- 17
- 3 077
Metrion Biosciences Ltd
United Kingdom
Registrace 17. 01. 2017
Metrion Biosciences is a specialist preclinical drug discovery CRO - your trusted partner for ion channel and cardiac safety screening. We provide highly skilled electrophysiology screening services for the support of client medicinal chemistry optimisation programmes, CiPA compliant cardiac safety profiling assays, neuroscience assays and translational assays.
Working closely with our collaborators, we also offer an expert integrated drug discovery service. Business models are flexible according to the scope of each programme, with both fee-for-service and collaborative options available.
Working closely with our collaborators, we also offer an expert integrated drug discovery service. Business models are flexible according to the scope of each programme, with both fee-for-service and collaborative options available.
In Vitro Assessment of Cardiac Risk in Drug Discovery
Learn how an hiPSC-CM model can help provide clear decision-making data for your project team that can avoid costly issues related to QTc and QRS cardiac liabilities in the clinic.
Presentations:
Opportunities to Leverage Non-clinical Data in a Regulatory Integrated QTc Assessment (Derek Leishman, Vice President Translational and Quantitative Toxicology, Eli Lilly and Company).
A Clinically Translatable hIPSC Cardiomyocyte Model to Predict QTc and QRS Cardiac Risk (Steve Jenkinson, Vice President Drug Discovery and Safety, Metrion Biosciences).
Chaired by Eddy Stevens, CSO, Metrion Biosciences.
Presentations:
Opportunities to Leverage Non-clinical Data in a Regulatory Integrated QTc Assessment (Derek Leishman, Vice President Translational and Quantitative Toxicology, Eli Lilly and Company).
A Clinically Translatable hIPSC Cardiomyocyte Model to Predict QTc and QRS Cardiac Risk (Steve Jenkinson, Vice President Drug Discovery and Safety, Metrion Biosciences).
Chaired by Eddy Stevens, CSO, Metrion Biosciences.
zhlédnutí: 75
Video
Studying ion channels on the lysosomal membrane
zhlédnutí 50Před 3 měsíci
To enable the study of ion channels found on the lysosomal membrane we perform the lysosomal patch-clamp technique.
Effect of hERG blocker ondansetron on action potential waveform in human stem cell cardiomyocytes
zhlédnutí 34Před 4 měsíci
Effect of the hERG blocker ondansetron on the action potential waveform in human stem cell cardiomyocytes
Demonstration of Endo-Lysosomal Patch Clamp Technique
zhlédnutí 219Před 5 měsíci
We demonstrate our endo-lysosomal extraction technique to enable the study of ion channels found on the lysosomal membrane.
Metrion's Neuroscience Services
zhlédnutí 242Před rokem
This video provides an overview of Metrion's neuroscience focused services including the Company's cell line generation capabilities, neuroscience related ion channel screening and translational work with iPSC neurons.
High Throughput Screening at Metrion Biosciences
zhlédnutí 557Před rokem
A summary of Metrion Biosciences' HTS services including liquid handling capabilities and high throughput automated electrophysiology screening services.
Cardiac Safety Services
zhlédnutí 151Před rokem
Metrion Biosciences offer a variety of cardiac safety screening services documented within this video. Please contact us for more information (info@metrionbiosciences.com).
Metrion Webinar - Dr. Manoj Patel
zhlédnutí 104Před rokem
Watch on demand the Metrion Biosciences webinar presented by Manoj K. Patel, Ph.D, Associate Professor at the University of Virginia where he speaks about “Gain-of-function mutations in Nav1.6 and epileptic seizures“.
Metrion Biosciences laboratory Tour
zhlédnutí 620Před 2 lety
Metrion Biosciences is a specialist ion channel contract research organisation providing drug discovery services to pharmaceutical and bioscience customers worldwide. In this video you can view our laboratories and learn more about our capabilities from members of the Metrion team.
Metrion Webinar - Dr Kris Kahlig
zhlédnutí 72Před 2 lety
Watch on demand the Metrion Biosciences Webinar presented by Dr Kris Kahlig from Praxis Precision Medicines. Kris presentation was titled: "Using Dynamic Action Potential Clamp Modeling of Nav1.2 Variants to Support the Prediction of Clinical Phenotype in DEE”.
Metrion Webinar - Dr Greg Carr - LIBD
zhlédnutí 105Před 2 lety
Dr Greg Carr from the Lieber Institute for Brain Development presents "A role for hERG potassium channels in cognitive function” as part of the Metrion Biosciences "Ion Channels in Drug Discovery" webinar series. The human Ether-a-go-go related gene (hERG; KCNH2) codes for a potassium channel subunit, Kv11.1, that is a critical component of the cardiac action potential. The hERG channel is a si...
Metrion Webinar - Presented by Professor David Sheppard
zhlédnutí 78Před 2 lety
Watch on demand the third Metrion Biosciences Webinar presented by Professor David Sheppard. David's talk is entitled: "Cystic Fibrosis: Rescuing Faulty Channels with Targeted Therapies". There are also a series of slides detailing the Q&A session which followed the webinar presentation.
Professor Stephen Tucker presents Metrion's second webinar
zhlédnutí 145Před 2 lety
Watch on demand the second webinar in the Metrion Biosciences Webinar Series, including a brief introduction from Metrion's CSO Dr Marc Rogers, followed by the main presentation from Professor Stephen Tucker from the University of Oxford. Stephen presents: “Defective X-gating caused by de novo mutations in the TASK-1 K2P channel (KCNK3) underlies a developmental disorder with sleep apnea”. The ...
Metrion Newsletter Summary June 2021
zhlédnutí 38Před 3 lety
A summary of the quarter two Metrion Biosciences newsletter presented by Sales and Marketing Manager Dr Sophie Rose.
Metrion Biosciences CEO Overview Presentation
zhlédnutí 271Před 3 lety
Metrion Biosciences' CEO, Dr Andy Southan presents an overview of Metrion's services and expertise.
Validation and optimization of automated patch clamp voltage-gated Ca2+ channel assays
zhlédnutí 50Před 4 lety
Validation and optimization of automated patch clamp voltage-gated Ca2 channel assays
Targeting ion channels in drug discovery
zhlédnutí 267Před 4 lety
Targeting ion channels in drug discovery