI-Powered Robotics Lab
zhlédnutí 484Před 7 měsíci
Built during the COVID-19 pandemic, Insilico Medicine's AI-powered robotics lab in Suzhou is an advanced, fully autonomous robotics facility that can process samples, identify targets, perform experiments, and validate results, all while providing data to strengthen Insilico's AI platform.
Insilico Medicine's AI-Powered Dancing Robots
zhlédnutí 298Před 7 měsíci
A demonstration of the unique trainability of the autonomous guided vehicles in Insilico Medicine's AI-powered robotics lab which are capable of performing cell culture, high throughput screening, next generation sequencing, cell imaging, and genomics analysis and prediction. The data generated from these robots feeds directly into Insilico's PandaOmics AI target discovery engine, improving the...
Legends of Longevity Biotechnology - the 10th ARDD Conference
zhlédnutí 662Před 8 měsíci
The non-profit conference "Aging Research for Drug Discovery" is the largest event in longevity biotechnology globally and in 2023 it will celebrate its 10th anniversary. Come to Copenhagen on August 28th and meet the Legends of Longevity Biotechnology. Or watch it online www.AgingPharma.org
Insilico Announces Preclinical Candidate for Inhalable Formulation of Generative AI IPF Drug
zhlédnutí 522Před 9 měsíci
📣 Announcing the preclinical candidate for an inhalation solution of ISM001-055, the first anti-fibrotic small molecule inhibitor developed leveraging Insilico's proprietary AI drug discovery platform Pharma.AI for the treatment of the chronic progressive lung disease Idiopathic Pulmonary Fibrosis (IPF). ● With promising preclinical results, Insilico is proceeding with IND filing as the first A...
More from Insilico's AI-powered robotics lab
zhlédnutí 462Před 10 měsíci
Insilico Medicine founder & CEO Alex Zhavoronkov shares the latest updates including 12 preclinical candidates and three clinical stage assets delivered from Insilico's end-to-end generative AI platform from inside Insilico's fully automated AI-powered robotics lab. "I think that AI can definitely transform the pharmaceutical industry in a big way." #pharma #ai #generativeai #drugdiscovery
Tour Insilico Medicine's AI-Powered Robotics Lab
zhlédnutí 2,8KPřed 10 měsíci
Insilico Medicine founder and CEO Alex Zhavoronkov gives a tour of Insilico’s AI-run robotics lab and describes a program to find new targets for colon cancer. Watch as autonomous guided vehicles take cell lines through microplating, imaging, incubation, and next generation sequencing. Collected data is fed into the AI, which selects the targets which will be validated using real compounds th...
Insilico Medicine's AI-Powered Robotics Lab
zhlédnutí 835Před 11 měsíci
Inside Insilico Medicine's next-generation AI-powered robotics lab.
Insilico Medicine Nominates 12th PCC Targeting ENPP1
zhlédnutí 249Před 11 měsíci
Insilico Medicine Nominates 12th PCC Targeting ENPP1
Introduction to Insilico Medicine's Free Course on Disease Modeling and Target Identification
zhlédnutí 678Před rokem
Introduction to Insilico Medicine's Free Course on Disease Modeling and Target Identification
Fireside chat with Michael Levitt: acceleration of AI-powered drug discovery
zhlédnutí 1,5KPřed rokem
Fireside chat with Michael Levitt: acceleration of AI-powered drug discovery
How AI Is Accelerating Drug Discovery
zhlédnutí 27KPřed rokem
How AI Is Accelerating Drug Discovery
Announcing ChatPandaGPT - 1st Chat Functionality in AI Drug Discovery
zhlédnutí 1,4KPřed rokem
Announcing ChatPandaGPT - 1st Chat Functionality in AI Drug Discovery
NVIDIA founder and CEO Jensen Huang GTC Keynote on Generative AI
zhlédnutí 826Před rokem
NVIDIA founder and CEO Jensen Huang GTC Keynote on Generative AI
Docuthon Judge Amelia Martyn-Hemphill
zhlédnutí 347Před rokem
Docuthon Judge Amelia Martyn-Hemphill
Insilico Medicine: An Extraordinary Journey
zhlédnutí 526Před rokem
Insilico Medicine: An Extraordinary Journey
Docuthon Judge Oren Rosenfeld
zhlédnutí 136Před rokem
Docuthon Judge Oren Rosenfeld
Grand Opening of Insilico Medicine's Generative AI and Quantum Computing R&D Center in Abu Dhabi
zhlédnutí 884Před rokem
Grand Opening of Insilico Medicine's Generative AI and Quantum Computing R&D Center in Abu Dhabi
Docuthon Judge: Alvaro Alvarez Ricciardelli
zhlédnutí 82Před rokem
Docuthon Judge: Alvaro Alvarez Ricciardelli
Insilico Medicine's 6th Generation Intelligent Robotics Lab
zhlédnutí 2,1KPřed rokem
Insilico Medicine's 6th Generation Intelligent Robotics Lab
Introducing Docuthon - A Documentary Hackathon for AI Drug Discovery
zhlédnutí 1,2KPřed rokem
Introducing Docuthon - A Documentary Hackathon for AI Drug Discovery
Decoding Cancer with AI
zhlédnutí 739Před rokem
Decoding Cancer with AI
Jensen Huang, Co-founder, President and CEO of NVIDIA at Insilico Medicine’s Pharma.AI Launch
zhlédnutí 2,1KPřed rokem
Jensen Huang, Co-founder, President and CEO of NVIDIA at Insilico Medicine’s Pharma.AI Launch
Pharma.AI Launch, November 14 2022
zhlédnutí 1,3KPřed rokem
Pharma.AI Launch, November 14 2022

Komentáře

  • @geroldbendix1651
    @geroldbendix1651 Před 5 dny

    The Miller Urey experiment, linking chemical evolution with biology isn't holistic or complete at all. It's basically a very thin straw which so-called scientist cling to. Just by a few amino acids you will get not DNA or more basically nucleic acids, what to speak of a living, self-reproducing cell. The whole evolution theory lasts on this very thin basis .It's nothing more than wishful thinking. These fools are mad for recognition and fame and every year they celebrate themselves, thinking themselves to be most advanced, but actually they are just polished animals. Why? Because they don't give any credit to the most intelligent of all scientists, God himself.

  • @johnasonharris2853
    @johnasonharris2853 Před 5 dny

    I appreciate the fact that a Nobel Laureate acknowledged credits for discoveries might not be fairly due to people, because of various circumstances.

  • @Encrypted628
    @Encrypted628 Před 6 dny

    Loved it. Prof. made the lecture so easy to follow and understand. Excellent.

  • @niamcd6604
    @niamcd6604 Před 28 dny

    OMG, what a surprise. The NEVER-Nobel committee gave yet another prize to a white old Man😮😮😮 Please, putting that on the title is OLD, obsolete, and nowadays offensive too. That prize is just a mediocre celebration of white male supremacy. Many of whom stole their work from others. Not to mention they give thar to one person instead of teams. And oh, let's not forget that SEVERAL scientists whose skin is dark brown are TO THIS DAY completely ignored. PLEASE! Hide that thing in the title and save ot for other white supremacists who care about that instead of ethical scientific research.

  • @reggiepalmer6157
    @reggiepalmer6157 Před měsícem

    Studying medicine and endocrinology for years as a bodybuilder, and graduating computer school in 1998. I dreamed of this happening and envisioned the future of medicine and health care finally being dominated by AI and ethical people. After witnessing with my own eyes in 1988 my girlfriend's mother get Cured of ovarian lymphatic and liver cancer stage 4. With a experimental drug from my girlfriend's Mother's roommate in college able to get medication through research and development from Dr BURZYNSKI. Only years later to watch the documentary BURZYNSKI the movie And to see just how scandalous and evil the FDA Drug companies and the medical community really is. Protect and bless all of you doing this great work.❤

  • @ganeshbhogaraju4558
    @ganeshbhogaraju4558 Před měsícem

    I will be happy, if you could share us with few techno managerial aspects of realtime problems that you deal with in your day to day activities.

  • @EYE-EM-Actor-TNT-EMT-BMT
    @EYE-EM-Actor-TNT-EMT-BMT Před měsícem

    Welcome to make branch in Bangladesh 🇧🇩

  • @davidmitchell3881
    @davidmitchell3881 Před 2 měsíci

    Fabulous case. Two thoughts. First could this be metastatic? Should he have a CT TAP? Second given that the inguinal lymph nodes are moderately enlarged perhaps an ultrasound might be useful. Ultrasound is better at identifing metastatic disease than CT for superficial lymph nodes. Biopsy might also be useful as the main lesion is tricky to biopsy

  • @bigal0172
    @bigal0172 Před 2 měsíci

    "Importantly, this success showed a massive milestone for our team and the broader generative AI field: from novel target discovery to Phase 1 testing in under 30 months. Relative to traditional drug discovery methodology, this AI-powered approach accomplished this feat in half the time and for a fraction of the cost." Amazing work! A true testament of the power of Generative AI.

  • @devyanipawar287
    @devyanipawar287 Před 2 měsíci

    Excellent !

  • @RajatThomas
    @RajatThomas Před 2 měsíci

    Super exciting! Keep up the great work.

  • @muninagarwala1987
    @muninagarwala1987 Před 2 měsíci

    Plz let me go there... I will not disappoint you.. I am very focused and dedicated...

  • @geeseylynn
    @geeseylynn Před 2 měsíci

    SEE PEOPLE! THIS IS THE CRAP! BOGUS! NARCISSISTIC! DO NOT FOLLOW THESE CRAZY PEOPLE!

  • @dipiti8739
    @dipiti8739 Před 2 měsíci

    AI will be badly misused to make lots and lots of garbage.

  • @tinacole1450
    @tinacole1450 Před 2 měsíci

    do you all utilize knime or know of any program which utilizing this tool in drug discovery ? I am trying to understand how to do similarity with it.

    • @niamcd6604
      @niamcd6604 Před 28 dny

      Forget about getting an answer, if our skin isn't bleached to white walls levels, they don't even see us.

  • @amirpy5426
    @amirpy5426 Před 2 měsíci

    Nice one, how about your plan for IPO? Any investment from Nvidia?

  • @SBalajii
    @SBalajii Před 3 měsíci

    this is great work! where can I learn more about timelines and ongoing trials?

  • @SAWARNCONCEPTpharmacy
    @SAWARNCONCEPTpharmacy Před 3 měsíci

    In the current status of Indian women people suffering from cervical cancer, Dear, insilco medicine please immediately prepare (manufacturing) cervical cancer drug for kill subatomic levels of cancer cells using AI techniques..... Thanku

  • @cityplanconsultores2188
    @cityplanconsultores2188 Před 3 měsíci

    cool

  • @AbiramiM-hu9tj
    @AbiramiM-hu9tj Před 4 měsíci

    What is the cost of inclinico

  • @sohanroking
    @sohanroking Před 4 měsíci

    Hi any course available about drug design course I am related to chemistry field

    • @niamcd6604
      @niamcd6604 Před 28 dny

      Keep dreaming. These large fake inflated egos are NOT here for science but to mentally m@sturb#te every time someone pretends to be impressed with their 'work'. Which most of the time is RESULT OF ACTUALLY LARGE TEAMS, and several other times STOLEN FROM STUDENTS.

  • @EZTechTraining
    @EZTechTraining Před 4 měsíci

    🎯 Key Takeaways for quick navigation: 01:08 🩸 *Blood pressure measurement on a smartwatch, like Omron's, is heavy and cumbersome, resulting in a bad experience (Tier E).* 01:49 🩸 *Measuring blood pressure on the upper arm is smooth, comfortable, and widely known, offering a great experience (Tier A).* 02:30 🩸 *Measuring blood pressure on the wrist, like with Lokavok, is similar to upper arm cuffs but smaller, falling into the "fine" category (Tier B).* 03:00 🍷 *Measuring blood alcohol content with digital devices can be fun and useful in countries with zero tolerance policies (Tier A).* 03:29 🍴 *Smart utensils like vibrating forks can teach users to eat slowly and change their behavior, resulting in a "fine" experience (Tier B).* 03:54 🌡️ *Measuring body temperature with a dedicated digital device can be useful but may seem redundant when integrated into other devices (Tier C).* 04:23 ❤️ *Measuring heart rate with smartwatches is a useful and effortless experience, categorized as "superb" (Tier S).* 04:51 🏋️ *Fitness tracking with various devices can be challenging to find the right fit but offers a smooth and great experience once chosen (Tier A).* 05:17 🛏️ *Measuring sleep quality under the mattress elevates the data but is not as essential as Smartwatch data, categorized as "fine" (Tier B).* 05:45 🛌 *Sleep quality headbands are an uncomfortable experience, earning an "awful" rating (Tier E).* 06:12 💤 *Measuring blood oxygen levels with dedicated devices is considered useless when most smartwatches can do the same, resulting in a "bad" experience (Tier D).* 06:52 ⏰ *Smart sleep alarms integrated into smartwatches are highly praised and deemed the most crucial feature for lifestyle improvement, rated as "superb" (Tier S).* 07:21 📈 *Measuring ECG on a smartwatch is convenient and helpful, falling under the "great" category (Tier A).* 07:48 💓 *ECG measurement on the chest with 24-hour devices provides accurate data, resulting in a "superb" experience (Tier S).* 08:18 🧡 *ECG measurement with your hands using devices like Cardia offers a superb experience, validated in clinical studies (Tier S).* 08:58 🧠 *Measuring EEG with a headband helps with meditation and mental health but is a tricky experience, leaning towards "meh" (Tier C).* 09:26 🤯 *Measuring stress with dedicated devices is considered unhelpful, especially when many smartwatches and apps offer stress tracking, resulting in a "bad" rating (Tier D).* 10:08 👀 *Measuring vision with devices like the IQ offers an extraordinary experience, being cheap, useful, and suitable for widespread use (Tier S).* 10:36 🩸 *Measuring blood glucose with skin patches is potential but comes with some discomfort and limitations, rated as "fine" (Tier B).* 11:59 👂 *Ear health devices like the HearScope allow users to check their inner ear health, providing useful data for physicians, categorized as "great" (Tier A).* 12:54 💨 *Measuring lung capacity, such as with the Smart Peak Flow for asthma management, offers a fine experience, despite some limitations (Tier B).* Made with HARPA AI

  • @AbellLincoln
    @AbellLincoln Před 4 měsíci

    God Gave Noah the Rainbow Sign No More Water but Fire Next Time 🌈🙏🔥📡🌎🎶💥🤵👰❤️‍🔥🤴👸

  • @missisipi9992
    @missisipi9992 Před 5 měsíci

    Спасибо вам Алекс, такая деятельность крайне нужна, медицина и фарма в плачевном состоянии

  • @marcarianlawfirm5926
    @marcarianlawfirm5926 Před 5 měsíci

    Find the Right Attorney for Your Case Can Seem Impossible. If you or someone you know has been seriously injured by the negligence of another person, or if you are facing a pharmacy law or medical malpractice lawyer, you need to speak to an attorney today. At the Marcarian Law Firm, we are ready to investigate your case today.

  • @gertykitchenbrand9569
    @gertykitchenbrand9569 Před 6 měsíci

    This is EVIL ON STEROIDS....CONTROLLED BY THE CABAL........GOD CREATED US TO NEVER NEED ANY DRUGS...

  • @akafrancais2182
    @akafrancais2182 Před 6 měsíci

    Вау

  • @SamuelOseiAsokwah
    @SamuelOseiAsokwah Před 6 měsíci

    I’m really interested in your works.. Thanks for the videos

  • @TolgaOzisik
    @TolgaOzisik Před 6 měsíci

    which model are these robot arms

  • @atrium2528
    @atrium2528 Před 6 měsíci

    Well, that's interesting.

  • @chesterman18g
    @chesterman18g Před 6 měsíci

    what did I just watch....

  • @josephvanname3377
    @josephvanname3377 Před 6 měsíci

    reversible computing

  • @CreeperLP81
    @CreeperLP81 Před 6 měsíci

    That looks awesome but why does it feel like a stop motion movie ?

  • @punishedfoxo
    @punishedfoxo Před 6 měsíci

    Not an e-stop in sight 😬

  • @user-ij4rz3jz7b
    @user-ij4rz3jz7b Před 7 měsíci

    ❤praise God 🐕 thank you Jesus Christ for being our savior ❤

  • @metamind095
    @metamind095 Před 7 měsíci

    Amazing setup you ve there! Please find a better analog to tabernanthalog that is derived from ibogaine...that has GDNF enhancing properties. Wish you all the best.

  • @georgejetson2637
    @georgejetson2637 Před 7 měsíci

    Took our juuurbs😂😂😂

  • @merlynraber3308
    @merlynraber3308 Před 7 měsíci

    When will the new dug be available?

  • @kinngrimm
    @kinngrimm Před 7 měsíci

    I am rather sceptical on the claim that AI would democratize anything, especially aslong they are owned and controllled by corporations. In a worst case scenario the opposite may become true as in part we see it in China and the USA where their gigantic survialance capabilities can be used in ways not conform to democratic principles either directly on their own population or indirectly on the population of other nations where it somehow then becomes ok. Medicly used AI may not be an exception there either.

  • @ALFTHADRADDAD
    @ALFTHADRADDAD Před 8 měsíci

    Tight

  • @alif_saiyyed
    @alif_saiyyed Před 8 měsíci

    Starts at 4.30

  • @SilverFan21k
    @SilverFan21k Před 8 měsíci

    Ha cool video

  • @Dan-xl8jv
    @Dan-xl8jv Před 8 měsíci

    Excellent presentation. Really gives a holistic overview of the field and the way alpha fold can’t achieve what it did without standing on the shoulder of past sixty years of work in producing the examples and data.

  • @BitsOfQuantum
    @BitsOfQuantum Před 8 měsíci

    That's great you work in drug discovery: thank you for your contributions. As you know better than me, drugs are temperature sensitive; how do you feel about big pharma shipping there medications in uncontrolled containers? For example, a chemotherapy pill which states not to exceed a certain temp.

    • @murkje
      @murkje Před 7 měsíci

      what a great question, just here incase you get an answer

  • @Telencephelon
    @Telencephelon Před 8 měsíci

    360p. That's advanced

  • @curingaging
    @curingaging Před 8 měsíci

    excited to be there!

  • @surfreadjumpsleep
    @surfreadjumpsleep Před 8 měsíci

    can we watch online while it happens or will it be released slowly over the year like prior years?

  • @surfreadjumpsleep
    @surfreadjumpsleep Před 8 měsíci

    excited about AI working on science.

  • @user-ih2tt4ji6g
    @user-ih2tt4ji6g Před 9 měsíci

    I am interested in drug discovery in computer design please.

  • @RitaArrigo
    @RitaArrigo Před 9 měsíci

    Loved the Idea of an AI for A Human, The digital twin of the Human Body